Oligomeric Hyaluronic Acid (Oligo-HA) Description

Oligomeric Hyaluronic Acid (Oligo-HA) is a new product developed by bio-enzymatic degradation technology. Its molecular weight varies from 3,000Da to 10,000Da, allowing it to be absorbed more easily by the skin and thus have a deep moisturizing effect.

Oligomeric Hyaluronic Acid (Oligo-HA) Specification

Oligomeric Hyaluronic Acid (Oligo-HA) has a molecular weight 3,000Da～10,000Da and the average molecule size is less than 25nm, so it penetrates easily into the skin and nourishes the skin.

Oligomeric Hyaluronic Acid (Oligo-HA) Applications

In the Cosmetic Field

• Transdermal absorption, deep moisturizing
• Repairing damaged cells and scavenging free radicals
• Anti-aging

In the Food Health Field

• Strong water retention and water retention capacity

In the Medical Field

• Antioxidant
• Anti-tumor
• Immunomodulatory
• Inflammatory and wound healing
• Pro-angiogenic

Oligomeric Hyaluronic Acid (Oligo-HA) is developed by bio-enzymatic degradation technology. In mammals, the enzymatic degradation of HA results from the action of three types of enzymes: hyaluronidase (hyase), b-d-glucuronidase, and β-Nacetyl-hexosaminidase. Throughout the body, these enzymes are found in various forms, intracellularly and in serum.

In general, hyase cleaves high molecular weight HA into smaller oligosaccharides while β-d-glucuronidase and β-N-acetylhexosaminidase further degrade the oligosaccharide fragments by removing nonreducing terminal sugars (Leach and Schmidt, 2004).

The degradation products of hyaluronan, oligosaccharides, and very low molecular weight hyaluronan, exhibit pro-angiogenic properties (Mio and Stern, 2002).

By catalyzing the hydrolysis of hyaluronic acid, a major constituent of the interstitial barrier, hyaluronidase lowers the viscosity of hyaluronic acid, thereby increasing tissue permeability. It is, therefore, used in medicine in conjunction with other drugs in order to speed their dispersion and delivery.

Reference

1. Necas , L. Bartosikova , P. Brauner , J. Kolar: Hyaluronic acid (hyaluronan): a review. Veterinarni Medicina, 53, 2008 (8): 397–411