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Top 5 Powerful Benefits of Dihydromyricetin in Health

Dihydromyricetin (DHM) is a natural flavonoid compound primarily found in plants such as Ampelopsis grossedentata and Artemisia annua. In recent years, DHM has garnered widespread attention for its various health benefits and potential medicinal value. This article introduces the top 5 health benefits of Dihydromyricetin.

Fig 1. Top 5 Benefits of DHM

1. DHM: The Antioxidant for Health and Wellness

Dihydromyricetin has excellent antioxidant activity, which offers several benefits.

Benefits of DHM in Antioxidant

DHM can scavenge free radicals. We know that excessive free radicals can cause cell damage and oxidative stress. Dihydromyricetin can react with free radicals and neutralize them.

Moreover, DHM can inhibit lipid peroxidation. Because the formation of lipid peroxides is prevented, the integrity of the cell membrane is protected.

In addition, Dihydromyricetin can upregulate the activity of antioxidant enzymes in the body. And then it can enhance the body’s antioxidant defense ability.

Applications Based on Antioxidant Properties:

This antioxidant effect shows great potential in various applications.

• Antioxidant Supplements: DHM is widely used in antioxidant supplements to help consumers neutralize excess free radicals, protect cells, slow aging, and prevent chronic diseases.
• Food Additives: DHM’s antioxidant properties make it an ideal natural food preservative, preventing lipid oxidation in foods, extending shelf life, and maintaining freshness and nutritional value.
• Anti-aging Skincare: Dihydromyricetin is commonly used in anti-aging skincare products. It can neutralize free radicals in the skin and prevent oxidative damage. Apart from that, DHM can reduce wrinkles and fine lines, and maintain skin elasticity and radiance.
• Sunscreen Products: DHM’s antioxidant effect helps counteract oxidative stress caused by UV radiation. It then protects the skin by reducing sun damage and photoaging.

2. DHM: The Natural Solution for Inflammation Relief

Extensive basic research and animal experiments have evidenced the anti-inflammatory effects of DHM. Clinical studies also provide compelling evidence of DHM’s anti-inflammatory efficacy in humans.

Benefits of DHM in Anti-inflammatory

Experimental evidence suggests that dihydromyricetin exerts its anti-inflammatory effects mainly through:

• Inhibition of Inflammatory Mediator Production: DHM reduces the production of cytokines and other inflammatory mediators.
• Regulation of Inflammatory Signaling Pathways: Dihydromyricetin modulates pathways such as NF-κB, which are crucial for the inflammatory response.
• Inhibition of Inflammatory Cell Migration and Activation: DHM prevents the movement and activation of cells involved in inflammation.

Fig 2. Anti-inflammatory effects of dihydromyricetin

Applications in Anti-inflammatory Treatments:

The above studies will provide a more solid scientific basis for the application of DHM in anti-inflammatory treatment.

• Anti-inflammatory Drugs: Dihydromyricetin is a promising candidate for developing drugs to treat various acute and chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
• Anti-inflammatory Health Supplements: Dihydromyricetin is used in health supplements to help consumers reduce chronic inflammation and prevent chronic diseases.
• Anti-inflammatory Skincare: DHM is used in skincare products to alleviate skin inflammation, such as acne and eczema, promoting skin health.
• Soothing Repair Products: The anti-inflammatory and antioxidant properties of Dihydromyricetin make it an ideal component in products designed to repair damaged skin and reduce inflammation.

More information: Dihydromyricetin (DHM) for Inflammatory Diseases and Anxiety Disorders

3. DHM: Nature’s Weapon Against Cancer

Multiple studies have shown that Dihydromyricetin can effectively inhibit the proliferation of various cancer cells in vitro, including liver cancer, breast cancer, gastric cancer, and lung cancer. In animal models, Dihydromyricetin has been proven to significantly suppress tumor growth. For instance, a study demonstrated that DHM significantly reduced tumor volume and weight in a mouse model of breast cancer while lowering tumor angiogenesis.[i]

Benefits of DHM in Anticancer:

• Inhibition of Cancer Cell Proliferation: DHM blocks the cell cycle, preventing cancer cells from dividing and growing.
• Induction of Cancer Cell Apoptosis: Dihydromyricetin triggers apoptosis, or programmed cell death, in cancer cells.
• Inhibition of Tumor Angiogenesis: DHM prevents the formation of new blood vessels that supply nutrients to tumors.
• Inhibition of Cancer Cell Invasion and Metastasis: DHM reduces the ability of cancer cells to invade surrounding tissues and spread to other parts of the body.

Applications in Cancer Treatment:

Although existing clinical research is still in its early stages, Dihydromyricetin, as a natural, low-toxic anticancer compound, has broad application prospects.

• Cancer Drug Development: DHM’s multiple anticancer mechanisms make it a potential candidate for developing anticancer drugs. It can be used alone or in combination with other chemotherapeutic agents to enhance efficacy and reduce side effects.
• Adjunctive Therapy: Dihydromyricetin can be used as an adjunctive treatment for cancer patients. It helps to mitigate the side effects of chemotherapy and radiation therapy.

4. DHM: Nature’s Defense for Liver Health

Dihydromyricetin is recognized for its potent antioxidant, anti-inflammatory, and antifibrotic properties, making it an effective liver-protective agent.

Benefits of DHM in Liver Protection:

Dihydromyricetin has a strong antioxidant effect and can reduce the damage of oxidative stress to liver cells. In addition, DHM can inhibit the production of inflammatory mediators, reduce inflammatory response, and thus protect the liver.

Additionally, dihydromyricetin can inhibit the progression of liver fibrosis. It reduces the degree of liver fibrosis by reducing the deposition of collagen and the activation of hepatic stellate cells.

DHM also can promote the regeneration and repair of liver cells and enhance the self-repair ability of the liver.

Applications in Liver Health:

DHM’s liver-protecting effect makes it widely used in health products and medicines.

• Liver Health Supplements: DHM is widely used in liver health supplements to improve liver function and prevent or mitigate alcohol-induced liver damage.
• Hangover Remedies: DHM is a key ingredient in hangover remedies. It aids in the acceleration of alcohol consumption and reduces hangover symptoms. Ultimately, it protects the liver from alcohol damage. Maybe you are interested: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?
• Anti-fibrotic drugs: Dihydromyricetin has anti-fibrotic properties. Therefore, It is a potential candidate for drugs to treat various fibrotic liver diseases.
• Hepatitis treatment: Dihydromyricetin is expected to reduce liver damage caused by viral hepatitis. So, it is used to develop drugs for hepatitis treatment.
• Functional foods: Dihydromyricetin is added to functional foods to enhance their health benefits.

5. DHM: A Natural Solution for Cardiovascular Health

Dihydromyricetin exhibits significant antithrombotic and lipid-lowering effects, which contribute to cardiovascular protection.

Benefits of DHM in Cardiovascular Protection

It can inhibit platelet aggregation and reduce the risk of thrombosis. In addition, DHM maintains the normal function of blood vessels by enhancing endothelial function, promoting vasodilation, and inhibiting vasoconstriction.

Applications in Cardiovascular Health:

DHM’s effects on the cardiovascular system have been applied in the healthcare and medical industries.

• Cardiovascular Health Supplements: DHM is used in supplements to help consumers prevent cardiovascular diseases and improve cardiovascular function. Its antioxidant and anti-inflammatory properties make it an ideal cardiovascular protective agent.
• Anti-Atherosclerotic Drugs: DHM’s anti-inflammatory and antioxidant actions make it a potential candidate for developing drugs to prevent and treat atherosclerosis.
• Lipid-Lowering Drugs: DHM’s ability to regulate lipid levels suggests it could be used in developing drugs to lower cholesterol and reduce the risk of cardiovascular diseases.

Additional Benefits of Dihydromyricetin

Dihydromyricetin is a versatile natural compound with a wide range of health benefits. In addition to the five benefits listed above, dihydromyricetin has other benefits.

1. Neuroprotective Effects

Dihydromyricetin has shown promising neuroprotective effects. DHM may help in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies suggest that DHM improves cognitive performance and memory by reducing oxidative stress and inflammation in the brain​.

2. Metabolic Health

DHM has been found to have beneficial effects on metabolic health.

• Improving Insulin Sensitivity: DHM enhances insulin sensitivity, which can help in managing blood sugar levels and reducing the risk of type 2 diabetes​.
• Reducing Fat Accumulation: DHM can inhibit the differentiation of preadipocytes into adipocytes, thus reducing fat accumulation and helping in weight management​.
• Lowering Blood Glucose Levels: DHM has been shown to lower fasting blood glucose levels in animal studies, indicating potential benefits for diabetic patients​.

Fig 3. blood glucose

3. Anti-aging Properties

Beyond its antioxidant effects, dihydromyricetin contributes to overall anti-aging. It’s because DHM may extend the lifespan of cells by protecting them from oxidative stress.​

4. Skin Health

DHM can reduce Hyperpigmentation and promote collagen production. In addition, dihydromyricetin’s antioxidant properties protect the skin from damage caused by UV radiation.

5. Immune System Support

DHM can modulate the immune system by enhancing immune response and regulating inflammatory responses.

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Conclusion

The multiple health benefits of Dihydromyricetin make it a valuable compound for various applications in health and medicine. Its powerful antioxidant, anti-inflammatory, anticancer, liver-protective, and cardiovascular-protective properties provide a strong foundation for developing new health supplements, functional foods, and pharmaceuticals. As research continues, DHM’s full potential in promoting health and preventing disease will likely be further realized, offering new avenues for enhancing human well-being.

[i] Chen, L., Yang, Z.S., Zhou, Y.Z., Deng, Y., Jiang, P., Tan, S.L. (2020). Dihydromyricetin inhibits cell proliferation, migration, and invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells. Journal of Cancer, 11(19), 5689-5699. https://doi.org/10.7150/jca.45970.