040-000-256 Metformin (Hydrochloride), CAS 1115-70-4

Description

Metformin Hydrochloride Specifications

Metformin Hydrochloride Description

Metformin is now a first-line agent for the treatment of type 2 diabetes, and can be used alone or in combination with sulfonylureas, thiazolidinediones or other hypoglycemic agents. It can increase the activity of AMPK and reduces blood glucose by more than 50% in mice, according to the research. In recent years, more and more research has focused on the role of metformin in cancer.

Metformin Hydrochloride Benefits

• Blood Sugar Control: Metformin works by reducing the amount of glucose (sugar) produced by the liver and improving the body’s response to insulin, a hormone that regulates the absorption of sugar into your cells. This helps to lower blood sugar levels and improve blood sugar control.
• Weight Management: Metformin can help with weight loss in some people with type 2 diabetes. It may reduce appetite and help people feel full longer, which can lead to a decrease in calorie intake.
• Cardiovascular Benefits: Metformin has been shown to have cardiovascular benefits. It may reduce the risk of heart disease and stroke in people with type 2 diabetes.

Metformin Hydrochloride Uses

• Type 2 Diabetes: Metformin is used together with diet and exercise to improve blood sugar control in adults and children with type 2 diabetes mellitus.
• Prediabetes: In some cases, metformin is used to treat people with prediabetes to prevent the progression to type 2 diabetes.
• Polycystic Ovary Syndrome (PCOS): Metformin is sometimes used to treat insulin resistance in women with PCOS, a hormonal disorder that can cause irregular periods, unwanted hair growth, and infertility.

Metformin Hydrochloride Side Effects

• Gastrointestinal Symptoms: These may include nausea, vomiting, stomach upset, diarrhea, and loss of appetite. These side effects often occur when starting the medication and may diminish over time.
• Vitamin B12 Deficiency: Long-term use of metformin can lead to vitamin B12 deficiency, which can cause anemia and nerve damage.
• Lactic Acidosis: Although rare, metformin can cause a serious, life-threatening condition called lactic acidosis, particularly in people with kidney problems, liver disease, or serious infections. Symptoms include severe drowsiness, dizziness, slow or irregular heartbeat, flushed face, shortness of breath, and stomach pain.

Reference:

1. Kim, E.K., Lee, S.H., Jhun, J.Y., et al. Metformin prevents fatty liver and improves the balance of white/brown adipose in an obesity mouse model by inducing FGF21. Mediators Inflamm. 5813030, (2016).
2. Lautatzis, ME; Goulis, DG; Vrontakis, M. Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. Metabolism: clinical and experimental. November 2013, 62 (11): 1522–34.
3. Dunn CJ, Peters DH. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs. May 1995, 49 (5): 721–49.