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040-000-284 Hydroxychloroquine Sulfate, CAS 747-36-4

hydroxychloroquine sulfate
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Synonyms 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate, Hydroxychloroquine sulphate, Ercoquin
Key words Autophagy inhibitor; also TLR9 inhibitor; COVID-19
Related products Remdesivir (development code GS-5734); Losartan Potassium, cell metabolism, autophagy

Stanford Chemicals Company is a leading Hydroxychloroquine Sulfate wholesale supplier in the USA. The bulk Hydroxychloroquine sulfate powder is for sale.

Description

Description

Hydroxychloroquine Sulfate Specifications

Product Name Hydroxychloroquine Sulfate
CAS Registry Number 747-36-4
Molecular Formula C18H28ClN3O5S
Molecular Weight 433.95 g/mol
Purity ≥99% (HPLC)
Package 1kg-25kg
Shelf life 2 years
Functions 1. Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro.

2. Also inhibits TLR9.

3. Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro.
Used for acute malaria, discoid lupus erythematosus (DLE), systemic lupus erythematosus, rheumatoid arthritis

Hydroxychloroquine Sulfate Description

Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. It was approved for medical use in the United States in 1955. It regulates the activity of the immune system and modifies the underlying disease process, rather than simply treating the symptoms. Hydroxychloroquine sulfate works by reducing inflammation in people with autoimmune diseases.

hydroxychloroquine sulfate

hydroxychloroquine sulfate

Hydroxychloroquine Sulfate Used for:

  1. Hydroxychloroquine is used to treat Rheumatoid arthritis, Discoid and systemic lupus erythematosus (SLE)
  2. Hydroxychloroquine can be used as an antimalarial drug to treat malaria
  3. Enzyme inhibitors

Reference:

  1. Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464 PMID: 26134285
  2. Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429 PMID: 24342772
  3. Catalano et al (2019) A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. Eur.J.Med.Chem. 183 PMID: 31550663
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