Specifications of Formononetin

Description of Formononetin

Formononetin is an O-methylated isoflavone that can be found in many herbs such as red clover. It is usually used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. It promotes endothelial repair and wound healing in a process involving the over-expression of Egr-1 transcription factor through the regulation of the ERK1/2 and p38 MAPK pathways.

Formononetin, present in soybean, Astragalus membranaceus, Pycnanthus angolensis, Sophora flavescens, and Trifolium pratense, has shown anti-inflammatory, anticancer, and antioxidant effects.

Benefits of Formononetin

Formononetin, present in soybean, Astragalus membranaceus, Pycnanthus angolensis, Sophora flavescens, and Trifolium pratense, has shown anti-inflammatory, anticancer, and antioxidant effects.

1. Antioxidant: Formononetin has antioxidant properties that can combat free radical damage, protect cellular health, and prevent various chronic diseases.
2. Anti-Cancer: Research shows that formononetin has potential in inhibiting the growth of certain types of cancer cells, particularly breast and prostate cancer.
3. Cardiovascular: It helps lower cholesterol levels, improve cardiovascular health, and reduce the risk of heart disease and stroke.
4. Anti-Inflammatory: Formononetin possesses anti-inflammatory properties that can help reduce inflammatory responses in the body, alleviating conditions related to chronic inflammation.

Applications of Formononetin

• Laboratory research
• Ingredient of drugs

Side Effects of Formononetin

Formononetin, while beneficial, can cause side effects such as allergic reactions (rashes, itching, breathing issues), gastrointestinal discomfort (nausea, bloating, diarrhea), and hormonal imbalances, particularly in those with hormone-sensitive conditions. It may also interact with certain medications and potentially affect liver function with long-term or high-dose use.

Reference:

1. Medjakovic, S.; Jungbauer, A. (2008). "Red Clover Isoflavones Biochanin A and Formononetin are Potent Ligands of the Human Aryl Hydrocarbon Receptor". The Journal of Steroid Biochemistry and Molecular Biology. 108 (1–2): 171–177.
2. Li, Shang; Dang, Yuanye; Zhou, Xuelin; Huang, Bin; Huang, Xiaohui; Zhang, Zherui; Kwan, Yiu Wa; Chan, Shun Wan; Leung, George Pak Heng; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man (2015). "Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway". Scientific Reports. 5: 16815.