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040-000-312 Febuxostat CAS 144060-53-7

febuxostat
SKU: 040-000-312 Category:
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Synonyms 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid, Adenuric, Atenuri, Uloric
Keywords Gout, Chronic hyperuricemia
Related products Colchicine, Acerola Cherry Extract
Description

Description

Febuxostat Specifications

Product Name Febuxostat
CAS Registry Number 144060-53-7
Molecular Formula C16H16N2O3S
Molecular Weight 316.4 g/mol
Purity >99%
Appearance White powder
Package 1kg-25kg
Shelf life 2 years
Functions Treatment of gout, Chronic hyperuricemia

Febuxostat Description

Febuxostat is an anti-gout medicine. Febuxostat has a significant inhibitory effect on both oxidized and reduced XOR. Febuxostat is used to lower uric acid levels in people with gout. Febuxostat works by reducing the amount of uric acid made by the body.

Febuxostat Applications

Febuxostat is used to lower hyperuricemia (high uric acid in the blood) in patients with gout who have been treated with allopurinol that did not work well or cannot be treated with allopurinol. This medicine is a xanthine oxidase inhibitor. It works by causing less uric acid to be produced by the body.

Reference:

  1. Okamoto, K., Eger, B.T., Nishino, T., et al. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J. Biol. Chem. 278(3), 1848-1855 (2003).
  2. Bisht, M., and Bist, S.S. Febuxostat: A novel agent for management of hyperuricemia in gout. Indian J. Pharm. Sci. 73(6), 597-600 (2011).
  3. Honorat, J.A., Nakatsuji, Y., Shimizu, M., et al. Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner. PLoS One 12(11), e0187215 (2017).
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