040-000-335 Dasatinib Monohydrate, CAS 863127-77-9
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| Synonyms | Dasatinib hydrate; N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; |
| Keywords | Anti-aging, cancer, remove senescent cells, treatment of leukemia |
| Related products | Metformin (Hydrochloride), Berberine, Acarbose |
Description
Description
Dasatinib Monohydrate Specifications
| Product Name | Dasatinib Monohydrate |
| CAS Registry Number | 863127-77-9 |
| Molecular Formula | C22H28ClN7O3S |
| Molecular Weight | 506.02 |
| Purity | >97.0 % |
| Appearance | White powder |
| Package | 1kg-25kg |
| Shelf life | 2 years |
| Functions | Remove senescent cells, treatment of leukemia |
Dasatinib Monohydrate Description
Dasatinib monohydrate is an inhibitor of Src family kinases, including c-Abl and Bcr-Abl tyrosine kinase activity. Dasatinib inhibits c-Abl and Bcr-Abl tyrosine kinase activity and shows efficacy against imatinib-resistant Bcr-Abl mutations.
Dasatinib monohydrate is a hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia.
Pharmacological effects of Dasatinib Monohydrate
- Antineoplastic drugs: Substances that inhibit or prevent tumor proliferation.
- Tyrosine kinase inhibitor: Protein kinase inhibitors that inhibit tyrosine protein kinases.
Dasatinib Monohydrate Applications
- Laboratory research
- Used as a pharmaceutical ingredient of anti-cancer drugs
Reference:
- Hořínková J, Šíma M, Slanař O.Prague Med Rep. 2019;120(2-3):52-63.
- Shah NP.Drugs Today (Barc). 2007 Jan;43(1):5-12.
- Palmer AK, Xu M, Tchkonia T, Kirkland JL.Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111
