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040-000-477 Silodosin

silodosin
SKU: 040-000-477 Category: Tag:
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Type Active Pharmaceutical Ingredient
CAS No. 160970-54-7
Chemical Formula C25H32F3N3O4
Appearance white powder
Density 1.249±0.06 g/cm3
Assay ≥99%
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Description

Description

Silodosin Introduction

Silodosin is an alpha-adrenergic receptor antagonist and has a very good therapeutic effect on urinary disturbances associated with benign prostatic hyperplasia.

Silodosin Specification

Boiling Point 601.4±55.0℃
Chemical Formula C25H32F3N3O4
Appearance white powder
Density 1.249±0.06 g/cm3
Storage conditions Keep in a dark place, Inert atmosphere,2-8℃

Silodosin Functions

Alpha1-adrenoceptors are G protein-coupled receptors. By binding to its natural ligands norepinephrine and epinephrine, it activates phospholipase C and downstream signaling molecules, including inositol triphosphates and diglycerides. Eventually, intracellular calcium levels increase so smooth muscle contracts.

Silodosin is an α1-adrenoceptor antagonist with the highest selectivity for the α1A-adrenoceptor subtype. By blocking the α1A-adrenoceptor signaling pathway, silodosin promotes relaxation of the prostate and urethral smooth muscle, thereby improving lower urinary tract symptoms such as urination.

Silodosin also targets afferent nerves in the bladder, relieving overactive bladder and storage symptoms.

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