Multiple Functions of Sodium Hyaluronate

From skincare to medicine, joint care to genetic engineering, sodium hyaluronate has become an indispensable part of modern technology and daily life.

Fig 1. Wide range of uses for hyaluronic acid

–A Multifunctional Skincare Ingredient

Sodium hyaluronate is a star in skincare products. It boasts excellent moisturizing properties, repairs the skin barrier, and fights aging. It quickly increases the skin’s water content, restoring its radiance. Whether it’s a luxury serum or an affordable mask, you’re likely to find its presence.

Read more: Hyaluronic Acid vs Glycerin: Which is More Hydrating

–A Star Ingredient in the Beauty Industry

It is not only a key ingredient in skincare but also a celebrity in the beauty field. From injectable fillers and skin tightening to restoring elasticity, sodium hyaluronate plays a crucial role.

— A Key Component of Artificial Tears

For modern individuals who spend extended periods staring at screens, dry eye syndrome has become a common issue. Sodium hyaluronate, with its excellent lubricating and moisturizing properties, is widely used in artificial tears, effectively alleviating eye discomfort and fatigue.

Read more: From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health

— A Miracle Ingredient for Joint Pain Relief

Joint problems are often caused by the loss of hyaluronic acid in synovial fluid. Sodium hyaluronate is used in joint injection solutions to provide lubrication, reduce friction and pain, and restore mobility for osteoarthritis patients.

— Significant Applications in Medicine

In surgeries, sodium hyaluronate serves as a tissue filler or drug carrier, accelerating tissue healing and reducing inflammation. Additionally, it is used in wound repair and oral care, demonstrating extraordinary medical value.

How Molecular Weight Affects Sodium Hyaluronate Uses

The molecular weight of sodium hyaluronate determines its characteristics in absorption, penetration, lubrication, and repair, making it a crucial reference for its specific applications.

Fig 2. HA with different molecular weights has different permeability

–High Molecular Weight HA: Preferred for Barrier and Lubrication

High molecular weight (>1,800 kDa) sodium hyaluronate tends to remain on the surface, forming a viscoelastic film.

• Joint Treatment: In osteoarthritis therapy, it enhances the viscoelasticity of joint fluid, reduces friction, and alleviates pain.
• Ophthalmology: Its lubricating properties protect the cornea and alleviate discomfort in dry eyes, particularly for contact lens wearers.
• Food Industry: Used as a food additive to improve oral and esophageal lubrication, aiding those with swallowing difficulties.

— Medium Molecular Weight HA: Balanced Properties for Broad Applications

Medium molecular weight (200–1,800 kDa) sodium hyaluronate offers a balance of surface action and penetration.

• Medical Dressings: Exhibits excellent tissue repair properties for burns and wounds, covering surfaces while promoting regeneration.
• Drug Delivery: Used as a matrix material for drug delivery systems, enabling slow drug release and improved bioavailability.

— Low Molecular Weight HA: Core for Penetration and Repair

Low molecular weight (5-200 kDa) sodium hyaluronate has excellent penetration properties, reaching deep into tissues or cells.

Aesthetic Treatments: Used for deep tissue filling in injections, such as correcting depressions or scar repair.

• Drug Development: Its penetration performance makes it an effective drug carrier for cancer and immune regulation treatments.
• Anti-inflammatory and Immune Regulation: It modulates inflammatory responses, aiding in pathological inflammation suppression in immunological research and therapies.

— Ultra-Low Molecular Weight HA: Exploring Frontier Functions

Ultra-low molecular weight (<5 kDa) sodium hyaluronate has drawn attention in modern medicine and biotechnology.

• Gene Therapy: Serves as a new type of gene delivery vector, efficiently transporting gene fragments into nuclei for gene editing and cancer treatment.
• Anti-Aging Research: Directly activates repair mechanisms at the cellular level, potentially reversing aging processes.

Table 1. Comparison of high, medium, low, and ultra-low molecular weight hyaluronic acid: HA with different molecular weights has different water solubility, viscoelasticity, and uses.

Read more: Comparative Analysis of Hyaluronic Acid with Different Molecular Weights

Production Method: Microbial Fermentation

The microbial fermentation method employs microorganisms such as streptococci to produce sodium hyaluronate through fermentation. This process is more eco-friendly and safer than traditional animal tissue extraction, avoiding allergic risks from animal sources. It also allows precise control of molecular weight and purity, meeting diverse industry needs.

Read more: How is Hyaluronic Acid Powder Made

Derivatives of Hyaluronic Acid

To expand the applications of sodium hyaluronate, scientists have developed various derivatives through chemical modifications. For example, cross-linked hyaluronic acid is a derivative where molecular chains are connected with cross-linking agents to form a more stable 3D network structure.

These modifications significantly enhance its resistance to degradation while maintaining elasticity and water retention. Cross-linked hyaluronic acid is primarily used in long-lasting cosmetic fillers for wrinkle removal and shaping. It is also used in joint cavity injections to increase lubrication and alleviate pain.

Stanford Chemical Company (SCC) is a pioneer in the development of hyaluronic acid. Products include food-grade, medical-grade, cosmetic-grade, injectable-grade hyaluronic acid, and hyaluronic acid derivatives (Sodium Acetylated Hyaluronate and Cross-linked Hyaluronic Acid Gel). We can also provide customers with customized molecular-weight sodium hyaluronate powder. For more information or specific applications, please visit our homepage.

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Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. Its salt form, sodium hyaluronate (SH), was initially isolated from the eye’s vitreous body. Sodium hyaluronate has a wide distribution in animal or human tissues, generally located in the extracellular matrix. It has a high concentration in the vitreous humor, aqueous humor, synovial fluid, skin, and umbilical cord.

Sodium hyaluronate is known for its excellent viscoelasticity, unique rheological properties, pseudoplasticity, non-toxicity, and superior biocompatibility.

Fig 1. Artificial tears with hyaluronic acid as the main ingredient

Basis for Sodium Hyaluronate in Ophthalmology Applications

It is highly moisturizing. Sodium hyaluronate can bind water several hundred times its weight, maintaining the ocular surface moisture balance. Its viscoelastic nature allows it to form a stable film on the eye surface, providing lubrication and protection while reducing friction.

As a natural constituent of human tissues, sodium hyaluronate possesses excellent biocompatibility with minimal risk of rejection or irritation. Furthermore, it provides an enhancement in corneal repair and regeneration, reduces inflammation, and soothes discomfort due to environmental stimuli or surgical procedures.

Given these properties, sodium hyaluronate is widely used in ophthalmic products such as artificial tears, surgical viscoelastic fillers, ophthalmic injectables, and corneal repair agents. Its applications range from routine eye care to advanced surgical procedures.

Fig 2. Viscoelasticity of hyaluronic acid

Applications of Sodium Hyaluronate in Eye Health

The uses of sodium hyaluronate in ophthalmology can be roughly divided into two categories. There is ophthalmic viscoelasticity, mainly used in all sorts of ophthalmic surgeries including glaucoma and cataract surgery; another one is eye drops, mainly used in treating dry eyes and corneal burns.

1. Ophthalmic Viscoelastic Agents

1.1 Role in Surgery

Sodium hyaluronate is used as a viscoelastic agent in many eye surgeries. It has a high molecular weight and excellent viscoelasticity, providing mechanical protection for the surgery to take place. Therefore, it maintains structure and prevents tissue collapse or damage caused by surgical instruments.

• Glaucoma Surgery

Sodium hyaluronate protects intraocular tissues, maintains the shape of the anterior chamber, and reduces friction and damage from surgical tools, thus enhancing safety.

• Cataract Surgery

It acts to safeguard the cornea endothelium and to serve as an aid to the implantation of an intraocular lens. It provides a clearer surgical field and minimizes mechanical trauma to the cornea during surgery.

• Trauma Repair Surgery

Sodium hyaluronate serves as a lubricant for the surgical procedure in ocular traumatized patients, inhibits the adhesion of tissues, and provides an optimal environment for healing after surgery.

• Corneal Laser Surgery

The protective film helps prevent excessive drying of tissues and reduces mechanical irritation from surgical instruments.

1.2 Recovery Post-Surgery

Sodium hyaluronate after surgery promotes the repair of tissues, reduces inflammation, and speeds up healing. It keeps the environment moistened to reduce any discomfort for the patients in recovery.

2. Eye Drops

Sodium hyaluronate is used in eye drops for moisturizing and lubrication, relieving dry eyes, protecting the ocular surface, and promoting corneal repair. It is suitable for sensitive people and postoperative care.

2.1 Treatment for Dry Eye

Dry Eye is a chronic condition caused by insufficient tear production or excessive evaporation, leading to symptoms such as dryness, fatigue, and a foreign body sensation. Sodium hyaluronate excels in treating dry eye due to its strong moisturizing properties.

• It forms a uniform protective film on the ocular surface, enhancing tear film stability and preventing tear evaporation.
• Its high water retention alleviates dryness and improves patient comfort.
• It enhances the repair ability of ocular surface cells, preventing more severe damage caused by chronic dryness.

2.2 Corneal Burn Repair

Sodium hyaluronate plays a vital role in treating corneal burns, where the cornea experiences water loss, cell damage, and inflammation. It helps in several ways:

• Moisturizing and Lubricating
• Promoting Cell Regeneration
• Reducing Inflammation

2.3 Daily Eye Care

Sodium hyaluronate-based eye drops are also widely used for daily eye care, especially by individuals who use electronic devices for extended periods or wear contact lenses. These drops effectively relieve discomfort caused by eye strain or insufficient tears, providing long-lasting hydration and lubrication.

Product Recommendations

Stanford Chemical Company (SCC) is one of the leading US-based wholesalers of hyaluronic acid, offering a range of pure hyaluronic acid powders in medical, food, cosmetic, and injectable grades. These cover high, medium, and low molecular weights and also support customization.

The main products in eye health:

References:

Sodium Hyaluronate Used in Anterior Segment Eye Surgery

Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes

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When it comes to skincare, there is an abundance of ingredients that claim to offer various benefits. The popular ingredients in the skincare world are bamboo extract, vitamin B5, and sodium hyaluronate. All of them are renowned for their hydrating property and potential to improve skin health. In this article, we will delve into the qualities of these three ingredients to determine which product might be more suited for your skin. Hope that you can have a better understanding of their features and benefits.

Bamboo Extract and Its Properties

The bamboo extract has long been used in Asia and beyond to offer benefits for skin, hair, and human well-being. This natural nutrient is particularly rich in silicon oxide, which is essential to support the skin’s tissues. Additionally, the bamboo extract also contains flavones, glycosides, and amino acids, which contribute to potential benefits for skincare.

The extract is known for a variety of skincare properties.

• Antioxidant: This antioxidant can neutralize free radicals and fight against skin aging. Namely, when cells confront UV rays, pollution, sugars, and other sources of stress, they produce large amounts of free radicals, which are prone to react with other molecules and cause damage. Yet, flavones inside bamboo extract release electrons to neutralize free radicals and alleviate skin aging symptoms consequently.
• Others: Besides, it could absorb excess sebum for oily skin and relieve irritation for sensitive skin. The absorption ability comes from its porous particles, while the anti-inflammatory effect brings about soft and silky skin.

Vitamin B5 and Its Properties

Vitamin B5, or pantothenic acid, is a beneficial B vitamin that is crucial for both skin health and body health. Yet, the precursor of vitamin B5, panthenol, is usually added to skincare products since B5 is unstable and easily affected by temperature and formula.

Chemical Structure of Panthenol [1]

• Hydration: Both of them could bind water molecules tightly. As an osmotic moisturizer with a small molecular weight, panthenol can penetrate the stratum corneum more effectively and moisturize the stratum corneum. At the same time, D-panthenol, a type of panthenol, contains three hydroxyl structures, which can maintain water for a long time and has excellent moisturizing ability.
• Anti-inflammation: Vitamin B5 can calm irritation under lots of conditions. It is needed to reduce inflammatory phenomena such as redness and swollen pimples, and it could also resist the spread of bacteria at that time. It helps reduce the number of acne-related facial blemishes as well.
• Repair: Their ability to stimulate the growth of epidermal cells can speed up skin repair whether it is a scratch or a pimple. In addition, you can use them for sunburn and even peeling skin.

Sodium Hyaluronate and Its Properties

Another ingredient that has been making waves in the beauty industry is sodium hyaluronate powder. It is the sodium salt of hyaluronic acid that is present in the extracellular matrix of neural tissues, the corneal endothelium, etc. The terms–sodium hyaluronate and hyaluronic acid–are often used interchangeably.

Chemical Structure of Sodium Hyaluronate [2]

• Intense Hydration: Hydration is the foundation of healthy skin. With its small molecular size, sodium hyaluronate has the ability to penetrate deep into the skin layers, providing moisture where it’s needed the most.
• Improved Skin Texture: Smooth and refined skin texture is a sign of a healthy complexion. By deeply hydrating the skin, the sodium salt helps soften rough patches, diminish the appearance of fine lines, and promote a more even skin tone.
• Boosted Collagen Production: Collagen is a vital protein that provides structure and elasticity to the skin. As we age, collagen production naturally declines, leading to sagging skin and the formation of wrinkles. Sodium hyaluronate can help boost collagen synthesis in the skin, promoting a more youthful and plump complexion.

Conclusion

In a word, bamboo extract is characterized by antioxidant properties; vitamin B5 is a moisturizing and soothing nutrient; sodium hyaluronate is a useful humectant with multiple skincare effects. More importantly, remember, everyone’s skin is unique, and what works for one person may not work for another. It’s always beneficial to perform patch tests and consult with skincare professionals for personalized advice.

Stanford Chemicals Company (SCC) provides high-quality sodium hyaluronate of different molecular weights and grades. For more information, please check our homepage.

Reference:

[1] Panthenol. (2023, January 2). In Wikipedia. https://en.wikipedia.org/wiki/Panthenol

[2] Sodium hyaluronate. (2023, January 29). In Wikipedia. https://en.wikipedia.org/wiki/Sodium_hyaluronate

The post 3 Types of Promising Skincare Ingredients: Bamboo Extract, Vitamin B5, and Sodium Hyaluronate appeared first on Stanford Chemicals.

Sodium hyaluronate, the salt form of hyaluronic acid, is a naturally occurring polysaccharide group of sugar in the human body. It is a popular ingredient in skincare and cosmetics due to its ability to hydrate and plump the skin. This sodium salt also has a wide range of applications in the medical field, particularly in anterior segment eye surgery. In this article, we will discuss the utilization and benefits of sodium hyaluronate in anterior segment surgery.

What Is Anterior Segment Surgery?

Anterior segment surgery involves operating on the structures in the front of the eye, such as the cornea, iris, and lens. These surgeries can range from cataract removal to corneal transplants. It is crucial to maintain the clarity of the cornea and the surrounding tissues to ensure a successful outcome. Sodium hyaluronate can play an essential role in achieving this.

Human Eyes

Benefits of Sodium Hyaluronate Employed in Anterior Segment Surgery

Sodium hyaluronate is a natural substance largely found in the extracellular matrix of connective tissues. It is in the aqueous humor and the vitreous, and it forms a protective coating on the corneal endothelium. Sodium hyaluronate and other viscoelastic substances, such as chondroitin sulfate and collagen, have been used for eye surgeries since the 1970s. These viscoelastic agents are used to protect and maintain the shape of the eye during surgery. They help create space for the surgeon to work and prevent damage to delicate structures as well.

Eye Anatomy

–Maintaining A Deep Anterior Chamber

The primary benefit of using this salt as a viscoelastic agent is its ability to maintain a stable anterior chamber during the operation. The anterior chamber is the fluid-filled space between the cornea and the iris, and maintaining its stability is essential for successful surgery. Sodium hyaluronate can help stabilize the anterior chamber by providing a cushioning effect and preventing the collapse of the chamber. Therefore, it is easier to separate and maneuver these tissues, and the damage to the cornea and other tissues can be minimized.

–Protecting the Corneal Endothelium

Besides, the excellent lubricating properties of sodium hyaluronate can help reduce the risk of damage to the corneal endothelium during surgery. The corneal endothelium is a layer of cells that lines the back of the cornea, which is crucial for maintaining corneal clarity. Damage to the corneal endothelium can result in complications such as corneal edema and decreased vision. If it got scratched, there would be serious vision problems because all light passes through it and any defect might lead to a “blind spot”.

–No Adverse Effect

Sodium hyaluronate is a substance widely present in the human body, and there is no report on its adverse effects. So, it is considered to have no adverse effects and is safe to take. It is also biocompatible, meaning it is well-tolerated by the body and does not cause adverse reactions. Moreover, sodium hyaluronate can be easily absorbed by the body and does not require removal after surgery.

Sodium hyaluronate is available in various forms, including gels, solutions, and ointments. The choice of form depends on the specific needs of the surgery and the surgeon’s preference. There is a variety of medical-grade sodium hyaluronates on our website. Send us an inquiry if you are interested.

Related reading: Medical-grade Sodium Hyaluronate Guide 2023: Functions & Applications

Examples of Sodium Hyaluronate Used in Anterior Segment Surgery

You can find sodium hyaluronate as a surgical aid during ophthalmic surgeries including cataract extraction, corneal transplant, glaucoma infiltration, and intraocular lens implantation. With sodium hyaluronate products, the safety and reliability of anterior segment eye surgeries have been improved.

–Cataract Operations

Sodium hyaluronate was used as a surgical device for two cataract surgeries: intracapsular cataract extraction (ICCE) with corneoscleral incision and corneal incision. There were 80 patients divided in two groups. The first group used sodium hyaluronate products, while the control group employed a balanced salt solution (BSS) instead. It was proven that this sodium salt has a protective effect on the cornea and no side effects, such as intraocular pressure or inflammatory reaction, have been observed. [2]

–Intraocular Foreign Body (IOFB)

Diverse surgical instruments have been employed to remove intraocular foreign bodies (IOFBs). A 38-year-old healthy man suffered from a glass IOFB in the left eye after a glass exploration. Medical-grade sodium hyaluronate gel was used to remove the IOFB, which could avoid damage to the retina and make it easier to grasp the flat glass fragment. [3]

Conclusion

In a word, sodium hyaluronate is a useful tool in anterior segment surgery. Its viscoelastic properties can help maintain a stable anterior chamber and protect delicate structures during surgery. Its lubricating properties can reduce the risk of damage to the corneal endothelium, and its biocompatibility makes it a safe choice for use in surgery. If you are undergoing anterior segment eye surgery, be sure to discuss the use of sodium hyaluronate with your surgeon and learn about how it can benefit your surgery.

Stanford Chemical Company is a leading supplier of medical-grade sodium hyaluronate. Cosmetic grade, food grade, and injection grade are also available. Check our homepage to look for the perfect sodium hyaluronate products for your projects.

Reference:

[1] Souto, Eliana B. & Zielińska, Aleksandra & Luis, M. & Carbone, Claudia & Martins-Gomes, Carlos & Souto, Selma & Silva, Amélia. (2019). Uveal melanoma: physiopathology and new in situ-specific therapies. Cancer Chemotherapy and Pharmacology. 84. 10.1007/s00280-019-03860-z.

[2] Åke S. Holmberg, Bo T. Philpson, (1984). Sodium Hyaluronate in Cataract Surgery: I. Report on the Use of Healon® in Two Different Types of Intracapsular Cataract Surgery. Ophthalmology, 91(1), 45-52. https://doi.org/10.1016/S0161-6420(84)34341-X.

[3] Zhang J, Mao H, Zou X, Deng G. (2020). Use of medical sodium hyaluronate gel in surgical removal of a glass intraocular foreign body. Journal of International Medical Research, 45-52. https://doi.org/10.1177/0300060520956856.

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Sodium hyaluronate is a chemical compound made from hyaluronic acid. As the name suggests, sodium hyaluronate is a salt of hyaluronic acid. This is just one of two known hyaluronate salts, as hyaluronic acid has two salts: potassium hyaluronate and sodium hyaluronate.

Hyaluronic acid is a naturally occurring acid. The body produces it in copious amounts in areas like the joints, the eyes, and the skin. Hyaluronic acid aids the lubrication of tissues. It can absorb and retain water levels up to 1000 times greater than its weight.

Sodium hyaluronate is synthesized from hyaluronic acid and has similar capabilities.

Sodium hyaluronate can absorb and retain water far above its weight. It has a smaller molecular structure than hyaluronic acid. It is, therefore, more stable than hyaluronic acid. It also has a more excellent oxidation resistance.

Hyaluronic acid and sodium hyaluronate are suitable in skincare products due to their moisturizing abilities. They also aid the skin in looking plumpy, supple, and fresh.

Differences Between Hyaluronic Acid and Sodium Hyaluronate

Hyaluronic acid is the naturally occurring material from which sodium hyaluronate is extracted. Many products which contain sodium hyaluronate have hyaluronic acid written on their label. This is a common mistake due to the similar nature of both substances. However, there are significant differences between them.

Hyaluronic acid is naturally occurring, while sodium hyaluronate is synthesized from hyaluronic acid. Due to this, sodium hyaluronate is more stable than hyaluronic acid.

Hyaluronic acid is also a macromolecule. Its large molecules hydrate the skin by forming a coat that prevents water loss. On the other hand, sodium hyaluronate has smaller molecules than hyaluronic acid. Therefore, its molecules can penetrate the epidermis and provide moisturization from within.

Sodium Hyaluronate’s Uses in Skin Care Products

We use sodium hyaluronate in a wide range of skin care products for various reasons. It is most commonly used as an ingredient in moisturizers due to its ability to retain large amounts of water.

Sodium hyaluronate is also sold alone as sodium hyaluronate powder. The powder can be mixed with water and applied to the skin alone or with other moisturizing products.

Sodium hyaluronate powder is beneficial for people who have dry skin. It acts as a lubricant by absorbing the water from the surroundings while preventing excessive loss of water from the skin.

Dry skin is a problem that typically becomes more pronounced as a person gets older. This is because the body no longer produces hyaluronic acid as it once did when younger. This leads to dryness of the skin and joint pain due to the dryness. Sodium hyaluronate powder can help lubricate the skin and joints without the usual levels of hyaluronic acid.

Due to its ability to absorb water, the application of sodium hyaluronate causes slight swelling of the skin. This swelling makes the skin look lush and supple as an individual gets older.

Apart from moisturizing the skin and lubricating the joints, sodium hyaluronate also has other uses in skincare products, some of which include:

• Makes Wrinkles Less Visible: Sodium hyaluronate powder moisturizes and reduces the visibility of wrinkles when applied to the skin. Wrinkles are usually pronounced when the skin is dry, so moisturizing makes them less visible.
• Helps Stop Skin Inflammation: When applied to the skin, sodium hyaluronate can help in stopping skin inflammation. Using sodium hyaluronate powder on the skin aids in the production of a chemical (beta-defensin 2) that aids in the healing of sore tissues.

Medical Uses of Sodium Hyaluronate

Other than its numerous uses in the skincare industry, Sodium Hyaluronate also has a lot of medical applications.

It is used in the treatment of osteoarthritis in the knee. Osteoarthritis sets in when the joints in the knee are no longer adequately lubricated because the levels of hyaluronic acid being produced are not enough. This leads to stiffness in the knee and pains, especially when walking. Shots of sodium hyaluronate as prescribed by the doctor help lubricate the knee.

Sodium hyaluronate is also used by doctors while performing surgery on the eye. It is mainly used to protect the cornea during surgical procedures on the eye. Reports show that it has no side effects and that operations carried out with sodium hyaluronate yield better results than those performed without it.

It is also used to treat dry eye and rhinitis conditions. Rhinitis occurs when there is inflammation in the nose.

Side Effects

Sodium Hyaluronate has no known side effects. It is safe, especially when used according to a doctor’s prescription. However, some people might have allergic reactions to one or more components. If you notice your skin reacting as you apply sodium hyaluronate, you should stop immediately and see a doctor.

Sodium Hyaluronate Forms

Sodium hyaluronate comes in several forms other than sodium hyaluronate powder. The purpose of use typically determines the method of administering it.

Some of the forms include:

• Gel
• Lotion
• Serum
• Face wash
• Eye drops
• Injection

At Stanford Chemicals, we provide cosmetic-grade Sodium Hyaluronate that is used in the manufacture of top-quality skin care products that moisturize dry skin and remove wrinkles. You can contact us now at (949) 812 6690 or (949) 468 0555 to learn more or place an order.

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What Are Dry Eyes?

A dry eye is a condition where the eyes cannot produce enough tears that provide the necessary lubrication for the eyes. Sodium Hyaluronate drops are very effective for preventing and treating eye dryness.

What Is Intraocular Pressure?

Intraocular pressure refers to the fluid pressure in the eye. During your regular eye examination, the doctor checks for your intraocular pressure. This tells the doctor the state of your eye health. From this, the doctor can see the signs of any optic nerve damage, which, if not corrected, can affect eyesight. A tonometry test measures the level of intraocular pressure. The normal range for intraocular pressure is about 10 – 20 mmHg.

Does Use of Sodium Hyaluronate Eye Drop Cause An Increase in Intraocular Pressure?

Sodium Hyaluronate is now recently adopted during surgeries on cataracts. It has excellent use as it forms a protective layer on the endothelium, preventing direct contact with the intraocular lens implant.

In a study by Muhammed Wassem et al., retrieved from the National Library of Medicine, the study concluded that Sodium Hyaluronate causes a significant increase in intraocular pressure in the early postoperative period just after cataract surgery.
Another study by Michael Passo et al. published in the British Journal of Ophthalmology showed that Sodium Hyaluronate increases intraocular pressure. The research centered on studying 24 patients who had cataract surgery where three different agents were used to reform the anterior chamber. The three agents used were air, sodium hyaluronate, and a combination of Hyaluronate and acetazolamide. The test subjects all had tonometry 16 hours before their surgery, and the same was done every eight hours after the surgery within 72 hours. The researchers found that the intraocular pressure doubled in the group treated with Hyaluronate on the first day following the surgery.

Why Intraocular Pressure Matters

The intraocular pressure helps keep the eye in shape, which ensures that all two million parts that make up the eyes are intact, allowing the eye to function properly. The eye may experience high pressure or low pressure. High pressure occurs when the fluid in the front of the eyes doesn’t drain out well, or the eyes produce more fluid than usual. The pressure can get so high, which is referred to as ocular hypertension, and may lead to glaucoma.

Low intraocular pressure, on the other hand, occurs when the fluid in the eyes is not enough. However, it is of no major concern like the high intraocular pressure. Low eye pressure may happen due to the leakage of fluids from the eyes after surgery. Low intraocular pressure may lead to blurry vision for some persons.

Before Using Sodium Hyaluronate

It is vital that before using any eye drop containing sodium hyaluronate, you should see if it is suitable for you by consulting a physician and an eye doctor. Ensure that your doctor knows if you:
1. Have ever reacted to eye drops containing preservatives?
2. Wear soft contact lenses.

How to Use Sodium Hyaluronate Eye Drops?

1. Ensure to thoroughly wash your hands before handling the bottle of the eye drop.
2. Remove the caps from the bottle carefully to prevent the content from spilling.
3. Tilt your head to the back slightly, and then pull the lower eyelid to create a pocket for the fluid.
4. Turn the bottle upside down near your eye and avoid touching the eyes.
5. Press the bottle until you release a drop into the eyes. If the first drop missed entering the eye, you could press the second time.
6. After the drop lands in the eyes, you can close the eyes for a minute or two to allow the liquid to touch all the parts of the eyes.
7. Ensure the dropper doesn’t touch your eye, your fingers, or any other surface. This could contaminate the drops left in the bottle.
8. Repeat the above steps for the second eye only if your eye doctor told you to use them on both eyes.
9. Close the bottle tightly after use again.

Can Sodium Hyaluronate Cause Problems?

Different reports and cases now show that Sodium Hyaluronate can occasionally cause mild irritation in the eye. However, not everyone experiences any of these allergies, and they quickly subside after a short time.

How to Store Sodium Hyaluronate Eye Drops?

1. Ensure to keep it in a cool and dry place. Away from heat and direct light.
2. Keep it away from the reach of children.
3. Ensure that you check the expiry date on the label and how long you can use it.

At Stanford Chemicals, we provide medical-grade Sodium Hyaluronate that is used in eye drops and contact lens solutions. You can contact us now at (949) 812 6690 or (949) 468 0555 to place your order.

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The main features of the chemical structure of hyaluronan were revealed by Karl Mayer and his research team in the 1950s. This incredibly useful biopolysacharide, considered the simplest glycosaminoglycan, is a type of long, linear, unbranched polymer composed of a repeating disaccharide unit consisting of two monosaccharides (ß(1,4)-N-acetyl-D-glucosamine and ß(1,3)-D-glucuronic acid). The term “hyaluronan” was introduced in 1986 to comply with the international nomenclature of polysaccharides.

Extensive studies have confirmed that this amazing chemical compound is distributed widely and naturally present in all living organisms, bacteria, and vertebrates. In addition, it plays an important physiological role in the human body, being concentrated mainly in the connective, epithelial, and neural tissues. HA has been isolated from various sources and its properties and functions have been studied in a wide range of research centers and laboratories.

Hyaluronic Acid has become famous mainly for its anti-aging effect and is promoted as a “fountain of youth.” But in fact, there is much more in addition to that.

Due to its unique viscoelastic nature, among the range of the most important biological functions of sodium hyaluronate are regulation of tissue hydration, maintenance of the elastoviscosity of liquid connective tissues such as joint synovial and eye vitreous fluid, numerous crucial roles in cell division, and the process of inflammation, just to mention a few.

Characteristics of vital significance, such as biocompatibility and non-immunogenicity, make this exceptional substance the perfect biomaterial for cosmetic, medical, and pharmaceutical applications.

The post The Victorious Discovery of Hyaluronic Acid appeared first on Stanford Chemicals.

Sodium hyaluronate is the fourth generation of bionic cosmetic additives.

The Source of Sodium hyaluronate

KARL MEYER found it in the bovine vitreous body in 1934. It is a macromolecule polysaccharide extracted from the bovine vitreous body. It has three characteristics: anti-aging and fresh-keeping packaging and adopting biotechnology.

Sodium hyaluronate is one of the components of human skin, is the most widely distributed acid mucosa in the body, exists in the matrix of connective tissue, and has a good moisturizing effect.

Characteristics of Sodium Hyaluronate

It has three characteristics: anti-aging and fresh-keeping packaging and biotechnology. Sodium hyaluronate is one of the components of human skin and the most widely distributed acidic mucose in the human body. It exists in the matrix of connective tissue and has a good moisturizing effect.

8 Benefits of Sodium Hyaluronate

1. Improving Pharmacodynamics

Hyaluronic acid is the main component of connective tissue such as the human interstitium, vitreous body, and synovial fluid. It has the characteristics of keeping water, maintaining extracellular space, regulating osmotic pressure, lubricating, and promoting cell repair in vivo. As a carrier of ophthalmic drugs, it can prolong the retention time of drugs on the eye surface by increasing the viscosity of eye drops, improving the bioavailability of drugs, and reducing the irritation of drugs to the eyes.

The adjuvant therapy can be injected directly into the articular cavity as a lubricant for the treatment of arthritis, such as SPIT injection.

2. Crease Resistance

The moisture level of the skin is closely related to the content of hyaluronic acid. With the increase of age, the content of hyaluronic acid in the skin decreases, which weakens the water-retaining function of the skin and produces wrinkles. Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity. When applied to the skin’s surface, it can form a moisture-permeable film to keep the skin moist and shiny. Small molecule hyaluronic acid can penetrate into the dermis, promote blood microcirculation, help the skin to absorb nutrients, and play a cosmetic and anti-wrinkle health role.

3. Moisturizing Effect

The moisturizing effect is the most important role of sodium hyaluronate in cosmetics. Compared with other moisturizers, the relative humidity of the surrounding environment has less influence on its moisturizing effect. The results show that sodium hyaluronate has the highest moisture absorption at low relative humidity (33%) and the lowest moisture absorption at high relative humidity (75%) compared with common moisturizers. This unique nature is adapted to the skin in different seasons, different environmental humidity, such as dry winter and wet summer, and the requirements of cosmetics moisturizing effect. The moisture retention of sodium hyaluronate is related to its mass and molecular weight.

4. Nutritional Effects

Sodium hyaluronate is an inherent biological substance in the skin, and exogenous sodium hyaluronate is a supplement to endogenous sodium hyaluronate in the skin. Sodium hyaluronate with low quality can penetrate into the skin epidermis, promote the supply of skin nutrition and waste excretion, thus preventing skin aging, and play a role in cosmetology and beauty. Skin maintenance is more important than other cosmetics and has become the modern people’s desire to maintain face consciousness.

5. Repair and Prevention of Skin Damage

Skin is burned or burned by sunlight, such as reddening, blackening, peeling, etc., mainly by ultraviolet rays in sunlight. Sodium hyaluronate can promote the regeneration of the injured skin by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen-free radicals. Pre-use also has a preventive effect. Its mechanism of action is different from the ultraviolet absorbent commonly used in sunscreen. Therefore, hyaluronic acid and ultraviolet absorbent in sunscreen skincare products have a synergistic effect, which can reduce the transmission of ultraviolet rays and repair the skin damage caused by a small number of ultraviolet rays, thus playing a dual protective role.

The combination of sodium hyaluronate and EGF (epidermal growth factor) can accelerate the regeneration of epidermal cells and make the skin tender, smooth and elastic. When the skin suffers from mild burns and scalds, the application of water cosmetics containing sodium hyaluronate on the surface can alleviate pain and accelerate the healing of the wounded skin.

6. Lubrication and Film Formation

Sodium hyaluronate is a kind of polymer with strong lubrication and film-forming properties. Skincare products containing sodium hyaluronate have obvious lubrication and good hand feeling when applied. When applied to the skin, a film can be formed on the surface of the skin, which makes the skin feel smooth and moist, and protects the skin. Haircare products containing sodium hyaluronate can form a layer of film on the surface of the hair, which can moisturize, lubricate, protect hair, eliminate static electricity, and make the hair easy to comb, elegant, and natural.

7. Thickening

Sodium hyaluronate has high viscosity in an aqueous solution, and 1% of its aqueous solution is gelatinous. It can play the role of thickening and stabilization in cosmetics.

8. Pharmacological Effects of Sodium Hyaluronate

Physiological active substances widely exist in animals and humans and are distributed in human skin, synovial fluid of joints, umbilical cord, aqueous humor, and vitreous body of eyes. Molecular weight is 500000-730000 Dalton. Its solution has high viscoelasticity and imitation. It is an adjuvant for ophthalmic surgery. It maintains a certain depth of the anterior chamber after injection into the anterior chamber, which is convenient for operation. It also protects corneal endothelial cells and intraocular tissues, reduces complications, and promotes wound healing.

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I have been asked by many customers about our organic chemicals – What’s the other 2% for 98% purity products? The purity you list is 98%HPLC, I’d like to know the other 2% impurities. Or similar questions like these.

If you only list your Dihydromyricetin as 98%HPLC, what are the other 2% impurities? Your highest pure sodium hyaluronate is only 95%, what are the other 5%? You just said you don’t know?

Actually, we may never know which the other 2% or 5% is, because it may never exist.

The main reason is the different test methods. Here I want to talk about the purity of organic chemicals.

The purity of organic chemicals is tested by totally different methods compared with inorganic materials. For example, ICP-MS can be used to test hafnia, while HPLC(High-performance liquid chromatography) is used for Dihydromyricetin. In the organic field, 98% means almost pure product. The other 2% can be small impurities or detection errors on a fully acceptable basis.

If you are very very strict, you can require 99%HPLC purity. But most of the time, it doesn’t make any sense. We can never offer a 100% HPLC product, even if the purity in the HPLC spectrum is 100%, a single peak, in the common test method it still can be 98%, which is caused by impurities in test solvent or different machines.

Why the purity of sodium hyaluronate is only 95%? Sodium hyaluronate is a kind of polymer. The test method is based on the method in European Pharmacopoeia. 95% is an almost pure product.

In this case, we may find some products tagged as purity of 103%. How and why it can be 103%?
The answer is also the test method. For instance, the external standard method could make this happen and this method is one of the most common approaches. Even sometimes we can find the purity requirement is 95%~105% in any pharmacopeia.

Wish you have a better understanding of the purity of organic chemicals.

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Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in the various connective tissue of humans. It occurs naturally in the human body and is central to regulating cell growth and renewal. In fact, it is found extensively in connective, epithelial, and neural cells. As such, hyaluronic acid has found its way into many skincare products, it can retain moisture, keep the skin firm, and prevent wrinkles by adding volume to the skin. It is also used to prevent the effects of aging. It is regarded as “the key to the fountain of youth.”

Sodium Hyaluronate aqueous solution of high viscosity will enable the water phase thickening; emulsified with the oil phase even after the fine paste, the role of a stable emulsion is to prevent cells produce a number of enzymes to reduce the formation of free radicals in the prevention of free radical damage to cell structure, resulting in lipid peroxidation and aging, such as the body has an important role.

Sodium Hyaluronate vs Hyaluronic Acid

The role of cosmetic grade sodium hyaluronate on the skin surface, molecules of hyaluronic acid can be formed on the surface of the skin layer of breathable film, the skin smooth and moist, and blocking external bacteria, dust, and UV intrusion, protecting the skin from infringement; small molecule transparent acid could infiltrate into the dermis, with a slight expansion of capillaries to increase blood circulation, improve intermediary metabolism, and promote the role of the skin to absorb nutrients, eliminate wrinkles with strong features, increase skin elasticity, slow down skin aging.

Hyaluronic acid can promote epidermal proliferation and differentiation of cells to remove oxygen-free radicals and can prevent and repair skin damage. The hyaluronic acid aqueous solution of high viscosity will enable the water phase thickening; emulsified with the oil phase even after the fine paste. The role of a stable emulsion is to prevent cells from producing a number of enzymes and to reduce the formation of free radicals in the prevention of free radical damage to cell structure, resulting in lipid peroxidation and aging, such as the body has an important role.

Sodium hyaluronate is used to treat skin ulcers such as bed sores or diabetic foot ulcers, as well as burn wounds, surgical incisions, cuts, abrasions, and other skin irritations.

Sodium hyaluronate topical is also used to treat dry or scaly skin.

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