The main ingredients of Solaraze gel are Diclofenac and hyaluronic acid whose supplier is Stanford Chemicals, a major hyaluronic acid supplier in California, United States with FDA, ISO, GMP, CE certificates.

The proposed mechanism of action of Solaraze gel in treating actinic keratoses is to block cyclooxygenase-2 (COX-2) to reduce angiogenesis and cellular proliferation. Topical diclofenac and hyaluronic acid, of which HA-E2.0 powder is a product, have been shown to be effective for the treatment of actinic keratosis on the mucosal lip, with a minimum of irritation.

Diclofenac 3% + hyaluronic acid 2.5% (Solaraze) is used twice a day for up to 90 days. Four weeks after 2 months of treatment, 100% of actinic keratoses were cleared in 33% of patients and, 100% of actinic keratoses were cleared in 50% of patients after 90 days of treatment.

Side effects caused by using topical diclofenac include itching, dry skin, erythema, exfoliation, localized edema, paresthesia, application site reactions, and less frequently, photosensitivity.

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