Hyaluronic acid (HA, or (C14H21NO11) n) is an important humectant. It is a polymer of disaccharides composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid is an important component of the human intercellular matrix, such as the body’s connective and neural tissues.

Hyaluronic acid locks water molecules inside the human body like skin and joints. It is applied to a variety of fields for its water retention function. HA can also promote cell proliferation and differentiation and remove oxygen-free radicals, so it is generally used to make skin-care products for moisture and anti-aging. Additionally, this humectant is also found in the medical field to treat arthritis and cataract.

Hyaluronic acid is commonly manufactured by industrial synthesis. Stanford Chemicals Company is an experienced supplier of hyaluronic acid of different grades. For more information about HA and related products, please check our website.

2.   What is sodium hyaluronate?

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of sugar, and it is composed of Na-glucoronate-N-acetyl glucosamine. This sodium salt could be found in the extracellular matrix of mammalian connective, neural tissues, and the corneal endothelium.

Sodium hyaluronate is a synonym for hyaluronic acid. In fact, the two terms are often used interchangeably in the skincare field. Sodium hyaluronate can keep moisture and promotes cell growth and renewal as well. This humectant is applied to different beauty products to keep moisture and reduce the effect of aging. It is also used in medical surgeries.  Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier.

Similarly, sodium hyaluronate is obtained from animal tissues or bacterial fermentation. Stanford Chemicals Company provides high-quality sodium hyaluronate within a short lead time.

3.   What are the differences between hyaluronic acid and sodium hyaluronate?

Hyaluronic acid and sodium hyaluronate are both popular choices for cosmetic uses. They are both hydrating and anti-aging. Consumers can find hyaluronic acid and its salt form in many products like serums and creams. They are also applied to oral supplements.

What is the biggest difference? Sodium hyaluronate has a smaller molecular size, which means that it can penetrate the skin better. Other than that, they both offer the same benefits.

They have a slight difference in terms of features.

• Sodium hyaluronate is more stable than hyaluronic acid. The salt form is a more stable version, and it could resist oxidation for its higher stability.
• It is easier for sodium hyaluronate to penetrate the skin surface and enhance the skin barrier. Sodium hyaluronate has a lower molecular size, so it could penetrate deeper and provide intense hydration.
• In short, hyaluronic acid attracts water molecules on the surface, while its sodium salt moist cells deeper. Other than that, they offer the same benefits for beauty lovers.

4.   Can you use hyaluronic acid and sodium hyaluronate together?

Beauty lovers can use hyaluronic acid and sodium hyaluronate together to moisturize their skin. These chemicals are both gentle and highly hydrating. Both ingredients are suitable for all skin types and compatible with other ingredients. Use them together for an intense hydration effect.

Cosmetic products like serums, moisturizers, and facial oil containing hyaluronic acid and sodium hyaluronate  can provide diverse benefits as listed:

• Hydration Effect: The key benefit of these two chemicals is hydration. They could continuously draw moisture in from the surrounding environment and provide lasting hydration for the skin in the long term.
• Repairing Effect: They are helpful to protect our body from harmful toxins like UV rays, environmental pollution, and drastic temperature changes.
• Protective Barrier: In the long term, hyaluronic acid and its sodium salt could form a complex mesh structure and strengthen the protective barrier for the skin. Wrinkles would be reduced and the plump and glowing skin would be obtained.

5.    Conclusion

Hyaluronic acid and sodium hyaluronate nearly represent the same chemical, and the two terms are often used interchangeably in the skincare and medical world. You can use them at the same time for a better hydrating effect. The slight difference is that sodium hyaluronate is more stable and penetrates the surface of the skin more easily than hyaluronic acid.

Stanford Chemicals Company is a pure organic hyaluronic acid wholesale supplier. Hyaluronic acids of medical grade, cosmetic grade, and food grade are available on our website. High molecular weight, middle molecular weight, and low molecular weight sodium hyaluronate are also available. They are applied to a range of fields including food supplements, cosmetics, eye drops, and pharmaceuticals. For more detailed information, please visit our website.

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Hyaluronic acid (abbreviated HA), or (C14H21NO11) n, was discovered in 1934 by Karl Meyer and John Palmer from the vitreous body in a cow’s eye. Its structure was analyzed later. It is a disaccharide unit glycosaminoglycan composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid belongs to the intercellular matrix of the human body, and it plays an essential role in water retention and regulation of osmotic pressure. Hyaluronic acid keeps moisture and offers a protective barrier for the human body, especially in the eyes, joints, and skin. It is an important chemical substance used in many industries, especially the cosmetic industry.

What Is Micro Hyaluronic Acid?

Micro hyaluronic acid is a type of hyaluronic acid with a relatively smaller size and larger impact. It is a low molecular weight HA (<5K Da), even lower than mini HA (<10K Da). As introduced at the beginning, hyaluronic acid is a polymer. Large molecules of hyaluronic acid, it is difficult to penetrate the skin. Yet tiny molecules could get deeper into the skin and promote cell proliferation and differentiation. So, smaller fragments like the Micro hyaluronic acid can penetrate the skin much easier and have a better regenerating effect.

Micro-HA Super Active Hyaluronic Acid is a new low molecular weight active ingredient. It is made by a unique enzymatic degradation technology with superb biological activity. Micro-HA can keep moisture, protect the skin against inflammation and sensitivity, and get into the epidermis and the dermis to scavenge free radicals. For more information about Micro-HA and related quality products, please check our website.

How to Get Micro Hyaluronic Acid?

There are three ways to obtain micro hyaluronic acid. Their advantages and disadvantages are listed as follows.

• Animal Sources: This was the earliest way to get Micro hyaluronic acid. However, it was abandoned for the low extraction rate, the huge cost, and the complex isolation process.
• Industrial Synthesis: It is the most common way to get Micro hyaluronic acid nowadays. Micro hyaluronic acid can be produced quickly and efficiently.
• Microbial Fermentation: It is a new method to produce hyaluronic acid to replenish the HA in the human body.

What Are the Benefits of Micro Hyaluronic Acid?

Micro Hyaluronic Acid in the Cosmetic Industry

Micro hyaluronic acid is widely used for cosmetic products. A range of products, from initial cream, lotion, essence capsules, and film paste to bath liquid, powder, lipstick, shampoo, and conditioner, use this substance and provide a great user experience for beauty lovers.

1. Hydration

The key benefit of micro hyaluronic acid is hydration. Micro hyaluronic acid contains numerous carboxyl and hydroxyl groups, so it can be linked with a large amount of water – it can absorb more than 1,000 times its weight in water. Generally, using a small amount of micro hyaluronic acid is like a big drink of water for your skin. What’s more, it could continue to draw moisture in from the surrounding environment and provide lasting hydration for the skin in the long term.

2. Repairing

Micro hyaluronic acid is helpful to protect our body from harmful toxins every day. A lot of things from UV rays to environmental pollution like drastic temperature changes can cause damage to our skin, such as more wrinkles, dark spots, and drier skin. Other harmful factors include excessive cleaning, excessive skin care, and excessive makeup. While micro hyaluronic acid promotes cell growth and accelerates the repairing of these damages.

3. Protection

It also has some preventive effects, such as regulating inflammatory factors, promoting cell proliferation and differentiation, and scavenging free radicals. In the long term, it forms a complex mesh structure and serves as a good protective barrier for the skin.

4. Increase Resilience

Micro hyaluronic acid is easy to penetrate into the epidermis and dermis because of its extremely low molecular weight. According to statistics, the absorptivity of Micro hyaluronic acid was 35.6% after 0.5 hours, 52.5% after 1 hour, 81.9% after 8 hours, and more than 90% after 24 hours. Compared with its equivalent, Micro hyaluronic acid is more protective.

Micro Hyaluronic Acid in Other Sectors

Micro hyaluronic acid is not only a substance used for skincare products. It is also used in medical sectors, research, etc.

• It is used to treat osteoarthritis of the knee via intra-articular injection.
• It is used to create artificial tears to treat dry eyes.
• Due to its high biocompatibility, it is used in tissue engineering research and regenerative medicine research.
• Medical hyaluronic acid could be used in eye surgery like cataract surgery, glaucoma surgery, and surgery to repair a retinal detachment.

Where to Buy the Best Micro Hyaluronic Acid?

Stanford Chemicals Company is a pure organic hyaluronic acid wholesale supplier in the USA. The company has rich experience in the production and sales of medical-grade, cosmetic-grade, and food-grade hyaluronic acid (HA). The high molecular weight, middle molecular weight, and low molecular weight hyaluronic acid powder are available as well. We offer hyaluronic acid raw materials to customers in the USA, Canada, and Europe. A detailed description of Micro hyaluronic acid is listed below. For further information, please make your inquiry.

020-000-118 Micro Hyaluronic Acid Specification

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What is hyaluronic acid?

Hyaluronic acid, a chemical substance with the molecular formula (C14H21NO11)n, is a disaccharide unit glycosaminoglycan composed of D-glucuronide and N-acetylglucosamine.

Why can hyaluronic acid be used as a skincare product?

Actually, the answer is simple: hyaluronic acid itself is part of human skin!

Hyaluronic acid is an important component of the intercellular matrix of the human body and can perform the physiological functions of water retention, maintenance of the extracellular space, and regulation of osmotic pressure. Because hyaluronic acid itself contains a large number of carboxyl and hydroxyl groups, it can combine with a large amount of water to play a stable role in water retention. Moreover, the intermolecular polymerization of hyaluronic acid itself forms a complex mesh structure, which makes hyaluronic acid more elastic, so it can serve as a good protective barrier for the skin. In addition to this, hyaluronic acid itself also has the function of regulating inflammatory factors, promoting cell growth, differentiation, and reconstruction, promoting cell proliferation and differentiation, and scavenging free radicals.

However, sometimes, this hyaluronic acid barrier can also go wrong, such as some people’s skin allergies, redness for no reason, some people’s daily hydration, or dry, tight, and flaky. Even with exfoliation, mask cleaning does not work, in this case, it may be that the skin barrier is damaged leading to the appearance of sensitive skin.

There are many reasons for this situation, chemical factors such as excessive cleaning, excessive skin care, and excessive makeup, environmental factors such as drastic temperature changes, wind, and sun, plus many people’s work and rest habits are not very healthy.

Although the human body can synthesize hyaluronic acid to form a skin barrier, multiple factors can cause the body’s hyaluronic acid to be insufficient to meet the skin’s needs, so in this case, replenishing hyaluronic acid is inevitable.

This is the fundamental reason why hyaluronic acid has become a popular choice for skin care products.

Does hyaluronic acid supplementation really work?

The answer is yes, it does.

In fact, there are numerous clinical studies that confirm that hyaluronic acid supplementation by itself will have a repairing effect on the skin.

By this point, I’m sure many of you already understand why hyaluronic acid is widely used in skincare products.

However, hyaluronic acid supplementation is not simple, as there are at least two important elements to note here.

One, the molecular weight of hyaluronic acid

As introduced at the beginning, hyaluronic acid itself is a polymer, and the n in the molecular formula (C14H21NO11)n indicates the polymerization of different numbers of single molecules of hyaluronic acid.

In brief, large molecules of hyaluronic acid with n greater than 10^6 hyaluronic acid molecules polymerize to form large molecules of hyaluronic acid that primarily serve to moisturize, lubricate and inhibit inflammatory responses.

The polymerization of hyaluronic acid with n between the 10th^4th and 6th power plays a role in promoting blood vessel formation and facilitating wound healing.

In contrast, oligomeric hyaluronic acid formed by the polymerization of hyaluronic acid with n less than 10^4 number has the effect of promoting proliferation, differentiation, and scavenging free radicals.

This suggests that for hyaluronic acid, it is not just a matter of seeing the ingredient and thinking it is all-powerful, but one should also consider the impact of its molecular weight.

Some hyaluronic acid repair products have already started to design products from the perspective of different molecular weights.

Second, the source of hyaluronic acid is an important biological material and composition.

The fact that hyaluronic acid is widely distributed, so also leads to a very complex source of hyaluronic acid.

Common sources are animal sources, microbial sources, and industrial synthesis.

The animal was the earliest way of source of hyaluronic acid, mainly from the corpuscles and vitreous humor of the bull’s eye, etc. However, the low extraction rate of hyaluronic acid from animal sources itself, the complicated isolation process, and the high price made it not available in bulk, which limited its application and made hyaluronic acid an expensive ingredient in the early days.

Industrial synthesis is now the most common way to source hyaluronic acid. With the help of industrial equipment, hyaluronic acid can be produced quickly and efficiently, which greatly reduces the cost of manufacturing hyaluronic acid, and this is the main reason why hyaluronic acid can reach millions of households, but the structure of industrially produced hyaluronic acid is not pure.

Microbial fermentation, on the other hand, is a new hyaluronic acid production method that has been developed in recent years and has both an efficient production level and a biological source of hyaluronic acid, which can guarantee a more complete hyaluronic acid composition and is currently used as the new hyaluronic acid of choice.

Overall, hyaluronic acid itself is a component of the skin, so for people with a damaged skin barrier, hyaluronic acid supplementation is an important way to go, and as a polymer, hyaluronic acid itself functions differently at different molecular weights, and it is best to supplement all of them. Of course, different sources of hyaluronic acid are also important options.

The post What Is the Role of Hyaluronic Acid in Skin Care Products? appeared first on Stanford Chemicals.

What Are Acne Scars?

Acne scars are visual defects that will stay with you for a lifetime. Some people don’t mind them too much whereas others will go to great lengths just to lessen their impact. A great middle ground has been reached where people can get rid of these scars temporarily with extreme ease and safety. You won’t have to get some dangerous injections or go under the knife. Hyaluronic acid has been known to lessen the visual impacts of aging and is also being used by many people to treat acne scars. I’m going to delve deeper into how this product works to get rid of your blemishes and reveal other important facts.

What Is Hyaluronic Acid?

Hyaluronic acid is a substance that originates from within your body. It is used as a natural filler and lubricant. The chemical is most commonly found within the skin and amongst cartilage. It is considered a filler because it occupies the space between elastin and collagen fibers. The reason this substance is so useful is that it is a water magnet that both attracts and holds water. This serves to hydrate your skin and make it more volume. Hyaluronic acid has been used as a treatment for diseases like arthritis for many years now, but its use has recently expanded to cosmetics.

What Are the Functions of Hyaluronic Acid?

The functionality of hyaluronic acid makes it a great candidate for lessening the visual impact of acne scars. It works best on certain types of acne scars which are of a circular shape and are on the smaller side of the scale. It’s not a miracle chemical, but it will certainly do a lot to make your acne scars blend in. This action is due to the volume it introduces which serves to even out your skin. The same principle applies to other lines and defects in the skin which can be smoothened out; these include frown lines and deep smile lines.

How Does Hyaluronic Acid Cure Acne Scars?

If you are looking for the biggest impact, hyaluronic acid injections are the best way to go although there are facial creams that also increase volume. These injections are usually done as an outpatient procedure. First, a medical professional will take a look at your skin; when it comes time for injection, the routine is standard. A local anesthetic is sometimes used to desensitize the area of injection. Afterward, a very fine hypodermic needle will be inserted under the scar and hyaluronic acid will be injected.

There are only a few negative effects to look out for. Many of these are byproducts of the injection process. Hyaluronic acid is a natural compound so these symptoms are not allergic reactions. Side effects include a slightly red or swollen area injection site, tenderness, and bruising.

This approach is not a permanent fix, and you will have to keep re-administering the substance to keep up the effects. Depending on the quality of hyaluronic acid used, the substance will be broken down and absorbed by your body in a matter of three months to two years.

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Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. Hyaluronic acid distributes widely in the human body, such as in connective, epithelial, and neural tissues. It can be obtained by extracting from cockscomb or through microorganism fermentation. The product in our company is all fermented products.

What are the types of Hyaluronic acid?

What does hyaluronic acid consist of?

Molecular Weight & Viscosity

What is hyaluronic acid and how does it work?

What is hyaluronic acid? HA is a humectant — a substance that retains moisture — and it is capable of binding over one thousand times its weight in water. This substance is naturally found in many areas of the human body, including the skin, eyes, and synovial fluid of the joints.

The post An Overview on Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Professors of Ophthalmology at Columbia University in the USA first isolated the substance from the bovine vitreous body.

What Are the Functions of Hyaluronic Acid?

What Does Hyaluronic Acid Do to Your Skin?

Conclusion

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