Understanding the Two Methods: Animal Extraction and Bacterial Fermentation

On the market, the production methods for hyaluronic acid can be divided into two categories: animal extraction and bacterial fermentation.

–Animal Extraction

As the name suggests, the animal extraction method involves extracting hyaluronic acid from animal tissues. Common sources include rooster combs, bovine vitreous humor, and fish skin, which are rich in natural hyaluronic acid.

Process:

• Processing and grinding the animal tissue.
• Extracting the hyaluronic acid through chemical treatment or enzymatic hydrolysis.
• Purifying the hyaluronic acid using methods like precipitation, centrifugation, and filtration.
• Drying and powdering the purified hyaluronic acid.

–Bacterial Fermentation

This method uses certain microorganisms to secrete a capsule during growth, and the main component of that capsule is hyaluronic acid. The fermentation process involves feeding the microorganisms nutrients like sugars and amino acids. Common bacteria used are streptococci and lactic acid bacteria.

Process:

• Selecting suitable strains of bacteria (e.g., streptococci).
• Cultivating the bacteria in fermentation tanks, where they produce hyaluronic acid.
• After fermentation, the mixture is filtered, precipitated, and ultra-filtered.
• The hyaluronic acid is then purified and dried into powder form.

Fig 1. Sodium Hyaluronate Powder

Comparing the Two Methods: Animal Extraction vs. Bacterial Fermentation

When comparing two processes, we cannot avoid the issues of raw materials, processes, costs, product quality, safety, etc. We will also compare these aspects.

1. Raw Materials

Animal extraction relies on material supplied by animals, and its resources are limited besides raising ethical issues. On the contrary, bacterial fermentation deals with renewable plant-based or synthetic nutrients in a controlled process, hence sustainable.

2. Process Characteristics:

Animal extraction involves the manipulation of biological materials that require high chemical usage. The extraction efficiency is low. Fermentation of bacteria is fully automated and controllable; optimized conditions raise the yield of production.

3. Cost

The extraction from animals is more expensive because the used animal tissues are not very much available, and there is a huge usage of chemicals involved. Handling animal tissues involves more labor and equipment costs due to their complexity.

Bacterial fermentation, on the one hand, is less expensive and suitable for large-scale production; to further reduce costs, the fermentation can be carried out on a batch or continuous basis, with raw materials required like sugars and water being low in price.

4. Product Quality and Safety:

Animal extraction uses animal tissues. The possibility, therefore, exists for contamination by the likes of pathogens like bacteria, viruses, or prions, and allergens. Strict safety testing is thus mandatory for all medical and cosmetic applications.

Hyaluronic acid produced by bacterial fermentation, on the other hand, has higher purity. By mimicking the optimum fermentation conditions with great care, and purifying it further, the risk of contamination can be reduced much further, thus being safer. This methodology produces hyaluronic acid-free of all animal components, appropriate for vegetarians and those forbearing animal products.

5. Control of Molecular Weight

The procedure for the extraction of hyaluronic acid from animals does complicate the complete control over molecular weight, which is usually higher. This, in turn, makes it more applicable for products that require high viscosity, such as lubricants or mucosal protectors.

Due to bacterial fermentation, better control of molecular weight through adjustments in the steps of fermentation and processing is possible. This flexibility enables various molecular weights for hyaluronic acid to be produced, allowing different applications.

Conclusion

• Animal Extraction: The extraction process is complex, with high costs, low yields, and inconsistent quality. It also poses a risk of contamination from animal sources, making it more suited for small-scale, high-end medical or specialized applications.
• Bacterial Fermentation: This method offers high production efficiency, lower costs, and high product purity. It allows for better control over molecular weight and is ideal for large-scale industrial production. As a result, it is the primary method used for modern hyaluronic acid production.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

The following figure shows the production process of sodium hyaluronate powder:

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Since its discovery, hyaluronic acid (HA) has garnered significant interest from scientists. Despite its simple chemical structure, its biological functions are extensive. Today, hyaluronic acid is widely used in cosmetics to moisturize the skin and reduce wrinkles. In aesthetic medicine, it is used as a dermal filler to add volume to facial wrinkles and hollow areas. In ophthalmic surgery, it serves as a viscoelastic agent for cataract and glaucoma surgeries, providing protection and lubrication for the eyes. In the field of orthopedics, it is used in intra-articular injections to help relieve osteoarthritis for several months. Sodium hyaluronate can be used in different fields such as skin care, medical treatment, and beauty, thanks to the different molecular weights of hyaluronic products.

Hyaluronic Acid Molecular Weight

Molecular Weight of Hyaluronic Acid

–What is the Molecular Weight of Hyaluronic Acid?

Hyaluronic acid (HA) is a naturally occurring polysaccharide molecule found in human tissues. Its molecular weight (M.W) is usually measured in Daltons (Da). The molecular weight of HA can vary greatly, ranging from a few thousand Daltons to several million Daltons. Common hyaluronic products are typically classified into high molecular weight, medium molecular weight, low molecular weight, and oligomeric hyaluronic acid based on their molecular weight.

–Methods for Measuring the Molecular Weight of HA

Gel Permeation Chromatography (GPC): GPC is one of the primary methods for measuring the molecular mass of HA. In this method, the sample is passed through a series of gel columns that separate molecules based on their size. The separated hyaluronic acid molecules are then detected in a detector to determine their molecular weight.

Light Scattering: Light scattering is another commonly used method for measuring the M.W of sodium hyaluronate. In this method, the hyaluronic acid sample solution is exposed to a laser beam, and its M.W is calculated based on the scattering pattern of the molecules.

Viscometry: This method determines the M.W of hyaluronic acid by measuring the viscosity of its solution. The molecular mass of hyaluronic acid correlates with its flow properties in solution, allowing the estimation of M.W through viscosity measurements.

Nuclear Magnetic Resonance (NMR): NMR can also be used to measure the M.W of sodium hyaluronate. By observing the NMR signals of a hyaluronic acid sample in a magnetic field, its molecular weight and molecular structure can be inferred.

Types of Hyaluronic Acid by Molecular Weight

1. High Molecular Weight HA:

• The M.W is higher than 1,800KDa
• Forms a breathable film on the skin surface, locking in moisture and preventing evaporation, providing long-lasting hydration.
• Poor penetration, does not absorb into the skin.

2. Medium Molecular Weight Sodium Hyaluronate:

• The M.W is between 200KDa and 1,800KDa.
• Forms a breathable film on the skin surface, locking in moisture and tightening the skin.

3. Low Molecular Weight Hyaluronic Acid:

• The M.W is between 5KDa and 200KDa.
• Penetrates the dermis layer of the skin, locking in moisture and promoting skin metabolism, making the skin moist, smooth, delicate, and elastic.
• Poor water retention ability on the skin surface.

4. Oligomeric Hyaluronic Acid:

• The M.W is less than 5KDa
• Composed of less than 50 monosaccharide units, with a degree of polymerization of less than 25, it can deeply penetrate the dermis layer.

Table 1 Comparison of HA with Different Molecular Weights

Table 1 compares the differences of hyaluronic acid with different molecular weights from the four dimensions of molecular weight, water solubility, moisturizing effect and durability.

Stanford Chemicals Company (SCC) is at the forefront of hyaluronic acid development, offering sodium hyaluronate powder in various molecular weights. For more information or specific applications, please visit our home page.

Common Applications of Hyaluronic Acid with Different Molecular Weights

There is currently a general view that the biological effects of hyaluronic acid depend largely on molecular mass. In the same way, hyaluronic acid is widely used in different fields depending on its molecular mass.

–Main Applications of High Molecular Weight HA

High molecular weight hyaluronic acid is mainly used in the fields of lubrication and moisturizing. It has strong moisturizing properties and biocompatibility, and is often used in medicine and cosmetics.

• Ophthalmic surgery: High molecular weight hyaluronic acid is often used as a viscoelastic agent in ophthalmic surgery (such as cataract surgery), where it can provide good lubrication and protection.
• Joint lubricant: In the treatment of osteoarthritis, as an intra-articular injection (such as SYNVISC), high molecular mass hyaluronic acid can improve the viscoelasticity of joint fluid, relieve pain and improve joint function.

–Main Applications of Medium Molecular Weight HA

Medium molecular weight hyaluronic acid is mainly used in the field of moisturizing and repairing. It has moderate moisturizing effect and good transdermal absorption, and is widely used in skin care products and medical dressings.

• Skin care products: For example, hyaluronic acid used in facial creams and essences can help the skin retain moisture, enhance skin barrier function, and promote cell regeneration.
• Medical dressings: Medium molecular mass hyaluronic acid is often used in burn and wound dressings to provide a moisturizing environment and promote wound healing.

–Main Applications of Low Molecular Weight HA

Low molecular weight HA is mainly used in the fields of permeability and anti-aging. It has better permeability and biological activity, and can penetrate deeper into the skin to stimulate cell activity.

• Anti-aging products: such as anti-wrinkle essences and eye creams. Low molecular mass hyaluronic acid can penetrate deep into the dermis, promote collagen production, and reduce fine lines and wrinkles.
• Oral supplements: Some oral hyaluronic acid supplements are designed to be absorbed through the intestines to improve skin hydration and anti-aging effects throughout the body.

–Main Applications of Oligomeric Molecular Weight HA

Oligomeric molecular weight HA is mainly used for deep moisturizing and repair. It has very high biological activity, can quickly penetrate the skin, and plays a role in cell repair and immune regulation.

• Deep moisturizing essence: In high-end skin care products, oligomeric molecular mass hyaluronic acid is often used as an active ingredient, quickly penetrating into the bottom layer of the skin to provide deep hydration.
• Regenerative repair products: such as post-traumatic repair cream or post-operative care products, oligomeric molecular mass hyaluronic acid can quickly repair the skin barrier and promote wound healing.

Conclusion

Hyaluronic acid is categorized into high molecular weight, medium molecular weight, low molecular weight, and oligomeric hyaluronic acid based on its M.W. Each type of HA, due to its unique physical and chemical properties, plays a distinct and important role in medicine and skincare products.

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Skincare is more than just about cleansing and moisturizing; it’s about discovering ingredients that truly transform your complexion. If you’re on a quest for revitalized and youthful-looking skin, look no further than Sodium Hyaluronate Powder. This remarkable ingredient derived from hyaluronic acid has gained immense popularity in the skincare world for its ability to deliver deep hydration and rejuvenate the skin. In this article, we’ll explore how Sodium Hyaluronate Powder can revitalize your skincare routine and help you achieve the healthy, glowing skin you desire.

Sodium Hyaluronate Powder

Understanding Sodium Hyaluronate Powder

Sodium Hyaluronate Powder is derived from hyaluronic acid, a naturally occurring substance in the body that holds moisture and keeps the skin hydrated. However, Sodium Hyaluronate Powder takes it a step further. It is a more stable and smaller molecule than hyaluronic acid, allowing for better absorption into the skin. As a result, this powder delivers intense hydration, promoting plump, supple, and youthful-looking skin.

Related reading: Sodium Hyaluronate: Skin Benefits, Products to Use, and More

Benefits of Sodium Hyaluronate Powder in Skincare Routine

Sodium Hyaluronate Powder stands out for its remarkable ability to transform the skin. It possesses both exceptional moisturizing properties and the ability to enhance the skin’s radiance.

–Deep Hydration

Hydration is the foundation of healthy skin, and Sodium Hyaluronate Powder excels in providing intense moisture. Its small molecular size allows it to penetrate deeply into the skin, delivering hydration where it is needed the most. By attracting and retaining water molecules, Sodium Hyaluronate Powder helps plump up the skin, reducing the appearance of fine lines and wrinkles. The result is a complexion that looks hydrated, supple, and youthful.

–Improved Skin Texture

Uneven skin texture can make the skin appear dull and lackluster. Sodium Hyaluronate Powder can help improve the texture of your skin, making it smoother and more refined. As it deeply hydrates the skin, it enhances the natural exfoliation process, helping slough off dead skin cells and revealing fresher, smoother skin underneath. Regular use of Sodium Hyaluronate Powder can lead to a more even, radiant complexion.

–Enhanced Skin Elasticity

Loss of elasticity is a common sign of aging, but Sodium Hyaluronate Powder can help combat this issue. By replenishing moisture levels, it restores the skin’s natural plumpness and firmness. The increased hydration improves the elasticity of the skin, making it appear more supple and resilient. This can help reduce the appearance of sagging skin and promote a more youthful-looking complexion.

–Anti-Aging Effects

Fine lines, wrinkles, and other signs of aging can be a cause for concern. Sodium Hyaluronate Powder has impressive anti-aging properties that can help diminish these visible signs. Its hydrating effects fill in the fine lines, making them appear less prominent. Additionally, by promoting optimal hydration, it can help improve the overall appearance of the skin, making it look smoother and more youthful. Adding Sodium Hyaluronate Powder to your skincare routine can be a game-changer in your fight against aging.

–Versatile Application

One of the great advantages of Sodium Hyaluronate Powder is its versatility in skincare products. It can be easily incorporated into various formulations such as serums, creams, lotions, and masks. Whether you prefer lightweight textures or more emollient formulas, you can find a product containing Sodium Hyaluronate Powder that suits your preferences. This allows you to tailor your skincare routine to your specific needs while reaping the benefits of this powerful ingredient.

Conclusion

In short, Sodium Hyaluronate Powder is a game-changer when it comes to revitalizing your skincare routine. Its deep hydration, skin texture-improving properties, enhanced elasticity, and versatility make it an invaluable addition to any skincare regimen. Incorporate Sodium Hyaluronate Powder into your routine and experience the transformative power it can have on your skin. Get ready to enjoy a revitalized complexion that radiates health and beauty.

Stanford Chemicals Company (SCC) offers reliable and safe Sodium Hyaluronate Powder for your business and research. Our production is strictly managed according to ISO 9001 and GMP standards. There are Sodium Hyaluronate Powders of different molecular weights on our website. Send us an inquiry if you are interested.

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Sodium Hyaluronate Powder for Skin

It provides comprehensive and multi-layered care for the skin. It provides long-lasting moisturization, reaching the bottom of the skin to restore hydration and radiance.
It is composed of various derivatives of sodium hyaluronate, cationic hyaluronic acid, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, 1,2-pentanediol, 1,2-secanediol, glycerin, and water.

What Happens If You Apply Sodium Hyaluronate Powder to Dry Skin?

1. Adsorbs on the surface of skin hairs, is rinse-resistant and plays a continuous hydrating role.
2. Forms a breathable film to lock in moisture and isolate it from UV rays.
3. It can nourish the skin and increase the elasticity of the skin.
4. Mild and non-irritating, the acetyl group introduced penetrates into the muscle base and moisturizes deeply.
5. Penetrates the skin, deeply hydrates, and revitalizes cellular activity.
6. Deep penetration to form an invisible dense protective film, anti-inflammatory and allergy-relieving cell barrier.
7. It can moisturize for a long time, reach the bottom of the muscle and replenish water efficiently, make the skin recover hydrated and glowing, and enhance the key role of permeability, water locking and moisturizing, anti-aging, etc. on the basis of single sodium hyaluronate moisturizing properties.

What Are the Features of Sodium Hyaluronate Powder?

1. Golden ratio: Based on the characteristics of sodium hyaluronate and its derivatives with different molecular weights, it is scientifically proportioned through research and testing.
2. Multi-level action: Multi-molecular weight sodium hyaluronate and its derivatives play different efficacy roles to build a three-dimensional action framework and stronger water-locking and moisturizing performance.
3, Safe and stable: raw material compliance production, quality system strict control, to ensure the quality of the product and safety.

What Are the Applications of Sodium Hyaluronate Powder?

Hair care: shampoo, conditioner, hair mask, etc.
Skincare: moisturizing water, lotion, cream, essence, etc.
Washing and care: facial cleanser, makeup remover, etc.
External medical devices: cold compresses, moisturizing patches, etc.

Conclusion

STANFORD CHEMICALS keeps improving its own R&D capability and quality management system,  insists on green scientific production, and helps SCC brand to build a powerful Sodium Hyaluronate Powder for functional skin care products!

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Sodium hyaluronate is a chemical compound made from hyaluronic acid. As the name suggests, sodium hyaluronate is a salt of hyaluronic acid. This is just one of two known hyaluronate salts, as hyaluronic acid has two salts: potassium hyaluronate and sodium hyaluronate.

Hyaluronic acid is a naturally occurring acid. The body produces it in copious amounts in areas like the joints, the eyes, and the skin. Hyaluronic acid aids the lubrication of tissues. It can absorb and retain water levels up to 1000 times greater than its weight.

Sodium hyaluronate is synthesized from hyaluronic acid and has similar capabilities.

Sodium hyaluronate can absorb and retain water far above its weight. It has a smaller molecular structure than hyaluronic acid. It is, therefore, more stable than hyaluronic acid. It also has a more excellent oxidation resistance.

Hyaluronic acid and sodium hyaluronate are suitable in skincare products due to their moisturizing abilities. They also aid the skin in looking plumpy, supple, and fresh.

Differences Between Hyaluronic Acid and Sodium Hyaluronate

Hyaluronic acid is the naturally occurring material from which sodium hyaluronate is extracted. Many products which contain sodium hyaluronate have hyaluronic acid written on their label. This is a common mistake due to the similar nature of both substances. However, there are significant differences between them.

Hyaluronic acid is naturally occurring, while sodium hyaluronate is synthesized from hyaluronic acid. Due to this, sodium hyaluronate is more stable than hyaluronic acid.

Hyaluronic acid is also a macromolecule. Its large molecules hydrate the skin by forming a coat that prevents water loss. On the other hand, sodium hyaluronate has smaller molecules than hyaluronic acid. Therefore, its molecules can penetrate the epidermis and provide moisturization from within.

Sodium Hyaluronate’s Uses in Skin Care Products

We use sodium hyaluronate in a wide range of skin care products for various reasons. It is most commonly used as an ingredient in moisturizers due to its ability to retain large amounts of water.

Sodium hyaluronate is also sold alone as sodium hyaluronate powder. The powder can be mixed with water and applied to the skin alone or with other moisturizing products.

Sodium hyaluronate powder is beneficial for people who have dry skin. It acts as a lubricant by absorbing the water from the surroundings while preventing excessive loss of water from the skin.

Dry skin is a problem that typically becomes more pronounced as a person gets older. This is because the body no longer produces hyaluronic acid as it once did when younger. This leads to dryness of the skin and joint pain due to the dryness. Sodium hyaluronate powder can help lubricate the skin and joints without the usual levels of hyaluronic acid.

Due to its ability to absorb water, the application of sodium hyaluronate causes slight swelling of the skin. This swelling makes the skin look lush and supple as an individual gets older.

Apart from moisturizing the skin and lubricating the joints, sodium hyaluronate also has other uses in skincare products, some of which include:

• Makes Wrinkles Less Visible: Sodium hyaluronate powder moisturizes and reduces the visibility of wrinkles when applied to the skin. Wrinkles are usually pronounced when the skin is dry, so moisturizing makes them less visible.
• Helps Stop Skin Inflammation: When applied to the skin, sodium hyaluronate can help in stopping skin inflammation. Using sodium hyaluronate powder on the skin aids in the production of a chemical (beta-defensin 2) that aids in the healing of sore tissues.

Medical Uses of Sodium Hyaluronate

Other than its numerous uses in the skincare industry, Sodium Hyaluronate also has a lot of medical applications.

It is used in the treatment of osteoarthritis in the knee. Osteoarthritis sets in when the joints in the knee are no longer adequately lubricated because the levels of hyaluronic acid being produced are not enough. This leads to stiffness in the knee and pains, especially when walking. Shots of sodium hyaluronate as prescribed by the doctor help lubricate the knee.

Sodium hyaluronate is also used by doctors while performing surgery on the eye. It is mainly used to protect the cornea during surgical procedures on the eye. Reports show that it has no side effects and that operations carried out with sodium hyaluronate yield better results than those performed without it.

It is also used to treat dry eye and rhinitis conditions. Rhinitis occurs when there is inflammation in the nose.

Side Effects

Sodium Hyaluronate has no known side effects. It is safe, especially when used according to a doctor’s prescription. However, some people might have allergic reactions to one or more components. If you notice your skin reacting as you apply sodium hyaluronate, you should stop immediately and see a doctor.

Sodium Hyaluronate Forms

Sodium hyaluronate comes in several forms other than sodium hyaluronate powder. The purpose of use typically determines the method of administering it.

Some of the forms include:

• Gel
• Lotion
• Serum
• Face wash
• Eye drops
• Injection

At Stanford Chemicals, we provide cosmetic-grade Sodium Hyaluronate that is used in the manufacture of top-quality skin care products that moisturize dry skin and remove wrinkles. You can contact us now at (949) 812 6690 or (949) 468 0555 to learn more or place an order.

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