The process of gradual accumulation of unfavorable biological and physical changes in a person over time is referred to as aging. Although the complete biological basis of aging is still not completely revealed, and plenty of theories are in competition for the best explanation, recent research has confirmed that some substances can retard, or even reverse most of those profound processes.

One of the best and most popular remedies is Hyaluronic Acid (HA), a naturally occurring substance in the body, which is abundant in our bodies at the beginning of our lives. It plays multiple important biochemical roles and is the filler and cushioning agent in many parts of the body. It has been reported that its manufacture is gradually decreasing over time and this reduction could play an important role in the aging process.

As we age HA body concentration is diminishing, which is why our aging has physical effects. Research has shown that there is an estimated 50% deficit of the necessary amount for optimal body cell functioning of the content of HA by the time we reach our mid-40s. This process is getting increasingly visible and our skin starts to lose its elasticity, with lines and wrinkles forming.

There are many reports and clinical studies indicating the beneficial effects of HA applications, whereas no data support the claim that HA products cause cancer. Recent research highlights that the interactions between hyaluronan and tumor cells indicate a possibility of new therapeutic strategies and would even offer a new anti-cancer strategy.

Hyaluronic acid possesses anti-oxidative properties and high water-holding capacity, ensuring the optimal hydration of the skin and hair. Roughly calculated, it could retain over 1000 times its weight in water within the cells of the skin, which places it among the best existing moisturizers. HA causes a rise in the fluid in between the cells, binding with water molecules. What is more, it helps to maintain optimal collagen levels. Collagen depletion is widely considered a leading factor for the loss of skin elasticity, something that relates closely to the visual consequences of the aging process. Its proper application in the correct quantities leads to increased smoothness, softening, and decreased wrinkles.

Furthermore, it is claimed that cosmetic-grade hyaluronic acid can remove harmful waste matter from cells, thus improving their function and overall blood circulation. In addition, it is a vital component of the connective tissue, which provides strength and flexibility to many parts of the body, such as the cartilage, blood vessels, and skin. Altogether, that can transform completely our appearance, making us healthy, productive, and youthful. The bettered muscular strength and mental alertness, cause us to look and feel more active, energized, and mobile.

HA is now widely available in the form of various anti-aging treatments and supplements, skin creams, and injectables. The most common application for micro HA is cosmetic procedures such as the elimination of skin defects and wrinkles.

The post How Can Hyaluronic Acid Combat Aging? appeared first on Stanford Chemicals.

The problem plaguing our customer

One of our customers faced a problem, macromolecule active ingredients (or at least 500KD) are historically difficult or impossible to deliver topically through tissue structures with the limitation of traditional methods.

The customer is a clinical-stage bio development company whose objective is to reduce society’s exposure to potentially harmful active agents by utilizing novel permeation technology to deliver active agents through tissue structures more efficiently.

“The topical delivery of large molecules through the skin, hair, eyes, mucosal surfaces, and bone are difficult using traditional hyaluronic acid.” said a medical director from one of our customers.

In the past, the most common form of hyaluronic acid in the pharmaceutical industry is high molecular weight HA, usually, more than 1800 K Da.

Low-molecular HA VS High-molecular HA

The difference between high-molecular hyaluronic acid (≥1,800 kDa) and low-molecular-weight HA (10 kDa ~1,000 kDa) is that the low-molecular-weight HA has been split into smaller fragments. The smaller fragments can no longer form a gel with water like the large molecules, but they can penetrate the skin much easier and have a better anti-irritant and regenerating effect once absorbed by the skin.

Why choose Stanford Chemicals?

In the past, the customer had purchased traditional mini HA (>10K Da) for its pharmaceutical delivery research. Over the years, Stanford Chemicals has developed HA with the low molecule that has stronger skin penetration, named micro hyaluronic acid (micro HA), which is a low molecular weight HA (<5K Da). It is even lower than the mini HA. The main functions of Micro HA are recovery and super moisturizing the tissues.

Stanford Chemical’s Micro-HA Super Active hyaluronic acid was used in Illustris molecule delivery technology to help facilitate a permeation process of the drugs in the human body. Micro hyaluronic acid as a drug carrier contributes to drug thickening, sustained release, transdermal absorption, and improved drug targeting.

By adopting the low molecular weight HA, the customer is able to provide a significant competitive advantage to molecule delivery, yielding enhanced safety and efficacy for patients.

Main Features of Micro HA

Since 5 kDa HA revealed a much more pronounced absorption activity through the skin than it could be observed for 10 kDa HA. Due to its micro size, micro-HA super active hyaluronic acid penetrates deep into the skin and other tissue structures easily, optimizing the absorption of compounds delivered through the skin, eyes, and mucosal. With the addition of micro HA, the cell proliferation rate of macromolecule active ingredients increased significantly; 0.125% micro HA can make the cell proliferation rate increase up to 94%.

There are 2 Benefits for Our customers

After utilizing our products Micro Hyaluronic Acid in its revolutionary delivery technology, they provide a significant competitive advantage with its novel approach to molecule delivery, yielding enhanced safety and efficacy for patients

“We are pleased to have used micro HA for Illustris’ innovative delivery technology,” said a technician from the pharmaceutical company, “We are eager to use micro HA and showcase its significant advantages over current drug delivery technology.”

Our customers benefited in the following ways:

Revolutionized HA solution for drug delivery system

The customer enables the delivery through tissue structures of macromolecule active ingredients (or at least 500KD) which are historically difficult or impossible to deliver topically and optimizes the delivery of active agents which previously permeated tissue structures inefficiently. It is easy for active ingredients to permeate the targeted site with Micro HA. Now, it enables the delivery of large molecules (up to 160KD) through tissue structures easily and optimizes the absorption of compounds typically delivered through skin, eyes, and mucosal surfaces.

Lower Cost

Stanford Chemicals (SCC) supplies high-purity micro HA at a very competitive price. Since the advanced specification of micro-HA, our customers can research its innovative delivery technology for pharmaceuticals easily. Therefore, this is a win-win result, it is also good news for the HA market. We are both happy with this transaction.

There are several benefits to using SCC micro HA throughout the pharmaceutical delivery process. For pharmaceutical companies with similar applications, our engineering team can provide a customized solution for your project. Feel free to contact us at [email protected].

The post Application of Micro Hyaluronic Acid as Carriers in Drug Delivery appeared first on Stanford Chemicals.

The topical delivery of large molecules through skin, hair, eyes, mucosal surfaces and bone is difficult using high molecular weight hyaluronic acid.

In the past, the most common form of hyaluronic acid is high molecular weight, usually, more than 1800 K Da.

The difference between regular, high-molecular hyaluronic acid (HA) and low-molecular-weight HA is that the low-molecular-weight HA has been split into smaller fragments.

Thereby, these smaller fragments can no longer form a gel with water like the large molecules, but they can penetrate the skin much easier and have actually a better anti-irritant and regenerating effect once absorbed by the skin.

super active hyaluronic acid

Now, after several years, our new product Micro-HA Super Active hyaluronic acid was used in Illustris molecule delivery technology to help facilitate a permeation process.

Micro HA is a kind of very low molecular weight HA (<5K Da). It is even lower than mini HA (<10K Da).

Micro Hyaluronic Acid helps plump skin to improve volume and suppleness. Due to its micro size, it penetrates deep into the skin to infuse moisture below the surface, providing skin replenishment and moisturization from the inside out.

Micro-HA Super Active Hyaluronic Acid is a new low molecular weight active ingredient produced by a unique enzymatic degradation technology with superb biological activity. Micro-HA can quickly penetrate the epidermis and the dermis to scavenge free radicals, reduce inflammation factor activity, repair damaged cells, and protect the skin against inflammation and sensitivity caused by various stimuli.

In the past, the traditional industry or traditional HA-related products are more suitable for adults. However, after several years, we have designed a brand new product of HA. It is named micro HA. Micro HA is a kind of very low molecular weight HA (<5K Da). It is even lower than mini HA (<10K Da). The main functions of Micro HA are recovery and super moisturizing the tissues. It can increase the protection of baby care from daily life.

One of the examples from our customers

One of our regular customers was focused on personal care products. In the past, they sell more products for adults, especially for women. However, after utilizing products Micro HA in their new products, they obtained a lot. It is not only can enrich their product sorts, but also expand the market sales for their company. Since the advanced specification of micro-HA, they can search the new products for baby care. Therefore, this is a win-win result, it is also good news for the HA market. We are both happy about this transaction.

The post Micro Hyaluronic Acid for Cosmetic Applications appeared first on Stanford Chemicals.