According to its purpose, HA can be divided into cosmetic-grade, food-grade, medical-grade, and injectable-grade. Of them, injectable-grade HA is extensively used in cosmetic surgery, joint therapy, and medical lubrication. How to choose suitable injectable-grade HA according to the particular requirement? Let’s discuss that.

What is Injectable-Grade Hyaluronic Acid

Injection-grade hyaluronic acid represents high-quality HA developed especially for medical and cosmetic injection purposes. It undergoes extensive purification processes to remove impurities and possible allergens, ensuring the following features:

• High Purity: It is of medical-grade quality, thus safe to be injected.
• High Biocompatibility: Very similar in structure to human tissues for maximum safety.
• Long-Lasting Stability: It degrades much more slowly, prolonging its effect.

This kind of HA is used for filling facial hollows, and lubricating joints, and can even enhance the smooth operation of surgical tools.

Key Considerations When Choosing Injectable-Grade Hyaluronic Acid

The key to selecting the right injectable-grade HA lies in understanding your application needs. Of course, we have summarized some core indicators here to help you understand your needs.

1. Molecular Weight

Molecular weight defines the viscoelasticity, absorption rate, and degradation time of HA. Generally speaking, high molecular weight works better for lubrication and support, while low to medium molecular weight serves for penetration and drug delivery.

2. Purity and Sterility

HA injections should have ultra-high purity, be free from impurities, and be manufactured under sterile conditions to minimize infection risk.

3. Biocompatibility

Good quality HA should be strictly tested for compatibility with human tissues to minimize inflammation or adverse reactions upon its use.

4. Certification and Credentials

Only choose products certified by international authorities such as FDA or CE to ensure good quality and safety.

Products meeting this criterion will perform well in the intended applications.

Read more: How is Hyaluronic Acid Powder Made

Suitable Molecular Weights for Different Scenarios

–Cosmetic Procedures

HA is commonly used in cosmetic procedures to fill facial hollows, reduce fine lines, and improve skin elasticity.

Studies have shown that HA with molecular weights in the range of 1,300 kDa–1,800 kDa provides optimal viscoelasticity and volumizing effects, which are crucial for facial contouring and dermal filler applications.[i]

The medium to high molecular weight provides the structural integrity needed to sculpt facial contours while maintaining biocompatibility and longer-lasting effects due to slower degradation rates.

–Joint Injections

For patients with osteoarthritis, HA injections are essential for pain relief and improved joint mobility.

The high molecular weight ensures a thick, viscous solution capable of providing cushioning for joints, mimicking natural synovial fluid.

–Medical Lubricants

HA is often used as a lubricant during surgical procedures to minimize friction between instruments and tissues, improving procedural efficiency.

Medium molecular weight (800 kDa–1,300 kDa) HA is well-documented for its flowability and lubricating properties, essential for reducing friction during surgical procedures.[ii]

Medium molecular weight strikes a balance between being easy to handle and highly effective as a lubricant, making it suitable for surgical applications requiring precise, smooth interactions.

Conclusion

It is easy to select the proper injectable-grade hyaluronic acid once the application scenario is clear. Cosmetic procedures require medium and high molecular weight products for excellent support and longevity of results. High molecular weight HA has better application in joint injections, as it maintains lubrication and cushioning.

Meanwhile, in medical lubricant applications, medium molecular weight HA remains flowable with safety features. Regardless of the application, always prioritize purity, sterility, and certifications to ensure safety and effectiveness.

Pure Injection Hyaluronic Acid (HA) Powder from Stanford Chemicals Company

Injection-grade hyaluronic acid from Stanford Chemicals Company (SCC) is GMP, CEP, and DMF certificated and the factory passed an on-site inspection by the US FDA. It is all fermented products, non-animal sources, non-GMO, and non-BSE/TSE risk.

Main Products:

References:

The 5 Common Uses of Injectable Hyaluronic Acid

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

[i] Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x. PMID: 19207319.

[ii] Cowman MK, Schmidt TA, Raghavan P, Stecco A. Viscoelastic Properties of Hyaluronan in Physiological Conditions. F1000Res. 2015 Aug 25;4:622. doi: 10.12688/f1000research.6885.1. PMID: 26594344; PMCID: PMC4648226.

The post How to Choose the Right Injectable-Grade Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. Its salt form, sodium hyaluronate (SH), was initially isolated from the eye’s vitreous body. Sodium hyaluronate has a wide distribution in animal or human tissues, generally located in the extracellular matrix. It has a high concentration in the vitreous humor, aqueous humor, synovial fluid, skin, and umbilical cord.

Sodium hyaluronate is known for its excellent viscoelasticity, unique rheological properties, pseudoplasticity, non-toxicity, and superior biocompatibility.

Fig 1. Artificial tears with hyaluronic acid as the main ingredient

Basis for Sodium Hyaluronate in Ophthalmology Applications

It is highly moisturizing. Sodium hyaluronate can bind water several hundred times its weight, maintaining the ocular surface moisture balance. Its viscoelastic nature allows it to form a stable film on the eye surface, providing lubrication and protection while reducing friction.

As a natural constituent of human tissues, sodium hyaluronate possesses excellent biocompatibility with minimal risk of rejection or irritation. Furthermore, it provides an enhancement in corneal repair and regeneration, reduces inflammation, and soothes discomfort due to environmental stimuli or surgical procedures.

Given these properties, sodium hyaluronate is widely used in ophthalmic products such as artificial tears, surgical viscoelastic fillers, ophthalmic injectables, and corneal repair agents. Its applications range from routine eye care to advanced surgical procedures.

Fig 2. Viscoelasticity of hyaluronic acid

Applications of Sodium Hyaluronate in Eye Health

The uses of sodium hyaluronate in ophthalmology can be roughly divided into two categories. There is ophthalmic viscoelasticity, mainly used in all sorts of ophthalmic surgeries including glaucoma and cataract surgery; another one is eye drops, mainly used in treating dry eyes and corneal burns.

1. Ophthalmic Viscoelastic Agents

1.1 Role in Surgery

Sodium hyaluronate is used as a viscoelastic agent in many eye surgeries. It has a high molecular weight and excellent viscoelasticity, providing mechanical protection for the surgery to take place. Therefore, it maintains structure and prevents tissue collapse or damage caused by surgical instruments.

• Glaucoma Surgery

Sodium hyaluronate protects intraocular tissues, maintains the shape of the anterior chamber, and reduces friction and damage from surgical tools, thus enhancing safety.

• Cataract Surgery

It acts to safeguard the cornea endothelium and to serve as an aid to the implantation of an intraocular lens. It provides a clearer surgical field and minimizes mechanical trauma to the cornea during surgery.

• Trauma Repair Surgery

Sodium hyaluronate serves as a lubricant for the surgical procedure in ocular traumatized patients, inhibits the adhesion of tissues, and provides an optimal environment for healing after surgery.

• Corneal Laser Surgery

The protective film helps prevent excessive drying of tissues and reduces mechanical irritation from surgical instruments.

1.2 Recovery Post-Surgery

Sodium hyaluronate after surgery promotes the repair of tissues, reduces inflammation, and speeds up healing. It keeps the environment moistened to reduce any discomfort for the patients in recovery.

2. Eye Drops

Sodium hyaluronate is used in eye drops for moisturizing and lubrication, relieving dry eyes, protecting the ocular surface, and promoting corneal repair. It is suitable for sensitive people and postoperative care.

2.1 Treatment for Dry Eye

Dry Eye is a chronic condition caused by insufficient tear production or excessive evaporation, leading to symptoms such as dryness, fatigue, and a foreign body sensation. Sodium hyaluronate excels in treating dry eye due to its strong moisturizing properties.

• It forms a uniform protective film on the ocular surface, enhancing tear film stability and preventing tear evaporation.
• Its high water retention alleviates dryness and improves patient comfort.
• It enhances the repair ability of ocular surface cells, preventing more severe damage caused by chronic dryness.

2.2 Corneal Burn Repair

Sodium hyaluronate plays a vital role in treating corneal burns, where the cornea experiences water loss, cell damage, and inflammation. It helps in several ways:

• Moisturizing and Lubricating
• Promoting Cell Regeneration
• Reducing Inflammation

2.3 Daily Eye Care

Sodium hyaluronate-based eye drops are also widely used for daily eye care, especially by individuals who use electronic devices for extended periods or wear contact lenses. These drops effectively relieve discomfort caused by eye strain or insufficient tears, providing long-lasting hydration and lubrication.

Product Recommendations

Stanford Chemical Company (SCC) is one of the leading US-based wholesalers of hyaluronic acid, offering a range of pure hyaluronic acid powders in medical, food, cosmetic, and injectable grades. These cover high, medium, and low molecular weights and also support customization.

The main products in eye health:

References:

Sodium Hyaluronate Used in Anterior Segment Eye Surgery

Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes

The post From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health appeared first on Stanford Chemicals.

HA Content in the Body

HA is an essential component of the extracellular matrix (ECM) and plays a crucial role in maintaining the shape, structure, and function of the skin. As we age, our metabolism slows, and the body’s ability to synthesize HA decreases. This reduction particularly affects the skin and joints.

On one hand, collagen and elastic fibers in the skin lack sufficient moisture, leading to a loss of elasticity and the appearance of wrinkles. On the other hand, the decrease in HA in joint fluid reduces the protective effects on cartilage, which can lead to joint pain, limited mobility, and even arthritis.

Fig 1. HA Content in the Body

Can Food-Grade Hyaluronic Acid Be Absorbed by the Body

The answer is Yes.

Oral HA is primarily absorbed through the intestines, where it is broken down by enzymes into smaller fragments. Some HA molecules are further broken down into smaller HA fragments or monosaccharides, which then enter the bloodstream. These fragments still help provide hydration and lubrication to the body.

Fig 2. Absorption of oral HA[i]

As shown in Figure 2, intestinal microbes degrade HA, which is then transported to the liver for metabolism or to other tissues like the skin, joints, and eyes. Excess HA is excreted from the body.

Reading more: Consuming Hyaluronic Acid to Prevent Joint Pain

Benefits of Food-Grade Hyaluronic Acid

Since HA can be transported to the skin, joints, and eyes, it has positive effects on their health.

1. Increasing Skin Hydration

HA has a powerful ability to retain moisture, which helps the skin stay hydrated, soft, and elastic. Oral HA can increase the skin’s water content, reducing fine lines and wrinkles, and making the skin appear younger. Additionally, HA supports the skin’s natural barrier, helping protect against external irritants.

Fig 3. Comparison of food-grade HA before and after consumption

Related products:

2. Lubricating Joints

HA serves as a lubricant in joint fluid, reducing friction between joints and improving movement. Oral HA can raise HA levels within the joints, helping relieve pain and discomfort caused by arthritis. HA also has mild anti-inflammatory properties, which help reduce inflammation around joints and delay joint degeneration.

Fig 4. The role of HA in joints

3. Relieving Eye Dryness

HA is a key component of the eye’s vitreous body and tear fluid, helping keep the eyes moist and reducing dry eye symptoms. HA supplements can relieve eye dryness and irritation, especially for people who use electronic devices for extended periods or wear contact lenses. Its moisturizing and lubricating effects help reduce eye strain and blurry vision, enhancing clarity.

4. Promoting Overall

Health Besides benefiting skin, joints, and eyes, food-grade HA also supports general health.

• Boosting the Immune System: HA helps support immunity and accelerates wound healing.
• Supporting Gut Health: HA helps repair the intestinal mucosa, aiding in maintaining a healthy digestive system.
• Antioxidant Protection: HA has antioxidant properties that neutralize free radicals, reducing cell damage and slowing aging.

Conclusion

Food-grade hyaluronic acid offers a natural way to support skin hydration, joint lubrication, and eye moisture, benefiting those who seek an internal approach to health and wellness. Regular intake of HA supplements can enhance these areas and contribute to overall well-being. As with any supplement, consult a healthcare professional to ensure it’s right for your needs and fits well within a balanced health regimen.

Stanford Chemical Company (SCC) is the leading wholesale supplier of pure organic hyaluronic acid in the United States. Our products include high, medium, and low molecular-weight sodium hyaluronate powders. Of course, we also support custom molecular weights. If you are interested, welcome to get a quote.

Our products have obtained relevant certifications, which show their safety.

• ISO 9001 (Quality Management System)
• ISO 14001 (Environmental Management System)
• ISO 22000 (Food Safety Management System)

[i] Zheng X, Wang B, Tang X, Mao B, Zhang Q, Zhang T, Zhao J, Cui S, Chen W. Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review. Carbohydr Polym. 2023 Jan 1;299:120153. doi: 10.1016/j.carbpol.2022.120153. Epub 2022 Sep 26. PMID: 36876779.

The post What Are the Benefits of Food-Grade Hyaluronic Acid appeared first on Stanford Chemicals.

History of Hyaluronic Acid

In 1934, scientists Karl Meyer and John Palmer first isolated HA from the vitreous of cow eyes, discovering its unique moisturizing and lubricating properties. HA’s medical applications began over 70 years ago. Using time as a clue, we can clearly see the application history of hyaluronic acid.

• 1934 – HA was first isolated.
• 1930s-40s – HA was extracted from synovial fluid, skin, umbilical cords, tumors, and rooster combs.
• 1940s-50s – HA began to be used in medicine and eye surgeries, especially in cataract treatments.
• 1951 – The chemical structure of HA was determined.
• 1970s – Cartilage proteoglycans were found to interact specifically with HA.
• 1980s – HA was widely used to treat arthritis and introduced into cosmetics and skincare.
• 1993 – Hyaluronate synthase was discovered and cloned from Group A streptococcus.
• 1999 – The first purification of active HA synthase.
• Today – HA is mainly produced through bacterial fermentation, an efficient and eco-friendly method widely applied in pharmaceuticals, skincare, and biotechnology.

Medical Value of Hyaluronic Acid

Hyaluronic acid has a wide range of applications in the medical field: cell proliferation and differentiation, regulation of inflammation, vascular generation, and treatment of tumor cancer.

Fig 1. Benefits of Medical-Grade HA

1. Promoting Cell Proliferation and Differentiation

HA is an important substance in cell proliferation and differentiation. As an essential component of the ECM, HA could create a proper microenvironment for cell regeneration to help in wound healing and repair of cartilage tissue. For example, HA enhances chondrocyte cell proliferation, which is very effective in cartilage regeneration and also in the functional recovery process.

2. Modulating Inflammation

HA is an important mediator in the regulation of inflammatory processes. It may modulate the activity of immune cells, thereby reducing excessive inflammation, which may prevent tissue damage. In this respect, intra-articular injections of HA may reduce pain and improve functional ability in certain clinical conditions such as osteoarthritis. It reduces inflammation during the healing of skin wounds and hence promotes tissue repair.

3. Enhancing Vascular Generation

HA contributes to the process of angiogenesis-or, new blood vessel formation-which is important in processes such as wound healing and tissue regeneration and some pathologies such as tumor growth. HA functions through interaction with its receptors to enhance migration and proliferation of endothelial cells and, thus, hastens vascular formation. This mechanism not only helps accelerate wound healing, but can also play a positive role in certain therapeutic areas, such as the treatment of ischemic diseases.

Read more: Top 10 Benefits of Hyaluronic Acid

4. Cancer Cells Inhibition

HA has been in focus in application to cancer treatment. In the case of low molecular weight HA, Exogenous LMW-HA may exert anti-tumor effects by directly triggering an immune response, decreasing the proliferation of tumor cells, or remodeling the tumor microenvironment. Though partially unclear, Exogenous LMW-HA has been proposed to interact with specific immune cells and interfere with tumor cell signaling. More recently, HA has been suggested for application in improving the diagnosis of cancer and as part of targeted drug delivery systems, offering higher specificity in cancer treatments.

Reference: Does Hyaluronic Acid Cause Cancer

Table 1. Overview of the medical value and application of hyaluronic acid

Biomedical Products Based on HA

Due to its biocompatibility, biodegradability, non-toxic, and non-immunogenic properties, several biomedical products have been developed based on HA:

• Injectables: Used for skin fillers, joint lubrication, and anti-aging treatments, such as facial fillers and joint injections.
• Oral Supplements: Often used to improve skin hydration, quality, and joint health.
• Drug Delivery Systems: HA serves as a carrier for slow drug release, improving absorption and bioavailability at specific sites.
• Ophthalmic Solutions: Such as artificial tears and corneal repair solutions, used to alleviate dry eyes and promote corneal healing.
• Wound Dressings: HA promotes wound healing and is used in treating burns, ulcers, and other injuries.
• Bone Tissue Engineering Materials: Used to promote bone and cartilage regeneration.
• Contact Lens Lubricants: Provides comfort and relieves dryness for contact lens wearers.

Fig 2. Biomedical Products Based on HA

Conclusion

As a biocompatible and biodegradable compound, HA holds immense potential as a bioactive molecule for various physiological and pathological conditions. Its applications span from skincare benefits to cancer treatment, inflammation regulation, and chronic disease management. With advancing technology, we can expect more efficient production processes and innovative therapeutic products in the future.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

List of Medical-Grade Sodium Hyaluronate Powder：

• HA-EM2.0-SC
• HA-EM2.4-SC
• HA-EM3.0-SC

Reference:

Iaconisi, G.N.; Lunetti, P.; Gallo, N.; Cappello, A.R.; Fiermonte, G.; Dolce, V.; Capobianco, L. Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review. Int. J. Mol. Sci. 2023, 24, 10296. https://doi.org/10.3390/ijms241210296

The post Exploring the Medical Value of Hyaluronic Acid (HA) appeared first on Stanford Chemicals.

Understanding the Two Methods: Animal Extraction and Bacterial Fermentation

On the market, the production methods for hyaluronic acid can be divided into two categories: animal extraction and bacterial fermentation.

–Animal Extraction

As the name suggests, the animal extraction method involves extracting hyaluronic acid from animal tissues. Common sources include rooster combs, bovine vitreous humor, and fish skin, which are rich in natural hyaluronic acid.

Process:

• Processing and grinding the animal tissue.
• Extracting the hyaluronic acid through chemical treatment or enzymatic hydrolysis.
• Purifying the hyaluronic acid using methods like precipitation, centrifugation, and filtration.
• Drying and powdering the purified hyaluronic acid.

–Bacterial Fermentation

This method uses certain microorganisms to secrete a capsule during growth, and the main component of that capsule is hyaluronic acid. The fermentation process involves feeding the microorganisms nutrients like sugars and amino acids. Common bacteria used are streptococci and lactic acid bacteria.

Process:

• Selecting suitable strains of bacteria (e.g., streptococci).
• Cultivating the bacteria in fermentation tanks, where they produce hyaluronic acid.
• After fermentation, the mixture is filtered, precipitated, and ultra-filtered.
• The hyaluronic acid is then purified and dried into powder form.

Fig 1. Sodium Hyaluronate Powder

Comparing the Two Methods: Animal Extraction vs. Bacterial Fermentation

When comparing two processes, we cannot avoid the issues of raw materials, processes, costs, product quality, safety, etc. We will also compare these aspects.

1. Raw Materials

Animal extraction relies on material supplied by animals, and its resources are limited besides raising ethical issues. On the contrary, bacterial fermentation deals with renewable plant-based or synthetic nutrients in a controlled process, hence sustainable.

2. Process Characteristics:

Animal extraction involves the manipulation of biological materials that require high chemical usage. The extraction efficiency is low. Fermentation of bacteria is fully automated and controllable; optimized conditions raise the yield of production.

3. Cost

The extraction from animals is more expensive because the used animal tissues are not very much available, and there is a huge usage of chemicals involved. Handling animal tissues involves more labor and equipment costs due to their complexity.

Bacterial fermentation, on the one hand, is less expensive and suitable for large-scale production; to further reduce costs, the fermentation can be carried out on a batch or continuous basis, with raw materials required like sugars and water being low in price.

4. Product Quality and Safety:

Animal extraction uses animal tissues. The possibility, therefore, exists for contamination by the likes of pathogens like bacteria, viruses, or prions, and allergens. Strict safety testing is thus mandatory for all medical and cosmetic applications.

Hyaluronic acid produced by bacterial fermentation, on the other hand, has higher purity. By mimicking the optimum fermentation conditions with great care, and purifying it further, the risk of contamination can be reduced much further, thus being safer. This methodology produces hyaluronic acid-free of all animal components, appropriate for vegetarians and those forbearing animal products.

5. Control of Molecular Weight

The procedure for the extraction of hyaluronic acid from animals does complicate the complete control over molecular weight, which is usually higher. This, in turn, makes it more applicable for products that require high viscosity, such as lubricants or mucosal protectors.

Due to bacterial fermentation, better control of molecular weight through adjustments in the steps of fermentation and processing is possible. This flexibility enables various molecular weights for hyaluronic acid to be produced, allowing different applications.

Conclusion

• Animal Extraction: The extraction process is complex, with high costs, low yields, and inconsistent quality. It also poses a risk of contamination from animal sources, making it more suited for small-scale, high-end medical or specialized applications.
• Bacterial Fermentation: This method offers high production efficiency, lower costs, and high product purity. It allows for better control over molecular weight and is ideal for large-scale industrial production. As a result, it is the primary method used for modern hyaluronic acid production.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

The following figure shows the production process of sodium hyaluronate powder:

The post How is Hyaluronic Acid Powder Made appeared first on Stanford Chemicals.

Understanding Hyaluronic Acid and Glycerin

–Hyaluronic Acid

If you’ve ever researched skincare ingredients, you have likely stumbled upon hyaluronic acid, also known as HA. Unlike most skincare ingredients, hyaluronic acid occurs in our skin. It is a sugar molecule that appears in the connective tissues of the body, eyes, and skin.

Benefits of Hyaluronic Acid:

• Powerful Moisturizer: HA has an intense capacity to attract and hold water, thus providing the skin with deep hydration.
• Improves Skin Elasticity: HA penetrates the dermis layer, which helps the skin retain elasticity. As a result, it tends to sag less and droop less often.
• Reduces Fine Lines and Wrinkles: Hyaluronic acid helps replenish skin moisture and maintain healthier skin barriers, and thereby, does an effective job of reducing the appearance of dry lines and fine wrinkles, offering some anti-aging benefits.
• Stimulates Skin Repair: Hyaluronic acid possesses anti-inflammatory properties, which can help in the process of skin repair and regeneration, thus reducing inflammation and irritation.
• Skin Barrier Protection: It forms a kind of barrier on the skin’s surface and inhibits water loss. It protects your skin from environmental damage, such as pollution and UV rays.

Besides skincare routines, hyaluronic acid is also valued in many medical and health fields due to its many properties, which can moisturize, lubricate, and repair. It provides lubrication to joints, helps reduce dry eyes, and speeds up the healing of wounds.

Fig 1. Comparison of skin effects before and after using hyaluronic acid

–Glycerin

Glycerin, also known as glycerol, is an odorless, colorless, thick liquid. It is the simplest form of polyol compound that occurs naturally in vegetable oils and animal fat. Glycerin exhibits strong hygroscopic activity by attracting moisture from the environment towards the skin and into it.

Benefits of Glycerin:

• Moisturizer: Glycerin prevents the skin from losing its moisture content. Dryness and rough skin are prevented by glycerin.
• Skin Repair: It repairs the skin barrier and therefore reduces dryness, flaking, and roughness. The overall skin health improves.
• Lubricating Effect: Glycerin possesses excellent lubricating properties; it reduces friction, hence soothing discomforts. It finds applications in skincare products and also in medical lubricants like oral ulcer protectants and lubricating eye drops.
• Promotes Wound Healing: Glycerin promotes wound healing due to its moisturizing action, which helps in maintaining a moist environment for wounds. This helps in faster healing of the wound and minimizes post-healing scar formation. This is the reason for its common inclusion in various ointments for wound care.

Hyaluronic Acid vs Glycerin: Differences in Hydration Mechanism and Effectiveness

Going back to the original question, as moisturizing ingredients, how do their hydration mechanisms and effectiveness differ?

–Hydration Mechanism

Hyaluronic acid can provide a barrier layer to the skin mainly because of its larger molecular structure, the molecule forms a locked structure that holds moisture. It can also be penetrated into the skin to absorb atmospheric moisture. The absorption and moisturizing effects of hyaluronic acid vary depending on its molecular weight. High-molecular-weight HA keeps itself at the surface of the skin to afford immediate hydration, whereas low-molecular-weight HA goes deeper into the skin and can provide longer-lasting hydration.

Glycerin, as a humectant, absorbs moisture from the environment and draws it into the skin layers, while also preventing water loss. Glycerin has good penetration, reaching into the stratum corneum to help keep the skin soft and supple.

–Hydration Effectiveness

Studies have compared the water absorption and retention capabilities of hyaluronic acid and glycerin (see Figures 2 and 3).

Fig 2. Relationship between water absorption of polysaccharides and time

Fig 3. Relationship between the moisture retention of polysaccharides and time

Based on these experimental results, hyaluronic acid may not have the best moisture absorption, but it excels in moisture retention. Conversely, glycerin is excellent at absorbing moisture but not as effective at retaining it. Therefore, if you want to keep your skin hydrated over the long term and improve its moisturizing capacity, products containing hyaluronic acid are the better choice.

Additionally, glycerin can sometimes feel sticky and “heavy” on the skin, making it less suitable for oily or acne-prone skin types. Hyaluronic acid, on the other hand, is lightweight and non-sticky, making it the ideal moisturizer for oily skin types.

Conclusion

Though hyaluronic acid and glycerin both offer merits, their choice depends upon your skin type and specific needs. Hyaluronic acid is perfect for those seeking deep, long-lasting hydration without the feeling of heaviness. Not only does hyaluronic acid hydrate the skin, but it also improves elasticity, decreases fine lines, and generally keeps the skin in good health.

Glycerin works better just for hydration and barrier repair and is also generally more suitable for dry or sensitive skin. Both of these ingredients may play a beneficial role in a skincare routine, yet the differences between them might help you decide on your particular skin concerns.

Stanford Chemical Company (SCC) is a premium supplier specializing in sodium hyaluronate powder. Our product range includes:

• Cosmetic Grade Hyaluronic Acid
• Food-Grade Hyaluronic Acid
• Injection Grade Hyaluronic Acid
• Medical Grade Hyaluronic Acid
• Zinc Hyaluronate

Our sodium hyaluronate powder is Ecocert certified and produced under strict ISO 9001 and GMP standards. All products are fermentation-based, non-animal origin, non-GMO, and carry no BSE/TSE risk.

Related articles:

High VS. Low Molecular Weight Hyaluronic Acid

Top 10 Benefits of Hyaluronic Acid

Reference:

[1] Gao Ruiying, Zhang Xiuyu, Mu Dan, Fu Zhong. Determination of moisture absorption and moisturizing properties of hyaluronic acid and other bioactive polysaccharides for cosmetics [J]. Guangdong Chemical Industry, 2009, 36(10): 230-232

The post Hyaluronic Acid vs Glycerin: Which is More Hydrating appeared first on Stanford Chemicals.

Hyaluronic acid is widely used in reconstructive surgeries, eye surgeries, and as a cosmetic filler for wrinkles. It has excellent physical and chemical properties and is highly biocompatible. However, in the body, hyaluronic acid is quickly broken down by hyaluronidase, an enzyme, which means it does not last long and requires frequent injections to be effective.

Sodium hyaluronate crosspolymer is created by modifying hyaluronic acid with crosslinking agents. This creates a three-dimensional gel structure that is more stable. It overcomes the short duration of sodium hyaluronate in the body while maintaining good biocompatibility and effectiveness.

What Is Sodium Hyaluronate Crosspolymer

Sodium hyaluronate crosspolymer is a derivative of hyaluronic acid. It is formed through a chemical crosslinking process. In this process, molecules of hyaluronic acid or sodium hyaluronate are chemically bonded together. The reaction forms covalent bonds between the hyaluronic acid molecules, resulting in a stable three-dimensional network structure.

Fig 1. Chemical structures of Crosslinked HA and free HA[1]

–Benefits for Skincare

• Long-lasting hydration
• Improved skin barrier function
• Skin smoothing
• Reduced appearance of fine lines

–Advantages: Stability of the Crosslinked Structure

The crosslinked three-dimensional network of sodium hyaluronate crosspolymer forms a stable moisturizing film on the skin’s surface. This film not only retains moisture and provides long-lasting hydration but also creates a physical barrier on the skin. This barrier helps protect the skin from external irritants and prevents moisture loss. Because of the stability of the crosslinked structure, sodium hyaluronate crosspolymer offers more durable and effective moisturizing properties in skincare products.

–Synonyms

Sodium hyaluronate crosspolymer may have different names or similar terms in cosmetic ingredient lists. These include:

• Crosslinked Hyaluronic Acid: This name emphasizes its nature as a crosslinked hyaluronic acid polymer.
• Hyaluronic Acid Crosspolymer: Another variant that describes its crosslinked structure.
• Hyaluronan Crosspolymer: Sometimes used to refer to the crosslinked polymer form of the sodium salt of hyaluronic acid.

Sodium Hyaluronate Crosspolymer vs. Hyaluronic Acid: Different Benefits for Skincare

Both sodium hyaluronate crosspolymer and hyaluronic acid provide moisturizing and anti-aging benefits, but they have significant differences in function and application.

Fig 2. Crosslinked HA benefits

1. Molecular Size and Penetration Ability

• Sodium Hyaluronate Crosspolymer: Due to its crosslinked structure, it has a larger molecular weight. It mainly stays on the surface of the skin and does not easily penetrate deeper layers. It forms a protective film that locks in moisture and provides continuous hydration on the skin’s surface.
• Hyaluronic Acid: Available in a range of molecular weights, from large to small. Smaller molecules can penetrate deeper into the skin, providing deep hydration, while larger molecules stay on the surface, offering immediate hydration.

2. Moisturizing Effect

• Sodium Hyaluronate Crosspolymer: Primarily provides long-lasting surface hydration. Its crosslinked structure allows it to form a durable moisturizing film on the skin, which helps prevent water loss.
• Hyaluronic Acid: Has a strong water-binding capacity, capable of holding many times its weight in water. High molecular weight hyaluronic acid provides surface hydration, while low molecular weight hyaluronic acid penetrates deeper for more intensive hydration.

3. Stability

• Sodium Hyaluronate Crosspolymer: Its crosslinked structure is stable and not easily broken down by enzymes in the skin. This allows it to remain on the skin longer, providing extended moisturizing benefits.
• Hyaluronic Acid: Although natural, it is more easily degraded by hyaluronidase in the skin, making its moisturizing effect shorter-lasting.

4. Skin Barrier Function

• Sodium Hyaluronate Crosspolymer: The protective film it forms on the skin helps strengthen the skin barrier, prevents moisture loss, and protects against environmental pollutants.
• Hyaluronic Acid: Mainly used for hydration, it does not provide a physical barrier but maintains skin health by drawing moisture into the skin.

5. Application Scenarios

• Sodium Hyaluronate Crosspolymer: Suitable for products requiring long-lasting hydration and enhanced skin barrier function, such as moisturizers, night masks, and anti-aging products.
• Hyaluronic Acid: Widely used in various skincare products, including hydrating serums, toners, masks, and eye creams. It is ideal for quick hydration and deep moisturizing needs.

Table 1. Sodium Hyaluronate Crosspolymer vs. Hyaluronic Acid

Table 1 summarizes the above content and compares the differences between the two in terms of molecular weight, Penetration, moisturizing effect, stability, skin care barrier effect, and application.

Where to Buy Sodium Hyaluronate Crosspolymer

Stanford Chemical Company (SCC) is a premium supplier specializing in sodium hyaluronate powder. Our product range includes:

• Cosmetic Grade Sodium Hyaluronate​
• Medical Grade Sodium Hyaluronate
• Injection Grade Sodium Hyaluronate
• Cross-linked HA Gel Hyaluronic Acid​
• Hymagic 4D Hyaluronic Acid
• Hyacross Hyaluronic Acid Elastomer
• Super Active Hyaluronic Acid

Our sodium hyaluronate powder is Ecocert certified and produced under strict ISO 9001 and GMP standards. All products are fermentation-based, non-animal origin, non-GMO, and carry no BSE/TSE risk.

Conclusion

Sodium hyaluronate crosspolymer and hyaluronic acid both offer unique benefits for skincare. Choosing the right ingredient depends on individual skin needs. For long-lasting hydration and barrier protection, sodium hyaluronate crosspolymer is the better choice. For immediate and deep hydration, hyaluronic acid is more suitable. Understanding these differences helps in selecting the best skincare products for your routine.

[1] Kim, Dae-Sung & Choi, Jun-Tae & Kim, Cheong & Shin, Yu-Ra & Park, Pil-gu & Kim, Hyemi & Lee, Jae Myun & Park, Jung-Hwan. (2020). Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and Sustained Release. Pharmaceutical Research. 37. 10.1007/s11095-020-2768-3.

The post What Are the Benefits of Sodium Hyaluronate Crosspolymer appeared first on Stanford Chemicals.

With the rapid development of modern medicine and cosmetic technology, injectable hyaluronic acid is attached importance to in many respects. Being an excellent moisturizer with its biocompatibility, hyaluronic acid has developed a wide scope of applications in the field of structure and function improvement. It plays a central role in skin, joint, and eye care and further in surgical treatment in the field of eye diseases. This article shall focus on the five most common applications of injectable hyaluronic acid and further consider its safety record and possible side effects.

What Is Injectable Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring polysaccharide in the connective tissues of the body, skin, and eyes. It is known to hold up to 1000 times its weight in water; this helps in lubricating and keeping tissues elastic. Other functions of hyaluronic acid are tissue hydration, cell repair, anti-inflammatory, and as a lubricant in joints and in eye surgery. The injectable hyaluronic acid is extracted and purified in a unique way so that it is safe for injection.

–The Benefits of Hyaluronic Acid

• Moisturizing and hydration: It is able to absorb a lot of water and hold it, thereby keeping skin and tissues hydrated and elastic.
• Tissue repair: The very nature of hyaluronic acid promotes cell growth and tissue repair; thus, it creates less scarring after injury.
• Anti-inflammatory and lubrication properties: In joints and eye surgery, this acts to reduce inflammation and friction, thereby protecting tissues from damage.

The 5 Common Uses

Due to above these properties, hyaluronic acid finds wide application in medical and cosmetic treatments alike.

1. Viscosupplementation

Hyaluronic acid is one of the essential elements used in orthopedics as a joint lubricant. In patients who have osteoarthritis, the reduction in the volume of the fluid may increase the friction and thereby result in pain and inflammation.

Hyaluronic acid is administered into the articulation space. And then it increases the viscosity of the fluid within the joint cavity, facilitating lubrication and cushioning. This relieves pains and improves functions, mostly for those suffering from osteoarthritis of the knee, and possibly delays surgical procedures.

Fig 1. Benefits of HA for joints

2. Ophthalmic Surgery Aid

Hyaluronic acid finds applications in ophthalmic surgery, primarily as an intra-ocular filler. Hyaluronic acid facilitates smooth functioning and protects the corneal endothelial cells. In addition, HA can maintain the structural integrity of the eyeball during procedures such as cataract removal or corneal transplants.

At the same time, its high viscosity and elasticity minimize trauma during surgery and allow a much smoother operation. HA further eases recovery from the surgery and reduces post-operative complications.

Fig 2. Ophthalmic Surgery Aid

3. Dermal Fillers

Hyaluronic acid has been one of the finest uses in non-surgical facial treatments as a dermal filler. HA, when injected into the skin, fills in wrinkles and restores volume to the skin, giving the skin elasticity and more radiance. Such products are used in plumping up the lips, smoothing out nasolabial folds, defining cheek bones, and the chin.

The advantage of hyaluronic acid when used as a filling material is that it appears natural and is reversible. That is, the injected substance can be dissolved with an enzyme injection in unsatisfactory results.

Fig 3. Comparison of HA facial filler effects

4. Skin Repair Products

Apart from its cosmetic and surgical uses, hyaluronic acid is used in many skin repair processes. Since hyaluronic acid is injectable, it can enhance the healing process and regeneration of the skin to treat burns, wounds, and other injuries caused after surgery.

It keeps the wounds moist and prevents scabbing. This, in turn, reduces the occurrence of scarring. It can also help sunken scars and improve the overall texture of the skin by filling these depressions.

Fig 4. Wound healing process

5. Low Scarring Cosmetic Fillers

Hyaluronic acid also enjoys wide application in minimally invasive aesthetic treatments. Given its very good modeling properties, combined with safety, it is applied not only to non-surgical aesthetic treatments. For example, nose reshaping, chin contouring, and tear trough filling but also for facial contours.

These treatments are in demand since they have quick results and short recovery time, with the results appearing natural. Hyaluronic acid injections adjust facial contours subtly to create a more personified, pain-free, riskless aesthetic outcome for surgery.

Is Injectable Hyaluronic Acid Safe

Injectable hyaluronic acid is quite safe due to its high compatibility with the body. Most people tolerate it well and do not experience serious adverse reactions after injection, though it may lead to some mild adverse reactions, including reddening, bruising, slight pain, and allergic reactions at the site of injection. However, all of these may be temporary and will subside on their own.

–Side Effects of Injectable HA

Rarely, they can also occur in more severe types, such as infection, nodules or lumps at the injection site, and skin necrosis. More specifically, erroneous injection techniques, particularly for facial filling with hyaluronic acid, may cause vexing complications, such as vascular occlusion. It is hence very important to select an experienced and qualified professional to give the injection and practice stringent sterile techniques in a bid to prevent these complications.

Where to Buy Safe Injectable HA

Stanford Chemical Company (SCC) is specialized in providing tailored molecular weight, injection-grade HAF-C-SC. The injection-grade hyaluronic acid from SCC is GMP, CEP, and DMF certified, and the factory passed an on-site inspection by the US FDA. Our Injection-Grade HA is all fermentation products, of non-animal origin, non-GMO, and non-BSE/TSE risk.

What differentiates our product is the origin. Our pure HA Powder comes just from fermentation processes, thus being completely free of animal sources, non-GMO, and Vegan. The hyaluronic acid thus presents a conscientious choice for those seeking products that are sourced ethically and naturally in tune with values of sustainability and purity.

Recommended products:

• HA-EP1.8-SC
• HA-EP2.4-SC
• HA-EP3.0-SC

Conclusion

Injectable hyaluronic acid is regarded as an important tool in modern medicine and cosmetic treatments due to its excellent biological properties and remarkable versatility. From dermal fillers and joint lubricants to the aid for ophthalmic surgery and minimally invasive fillers in cosmetic procedures, HA has found application in these areas and hence shown its effectiveness in promoting health and beauty. Even though relatively safe, proper injection techniques help assure the best aesthetic result and will limit potential side effects. As advances in technology continue, the scope for which hyaluronic acid is used will expand and offer users ever more possibilities.

Related articles:

Solubility of Hyaluronic Acid in Different Solvents and Its Influencing Factors

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

Top 10 Benefits of Hyaluronic Acid

The post The 5 Common Uses of Injectable Hyaluronic Acid appeared first on Stanford Chemicals.

What is Hyaluronic Acid

Hyaluronic Acid (HA) is a polysaccharide naturally found in the connective tissues, skin, joint fluid, and eyes of the human body. It has a unique ability to retain water and is an important structural component in living organisms.

Benefits of Hyaluronic Acid

Due to its biocompatibility and versatility, HA is widely used in medicine, cosmetology, and bioengineering.

1. Joint Health

Hyaluronic acid plays a crucial role in joint health as a major component of synovial fluid, which lubricates and cushions the joints. It helps reduce friction between the joints, alleviating pain and improving mobility. This is particularly beneficial for individuals with osteoarthritis, as HA can help relieve symptoms and slow disease progression.

2. Ophthalmic Applications

In ophthalmology, hyaluronic acid is widely used in eye drops to relieve dry eye symptoms, providing long-lasting lubrication and comfort. During eye surgeries, HA is used to protect and repair corneal tissue, accelerate postoperative recovery, and reduce complications.

3. Tissue Repair and Regeneration

Hyaluronic acid promotes tissue repair and regeneration by stimulating cell proliferation and migration, speeding up the wound-healing process. It is beneficial in treating burns, ulcers, and other skin injuries, helping to reduce scar formation and enhance the quality of skin repair.

4. Anti-inflammatory and Immune Regulation

Hyaluronic acid exhibits significant anti-inflammatory and immune-regulating properties. It can reduce the release of inflammatory mediators, lowering inflammation and minimizing tissue damage. Additionally, HA can modulate the immune system, enhancing the body’s defense mechanisms and helping to alleviate chronic inflammatory conditions.

5. Beauty and Skincare

In the field of beauty and skincare, hyaluronic acid is highly prized for its exceptional moisturizing capabilities. It can deeply hydrate the skin, increasing its water content, making it soft, and smooth, and reducing the appearance of fine lines and wrinkles. HA also promotes collagen production, enhancing skin elasticity and firmness, thus improving overall skin quality.

What is Molecular Weight

Molecular weight (MW), also known as relative molecular mass, is the sum of the masses of all the atoms in a molecule. It is used to measure the size of a molecule and is typically expressed in Daltons (Da) or atomic mass units (AMU).

Calculating the MW of hyaluronic acid is complex because it is a high-molecular-weight polysaccharide made up of repeating disaccharide units (glucuronic acid and N-acetylglucosamine). The molecular weight depends on the chain length, i.e., the number of disaccharide units.

Fig 1. Hyaluronic acid chemical structure

In practice, the molecular weight of HA is usually expressed as a range. Low molecular weight HA is less than 200 kDa, medium molecular weight HA ranges from 200 to 1800 kDa, and high molecular weight HA is greater than 1800 kDa. These ranges represent the average number of disaccharide units in HA molecules, not precise single values.

How Molecular Weight Affects Hyaluronic Acid’s Efficacy

The molecular weight of HA significantly influences its biological activity and efficacy.

1. Differences in Viscoelasticity and Lubricity

High molecular weight HA (typically over 1800 kDa) is widely used to treat arthritis due to its excellent viscoelastic and lubricating properties. It enhances the viscosity of joint fluid, reducing friction, pain, and inflammation. This type of HA is usually injected directly into the joint cavity for maximum effect. On the other hand, Medium molecular weight HA (200-1800 kDa) is also used for joint health, often found in oral or injectable supplements. It provides lubrication and cushioning within the joint cavity, improving joint mobility and flexibility.

In ophthalmic surgery, high molecular weight HA is commonly used, such as in cataract surgery and corneal transplants. Its high viscosity and viscoelasticity protect eye tissues, reducing mechanical damage during surgery. Conversely, low molecular weight HA (usually less than 200 kDa) is often used in eye drops. It effectively keeps the eyes moist, alleviating dry eye symptoms and improving eye comfort.

Fig 2. Low molecular weight hyaluronic acid eye drops

2. Different Effects on Wound Healing

Tissue Repair and Regeneration: In tissue engineering and regenerative medicine, high molecular weight HA is often used as a critical component of biomaterials and tissue engineering. Its structure can mimic the natural extracellular matrix, providing support and signals for cells, promoting cell migration, and tissue regeneration. Low molecular weight HA, due to its smaller molecular size, can better penetrate tissues, promoting wound healing and skin repair by activating fibroblasts and keratinocytes, accelerating the tissue regeneration process.

Fig 3. In the process of wound healing, different molecular weight hyaluronic acid has different effects

3. Variations in Anti-inflammatory and Immunomodulatory Effects

Anti-inflammatory and Immune Regulation: The role of HA in anti-inflammatory and immune regulation is also influenced by its molecular weight. Medium molecular weight HA shows certain advantages in anti-inflammatory and immune regulation. It can bind to cell surface receptors, regulating immune responses, and reducing inflammation, and is used to treat inflammatory diseases such as ulcerative colitis and Crohn’s disease. Low molecular weight HA has shown potential in some studies to regulate the immune system and promote antigen presentation, and immune responses, making it promising in vaccine development.

4. Varied Moisturizing Effects

Beauty and Skincare: In beauty and skincare, high molecular weight HA is mainly used for surface hydration in skincare products, forming a protective layer, reducing water loss, and enhancing skin smoothness. In contrast, low molecular weight HA can penetrate deeper into the skin, promoting hydration in the dermis layer, enhancing skin elasticity, and reducing fine lines and wrinkles, providing deeper skincare effects.

Fig 4. Varied Moisturizing Effects of High VS. Low Hyaluronic Acid

Conclusion

In summary, the molecular weight of HA significantly impacts its efficacy in different fields. High molecular weight HA is mainly used in applications requiring viscoelasticity and lubrication, such as joint health and ophthalmic surgery. In contrast, low molecular weight HA, due to its good permeability and biological activity, is more suitable for tissue repair, anti-inflammatory, immune regulation, and deep skin care. Choosing the appropriate molecular weight of HA can maximize its efficacy and meet the needs of different applications.

Stanford Chemical Company (SCC) is a pioneer in the development of hyaluronic acid. In addition to providing customers with food-grade, medical-grade, cosmetic-grade, and injectable-grade hyaluronic acid, we can also provide users with sodium hyaluronate powder with different molecular weights. For more information or specific applications, please visit our homepage.

Related reading:

Comparative Analysis of Hyaluronic Acid with Different Molecular Weights

High VS. Low Molecular Weight Hyaluronic Acid

The post High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy appeared first on Stanford Chemicals.

1. Hyaluronic Acid for Skin: Moisturizing and Anti-Aging

Hyaluronic acid is a component of the dermis layer of the skin, capable of retaining 100 times its weight in water. This is the source of its powerful moisturizing ability. Therefore, using HA can keep the skin hydrated, effectively improving dryness, roughness, and peeling.

For the skin, hyaluronic acid is not just a moisturizer; it also effectively combats aging. This is because HA can fill the gaps within the skin, smoothing out wrinkles and fine lines. Additionally, it increases skin elasticity, making the skin firmer and reducing sagging. As we age, supplementing with HA is a highly effective anti-aging strategy.

Read more:

Hyaluronic Acid Powder: The Acne-Prone Skin Savior

2. Hyaluronic Acid for Facial Contours: Filling Hollows and Smoothing Wrinkles

HA is a primary choice in cosmetic procedures for enhancing facial contours. Hyaluronic acid injections can fill in sunken areas of the face, such as the cheeks, temples, and chin, creating smoother and more defined facial lines. Additionally, it can smooth deep wrinkles, such as nasolabial folds and crow’s feet, lifting sagging facial skin and restoring a youthful, firm appearance.

Fig 1. Hyaluronic Acid for Facial Contours: Before and After

3. Hyaluronic Acid for Lips: Safe Lip Augmentation

Injectable-grade hyaluronic acid is a common method for lip augmentation. By injecting HA, the appearance of the lips can be significantly improved, making them fuller and more defined. Additionally, HA injections can effectively reduce fine lines and wrinkles on the lip surface.

Even without injections, applying HA directly to the lips has benefits. Because of its moisturizing properties, it helps the lips retain moisture, preventing dryness and cracking. Moreover, its anti-inflammatory properties can alleviate symptoms of lip inflammation, reducing redness and discomfort.

Fig 2. Injectable-grade HA on Lips: Before and After

Read more:

Fuller Lips Made Easy: The Power of Hyaluronic Acid

4. Hyaluronic Acid for Wound: Promoting Healing and Reducing Scars

The strong moisturizing capability of hyaluronic acid is not only beneficial for the skin but also accelerates wound healing. It forms a protective film, locking in moisture and preventing the wound from drying and scabbing. Additionally, HA has anti-inflammatory properties, reducing inflammation at the wound site.

Another important role of HA in wound healing is promoting skin regeneration. It facilitates cell migration and proliferation, crucial steps in the healing process. Moreover, HA can reduce scar formation by promoting collagen synthesis, which enhances the strength and elasticity of new tissue, thus minimizing scarring.

Fig 3. The three phases of wound healing

Read more:

Medical Grade Hyaluronic Acid and Wound Healing

5. Hyaluronic Acid for Eyes: Relieving Dryness and Protecting the Cornea

Hyaluronic acid can keep the surface of the eyeball moist, significantly relieving dryness, irritation, and discomfort. Thus, eye drops and gels containing HA are widely used to treat dry eye syndrome and other eye discomforts.

In addition to relieving dry eye symptoms, hyaluronic acid has numerous benefits in eye surgeries. It forms a protective film, preventing dust, bacteria, and other harmful substances from damaging the cornea. In cataract and other intraocular surgeries, hyaluronic acid serves as a filling material, helping maintain the stability of intraocular structures and protecting intraocular tissues. Furthermore, it can be used as a surgical aid, reducing intraoperative damage and promoting postoperative healing.

Read more：

Sodium Hyaluronate for Dry Eyes and How It May Increase Intraocular Pressure

6. Hyaluronic Acid for Joints: Relieving Pain and Delaying Degeneration

Hyaluronic acid has a significant effect on alleviating joint inflammation. It is a crucial component of synovial fluid, providing excellent lubrication. It reduces friction between joint surfaces, protecting cartilage and reducing pain and discomfort during joint movement.

By improving lubrication and reducing pain, HA can enhance joint flexibility and stability, reducing stiffness. Additionally, it protects and repairs joint cartilage, slowing its degeneration.

Fig 4. Anatomy of the healthy and osteoarthritic knee joint[i]

Read more:

Hyaluronic Acid VS. Glucosamine VS. Chondroitin: Which Is Best for Joints?

7. Hyaluronic Acid for Bones: Preventing Osteoporosis

Hyaluronic acid is a key component of the bone matrix, playing an important role in bone health. It provides structural support to bones, promoting the formation and maintenance of the bone matrix.

In the healing process of fractures and bone injuries, HA also plays a crucial role. It promotes the proliferation and differentiation of osteoblasts, accelerating bone regeneration and repair, thus shortening the healing time. Moreover, its anti-inflammatory properties reduce inflammation after bone injuries.

Hyaluronic acid helps prevent osteoporosis by promoting the deposition of minerals (such as calcium and phosphorus) in bones, increasing bone density and strength.

8. Hyaluronic Acid for Hair: Preventing Dryness and Enhancing Strength

Hair that lacks moisture becomes dry and frizzy. Hyaluronic acid, with its moisturizing ability, helps hair retain moisture, making it softer and smoother. Similarly, it keeps the scalp hydrated, preventing dryness and flaking, and promoting a healthy environment for hair growth.

Moreover, HA enhances hair strength and elasticity, reducing breakage and split ends. Its antioxidant properties also benefit hair health by neutralizing free radicals and reducing oxidative stress damage, maintaining the health of the hair.

9. Hyaluronic Acid for Brain: Protecting Nerves

Hyaluronic acid plays a significant role in neuroprotection. It protects nerve cells from external damage, reducing apoptosis and injury. Additionally, hyaluronic acid is an important component of the brain’s extracellular matrix, providing structural support and maintaining the health of the extracellular matrix.

Researchers have noticed the potential of HA in improving cognitive function. By enhancing the health and function of nerve cells, HA may support learning and memory. Its anti-inflammatory and neuroprotective effects could also help reduce age-related cognitive decline.

Fig 5. Different forms of HA scaffolds[ii]

10. Hyaluronic Acid for Teeth: Protecting Gums

Hyaluronic acid significantly protects and repairs gum tissue. It can keep gum tissue hydrated and enhance the barrier function of the gums, preventing bacteria and toxins from invading. Additionally, HA has excellent anti-inflammatory effects. It can inhibit the release of inflammatory factors, alleviating gum inflammation and periodontal disease.

The ability of hyaluronic acid to promote wound healing plays a crucial role in accelerating the healing of oral injuries and post-surgical recovery. Therefore, after tooth extractions or implants, HA can speed up wound healing and reduce postoperative complications.

Conclusion

Hyaluronic acid’s multifaceted benefits span across various aspects of health and beauty, from maintaining skin hydration and enhancing facial contours to promoting joint and bone health. Its unique properties make it an invaluable component in medical treatments and cosmetic applications, improving overall quality of life. As research continues to uncover new potential uses, hyaluronic acid is set to remain a cornerstone of health and wellness.

Stanford Chemical Company (SCC) is an excellent supplier of Sodium Hyaluronate Powder. We provide cosmetic-grade, food-grade, medical-grade, and injection-grade sodium hyaluronate powder. For more information about these materials, please check out our home page.

[i] Fig 4. Anatomy of the healthy and osteoarthritic knee joint. Created via canvas. Source: Smith, Abbi & Sigurbjörnsdóttir. (2022). Hedgehog signaling in bone and osteoarthritis: the role of Smoothened and cholesterol. The FEBS Journal. 290. 10.1111/febs.16440.

[ii] Jensen, G.; Holloway, J.L.; Stabenfeldt, S.E. Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine. Cells 2020, 9, 2113. https://doi.org/10.3390/cells9092113

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