The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer found in the aqueous and vitreous humor of the eye and in the fluid of articulating joints.

Hyaluronic acid(HA) is a straight-chain macromolecular mucopolysaccharide composed of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. It widely consists of the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia, and cockscomb, etc.

Most cosmetic manufacturers make use of high molecular weight HA. This ingredient, when used at optimal levels of inclusion, is an incredibly effective moisture-binding element, providing superficial hydration of the epidermis for many hours. However, this ingredient is a macro-molecule and is too large to penetrate into the deeper layers of the skin.

Low molecular weight HA, on the other hand, has been engineered to exist as a far smaller molecule that is able to penetrate through the epidermis to provide deep hydration. It has been scientifically proven that increased levels of hyaluronic acid in the deeper layers of the skin actually stimulate the production of collagen fibers, which in turn will result in a firmer, more toned appearance.

HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. Its aqueous solution has outstanding moisture-keeping ability, high viscoelasticity, and lubricity. It is widely used in cosmetics, pharmacy and health, and beautiful food.

Biochemical drugs with high clinical value, are widely used in all kinds of eye surgery, such as crystal implantation, corneal transplantation, glaucoma surgery, etc.

It can also be used to treat arthritis and accelerate wound healing.

It is used in cosmetics, it can have a unique skin protection effect, can keep skin moist and smooth, delicate, soft, and elastic, has anti-wrinkle,  beauty care, and restore the skin physiology function.

1. Food supplements:

Hyaluronic Acid Powder through oral administration after digestion absorption, increases in vivo Hyaluronic Acid synthesis of the precursor, causing the skin and other organizations’ Hyaluronic Acid resultant quantity increases, thus enabling the skin the water retention property to increase, gaining rich elasticity, and reducing wrinkles.

2. Cosmetics applications:

Hyaluronic Acid Powder has an outstanding moisture-keeping ability, thus called the Natural Moisturizing Factor in the world. Hyaluronic Acid is a common ingredient in skin-care products, which can be used as a very effective topical humectant, which can be used for facial wrinkles, reduction of folds and wrinkles, and removal of scars.

3. Medical applications:

Hyaluronic Acid Powder could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair the retinal detachment.

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What is Hyaluronic Acid?

Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. Hyaluronic acid distributes widely in the human body, such as in connective, epithelial, and neural tissues. Hyaluronic acid is a natural polysaccharide, a transparent, sticky colloidal substance that is filled in the space of cells and collagen fibers in the human body and is covered in some connective tissue. Hyaluronic acid not only maintains the elastic function of the skin but also locks a large number of water molecules. It has a moisturizing and lubricating function on the tissue and is also a component of the ocular lens and joint lubricating fluid. So it is often used to make beauty cosmetics and drugs for arthritis and cataracts.

What is sodium hyaluronate?

Sodium Hyaluronate can support Sodium hyaluronate levels in the body. It can help people have full energy and youthful vigor. Besides, oral Sodium Hyaluronate is useful in maintaining skin elasticity by moisturizing the skin from the dermis to the epidermis. Sodium Hyaluronate is also an impressive pain reliever. It can help people ease the injury of joints, especially their knees. Sodium Hyaluronate along with other ingredients including collagen, vitamins, chondroitin sulfate, glucosamine, and plant extracts can make tablets, capsules, and oral solutions which are good for skin care and joint care.

Where does hyaluronic acid come from?

Hyaluronic acid is a natural and undeficient hyaluronic acid salt in human tissue, a straight-chain macromolecule polysaccharide consisting of a double sugar unit (glucuronic acid -N- acetylglucosamine), with an average molecular weight of 1 million to 10 million Dalton and a structure of the tissue. Overall maintenance and intercellular transport have important functions. The basic structure of hyaluronic acid is a large polysaccharide hyaluronic acid composed of two disaccharide units GlcNAc and GlcA. It can be obtained by extracting from cockscomb or through microorganism fermentation. The product in our company is all fermented products.

In 1934, Meyer, Professor of Ophthalmology at Columbia University, first isolated hyaluronic acid from the bovine vitreous body and analyzed its structure. Since uronic acid is extracted from Hyaloid, it is named Hyaluronic acid. According to the Meyer study, the structure of hyaluronic acid is mainly composed of disaccharide, N-acetyl-D-glucosamine, and D-glucuronic acid, which are linked by the beta -1-3 bond. Hyaluronic acid is widely found in natural connective tissue, mucous tissue, eyeball lens, and some bacterial capsular in nature. Hyaluronic acid has the same chemical composition and structure. This biological compatibility, absorbability, and hyaluronic acid as a medical polymer material will have no immune reaction, the material can be decomposed by the organism.

What are the main functions of hyaluronic acid?

1. Food supplements:
Hyaluronic Acid through oral administration after digestion absorption, increases in vivo Hyaluronic Acid synthesis of the precursor, causing the skin and other organizations’ Hyaluronic Acid resultant quantity increases, thus enabling the skin the water retention property to increase, rich elasticity, and wrinkle reduction.

2. Cosmetics applications:
Hyaluronic Acid has an outstanding moisture-keeping ability, thus called Natural Moisturing Factor in the world. Hyaluronic Acid is a common ingredient in skin-care products, which can be used as a very effective topical humectant, for facial wrinkles, reduction of folds and wrinkles, and removal of scars.

3. Medical applications:
Medical Hyaluronic Acid could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair a retinal detachment.

Hyaluronic Acid can also be used to treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which is believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.

Hyaluronic Acid has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the Hyaluronic Acid to facilitate cell migration into the wound.

What hyaluronic acid does for the skin?

Sodium hyaluronate is a natural biological molecule, that widely exists in the skin and other tissues. It has an excellent moisturizing effect and is called the ideal Natural Moisturizing Factor internationally. It is currently the best moisturizing substance found in cosmetics in nature.
At present, international HA cosmetics have expanded from the initial cream, lotion, make-up water, essence capsule, film paste to bath liquid, powder, lipstick, shampoo, and conditioner, mousse, and so on. There are:

(1) Moisturizing effect

The moisturizing effect is the most important role of HA in cosmetics. Compared with other moisturizers, its characteristic is that the relative humidity of the surrounding environment has less influence on moisture retention. Moisturizing agents commonly used in cosmetics include glycerol and propylene glycol, sorbitol, polyethylene glycol, sodium lactate, sodium pyrrolidone carboxylate, and so on.

Its unique properties are adapted to the skin in different seasons, and different environmental humidity, such as dry winter and humid summer, and the moisturizing effect of cosmetics requirements. The moisture retention of HA is related to Mr. The higher the Mr, the better the moisture retention. As a moisturizer, HA is seldom used alone and is often used in conjunction with other moisturizers.

(2) Nutrition

HA is the inherent biological material of the skin. Exogenous HA is a supplement to the endogenous HA of the skin. HA can penetrate into the skin epidermis, promote skin nutrition supply, and waste excretion to prevent skin aging. Skincare is more important than other make-up. It has become the modern people’s sense of beauty.

(3) Repair and prevention of skin injury

Skin burns caused by sun exposure, such as reddening, blackening, peeling, etc., are mainly caused by ultraviolet rays in the sun. HA promotes the regeneration of injured skin by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen-free radicals. Prior use also has some preventive effects. The mechanism of action is different from the ultraviolet absorbent commonly used in sunscreen. Therefore, the combination of HA and ultraviolet absorbent in sunscreen products has a synergistic effect: reducing ultraviolet radiation penetration and repairing the skin damage caused by a small amount of ultraviolet radiation penetration, playing a dual protective role.

The combination of HA with EGF and heparin can accelerate the regeneration of epidermal cells and make the skin tender, smooth and elastic. When the skin is slightly burned and scalded, applying HA-containing cosmetics can relieve pain and accelerate the healing of the wounded skin.

(4) Lubricity and film-forming property

HA is a high molecular polymer with strong lubrication and film-forming properties. Skincare products containing HA have clear lubrication and feel good. After being applied to the skin, a film can be formed on the surface of the skin, resulting in a good sense of smoothness and wetness of the skin, playing a protective role on the skin. HA-containing hair care products can form a film on the surface of the hair, play a role in moisturizing, lubricating, protecting hair, and eliminating static electricity, so that hair is easy to comb, elegant, and natural.

Is hyaluronic acid good for your eyes?

Yes, hyaluronic acid can be applied to the eye drops industry, and can be used in ophthalmic surgery, including the removal of cataracts, corneal transplants, and repair of retinal and other eye injuries. Hyaluronic Acid Powder has an outstanding moisture-keeping ability, thus called Natural Moisturing Factor in the world.

What Does Hyaluronic Acid Do For Joints?

There are many reasons for knee pain, one of which is the pain caused by the reduction of synovial fluid in the knee joint. And why does synovial fluid decrease? One is the pain caused by wear and tear of the cartilage on the articular surface of the femur and tibia due to insufficient synovial fluid secreted by the human body as people get older. The other is excessive exercise and heavy physical work so that synovial fluid loss in the joint is too fast, and the human body’s secretion of synovial fluid is in short supply.

The presence of sodium hyaluronate in the synovial fluid can give the synovial fluid a high degree of viscoelasticity and lubrication, reduce the impact of human walking and movement on the bone, and then reduce the friction of bones.

In addition, polyglycolic acid, which is composed of sodium hyaluronate and proteoglycan, is the basic unit of the cartilage matrix. There is a thin amorphous layer on the surface of the cartilage, which is also a complex of sodium hyaluronate and protein. It is only by them that the cartilage can relieve the force on the knee.

When knee pain occurs, sodium hyaluronate is injected into the knee joint to restore the synovial fluid in the pathological condition to the normal state, thereby restoring lubrication and continuing to act as a knee barrier and protection function. Breaking the vicious circle of viscoelasticity reduction barrier and protection reduction cartilage further destruction release of enzymes and inflammatory factors further reduce the viscoelasticity of synovial fluid in the process of osteoarthropathy. It creates a natural repair time for the joints of the lesion so that the injured cartilage can be naturally repaired and healed.

Is Hyaluronic Acid Edible?

Yes, hyaluronic acid is no weird, exotic berry or unheard-of extract from a tropical island. In the body, hyaluronic acid is a major component of connective tissues found in the skin, cartilage, joints, and eyes.

Where to buy the best hyaluronic acid powder?

Stanford Chemicals is the leading chondroitin sulfate and sodium hyaluronate supplier in the USA. We are specializing in the research, manufacture, and sale of a wide variety of Chondroitin sulfate and Sodium Hyaluronate including OEM products like chondroitin sulfate powder and Sodium Hyaluronate powder with pharma-grade sodium hyaluronate for injection and eye drops for almost 16 years. Besides, if you are looking for sodium hyaluronate for pharma-grade, cosmetic-grade, and food-grade, we are your best choice.

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