Application of Micro Hyaluronic Acid as Carriers in Drug Delivery

Maria Higgins — Fri, 12 Apr 2019 03:34:58 +0000

In recent decades, Hyaluronic acid (HA) has been used as a new polymer in drug delivery – a system that combines traditional drug delivery methods with engineered technology to specifically target where a drug is released in the body and/or the rate at which it gets released. HA was chosen since it has good biocompatibility, biodegradability, and high viscoelasticity, and can be combined with a specific receptor on the cell surface.

The problem plaguing our customer

One of our customers faced a problem, macromolecule active ingredients (or at least 500KD) are historically difficult or impossible to deliver topically through tissue structures with the limitation of traditional methods.

The customer is a clinical-stage bio development company whose objective is to reduce society’s exposure to potentially harmful active agents by utilizing novel permeation technology to deliver active agents through tissue structures more efficiently.

“The topical delivery of large molecules through the skin, hair, eyes, mucosal surfaces, and bone are difficult using traditional hyaluronic acid.” said a medical director from one of our customers.

In the past, the most common form of hyaluronic acid in the pharmaceutical industry is high molecular weight HA, usually, more than 1800 K Da.

Low-molecular HA VS High-molecular HA

The difference between high-molecular hyaluronic acid (≥1,800 kDa) and low-molecular-weight HA (10 kDa ~1,000 kDa) is that the low-molecular-weight HA has been split into smaller fragments. The smaller fragments can no longer form a gel with water like the large molecules, but they can penetrate the skin much easier and have a better anti-irritant and regenerating effect once absorbed by the skin.

Why choose Stanford Chemicals?

In the past, the customer had purchased traditional mini HA (>10K Da) for its pharmaceutical delivery research. Over the years, Stanford Chemicals has developed HA with the low molecule that has stronger skin penetration, named micro hyaluronic acid (micro HA), which is a low molecular weight HA (<5K Da). It is even lower than the mini HA. The main functions of Micro HA are recovery and super moisturizing the tissues.

Stanford Chemical’s Micro-HA Super Active hyaluronic acid was used in Illustris molecule delivery technology to help facilitate a permeation process of the drugs in the human body. Micro hyaluronic acid as a drug carrier contributes to drug thickening, sustained release, transdermal absorption, and improved drug targeting.

By adopting the low molecular weight HA, the customer is able to provide a significant competitive advantage to molecule delivery, yielding enhanced safety and efficacy for patients.

Main Features of Micro HA

Since 5 kDa HA revealed a much more pronounced absorption activity through the skin than it could be observed for 10 kDa HA. Due to its micro size, micro-HA super active hyaluronic acid penetrates deep into the skin and other tissue structures easily, optimizing the absorption of compounds delivered through the skin, eyes, and mucosal. With the addition of micro HA, the cell proliferation rate of macromolecule active ingredients increased significantly; 0.125% micro HA can make the cell proliferation rate increase up to 94%.

There are 2 Benefits for Our customers

After utilizing our products Micro Hyaluronic Acid in its revolutionary delivery technology, they provide a significant competitive advantage with its novel approach to molecule delivery, yielding enhanced safety and efficacy for patients

“We are pleased to have used micro HA for Illustris’ innovative delivery technology,” said a technician from the pharmaceutical company, “We are eager to use micro HA and showcase its significant advantages over current drug delivery technology.”

Our customers benefited in the following ways:

Revolutionized HA solution for drug delivery system

The customer enables the delivery through tissue structures of macromolecule active ingredients (or at least 500KD) which are historically difficult or impossible to deliver topically and optimizes the delivery of active agents which previously permeated tissue structures inefficiently. It is easy for active ingredients to permeate the targeted site with Micro HA. Now, it enables the delivery of large molecules (up to 160KD) through tissue structures easily and optimizes the absorption of compounds typically delivered through skin, eyes, and mucosal surfaces.

Lower Cost

Stanford Chemicals (SCC) supplies high-purity micro HA at a very competitive price. Since the advanced specification of micro-HA, our customers can research its innovative delivery technology for pharmaceuticals easily. Therefore, this is a win-win result, it is also good news for the HA market. We are both happy with this transaction.

There are several benefits to using SCC micro HA throughout the pharmaceutical delivery process. For pharmaceutical companies with similar applications, our engineering team can provide a customized solution for your project. Feel free to contact us at [email protected].

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Why Is Hyaluronic Acid Important?

Maria Higgins — Thu, 02 Aug 2018 19:55:37 +0000

The Main Functions of Hyaluronic Acid Are as Follows:

1. Improve the function of the joint

2. Natural moisturizing lubricants

3, To prevent arteriosclerosis, pulse disorders, brain atrophy, and other diseases.

Hyaluronic acid itself is negatively charged and occurs in the softest connective tissue of animals. Its aqueous solution is a viscoelastic fluid filled with cells and collagen fibrous space and covered with some epidermal tissue. In the animal body, its main function is to protect and lubricate cells, regulate the cell movement on this viscoelastic matrix, stabilize the collagen network structure, and protect it from mechanical damage.

Because hyaluronic acid is a natural lubricating and shock-absorbing polymer, it is used as a lubricant for the tendon, tendon sheath, and synovial membrane. Hyaluronic acid is widely distributed in the connective tissue of the human body. Hyaluronic acid, which exists in the skin, plays an important role in the metabolism of the human epidermis.

The destruction or maladjustment of human hyaluronic acid can cause diseases. The decrease and destruction of hyaluronic acid in the skin can cause skin loss in the skin, wrinkling, and loss of elasticity and make the human epidermis aging. Therefore, hyaluronic acid is also called an antiaging factor.

Hyaluronic acid HA is one of the main matrix components of the skin and dermis of human skin. Its physiological function is to make water into the space of cells and to combine with protein to form protein gel, stick the cells together, play the normal cell metabolism, keep the cell water, and protect the cells from disease.

To restore skin tissue, improve wound healing and regeneration ability, reduce scar, and enhance immunity. Hyaluronic acid is also a major component of the extracellular matrix of proliferating cells and migratory cells, especially in embryonic tissues. Because of its own characteristics, hyaluronic acid can keep cells apart from each other, making cells easy to migrate and proliferate and preventing cell differentiation.

During development, hyaluronic acid seems to prevent cells from differentiating prematurely before proliferating enough or migrating into place. In medicine, hyaluronic acid HA is used in non-steroidal anti-inflammatory drugs, arthritis treatment, ophthalmology, and cardiac surgery, and has a unique role in the treatment of scalds, burns, frostbite, artificial skin, and so on.

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hyaluronic acid HA – Stanford Chemicals