Dihydromyricetin (DHM) from the Japanese raisin tree carries a rich history in traditional medicine. It has traditional applications in mitigating upset stomachs and purportedly easing hangover symptoms. DHM also finds a place in modern supplements.

DHM from Raison Trees [1]

This article is going to discuss the diverse aspects of DHM. Hope that you can learn about its potential side effects, interactions with medications, etc.

What Are DHM?

Dihydromyricetin (DHM) is a prominent flavonoid compound. It is renowned for its origins in the Japanese raisin tree, termed Hovenia dulcis. You can also find its presence in various other plant sources.

This natural compound also has an alternate name ampelopsin. It holds a distinguished place in traditional medicine, particularly in Asian cultures.

• Antioxidant Powerhouse: DHM showcases robust antioxidant properties. This feature aids in combating oxidative stress and neutralizing free radicals. It potentially benefits overall health as well.
• Hangover Relief: DHM is not only notable for its historical use in traditional medicine. It also finds applications in modern supplements. This remedy alleviates hangover symptoms and settles upset stomachs.
• Liver Protection and Overall Health: DHM can support liver health and function. It has become a subject of ongoing research in liver protection. It is also being researched for its potential to mitigate oxidation and inflammation.

Related reading: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?

Does DHM Have Any Side Effects?

The reported side effects of DHM remain notably limited based on current available research. There are lots of related studies. Most of them are carried out on animals. These experiments consistently illustrate a lack of adverse effects, even when administered at relatively high doses.

Sparse customer reviews note occasional mild discomfort like abdominal discomfort, nausea, or diarrhea. However, these instances are infrequent and largely anecdotal. While human studies on this topic are limited, the developing safety profile shows promise.

In a word, the existing evidence hints at a safety profile for DHM. As the scientific exploration continues, a more thorough understanding of DHM’s safety profile will offer clearer insights.

Can DHM Have Interactions with Medications?

The potential interactions between supplements such as DHM and prescribed medications are a significant concern in healthcare considerations.

There are limited studies examining DHM’s impact on liver enzymes in animal models. Their varying outcomes prompt caution in DHM’s use. Namely, these herbal supplements might influence the liver enzymes responsible for metabolizing medications. This influence may result in altered drug effectiveness or potential toxicity risks.

Thus, it is advisable to seek guidance from healthcare professionals before integrating DHM with prescribed medications. In this way, we can mitigate potential adverse effects and ensure patient safety.

What Is the Recommended Amount of DHM?

Determining the ideal dosage of DHM for human consumption is an ongoing area of research.

Recent animal studies investigating DHM dosages have presented encouraging outcomes. These studies consistently administer high doses of DHM to animal subjects without observable adverse reactions. However, despite these promising findings in animal models, the establishment of precise and safe DHM dosages for human consumption requires further extensive research.

This pursuit aims to enhance safety measures and optimize the advantageous use of DHM across various applications.

How to Get Quality DHM?

Ensuring the quality of DHM requires several factors and reliable suppliers:

–Opt for Reputable Manufacturers:

Select DHM supplements or products from established and reputable manufacturers. Look for companies that operate in certified Good Manufacturing Practice (GMP) facilities. Manufacturers adhering to GMP guidelines ensure stringent quality control measures.

–Thoroughly Examine Product Labels:

Carefully scrutinize product labels to assess the ingredients and purity of DHM-containing supplements. Look for clear and transparent labeling. For instance, check the concentration of DHM per serving, additional additives, and any potential allergens.

Products with detailed and accurate labeling often reflect a commitment to quality and transparency.

–Research Supplier Track Record:

Conduct research on suppliers or manufacturers of DHM-containing products. You can refer to local authorities’ databases or consumer protection agencies. Check for any reported issues or complaints against these suppliers.

Verified positive track records and the absence of regulatory issues work. Such evidences provide confidence in the reliability and quality of the supplier’s offerings.

–Seek Third-Party Testing and Certifications:

Look for DHM supplements that undergo third-party testing by independent laboratories. Certifications or endorsements from reputable third-party organizations attest to the product’s quality, purity, and compliance with safety standards. Products with such certifications often display a higher level of commitment to quality and transparency.

–Consider Customer Reviews and Recommendations:

Explore customer reviews and feedback regarding DHM supplements or products from various suppliers. Genuine customer experiences can offer insights into the product’s efficacy, potential side effects, and overall satisfaction. Positive reviews and recommendations from consumers can guide them towards trustworthy suppliers offering quality DHM products.

–Consult Healthcare Professionals:

Consult healthcare professionals or nutritionists before choosing DHM supplements or putting them into your routine. Be more careful if you have existing health conditions or are taking medications. Healthcare professionals can offer personalized guidance and recommendations tailored to your specific health needs.

Conclusion

Current research and customer reviews suggest DHM is generally safe. Yet, comprehensive human studies are essential for conclusive evidence. As research into DHM continues, its safety profile and potential benefits will likely become clearer. So, it can provide more definitive guidance for consumers.

At Stanford Chemicals Company (SCC), we offer exclusively the finest quality Dihydromyricetin (DHM). Our DHM undergoes meticulous testing procedures to ensure both purity and effectiveness. For further information, please explore our homepage.

Reference:

[1] Raison Trees. (2024, August 9). In Wikipedia. https://en.wikipedia.org/wiki/Hovenia_dulcis

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In recent years, the exploration of natural compounds in the realm of medicinal research has gained significant attention. Among these compounds, dihydromyricetin (DHM) has emerged as a subject of interest.

This article is going to explore its properties in addressing two distinct yet interconnected health concerns: inflammatory diseases and anxiety disorders. Hope that you can have a further understanding of DHM’s uses.

Clinical Researches

What Is Dihydromyricetin (DHM)?

Dihydromyricetin comes from the ampelopsis plant species. It is a flavonoid known for its antioxidant and anti-inflammatory attributes. It has spurred investigations into its potential applications in combating various health issues.

–Antioxidant Powerhouse

One of the standout features is its robust antioxidant capacity. DHM has the ability to scavenge these free radicals. It serves as a potent defender against oxidative stress. Thus, DHM potentially aids in the prevention of various chronic diseases and promotes overall health.

–Anti-Inflammatory Properties

DHM has demonstrated notable anti-inflammatory effects in several studies. DHM has the potential to inhibit inflammatory pathways and reduce inflammation markers. It can manage inflammatory diseases like arthritis, inflammatory bowel diseases, and other systemic inflammatory conditions.

–Liver Protection and Detoxification

Research has indicated DHM properties to protect livers. Namely, it plays a role in safeguarding the liver from damage caused by toxins and oxidative stress. It supports liver function, aids in detoxification processes, and promotes liver health.

–Neuroprotective Effects

The influence of DHM extends to the brain. These are studies highlighting its neuroprotective potential. It has shown promise in protecting neurons from damage and supporting cognitive function. Moreover, DHM’s interaction with neurotransmitter pathways hints at its possible role in managing anxiety and stress-related disorders.

Related reading: DHM Dihydromyricetin: The Hangover Helper You Need

How Can Dihydromyricetin (DHM) Alleviate Inflammatory Diseases?

DHM shows new potential in the realm of medicinal research. Here are two notable examples:

Inflammation is a natural response by the immune system. It can escalate into chronic conditions if unchecked. DHM has shown promise in mitigating inflammation markers and modulating inflammatory pathways. Thus, DHM offers a glimpse of hope in managing inflammatory diseases.

–Mechanisms:

Research studies have indicated DHM’s ability to hinder the activation of certain inflammatory signaling molecules. By doing so, it potentially curtails the cascade of events that lead to heightened inflammatory responses. This property has attracted attention in the medical community for its possible implications in conditions like arthritis, inflammatory bowel diseases, and other systemic inflammatory disorders. [1]

–Other Potentials:

The anti-inflammatory potential of DHM extends beyond molecular pathways. Studies have observed its ability to reduce oxidative stress, which is a crucial factor in the progression of inflammatory diseases. By combating oxidative damage, DHM demonstrates a multifaceted approach to potentially mitigating the severity of these conditions.

How Does DHM Work in Anxiety Disorder Management?

Anxiety disorders are characterized by excessive worry, fear, and physiological responses. It affects millions worldwide. Emerging research hints at DHM’s capability to influence neurotransmitter activity in the brain. Thus, it serves as a potential treatment avenue for anxiety-related conditions.

–Mechanisms:

Neurotransmitters like GABA (gamma-aminobutyric acid) play a pivotal role in regulating anxiety. DHM has exhibited modulatory effects on GABA receptors, which could contribute to its anxiolytic properties. By enhancing GABAergic transmission, DHM might assist in calming the nervous system and reducing anxiety symptoms. [2]

–Other Potentials:

Furthermore, studies exploring DHM’s impact on brain receptors associated with anxiety responses have revealed promising results. Its interaction with specific neural pathways suggests a potential to alleviate anxiety symptoms by regulating the intricate balance of neurotransmitters involved in mood regulation.

The Need for Further Research

While preliminary findings regarding DHM’s efficacy in addressing inflammatory diseases and anxiety disorders are encouraging, it’s crucial to acknowledge the need for extensive research.

Clinical trials involving human subjects are indispensable to validate the safety, efficacy, and optimal dosage of DHM as a therapeutic agent. Comprehensive studies will offer a clearer understanding of its mechanisms of action and its potential side effects.

Conclusion: A Glimpse of Promise

The evolving landscape of natural compounds in healthcare continues to unravel potential solutions for prevalent health concerns. Dihydromyricetin, with its anti-inflammatory and potential anxiolytic properties, stands at the threshold of therapeutic advancement.

The journey of DHM from botanical origins to clinical applications holds promise in reshaping the approach to managing inflammatory diseases and anxiety disorders. While the initial research showcases its potential, further exploration and rigorous scientific inquiry are imperative to harness its full therapeutic potential and pave the way for its integration into mainstream healthcare practices.

As research advances, the potential of dihydromyricetin may offer hope for individuals grappling with the burdens of inflammatory diseases and anxiety disorders, presenting a natural alternative in the pursuit of improved health and well-being. For more information, please check our homepage at https://www.stanfordchem.com/.

Reference:

[1] Sun Y, Liu S, Yang S, Chen C, Yang Y, Lin M, Liu C, Wang W, Zhou X, Ai Q, Wang W, Chen N. Mechanism of Dihydromyricetin on Inflammatory Diseases. Front Pharmacol. 2022 Jan 18;12:794563. doi: 10.3389/fphar.2021.794563. PMID: 35115939; PMCID: PMC8804380.

[2] Dr Jing Liang (2021, January 29). Dihydromyricetin shows promise as an anxiety disorder treatment. Research Outreach. Retrieved December 27, 2023, from https://researchoutreach.org/articles/dihydromyricetin-shows-promise-anxiety-disorder-treatment/

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Dihydromyricetin (DHM) has emerged as a subject of growing interest in clinical research due to its diverse pharmacological properties and potential therapeutic applications. Current investigations are shedding light on its promising implications across various health conditions. This condition paves the way for potential clinical uses and future directions in medical practice.

Research and Innovations

This article is going to discuss the features and uses of DHM. Hope that you can have a better comprehensive understanding.

What Is Dihydromyricetin (DHM)?

Dihydromyricetin (DHM) is a natural flavonoid compound. It is derived from certain plant sources, notably from the Hovenia Dulcis tree. It’s recognized for its various pharmacological properties and has gained attention for its potential health benefits.

DHM possesses several notable characteristics:

1. Antioxidative Properties: It exhibits strong antioxidative effects, so it helps to neutralize free radicals in the body, and reduces oxidative stress and potential cell damage caused by reactive oxygen species.
2. Anti-inflammatory Activity: DHM demonstrates anti-inflammatory properties. Thus, it may help alleviate inflammation-related issues by modulating the body’s inflammatory responses.
3. Hepatoprotective Effects: It’s been studied for its potential to protect the liver from damage caused by toxins or alcohol consumption. DHM shows promise in supporting liver health and mitigating liver damage.
4. Metabolic Effects: Recent research indicates DHM’s role in influencing metabolic processes. It’s being investigated for its potential in regulating glucose metabolism, improving insulin sensitivity, and its effects on lipid metabolism.

Further research is ongoing to ascertain its effectiveness and optimal usage in clinical settings.

Related reading: DHM Dihydromyricetin: The Hangover Helper You Need

What Are the Clinical Uses of Dihydromyricetin (DHM)？

The clinical uses of DHM are still being extensively researched and explored. Ongoing studies and preliminary research suggest several potential clinical uses for DHM:

–Metabolic Disorders:

DHM is able to regulate metabolic parameters. That has attracted attention in addressing conditions like diabetes, obesity, and dyslipidemia. Clinical studies exploring its impact on insulin sensitivity, glucose regulation, and lipid metabolism are underway. It also has potential as an adjunct therapy for managing metabolic disorders.

In the realm of diabetes, early research has shown promising outcomes related to DHM’s influence on insulin sensitivity. Studies suggest that DHM might assist in enhancing insulin sensitivity, a critical aspect of managing diabetes. By potentially improving the body’s response to insulin, DHM could offer a pathway toward better glycemic control and, in turn, help regulate blood sugar levels more effectively.

Moreover, investigations into DHM’s effects on glucose regulation have yielded intriguing results. Preliminary studies hint at its ability to modulate glucose metabolism, potentially contributing to maintaining optimal blood glucose levels. This avenue of research presents a promising prospect for individuals grappling with diabetes or those at risk of developing the condition.

–Liver Health:

There is much more research focusing on DHM’s effects on liver-related issues, particularly non-alcoholic fatty liver disease (NAFLD) because DHM has the capacity to mitigate hepatic steatosis and reduce inflammation in the liver. Clinical trials investigating its role in liver health and potential applications in liver disease management are ongoing.

NAFLD is a prevalent liver condition. NAFLD is characterized by the accumulation of fat in the liver cells. This condition often occurs in individuals without excessive alcohol consumption. DHM has emerged as a potential therapeutic agent due to its observed effects on mitigating hepatic steatosis. Preliminary research suggests that DHM might hold promise in reducing the buildup of fat in liver cells, which is a crucial step in managing NAFLD.

Moreover, the compound’s anti-inflammatory properties have been of particular interest in the context of liver health. Inflammation plays a pivotal role in the progression of liver diseases, including NAFLD. DHM’s potential to reduce inflammation in the liver has sparked clinical trials aiming to delve deeper into its mechanisms and effectiveness in attenuating liver inflammation.

–Anti-inflammatory Properties:

DHM’s anti-inflammatory characteristics have implications for conditions associated with chronic inflammation, such as metabolic syndrome and related disorders. Clinical studies aim to elucidate its impact on inflammatory markers and its role in reducing systemic inflammation.

–Neuroprotective Potential:

Preliminary research suggests DHM’s neuroprotective properties. That means it has the potential to address neurological conditions. Clinical investigations focusing on its effects on neurodegenerative diseases and cognitive health are in progress, exploring its possible therapeutic role.

–Safety and Tolerance:

Ongoing clinical trials are assessing DHM’s safety profile, including its dosage, potential side effects, and long-term safety. Understanding its pharmacokinetics and ensuring its tolerability in various patient populations is critical for its clinical translation.

However, while the findings above are promising, comprehensive clinical trials elucidating DHM’s efficacy, safety profile, and optimal usage in varied patient populations are still needed for clinical practice. Continued research endeavors will shape its potential as a valuable therapeutic tool in addressing a spectrum of health conditions.

Conclusion

Dihydromyricetin (DHM) stands at the forefront of clinical exploration due to its various pharmacological properties and therapeutic applications. As research continues to unravel its diverse mechanisms and effects, DHM shows promising prospects across various health conditions. Its antioxidative, anti-inflammatory, hepatoprotective, and metabolic-regulatory attributes have sparked keen interest in the medical community.

Stanford Chemicals Company (SCC) exclusively offers top-tier Dihydromyricetin (DHM) and firmly backs our product’s quality. Our DHM is produced within the United States. These products undergo rigorous testing protocols to ensure unmatched purity and effectiveness. Feel free to reach out to us if you’re interested.

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The Biological Experiment of Dihydromyricetin Extract

It is reported that on January 13, 2012, the Oriental Morning Post reported that researchers at the University of California in Los Angeles developed a new drug using Fructus aurantii extract, which could be injected into mice to relieve alcohol, which could relieve the “top” symptoms in a short period of time.

The researchers used the Fructus aurantii extract Dihydromyricetin (DHM) to observe the antialcoholism efficacy of different medicinal herbs. They let the mice drink a certain amount of alcohol in 2 hours, which was equivalent to drinking 15 to 20 bottles of beer. As expected, most of the mice were drunk and the rest had not been touched even after being knocked down. Within 1 hour, the symptoms of drunkenness began to weaken, and mice gradually resumed their control of the body.

In the second part of the experiment, the researchers injected the mice with alcohol and injected them with dihydromyricetin, and found that the mice increased their ability to control their own behavior, delayed the onset of drunken symptoms, and recovered about 15 minutes after drunkenness.

Moreover, rats injected with dihydromyricetin for two days in a row were less excited, had spasticity and other drunken symptoms, and were not “greedy”, which meant that dihydromyricetin had a certain inhibitory effect on alcohol addiction.

It is observed that the effect of dihydromyricetin is effective. Drinking and ingestion of rattan tea containing dihydromyricetin can quickly remove alcohol and make the problem of hangovers effectively restrained.

Antibacterial Effect of Dihydromyricetin Extract

The pharmacological experiments showed that Dihydromyricetin had bacteriostasis effect on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, bacilli, Saccharomyces cerevisiae, myxomyces, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor, and Rhizopus, especially gram positive, gram negative cocci.

It has many functions:

1) Dihydromyricetin can Clear the free radical in the body and Antioxidation:

The vine tea extract can effectively level down lipid peroxidation. It can prevent the oxidative damage of antioxidase in the body caused by the free radical. Then it can improve the oxidation resistance of the human body;

2) Dihydromyricetin can Antibiotic Action:

The vine tea extract has the strong inhibitory action of staphylococcus aureus and Bacillus subtilis. It also has inhibitory action of Aspergillus flavus, Aspergillus niger, Penicillium, and Alternaria. Dihydromyricetin has the inhibitory action of Staphylococcus aureus, Staphylococcus aureus(S. aureus), and Pseudomonas aeruginosa.

3) Dihydromyricetin can Protect the Liver:

Dihydromyricetin has a strong inhibitory action on the rise of ALT and AST in the blood Serum. It can lower the total bilirubin in the blood serum. So it has the strong action of lowing the aminotransferase and jaundice. The vine tea extract can restrain liver fibrosis in the rat.

4) Dihydromyricetin can Reduce the levels of blood sugar and blood fat:

Dihydromyricetin can reduce the blood fat levels in the mouse. It can decrease the damage to liver cells caused by high blood fat levels and improve the antioxidation ability. At the same time, it can lower the levels of high blood sugar.

5) Dihydromyricetin can Anti-inflammation:

The vine tea extract can effectively restrain the mouse pinna swelling caused by xylene. It can also restrain the writhing response in the mouse caused by acetic acid.

6) Dihydromyricetin can Anti-tumor:

The vine tea extract has effectively restrained to cell proliferation of some tumor cells.

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