I. Hyaluronic Acid for Eyes

1. What are the benefits of hyaluronic acid for the eyes?

Hyaluronic acid is a water-retaining and lubricating substance. It retains moisture in the eyes and lubricates ocular tissues. It also enhances and repairs corneal damage, which brings great relief to symptoms of dryness, irritation, and eye fatigue.

Clinical trials have shown that sodium hyaluronate eye drops (sodium salt of HA) significantly improve discomfort in dry eye patients and promote the healing process of micro damage on the corneal surface.

Reference: From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health

2. What are applications of hyaluronic acid in eye care?

In ophthalmology, HA is primarily used in two areas: daily eye care and ophthalmic surgical assistance. For daily care, it serves as a key ingredient in artificial tears. In eye surgeries, it acts as a viscoelastic agent to protect intraocular tissues. For specific case studies, please refer to our related articles.

References:

• Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes
• Sodium Hyaluronate Used in Anterior Segment Eye Surgery

3. Which is better for the eyes: hyaluronic acid or ectoine?

Both HA and ectoine are excellent eye care ingredients, but they work differently. Hyaluronic acid primarily functions through physical water retention, while ectoine is more effective in protecting cells from environmental stress. The choice depends on specific eye conditions. For a detailed comparison, please refer to our dedicated article.

Reference: Sodium Hyaluronate vs. Ectoine: Which Is Better for Skin and Eyes?

Product Recommendations

Stanford Chem Company (SCC) provides pure medical-grade HA powder specifically developed for ophthalmic applications.

II. Hyaluronic Acid for Skin

1. How strong is hyaluronic acid’s hydrating ability?

Hyaluronic acid is known as the “natural moisturizing factor” due to its exceptional water-binding capacity. Scientific data shows that 1 gram of HA can hold up to 1,000 times its weight in water, making it an essential hydrating ingredient in skincare.

2. What are the benefits of hyaluronic acid for skin?

Beyond its superior moisturizing effects, HA also promotes skin barrier repair and improves elasticity. Recent studies suggest it may delay skin aging by regulating specific signaling pathways, opening new possibilities for anti-aging product development.

Reference: What Does Sodium Hyaluronate Do for the Skin?

3. Is a lower molecular weight always better?

There is a common misconception that the lower the molecular weight, the better and that molecules over 500 Da are too large to penetrate the skin. However, different molecular weights offer different benefits, and larger molecules can still permeate through advanced formulation techniques. A 2024 study found that high-molecular-weight HA penetrates the skin effectively, providing anti-inflammatory, reparative, and antioxidant effects.[1]

Therefore, molecular weight selection should be informed by science. The ideal product should comprise a mixture of HA with various molecular weights.

4. Hyaluronic acid vs. collagen: Which one should you choose?

These two ingredients work differently—HA primarily hydrates, while collagen provides structural support. The best approach is to use them together for synergistic effects, as detailed in our research article.

Reference: Hyaluronic Acid and Collagen: The Perfect Combination for Healthy Skin

5. Hyaluronic acid, retinol, and vitamin C: Which is best for skincare?

Each of these active ingredients excels in different areas: HA for hydration, retinol for wrinkle reduction, and vitamin C for antioxidant protection. The choice depends on skin needs and tolerance, and sometimes combining them yields better results. Our comparative study provides detailed usage recommendations.

Reference: Hyaluronic Acid vs. Retinol vs. Vitamin C: Which Is Best for Skincare?

6. Can hyaluronic acid cause acne?

Pure HA itself does not cause acne, as it is non-comedogenic. However, some HA products may contain other additives that could trigger breakouts. Always check the full ingredient list, especially if you have oily or acne-prone skin.

Reference: Can Hyaluronic Acid Cause Acne?

Product Recommendations

Our cosmetic-grade sodium hyaluronate powder features high purity with minimal impurities. Compared to other market products, it contains higher glucuronic acid content and lower levels of protein, heavy metals, and nucleic acids.

III. Hyaluronic Acid for Joints

1. Why is hyaluronic acid able to relieve arthritis?

Hyaluronic acid is a major component of synovial fluid, producing lubrication and cushioning in joints. In patients with arthritis, the concentration and molecular weight of HA in joint fluid are reduced. Exogenous sodium hyaluronate supplementation can improve joint function and relieve pain symptoms.

2. Hyaluronic acid or chondroitin sulfate: Which is better for joints?

Both supporters ensure joint health but differently. HA primarily facilitates joint lubrication, while chondroitin sulfate is all about cartilage protection. They are usually prescribed clinically together for general joint support.

Reference: Hyaluronic Acid vs. Glucosamine vs. Chondroitin: Which Is Best for Joints?

3. Does oral hyaluronic acid alleviate joint pain?

The oral bioavailability of HA has been a subject of research emphasis. The clinical evidence available presently suggests that certain molecular-weight oral HA is incompletely absorbed but demonstrates improvement of joint symptoms, though its effects are typically more delayed compared to injections.

4. What are the side effects of hyaluronic acid joint injections?

Intra-articular HA injection is also safe. Injection-site pain or inflammation is a common mild reaction occasionally seen in a few patients. Severe side effects are exceedingly rare.

Product Recommendations

Our injection-grade HA is mainly used for intra-articular and intraocular injections. It also serves in orthopedic surgery, human/animal (e.g., horses, dogs) joint dysfunction treatment, post-surgical adhesion prevention, and drug delivery.

IV. Hyaluronic Acid for Scalp

1. Is hyaluronic acid good for hair?

Yes. HA preserves scalp moisture and enhances hair luster. It really makes a big difference for hydrating hair, particularly dry or damaged hair.

2. Can normal hyaluronic acid be applied to the scalp?

Skincare-grade HA can be applied to the scalp, but concentration and formulation are important. For best outcomes, use hair-care products formulated specifically considering scalp physiology.

3. Is hyaluronic acid in shampoos safe?

HA shampoos are safe. Keep in mind that other shampoo ingredients can have an impact on HA stability. Always test the whole formula for compatibility.

Conclusion

We hope this guide helps you understand and use hyaluronic acid products more effectively. For professional inquiries, please contact us: Get A Quote.

[1] Hui Xing, Xiangjun Pan, Yihan Hu, High molecular weight hyaluronic acid-liposome delivery system for efficient transdermal treatment of acute and chronic skin photodamage, Acta Biomaterialia, Volume 182, 2024, Pages 171-187, ISSN 1742-7061, https://doi.org/10.1016/j.actbio.2024.05.026.

The post The Comprehensive Guide to Hyaluronic Acid appeared first on Stanford Chemicals.

Multiple Functions of Sodium Hyaluronate

From skincare to medicine, joint care to genetic engineering, sodium hyaluronate has become an indispensable part of modern technology and daily life.

Fig 1. Wide range of uses for hyaluronic acid

–A Multifunctional Skincare Ingredient

Sodium hyaluronate is a star in skincare products. It boasts excellent moisturizing properties, repairs the skin barrier, and fights aging. It quickly increases the skin’s water content, restoring its radiance. Whether it’s a luxury serum or an affordable mask, you’re likely to find its presence.

Read more: Hyaluronic Acid vs Glycerin: Which is More Hydrating

–A Star Ingredient in the Beauty Industry

It is not only a key ingredient in skincare but also a celebrity in the beauty field. From injectable fillers and skin tightening to restoring elasticity, sodium hyaluronate plays a crucial role.

— A Key Component of Artificial Tears

For modern individuals who spend extended periods staring at screens, dry eye syndrome has become a common issue. Sodium hyaluronate, with its excellent lubricating and moisturizing properties, is widely used in artificial tears, effectively alleviating eye discomfort and fatigue.

Read more: From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health

— A Miracle Ingredient for Joint Pain Relief

Joint problems are often caused by the loss of hyaluronic acid in synovial fluid. Sodium hyaluronate is used in joint injection solutions to provide lubrication, reduce friction and pain, and restore mobility for osteoarthritis patients.

— Significant Applications in Medicine

In surgeries, sodium hyaluronate serves as a tissue filler or drug carrier, accelerating tissue healing and reducing inflammation. Additionally, it is used in wound repair and oral care, demonstrating extraordinary medical value.

How Molecular Weight Affects Sodium Hyaluronate Uses

The molecular weight of sodium hyaluronate determines its characteristics in absorption, penetration, lubrication, and repair, making it a crucial reference for its specific applications.

Fig 2. HA with different molecular weights has different permeability

–High Molecular Weight HA: Preferred for Barrier and Lubrication

High molecular weight (>1,800 kDa) sodium hyaluronate tends to remain on the surface, forming a viscoelastic film.

• Joint Treatment: In osteoarthritis therapy, it enhances the viscoelasticity of joint fluid, reduces friction, and alleviates pain.
• Ophthalmology: Its lubricating properties protect the cornea and alleviate discomfort in dry eyes, particularly for contact lens wearers.
• Food Industry: Used as a food additive to improve oral and esophageal lubrication, aiding those with swallowing difficulties.

— Medium Molecular Weight HA: Balanced Properties for Broad Applications

Medium molecular weight (200–1,800 kDa) sodium hyaluronate offers a balance of surface action and penetration.

• Medical Dressings: Exhibits excellent tissue repair properties for burns and wounds, covering surfaces while promoting regeneration.
• Drug Delivery: Used as a matrix material for drug delivery systems, enabling slow drug release and improved bioavailability.

— Low Molecular Weight HA: Core for Penetration and Repair

Low molecular weight (5-200 kDa) sodium hyaluronate has excellent penetration properties, reaching deep into tissues or cells.

Aesthetic Treatments: Used for deep tissue filling in injections, such as correcting depressions or scar repair.

• Drug Development: Its penetration performance makes it an effective drug carrier for cancer and immune regulation treatments.
• Anti-inflammatory and Immune Regulation: It modulates inflammatory responses, aiding in pathological inflammation suppression in immunological research and therapies.

— Ultra-Low Molecular Weight HA: Exploring Frontier Functions

Ultra-low molecular weight (<5 kDa) sodium hyaluronate has drawn attention in modern medicine and biotechnology.

• Gene Therapy: Serves as a new type of gene delivery vector, efficiently transporting gene fragments into nuclei for gene editing and cancer treatment.
• Anti-Aging Research: Directly activates repair mechanisms at the cellular level, potentially reversing aging processes.

Table 1. Comparison of high, medium, low, and ultra-low molecular weight hyaluronic acid: HA with different molecular weights has different water solubility, viscoelasticity, and uses.

Read more: Comparative Analysis of Hyaluronic Acid with Different Molecular Weights

Production Method: Microbial Fermentation

The microbial fermentation method employs microorganisms such as streptococci to produce sodium hyaluronate through fermentation. This process is more eco-friendly and safer than traditional animal tissue extraction, avoiding allergic risks from animal sources. It also allows precise control of molecular weight and purity, meeting diverse industry needs.

Read more: How is Hyaluronic Acid Powder Made

Derivatives of Hyaluronic Acid

To expand the applications of sodium hyaluronate, scientists have developed various derivatives through chemical modifications. For example, cross-linked hyaluronic acid is a derivative where molecular chains are connected with cross-linking agents to form a more stable 3D network structure.

These modifications significantly enhance its resistance to degradation while maintaining elasticity and water retention. Cross-linked hyaluronic acid is primarily used in long-lasting cosmetic fillers for wrinkle removal and shaping. It is also used in joint cavity injections to increase lubrication and alleviate pain.

Stanford Chemical Company (SCC) is a pioneer in the development of hyaluronic acid. Products include food-grade, medical-grade, cosmetic-grade, injectable-grade hyaluronic acid, and hyaluronic acid derivatives (Sodium Acetylated Hyaluronate and Cross-linked Hyaluronic Acid Gel). We can also provide customers with customized molecular-weight sodium hyaluronate powder. For more information or specific applications, please visit our homepage.

The post Sodium Hyaluronate: Uses, Molecular Weight, Production and Derivatives appeared first on Stanford Chemicals.

According to its purpose, HA can be divided into cosmetic-grade, food-grade, medical-grade, and injectable-grade. Of them, injectable-grade HA is extensively used in cosmetic surgery, joint therapy, and medical lubrication. How to choose suitable injectable-grade HA according to the particular requirement? Let’s discuss that.

What is Injectable-Grade Hyaluronic Acid

Injection-grade hyaluronic acid represents high-quality HA developed especially for medical and cosmetic injection purposes. It undergoes extensive purification processes to remove impurities and possible allergens, ensuring the following features:

• High Purity: It is of medical-grade quality, thus safe to be injected.
• High Biocompatibility: Very similar in structure to human tissues for maximum safety.
• Long-Lasting Stability: It degrades much more slowly, prolonging its effect.

This kind of HA is used for filling facial hollows, and lubricating joints, and can even enhance the smooth operation of surgical tools.

Key Considerations When Choosing Injectable-Grade Hyaluronic Acid

The key to selecting the right injectable-grade HA lies in understanding your application needs. Of course, we have summarized some core indicators here to help you understand your needs.

1. Molecular Weight

Molecular weight defines the viscoelasticity, absorption rate, and degradation time of HA. Generally speaking, high molecular weight works better for lubrication and support, while low to medium molecular weight serves for penetration and drug delivery.

2. Purity and Sterility

HA injections should have ultra-high purity, be free from impurities, and be manufactured under sterile conditions to minimize infection risk.

3. Biocompatibility

Good quality HA should be strictly tested for compatibility with human tissues to minimize inflammation or adverse reactions upon its use.

4. Certification and Credentials

Only choose products certified by international authorities such as FDA or CE to ensure good quality and safety.

Products meeting this criterion will perform well in the intended applications.

Read more: How is Hyaluronic Acid Powder Made

Suitable Molecular Weights for Different Scenarios

–Cosmetic Procedures

HA is commonly used in cosmetic procedures to fill facial hollows, reduce fine lines, and improve skin elasticity.

Studies have shown that HA with molecular weights in the range of 1,300 kDa–1,800 kDa provides optimal viscoelasticity and volumizing effects, which are crucial for facial contouring and dermal filler applications.[i]

The medium to high molecular weight provides the structural integrity needed to sculpt facial contours while maintaining biocompatibility and longer-lasting effects due to slower degradation rates.

–Joint Injections

For patients with osteoarthritis, HA injections are essential for pain relief and improved joint mobility.

The high molecular weight ensures a thick, viscous solution capable of providing cushioning for joints, mimicking natural synovial fluid.

–Medical Lubricants

HA is often used as a lubricant during surgical procedures to minimize friction between instruments and tissues, improving procedural efficiency.

Medium molecular weight (800 kDa–1,300 kDa) HA is well-documented for its flowability and lubricating properties, essential for reducing friction during surgical procedures.[ii]

Medium molecular weight strikes a balance between being easy to handle and highly effective as a lubricant, making it suitable for surgical applications requiring precise, smooth interactions.

Conclusion

It is easy to select the proper injectable-grade hyaluronic acid once the application scenario is clear. Cosmetic procedures require medium and high molecular weight products for excellent support and longevity of results. High molecular weight HA has better application in joint injections, as it maintains lubrication and cushioning.

Meanwhile, in medical lubricant applications, medium molecular weight HA remains flowable with safety features. Regardless of the application, always prioritize purity, sterility, and certifications to ensure safety and effectiveness.

Pure Injection Hyaluronic Acid (HA) Powder from Stanford Chemicals Company

Injection-grade hyaluronic acid from Stanford Chemicals Company (SCC) is GMP, CEP, and DMF certificated and the factory passed an on-site inspection by the US FDA. It is all fermented products, non-animal sources, non-GMO, and non-BSE/TSE risk.

Main Products:

References:

The 5 Common Uses of Injectable Hyaluronic Acid

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

[i] Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x. PMID: 19207319.

[ii] Cowman MK, Schmidt TA, Raghavan P, Stecco A. Viscoelastic Properties of Hyaluronan in Physiological Conditions. F1000Res. 2015 Aug 25;4:622. doi: 10.12688/f1000research.6885.1. PMID: 26594344; PMCID: PMC4648226.

The post How to Choose the Right Injectable-Grade Hyaluronic Acid appeared first on Stanford Chemicals.