Methotrexate Description

Methotrexate was first used to fight cancer and was less toxic than other treatments. It can inhibit DNA synthesis, so it can be good medicine for cancer.

Methotrexate is a cell cycle blocker with different effects. In the late G1 / S phase, methotrexate blocks the cell cycle and therefore inhibits the synthesis of DNA, RNA, thymidine and proteins. In the past, inhibiting the enzymes involved in purine metabolism, leading to the accumulation of adenosine, or inhibiting the expression of intercellular adhesion molecules on T cells, is the main mechanism of action of methotrexate. Previous studies have observed that this compound irreversibly inhibits dihydrofolate reductase (DHFR) and thymidine synthase (TS). Methotrexate has been shown to regulate inflammation by promoting adenosine release or inhibiting the transmethylation response. In adherent splenocytes, methotrexate reduces IL-1 production.

Methotrexate Application

·Raw material of early rheumatoid drugs
·Raw materials of anti-cancer drugs
·For a variety of acute leukemia, chorionic epithelial cell carcinoma, malignant mole and psoriasis

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