Vitamin A

Vitamin A is a general term that includes several compounds with similar biological activities, such as retinol, retinal, and retinoic acid.

Retinol is the most common and fundamental form of vitamin A. Retinol can be metabolized in the body to form retinal, which plays a crucial role in vision, helping the eyes adapt to different lighting conditions.

Retinoic acid is mainly involved in cell growth and differentiation, contributing to skin health, immune function, and gene expression. Overall, the benefits of VA include:

• Preventing night blindness and vision loss, aiding in the treatment of various eye diseases;
• Helping prevent respiratory system infections;
• Supporting normal immune system function;
• Promoting faster recovery during illness;
• Maintaining healthy tissues and organs;
• Helping the skin resist aging and improving skin texture;
• Supporting growth, strengthening bones, and maintaining healthy skin, hair, teeth, and gums;
• Aiding in the treatment of emphysema and hyperthyroidism.

Vitamin B Complex

Vitamin B complex refers to a group of vitamins, including vitamin B1, B2, B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folic acid), and B12.

The B vitamins work synergistically, meaning that taking all the B vitamins together is more effective than taking them individually. Also, if the intake ratios of B1, B2, and B6 are uneven (e.g., 50mg of B1, 50mg of B2, and 50mg of B6), their effectiveness may be reduced. Although the different B vitamins work together in many metabolic and physiological processes, they have distinct physiological functions and benefits.

Table 1. Summary of the effects of members of the B vitamin family

Vitamin C

The chemical name for vitamin C is ascorbic acid. It is a water-soluble vitamin and one of the most well-known nutrients. Not only is it a beauty elixir, but it is also an antioxidant that protects cells and even has anti-cancer properties. VC is commonly found in fruits and vegetables but can be easily degraded by external environmental changes.

Benefits of VC:

• Enhances skin elasticity and prevents age spots;
• Promotes wound healing, treats external injuries, burns, and gum bleeding, and speeds up post-surgical recovery;
• Prevents viral and bacterial infections and boosts immune system function;
• Lowers cholesterol levels in the blood and reduces the risk of venous thrombosis;
• Treats and prevents common colds;
• Reduces the effects of many allergy-causing substances;
• Helps with iron absorption and folic acid breakdown, preventing scurvy;
• Helps prevent the formation of the carcinogen nitrosamine, providing anti-cancer benefits;
• Promotes collagen production, preventing aging and prolonging life.

Vitamin D

Vitamin D is a term that encompasses a group of fat-soluble vitamins, primarily including D2 (ergocalciferol) and D3 (cholecalciferol). Vitamin D helps regulate calcium and phosphorus balance in the body, promoting healthy bones and teeth.

Cholecalciferol (D3) is one of the main forms of vitamin D and is synthesized by the skin when exposed to sunlight. It can also be obtained from certain animal foods and supplements.

Benefits of VD:

• Enhances the absorption of calcium and phosphorus, strengthening bones and teeth;
• Supports growth and development, helping infants and young children grow properly and preventing rickets;
• Assists in the absorption of VA;
• Helps prevent calcium loss and osteoporosis during menopause.

Vitamin E

Vitamin E refers to a group of fat-soluble compounds, with tocopherols and tocotrienols being the most common. It acts as an antioxidant, protecting cells from damage caused by free radicals and supporting immune function and skin health.

Benefits of VE:

• Delays cellular aging, moisturizes the skin, reduces pigmentation, and maintains a youthful appearance
• Cleanses the blood and lowers LDL cholesterol levels, preventing atherosclerosis;
• Promotes the formation of healthy red blood cells and prevents blood clotting;
• Lowers blood pressure and reduces the risk of ischemic heart disease;
• Enhances liver detoxification, protects the body, and reduces fatigue;
• Stimulates the secretion of sex hormones, improves fertility, and prevents miscarriage.

Vitamin K

Vitamin K, often called the “clotting vitamin,” is a fat-soluble vitamin with several forms, including K1 (phylloquinone or plant-based phylloquinone), K2 (menaquinone), and K3 (menadione). Vitamin K is essential for blood clotting and bone health, primarily promoting the synthesis of blood clotting factors to help prevent excessive bleeding.

Vitamin P

Vitamin P, commonly known as rutin or bioflavonoids, is not strictly a vitamin but is often classified as one. Vitamin P is a water-soluble nutrient that the body cannot synthesize, so it must be obtained from food. It is essential for the digestion and absorption of VC, reduces capillary fragility, decreases vascular permeability, enhances the activity of VC, and helps prevent cerebral hemorrhage, retinal hemorrhage, and purpura.

Conclusion

In summary, vitamins are crucial for health, each with unique benefits:

VA supports vision and skin, the B complex aids metabolism, VC boosts immunity, VD strengthens bones, VE protects cells, and Vitamin K aids blood clotting. Ensuring a balanced intake helps maintain overall well-being.

Stanford Chemical Company (SCC) has over 16 years of experience in the manufacture and distribution of phytochemicals, pharmaceutical intermediates, catalysts and more. Our products include hyaluronic acid, herbal extracts, food additives, nutraceutical ingredients and so on, totaling nearly 800 products. Feel free to Get A Quote to learn more if you are interested.

The post Vitamin Guide: 14 Important Vitamins for Health appeared first on Stanford Chemicals.

1. Hydration and Moisture Retention

Whether your skin is dry, oily, or a mix of both, moisturizing has proven to be an unavoidable routine in skincare. Hydration is also essential for skin barrier integrity. Below are some of the most popular common moisturizing ingredients available in the market.

Fig 1. Moisturizing is the first step in skin care

（1）Hyaluronic Acid

Hyaluronic acid has been basking in skincare fame for over 30 years because of the mighty skincare benefits it possesses. Being an excellent humectant, it can absorb and retain many times-more than 1,000 times its weight in water. Besides that, it forms a defensive layer on the skin surface which protects water from evaporating too fast.

（2）Polyglutamic Acid

For those looking for an alternative to hyaluronic acid, polyglutamic acid is an excellent choice. It can capture more moisture than hyaluronic acid, twice as much. It penetrates deeper into the skin, stimulating natural moisturizing factors. Another big plus is that this product has low viscosity, contributing to less stickiness and freshness in the skin.

（3）Glycerin

Glycerin is an active humectant that attracts moisture from the surroundings and locks it in the skin to help maintain the moisture balance of the skin. This prevents dryness and dehydration, hence it maintains soft and smooth skin. It also enhances the absorption of active skincare ingredients.

（4）Panthenol

Also known as vitamin B5, panthenol is an active moisturizer that attracts and retains water in the skin and forms a protective layer on the skin’s surface to prevent water loss.

2. Anti-Aging and Anti-Wrinkle

With growing age, skin slowly starts to lose its elasticity and firmness. Collagen and elastin production decelerates, which eventually leads to fine lines and wrinkles. Moreover, UV rays, pollution, and stress accelerate the aging process of the skin. Anti-aging and anti-wrinkle ingredients improve not only one’s appearance but also care for the health of the skin by minimizing possible external damage.

Fig 2. Anti-wrinkle makes us look younger

（1）Retinol

Retinol is probably the star of the anti-aging world. Such an ingredient increases the production of collagen within the skin, which will help reduce fine lines and wrinkles. Moreover, such a vitamin accelerates cell turnover, promoting new skin cell generation. The process will improve the skin texture and tone by getting rid of dark blemishes.

（2）Vitamin C

Vitamin C is an antioxidant with great power that neutralizes free radicals, protecting the skin from environmental damage such as UV rays. It enhances the production of collagen, which in turn gives skin elasticity, hence reducing fine lines. Vitamin C further brightens the skin, reducing pigmentation and helping the skin have a more youthful look.

（3）Peptides

Peptides are small protein fragments that easily penetrate the skin, stimulating collagen and elastin production. The peptides will strengthen the structure of the skin; fine lines and wrinkles are reduced effectively, and firmness and elasticity are enhanced. Besides, it enhances the skin barrier function and generally increases the health of the skin while making it fuller.

（4）Coenzyme Q10

Coenzyme Q10 is a powerful antioxidant that shields skin cells from free radical damage, thereby providing a considerable reduction in the appearance of environmental stressors that contribute to aging. It boosts the energy at a cellular level by increasing the manufacture of ATP, enhancing the repair and regeneration of cells, thereby reducing fine lines and wrinkles, or at least diminishing their appearance. The skin turgor will also be much improved.

（5）Resveratrol

Resveratrol is an antioxidant plant extract that has an excellent anti-aging effect. It scavenges the free radicals, thus avoiding skin damage from oxidative stress and inflammation, which contributes to early aging. Continuous use of resveratrol diminishes the appearance of fine lines while improving skin smoothness and firmness.

（6）Astaxanthin

Astaxanthin is an astoundingly strong natural antioxidant, way more powerful than vitamin C and vitamin E. It significantly reduces UV damage, preventing photoaging. By improving skin hydration, it improves elasticity and reduces wrinkles, thus leaving the skin smoother.

（7）Alpha Lipoic Acid

Alpha lipoic acid is an effective antioxidant; besides neutralizing free radicals, it regenerates other antioxidants such as vitamin C and vitamin E, hence enhancing the anti-aging effect by increasing the density. It minimizes inflammation, fine lines, and wrinkles, hence enhancing skin tone and brightness.

（8）Vitamin E

It is a classic antioxidant that helps protect the skin from oxidative stress while delaying the aging process. Vitamin E helps to repair broken skin cells and firm up the skin barrier, reducing occurrences of fine lines and wrinkles.

Read more: Hyaluronic Acid vs. Retinol vs. Vitamin C: Which Is Best for Skincare?

3. Skin Repair

When the skin barrier is compromised, it will release moisture more easily and become exposed to more external irritants. This generally means more inflammation and dry sensitivity. Hence, skin repair is another important step of skin care.

Fig 3. Repair skin damage and make skin healthier

（1）Centella Asiatica Extract

Centella Asiatica is one of the major ingredients in skin repair. It contains various components like asiaticoside-the major phenolic compound responsible for scar healing. Centella Asiatica enhances the production of collagen and reduces inflammation by regenerating and improving skin elasticity of the destroyed skin barrier.

（2）Ceramides

Ceramides are natural constituents of the skin barrier. They repair damaged lipid barriers, reducing skin irritations due to dryness. The ceramides help your skin protect against external irritants and pollutants-softening the skin and making it supple.

（3）Allantoin

Allantoin is an active repairing ingredient well known for its soothing action, as well as cell regeneration. It soothes itching, redness, and roughness occurring due to dryness while allowing the stimulation of the healing process and thus leaving the skin smooth and soft.

（4）Squalane

It is an emollient agent, just like the skin’s natural oils. Squalane improves the barrier integrity of skin, restores dry and injured skin, and exerts antioxidant and anti-inflammatory effects, thus decreasing skin irritation.

Among the above ingredients, hyaluronic acid and panthenol have prominent skin-repairing properties. Hyaluronic acid especially accelerates wound healing.

4. Acne Treatment

Acne is one of the fundamental skin problems brought about by blockage of pores, production of excess oil, and infection. Treatment of acne also enables you to maintain healthy skin.

Fig 4. Causes of acne: clogged pores, excess oil production, and infection

（1）Salicylic Acid

Salicylic acid is a beta hydroxy acid; it is also lipid-soluble, which allows it to penetrate into the pores and dissolve excess oil and dead skin cells that block pores in the first instance. This helps reduce and prevent acne, while it also gently exfoliates the surface of the skin to improve the rough texture associated with acne. Its anti-inflammatory properties further help reduce redness and swelling associated with acne.

（2）Glycolic Acid

Glycolic acid is an AHA, which accelerates cell turnover, removing the superficial layer of dead skin cells, thus avoiding clogged pores and acne breakouts. It also improves post-acne pigmentation and scarring by improving skin texture and evening out the skin.

（3）Benzoyl Peroxide

The active ingredient benzoyl peroxide is a very potent anti-acne ingredient that truly delivers deep into the pores and kills acne-causing bacteria, such as Propionibacterium acnes. It also exfoliates the skin, removing dead skin cells and oil within the pores, which helps them not to get blocked and, therefore, prevents new acne.

（4）Tea Tree Oil

Tea tree oil is a natural ingredient incorporating antibacterial and anti-inflammatory properties into its effectiveness in battling acne-causing bacteria and reducing inflammation and redness. Gentle on the skin, it provides antibacterial action that helps purify the skin and decreases bacterial build-up inside the pores.

Conclusion

Being aware of the various benefits of different skincare ingredients will enable you to know exactly which products to choose based on specific needs. Understanding what ingredients suit your skin type and needs better enables you to tailor an effective skincare routine that resolves any hydration concerns, anti-aging, repair, or treatment of acne for healthier and more radiant-looking skin.

Stanford Chemicals Company (SCC) has over 16 years of experience in the manufacture and sale of skin care and personal care ingredients. We offer skin care ingredient raw materials to meet a variety of skin care needs.

Table 1. List of Common Skincare Ingredients

The post Common Skin Care Ingredients You Need to Know appeared first on Stanford Chemicals.

With the rapid development of modern medicine and cosmetic technology, injectable hyaluronic acid is attached importance to in many respects. Being an excellent moisturizer with its biocompatibility, hyaluronic acid has developed a wide scope of applications in the field of structure and function improvement. It plays a central role in skin, joint, and eye care and further in surgical treatment in the field of eye diseases. This article shall focus on the five most common applications of injectable hyaluronic acid and further consider its safety record and possible side effects.

What Is Injectable Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring polysaccharide in the connective tissues of the body, skin, and eyes. It is known to hold up to 1000 times its weight in water; this helps in lubricating and keeping tissues elastic. Other functions of hyaluronic acid are tissue hydration, cell repair, anti-inflammatory, and as a lubricant in joints and in eye surgery. The injectable hyaluronic acid is extracted and purified in a unique way so that it is safe for injection.

–The Benefits of Hyaluronic Acid

• Moisturizing and hydration: It is able to absorb a lot of water and hold it, thereby keeping skin and tissues hydrated and elastic.
• Tissue repair: The very nature of hyaluronic acid promotes cell growth and tissue repair; thus, it creates less scarring after injury.
• Anti-inflammatory and lubrication properties: In joints and eye surgery, this acts to reduce inflammation and friction, thereby protecting tissues from damage.

The 5 Common Uses

Due to above these properties, hyaluronic acid finds wide application in medical and cosmetic treatments alike.

1. Viscosupplementation

Hyaluronic acid is one of the essential elements used in orthopedics as a joint lubricant. In patients who have osteoarthritis, the reduction in the volume of the fluid may increase the friction and thereby result in pain and inflammation.

Hyaluronic acid is administered into the articulation space. And then it increases the viscosity of the fluid within the joint cavity, facilitating lubrication and cushioning. This relieves pains and improves functions, mostly for those suffering from osteoarthritis of the knee, and possibly delays surgical procedures.

Fig 1. Benefits of HA for joints

2. Ophthalmic Surgery Aid

Hyaluronic acid finds applications in ophthalmic surgery, primarily as an intra-ocular filler. Hyaluronic acid facilitates smooth functioning and protects the corneal endothelial cells. In addition, HA can maintain the structural integrity of the eyeball during procedures such as cataract removal or corneal transplants.

At the same time, its high viscosity and elasticity minimize trauma during surgery and allow a much smoother operation. HA further eases recovery from the surgery and reduces post-operative complications.

Fig 2. Ophthalmic Surgery Aid

3. Dermal Fillers

Hyaluronic acid has been one of the finest uses in non-surgical facial treatments as a dermal filler. HA, when injected into the skin, fills in wrinkles and restores volume to the skin, giving the skin elasticity and more radiance. Such products are used in plumping up the lips, smoothing out nasolabial folds, defining cheek bones, and the chin.

The advantage of hyaluronic acid when used as a filling material is that it appears natural and is reversible. That is, the injected substance can be dissolved with an enzyme injection in unsatisfactory results.

Fig 3. Comparison of HA facial filler effects

4. Skin Repair Products

Apart from its cosmetic and surgical uses, hyaluronic acid is used in many skin repair processes. Since hyaluronic acid is injectable, it can enhance the healing process and regeneration of the skin to treat burns, wounds, and other injuries caused after surgery.

It keeps the wounds moist and prevents scabbing. This, in turn, reduces the occurrence of scarring. It can also help sunken scars and improve the overall texture of the skin by filling these depressions.

Fig 4. Wound healing process

5. Low Scarring Cosmetic Fillers

Hyaluronic acid also enjoys wide application in minimally invasive aesthetic treatments. Given its very good modeling properties, combined with safety, it is applied not only to non-surgical aesthetic treatments. For example, nose reshaping, chin contouring, and tear trough filling but also for facial contours.

These treatments are in demand since they have quick results and short recovery time, with the results appearing natural. Hyaluronic acid injections adjust facial contours subtly to create a more personified, pain-free, riskless aesthetic outcome for surgery.

Is Injectable Hyaluronic Acid Safe

Injectable hyaluronic acid is quite safe due to its high compatibility with the body. Most people tolerate it well and do not experience serious adverse reactions after injection, though it may lead to some mild adverse reactions, including reddening, bruising, slight pain, and allergic reactions at the site of injection. However, all of these may be temporary and will subside on their own.

–Side Effects of Injectable HA

Rarely, they can also occur in more severe types, such as infection, nodules or lumps at the injection site, and skin necrosis. More specifically, erroneous injection techniques, particularly for facial filling with hyaluronic acid, may cause vexing complications, such as vascular occlusion. It is hence very important to select an experienced and qualified professional to give the injection and practice stringent sterile techniques in a bid to prevent these complications.

Where to Buy Safe Injectable HA

Stanford Chemical Company (SCC) is specialized in providing tailored molecular weight, injection-grade HAF-C-SC. The injection-grade hyaluronic acid from SCC is GMP, CEP, and DMF certified, and the factory passed an on-site inspection by the US FDA. Our Injection-Grade HA is all fermentation products, of non-animal origin, non-GMO, and non-BSE/TSE risk.

What differentiates our product is the origin. Our pure HA Powder comes just from fermentation processes, thus being completely free of animal sources, non-GMO, and Vegan. The hyaluronic acid thus presents a conscientious choice for those seeking products that are sourced ethically and naturally in tune with values of sustainability and purity.

Recommended products:

• HA-EP1.8-SC
• HA-EP2.4-SC
• HA-EP3.0-SC

Conclusion

Injectable hyaluronic acid is regarded as an important tool in modern medicine and cosmetic treatments due to its excellent biological properties and remarkable versatility. From dermal fillers and joint lubricants to the aid for ophthalmic surgery and minimally invasive fillers in cosmetic procedures, HA has found application in these areas and hence shown its effectiveness in promoting health and beauty. Even though relatively safe, proper injection techniques help assure the best aesthetic result and will limit potential side effects. As advances in technology continue, the scope for which hyaluronic acid is used will expand and offer users ever more possibilities.

Related articles:

Solubility of Hyaluronic Acid in Different Solvents and Its Influencing Factors

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

Top 10 Benefits of Hyaluronic Acid

The post The 5 Common Uses of Injectable Hyaluronic Acid appeared first on Stanford Chemicals.

Fig 1. Benefits of apigenin

What is Apigenin?

Apigenin, also known as parsley flavonoid, is a natural flavonoid compound. It is widely found in various vegetables and fruits in nature, such as celery, garlic, broccoli, onions, apples, oranges, and more, with the highest content found in celery. For centuries, some plants containing apigenin have been used as ingredients in traditional Chinese medicine to treat diseases such as neuralgia, Parkinson’s disease, and asthma.

Fig 2. parsley flavonoid structure

A Natural Cancer Fighter

Research has shown that apigenin has multiple mechanisms of anti-tumor effects and is quite effective.

–Mechanisms of Action:

Fig 3. Anti-tumor mechanism of parsley flavonoid

One of the fundamental biological characteristics of tumors is uncontrolled proliferation, which is based on the dysregulation of cell cycle control. Apigenin can inhibit the proliferation of tumor cells by regulating the cell cycle.

Parsley flavonoid can induce apoptosis by inhibiting the PI3K/AKT/mTOR pathway. Studies have shown that it can induce autophagic cell death by increasing the production of reactive oxygen species (ROS), leading to DNA damage.

Inhibiting the invasion and metastasis of tumor cells is crucial for tumor treatment, which is also an important mechanism of apigenin’s anti-tumor effects. For example, parsley flavonoid can inhibit the invasion and metastasis of lung cancer cells by regulating the PI3K/AKT signaling pathway.

Angiogenesis is an important process in tumor proliferation. Parsley flavonoid inhibits tumor angiogenesis, thereby depriving tumors of blood, oxygen, and nutrients necessary for survival, which is significant for its anti-tumor properties.

–Clinical Applications:

• Breast Cancer: Studies have shown that apigenin can inhibit the proliferation and promote the apoptosis of breast cancer cells.
• Colon Cancer: It effectively inhibits the growth of colon cancer cells by modulating the Wnt/β-catenin signaling pathway.
• Prostate Cancer: In prostate cancer, it can inhibit the expression of androgen receptors, thereby reducing the proliferation of cancer cells.

The Cardiovascular Protective Power of Apigenin

Apigenin has protective effects on the cardiovascular system, primarily through anti-inflammatory, antioxidant, lipid metabolism improvement, and inhibition of platelet aggregation. It can reduce the oxidation of low-density lipoprotein (LDL), preventing atherosclerosis.

–Mechanisms of Action:

• Antioxidant: Apigenin can increase the activity of endogenous antioxidant enzymes such as SOD and CAT, reducing oxidative stress.
• Anti-inflammatory Effects: By inhibiting the NF-κB and MAPK signaling pathways, parsley flavonoid reduces the release of inflammatory mediators (e.g., TNF-α and IL-6).
• Improvement of Lipid Metabolism: It can lower plasma cholesterol and triglyceride levels while increasing high-density lipoprotein (HDL) levels.
• Inhibition of Platelet Aggregation: It can inhibit the synthesis of TXA2 (thromboxane A2), thereby reducing platelet aggregation and thrombosis.

Fig 4. “Homeostatic cytokine” “inflammatory cytokine” signals.

–Practical Applications:

• Atherosclerosis: Apigenin can reduce the risk of atherosclerosis by inhibiting endothelial inflammation and oxidative stress.
• Hypertension: It has vasodilatory effects and stabilizes blood pressure, making it useful as an adjunct in managing hypertension.
• Myocardial Ischemia Protection: In ischemia-reperfusion injury, it improves cardiac function by reducing myocardial apoptosis and oxidative damage.

Natural Savior for Neurodegenerative Diseases

Studies have shown that parsley flavonoid can play a significant role in neurodegenerative diseases through various biological mechanisms. Its effects on Alzheimer’s disease (AD) and Parkinson’s disease (PD) have attracted increasing attention.

–Role of Apigenin in Alzheimer’s Disease

Alzheimer’s disease is a neurodegenerative disorder characterized by a gradual decline in cognitive function, primarily caused by the deposition of β-amyloid protein (Aβ) and neurofibrillary tangles. Apigenin has a significant effect on inhibiting Aβ production and promoting its clearance. It reduces Aβ deposition in the brain by inhibiting the activity of β-secretase (BACE1), thereby lowering the risk of Aβ accumulation. Additionally, it enhances the phagocytic function of macrophages and microglia in the brain, accelerating Aβ clearance and further reducing its accumulation.

Apigenin can also improve synaptic function and cognitive ability. It promotes the expression of brain-derived neurotrophic factor (BDNF), enhances synaptic plasticity, and thus improves learning and memory abilities.

–Role of Apigenin in Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder characterized primarily by motor dysfunction, mainly due to the loss of dopaminergic neurons in the midbrain and the formation of Lewy bodies from α-synuclein aggregation. Apigenin has a protective effect on dopaminergic neurons. It provides antioxidant protection and reduces neuronal damage by reducing oxidative stress and lowering ROS production. Additionally, the parsley flavonoid can alleviate neuroinflammation in Parkinson’s disease.

Natural Solutions for Anti-Type 2 Diabetes

Type 2 diabetes is a metabolic disease characterized by insulin resistance and hyperglycemia. Apigenin has shown significant effects on improving glucose metabolism, enhancing insulin sensitivity, and protecting pancreatic β-cells. The parsley flavonoid can activate the AMPK (adenosine monophosphate-activated protein kinase) pathway, thereby enhancing glucose uptake and utilization by cells and improving overall insulin sensitivity. Furthermore, it reduces liver glucose output by downregulating the expression of gluconeogenesis-related enzymes (such as PEPCK and G6Pase), helping to control blood sugar levels.

Apigenin also can protect pancreatic β-cells. It reduces oxidative and inflammatory damage to β-cells, maintaining their function and survival, which is significant in slowing the progression of type 2 diabetes and the occurrence of complications.

A Powerful Natural Antioxidant for Health

Apigenin is a potent natural antioxidant that can effectively scavenge free radicals and reduce oxidative stress on cells. By removing reactive oxygen species (ROS) and reactive nitrogen species (RNS), it reduces oxidative damage to cell membranes, proteins, and DNA. This antioxidant capacity helps protect various tissues and organs in the body, slow down aging, and reduce the risk of diseases.

The antioxidant effects of apigenin are applied in multiple fields. In cosmetics, apigenin is used as an antioxidant ingredient to reduce skin damage and inflammatory responses caused by UV rays, preventing skin photoaging. In food and nutrition, it is used to slow down aging and improve overall health. Additionally, it is used to protect the cardiovascular system and liver, alleviating oxidative stress and tissue damage caused by drugs or environmental toxins.

Nature’s Answer to Stress and Anxiety Relief

Apigenin has sedative and anti-anxiety effects, primarily achieved by regulating neurotransmitter balance and reducing neuroinflammation. It also can enhance the activity of GABA (γ-aminobutyric acid) receptors, increasing the inhibitory effect of the central nervous system, resulting in calming and relaxation effects. This helps alleviate anxiety, reduce stress, and improve sleep quality. Additionally, apigenin regulates neurotransmitter levels such as 5-HT (5-hydroxytryptamine) and dopamine, improving mood and cognitive function.

Apigenin can be used as a natural substance for adjunctive therapy of anxiety disorders, insomnia, and stress management. In animal studies, this extract has been shown to reduce anxiety behaviors and improve emotional stability significantly. In sleep research, it has demonstrated a sleep-promoting effect, extending sleep duration and improving sleep quality.

Safety of Apigenin

Apigenin is primarily sourced from common foods and has been consumed by humans for a long time, generally considered safe. Animal and in vitro studies also indicate that it has low toxicity at regular doses. In human clinical studies, apigenin supplements have generally not shown significant side effects at reasonable doses. However, given the individual differences, some people may be allergic to apigenin or its metabolites.

FAQs About the Side Effects:

1. Can apigenin cause diarrhea?

There’s limited evidence specifically linking apigenin to diarrhea. However, high doses of any supplement or herbal extract might cause gastrointestinal issues, including diarrhea. If you experience gastrointestinal discomfort, it could be due to the apigenin supplement or other ingredients in the product.

2. Can apigenin cause headaches?

Headaches are not commonly reported as a side effect of apigenin. However, if you’re sensitive to supplements or taking them in combination with other substances, you might experience headaches. It’s essential to monitor how you feel and consult with a healthcare provider if you have persistent headaches.

3. Can apigenin cause insomnia?

Apigenin is often noted for its potential calming effects and is sometimes used to help with sleep and anxiety. It is unlikely to cause insomnia. In fact, it may help with sleep in some individuals. If you experience insomnia after taking, it might be worth looking into other factors that could be affecting your sleep, such as other medications or stress.

Prospects

As a naturally occurring flavonoid compound, apigenin has good biological safety and high medicinal value. Parsley flavonoid can potentially improve inflammation, cardiovascular disease, neurodegenerative diseases, tumors, and diabetes through multiple targets and pathways, and its teratogenic toxicity is relatively lower compared to other flavonoid compounds.

Stanford Chemical Company (SCC) is a premium supplier of hyaluronic acid and herbal extracts. We provide our customers with apigenin extracts with a purity of 98%. For more information or specific applications, please visit our home page.

Related reading:

Top 5 Powerful Benefits of Dihydromyricetin in Health

Top 10 Benefits of Hyaluronic Acid

References:

[1]. Syed, D. N., et al. (2013). “Apigenin suppresses prostate cancer progression through downregulation of the androgen receptor.” The FASEB Journal, 27(3), 1057-1069.

[2]. Li, R., et al. (2016). “Apigenin Attenuates Hypertension-Induced Cardiac Hypertrophy and Abnormal Ca2+ Handling in Mice.” Journal of Molecular and Cellular Cardiology, 99, 30-40.

[3]. Zhang, X., et al. (2014). “Apigenin Attenuates Alzheimer’s Disease-Like Pathology and Behavioral Deficits by Inhibiting BACE1 and Tau Hyperphosphorylation in Mice.” Journal of Alzheimer’s Disease, 41(3), 935-949.

[4]. Yin, H., et al. (2017). “Apigenin as a Protective Agent Against Parkinson’s Disease in an Animal Model.” Neurochemical Research, 42(12), 3278-3286.

The post Top 6 Benefits of Apigenin for Health appeared first on Stanford Chemicals.

1. Hyaluronic Acid for Skin: Moisturizing and Anti-Aging

Hyaluronic acid is a component of the dermis layer of the skin, capable of retaining 100 times its weight in water. This is the source of its powerful moisturizing ability. Therefore, using HA can keep the skin hydrated, effectively improving dryness, roughness, and peeling.

For the skin, hyaluronic acid is not just a moisturizer; it also effectively combats aging. This is because HA can fill the gaps within the skin, smoothing out wrinkles and fine lines. Additionally, it increases skin elasticity, making the skin firmer and reducing sagging. As we age, supplementing with HA is a highly effective anti-aging strategy.

Read more:

Hyaluronic Acid Powder: The Acne-Prone Skin Savior

2. Hyaluronic Acid for Facial Contours: Filling Hollows and Smoothing Wrinkles

HA is a primary choice in cosmetic procedures for enhancing facial contours. Hyaluronic acid injections can fill in sunken areas of the face, such as the cheeks, temples, and chin, creating smoother and more defined facial lines. Additionally, it can smooth deep wrinkles, such as nasolabial folds and crow’s feet, lifting sagging facial skin and restoring a youthful, firm appearance.

Fig 1. Hyaluronic Acid for Facial Contours: Before and After

3. Hyaluronic Acid for Lips: Safe Lip Augmentation

Injectable-grade hyaluronic acid is a common method for lip augmentation. By injecting HA, the appearance of the lips can be significantly improved, making them fuller and more defined. Additionally, HA injections can effectively reduce fine lines and wrinkles on the lip surface.

Even without injections, applying HA directly to the lips has benefits. Because of its moisturizing properties, it helps the lips retain moisture, preventing dryness and cracking. Moreover, its anti-inflammatory properties can alleviate symptoms of lip inflammation, reducing redness and discomfort.

Fig 2. Injectable-grade HA on Lips: Before and After

Read more:

Fuller Lips Made Easy: The Power of Hyaluronic Acid

4. Hyaluronic Acid for Wound: Promoting Healing and Reducing Scars

The strong moisturizing capability of hyaluronic acid is not only beneficial for the skin but also accelerates wound healing. It forms a protective film, locking in moisture and preventing the wound from drying and scabbing. Additionally, HA has anti-inflammatory properties, reducing inflammation at the wound site.

Another important role of HA in wound healing is promoting skin regeneration. It facilitates cell migration and proliferation, crucial steps in the healing process. Moreover, HA can reduce scar formation by promoting collagen synthesis, which enhances the strength and elasticity of new tissue, thus minimizing scarring.

Fig 3. The three phases of wound healing

Read more:

Medical Grade Hyaluronic Acid and Wound Healing

5. Hyaluronic Acid for Eyes: Relieving Dryness and Protecting the Cornea

Hyaluronic acid can keep the surface of the eyeball moist, significantly relieving dryness, irritation, and discomfort. Thus, eye drops and gels containing HA are widely used to treat dry eye syndrome and other eye discomforts.

In addition to relieving dry eye symptoms, hyaluronic acid has numerous benefits in eye surgeries. It forms a protective film, preventing dust, bacteria, and other harmful substances from damaging the cornea. In cataract and other intraocular surgeries, hyaluronic acid serves as a filling material, helping maintain the stability of intraocular structures and protecting intraocular tissues. Furthermore, it can be used as a surgical aid, reducing intraoperative damage and promoting postoperative healing.

Read more：

Sodium Hyaluronate for Dry Eyes and How It May Increase Intraocular Pressure

6. Hyaluronic Acid for Joints: Relieving Pain and Delaying Degeneration

Hyaluronic acid has a significant effect on alleviating joint inflammation. It is a crucial component of synovial fluid, providing excellent lubrication. It reduces friction between joint surfaces, protecting cartilage and reducing pain and discomfort during joint movement.

By improving lubrication and reducing pain, HA can enhance joint flexibility and stability, reducing stiffness. Additionally, it protects and repairs joint cartilage, slowing its degeneration.

Fig 4. Anatomy of the healthy and osteoarthritic knee joint[i]

Read more:

Hyaluronic Acid VS. Glucosamine VS. Chondroitin: Which Is Best for Joints?

7. Hyaluronic Acid for Bones: Preventing Osteoporosis

Hyaluronic acid is a key component of the bone matrix, playing an important role in bone health. It provides structural support to bones, promoting the formation and maintenance of the bone matrix.

In the healing process of fractures and bone injuries, HA also plays a crucial role. It promotes the proliferation and differentiation of osteoblasts, accelerating bone regeneration and repair, thus shortening the healing time. Moreover, its anti-inflammatory properties reduce inflammation after bone injuries.

Hyaluronic acid helps prevent osteoporosis by promoting the deposition of minerals (such as calcium and phosphorus) in bones, increasing bone density and strength.

8. Hyaluronic Acid for Hair: Preventing Dryness and Enhancing Strength

Hair that lacks moisture becomes dry and frizzy. Hyaluronic acid, with its moisturizing ability, helps hair retain moisture, making it softer and smoother. Similarly, it keeps the scalp hydrated, preventing dryness and flaking, and promoting a healthy environment for hair growth.

Moreover, HA enhances hair strength and elasticity, reducing breakage and split ends. Its antioxidant properties also benefit hair health by neutralizing free radicals and reducing oxidative stress damage, maintaining the health of the hair.

9. Hyaluronic Acid for Brain: Protecting Nerves

Hyaluronic acid plays a significant role in neuroprotection. It protects nerve cells from external damage, reducing apoptosis and injury. Additionally, hyaluronic acid is an important component of the brain’s extracellular matrix, providing structural support and maintaining the health of the extracellular matrix.

Researchers have noticed the potential of HA in improving cognitive function. By enhancing the health and function of nerve cells, HA may support learning and memory. Its anti-inflammatory and neuroprotective effects could also help reduce age-related cognitive decline.

Fig 5. Different forms of HA scaffolds[ii]

10. Hyaluronic Acid for Teeth: Protecting Gums

Hyaluronic acid significantly protects and repairs gum tissue. It can keep gum tissue hydrated and enhance the barrier function of the gums, preventing bacteria and toxins from invading. Additionally, HA has excellent anti-inflammatory effects. It can inhibit the release of inflammatory factors, alleviating gum inflammation and periodontal disease.

The ability of hyaluronic acid to promote wound healing plays a crucial role in accelerating the healing of oral injuries and post-surgical recovery. Therefore, after tooth extractions or implants, HA can speed up wound healing and reduce postoperative complications.

Conclusion

Hyaluronic acid’s multifaceted benefits span across various aspects of health and beauty, from maintaining skin hydration and enhancing facial contours to promoting joint and bone health. Its unique properties make it an invaluable component in medical treatments and cosmetic applications, improving overall quality of life. As research continues to uncover new potential uses, hyaluronic acid is set to remain a cornerstone of health and wellness.

Stanford Chemical Company (SCC) is an excellent supplier of Sodium Hyaluronate Powder. We provide cosmetic-grade, food-grade, medical-grade, and injection-grade sodium hyaluronate powder. For more information about these materials, please check out our home page.

[i] Fig 4. Anatomy of the healthy and osteoarthritic knee joint. Created via canvas. Source: Smith, Abbi & Sigurbjörnsdóttir. (2022). Hedgehog signaling in bone and osteoarthritis: the role of Smoothened and cholesterol. The FEBS Journal. 290. 10.1111/febs.16440.

[ii] Jensen, G.; Holloway, J.L.; Stabenfeldt, S.E. Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine. Cells 2020, 9, 2113. https://doi.org/10.3390/cells9092113

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Fig 1. Top 5 Benefits of DHM

1. DHM: The Antioxidant for Health and Wellness

Dihydromyricetin has excellent antioxidant activity, which offers several benefits.

Benefits of DHM in Antioxidant

DHM can scavenge free radicals. We know that excessive free radicals can cause cell damage and oxidative stress. Dihydromyricetin can react with free radicals and neutralize them.

Moreover, DHM can inhibit lipid peroxidation. Because the formation of lipid peroxides is prevented, the integrity of the cell membrane is protected.

In addition, Dihydromyricetin can upregulate the activity of antioxidant enzymes in the body. And then it can enhance the body’s antioxidant defense ability.

Applications Based on Antioxidant Properties:

This antioxidant effect shows great potential in various applications.

• Antioxidant Supplements: DHM is widely used in antioxidant supplements to help consumers neutralize excess free radicals, protect cells, slow aging, and prevent chronic diseases.
• Food Additives: DHM’s antioxidant properties make it an ideal natural food preservative, preventing lipid oxidation in foods, extending shelf life, and maintaining freshness and nutritional value.
• Anti-aging Skincare: Dihydromyricetin is commonly used in anti-aging skincare products. It can neutralize free radicals in the skin and prevent oxidative damage. Apart from that, DHM can reduce wrinkles and fine lines, and maintain skin elasticity and radiance.
• Sunscreen Products: DHM’s antioxidant effect helps counteract oxidative stress caused by UV radiation. It then protects the skin by reducing sun damage and photoaging.

2. DHM: The Natural Solution for Inflammation Relief

Extensive basic research and animal experiments have evidenced the anti-inflammatory effects of DHM. Clinical studies also provide compelling evidence of DHM’s anti-inflammatory efficacy in humans.

Benefits of DHM in Anti-inflammatory

Experimental evidence suggests that dihydromyricetin exerts its anti-inflammatory effects mainly through:

• Inhibition of Inflammatory Mediator Production: DHM reduces the production of cytokines and other inflammatory mediators.
• Regulation of Inflammatory Signaling Pathways: Dihydromyricetin modulates pathways such as NF-κB, which are crucial for the inflammatory response.
• Inhibition of Inflammatory Cell Migration and Activation: DHM prevents the movement and activation of cells involved in inflammation.

Fig 2. Anti-inflammatory effects of dihydromyricetin

Applications in Anti-inflammatory Treatments:

The above studies will provide a more solid scientific basis for the application of DHM in anti-inflammatory treatment.

• Anti-inflammatory Drugs: Dihydromyricetin is a promising candidate for developing drugs to treat various acute and chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
• Anti-inflammatory Health Supplements: Dihydromyricetin is used in health supplements to help consumers reduce chronic inflammation and prevent chronic diseases.
• Anti-inflammatory Skincare: DHM is used in skincare products to alleviate skin inflammation, such as acne and eczema, promoting skin health.
• Soothing Repair Products: The anti-inflammatory and antioxidant properties of Dihydromyricetin make it an ideal component in products designed to repair damaged skin and reduce inflammation.

More information: Dihydromyricetin (DHM) for Inflammatory Diseases and Anxiety Disorders

3. DHM: Nature’s Weapon Against Cancer

Multiple studies have shown that Dihydromyricetin can effectively inhibit the proliferation of various cancer cells in vitro, including liver cancer, breast cancer, gastric cancer, and lung cancer. In animal models, Dihydromyricetin has been proven to significantly suppress tumor growth. For instance, a study demonstrated that DHM significantly reduced tumor volume and weight in a mouse model of breast cancer while lowering tumor angiogenesis.[i]

Benefits of DHM in Anticancer:

• Inhibition of Cancer Cell Proliferation: DHM blocks the cell cycle, preventing cancer cells from dividing and growing.
• Induction of Cancer Cell Apoptosis: Dihydromyricetin triggers apoptosis, or programmed cell death, in cancer cells.
• Inhibition of Tumor Angiogenesis: DHM prevents the formation of new blood vessels that supply nutrients to tumors.
• Inhibition of Cancer Cell Invasion and Metastasis: DHM reduces the ability of cancer cells to invade surrounding tissues and spread to other parts of the body.

Applications in Cancer Treatment:

Although existing clinical research is still in its early stages, Dihydromyricetin, as a natural, low-toxic anticancer compound, has broad application prospects.

• Cancer Drug Development: DHM’s multiple anticancer mechanisms make it a potential candidate for developing anticancer drugs. It can be used alone or in combination with other chemotherapeutic agents to enhance efficacy and reduce side effects.
• Adjunctive Therapy: Dihydromyricetin can be used as an adjunctive treatment for cancer patients. It helps to mitigate the side effects of chemotherapy and radiation therapy.

4. DHM: Nature’s Defense for Liver Health

Dihydromyricetin is recognized for its potent antioxidant, anti-inflammatory, and antifibrotic properties, making it an effective liver-protective agent.

Benefits of DHM in Liver Protection:

Dihydromyricetin has a strong antioxidant effect and can reduce the damage of oxidative stress to liver cells. In addition, DHM can inhibit the production of inflammatory mediators, reduce inflammatory response, and thus protect the liver.

Additionally, dihydromyricetin can inhibit the progression of liver fibrosis. It reduces the degree of liver fibrosis by reducing the deposition of collagen and the activation of hepatic stellate cells.

DHM also can promote the regeneration and repair of liver cells and enhance the self-repair ability of the liver.

Applications in Liver Health:

DHM’s liver-protecting effect makes it widely used in health products and medicines.

• Liver Health Supplements: DHM is widely used in liver health supplements to improve liver function and prevent or mitigate alcohol-induced liver damage.
• Hangover Remedies: DHM is a key ingredient in hangover remedies. It aids in the acceleration of alcohol consumption and reduces hangover symptoms. Ultimately, it protects the liver from alcohol damage. Maybe you are interested: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?
• Anti-fibrotic drugs: Dihydromyricetin has anti-fibrotic properties. Therefore, It is a potential candidate for drugs to treat various fibrotic liver diseases.
• Hepatitis treatment: Dihydromyricetin is expected to reduce liver damage caused by viral hepatitis. So, it is used to develop drugs for hepatitis treatment.
• Functional foods: Dihydromyricetin is added to functional foods to enhance their health benefits.

5. DHM: A Natural Solution for Cardiovascular Health

Dihydromyricetin exhibits significant antithrombotic and lipid-lowering effects, which contribute to cardiovascular protection.

Benefits of DHM in Cardiovascular Protection

It can inhibit platelet aggregation and reduce the risk of thrombosis. In addition, DHM maintains the normal function of blood vessels by enhancing endothelial function, promoting vasodilation, and inhibiting vasoconstriction.

Applications in Cardiovascular Health:

DHM’s effects on the cardiovascular system have been applied in the healthcare and medical industries.

• Cardiovascular Health Supplements: DHM is used in supplements to help consumers prevent cardiovascular diseases and improve cardiovascular function. Its antioxidant and anti-inflammatory properties make it an ideal cardiovascular protective agent.
• Anti-Atherosclerotic Drugs: DHM’s anti-inflammatory and antioxidant actions make it a potential candidate for developing drugs to prevent and treat atherosclerosis.
• Lipid-Lowering Drugs: DHM’s ability to regulate lipid levels suggests it could be used in developing drugs to lower cholesterol and reduce the risk of cardiovascular diseases.

Additional Benefits of Dihydromyricetin

Dihydromyricetin is a versatile natural compound with a wide range of health benefits. In addition to the five benefits listed above, dihydromyricetin has other benefits.

1. Neuroprotective Effects

Dihydromyricetin has shown promising neuroprotective effects. DHM may help in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies suggest that DHM improves cognitive performance and memory by reducing oxidative stress and inflammation in the brain​.

2. Metabolic Health

DHM has been found to have beneficial effects on metabolic health.

• Improving Insulin Sensitivity: DHM enhances insulin sensitivity, which can help in managing blood sugar levels and reducing the risk of type 2 diabetes​.
• Reducing Fat Accumulation: DHM can inhibit the differentiation of preadipocytes into adipocytes, thus reducing fat accumulation and helping in weight management​.
• Lowering Blood Glucose Levels: DHM has been shown to lower fasting blood glucose levels in animal studies, indicating potential benefits for diabetic patients​.

Fig 3. blood glucose

3. Anti-aging Properties

Beyond its antioxidant effects, dihydromyricetin contributes to overall anti-aging. It’s because DHM may extend the lifespan of cells by protecting them from oxidative stress.​

4. Skin Health

DHM can reduce Hyperpigmentation and promote collagen production. In addition, dihydromyricetin’s antioxidant properties protect the skin from damage caused by UV radiation.

5. Immune System Support

DHM can modulate the immune system by enhancing immune response and regulating inflammatory responses.

Stanford Chemical Company (SCC) is a premium supplier of hyaluronic acid and herbal extracts. We offer Dihydromyricetin and Medical-grade Pure HA Powder. For more information on these products or specific applications, please contact us and check out our home pages.

Conclusion

The multiple health benefits of Dihydromyricetin make it a valuable compound for various applications in health and medicine. Its powerful antioxidant, anti-inflammatory, anticancer, liver-protective, and cardiovascular-protective properties provide a strong foundation for developing new health supplements, functional foods, and pharmaceuticals. As research continues, DHM’s full potential in promoting health and preventing disease will likely be further realized, offering new avenues for enhancing human well-being.

[i] Chen, L., Yang, Z.S., Zhou, Y.Z., Deng, Y., Jiang, P., Tan, S.L. (2020). Dihydromyricetin inhibits cell proliferation, migration, and invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells. Journal of Cancer, 11(19), 5689-5699. https://doi.org/10.7150/jca.45970.

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In the pursuit of a restful night’s sleep, many turn to the gentle yet effective powers of herbal extracts. Unlike their pharmaceutical counterparts, these natural sleep aids offer a soothing path to slumber without the harsh side effects or risk of dependency.

Among the plethora of herbs known for their sleep-inducing qualities, Valerian Root, Lavender, and Chamomile stand out for their proven benefits and widespread use. Let’s discuss the mechanisms, benefits, and cases where these natural wonders can transform sleepless nights into peaceful rest.

Herbal Extracts: Natural Sleep Aids

The use of herbal extracts as remedies for sleeplessness and anxiety dates back centuries, offering a time-honored solution to modern-day stressors that disrupt sleep. These natural remedies work in harmony with the body’s own rhythms, fostering relaxation and sleep without overstimulation or subsequent grogginess.

It is also reported that a comprehensive search of the PubMed database, conducted up to May 3, 2020, focusing on randomized, double-blind, placebo-controlled trials, noncontrolled trials, and cohort studies involving both children and adults, was carried out to evaluate the efficacy of oral herb supplements in treating sleep disorders.

The search, which utilized terms such as “oral food supplement” and “sleep disorders,” identified seven emerging compounds from 38 relevant reports, with Valerian, Chamomile, and Lavender being the most frequently investigated plant extracts for insomnia. These sleep aids, derived from plant extracts, are generally recognized as safe and well-tolerated by individuals. [1]

1. Valerian Root

Valerian Root serves as the most powerful natural sleep aid. It functions by increasing the availability of gamma-aminobutyric acid (GABA), a neurotransmitter that helps regulate nerve impulses in the brain and nervous system. GABA’s role is crucial in inducing a natural state of relaxation and sleep, making Valerian Root a potent ally against insomnia.

1.1 Benefits:

Studies have shown that Valerian Root can significantly improve sleep quality and reduce the time it takes to fall asleep. It’s particularly beneficial for those who consider themselves poor or light sleepers, as it deepens sleep and enhances overall sleep satisfaction without the side effects commonly associated with prescription sleep aids.

1.2 Cases Reported:

A comprehensive review of 60 studies involving 6,894 participants was conducted, drawing on databases like PubMed, ScienceDirect, and the Cochrane Library. This review focused on assessing Valerian’s impact on improving sleep quality and reducing anxiety.

• The review, covering subjects aged 7 to 80, found Valerian to be safe, with no severe adverse events reported.
• Ultimately, Valerian shows promise as a treatment for sleep issues and related disorders.
• The study also underscores the need for improved quality control and standardization of Valerian products to enhance their reliability and therapeutic effectiveness. [2]

2. Lavender

Lavender is another key sleep aid with a distinctive fragrance and purple blooms. Its calming effects are attributed to its aromatic compounds, which can be inhaled to signal the brain to relax. Lavender oil affects the limbic system, the part of the brain that controls emotions, helping to decrease anxiety and facilitate the onset of sleep.

2.1 Benefits:

Research indicates that Lavender can improve sleep quality, particularly in those suffering from stress-related insomnia or anxiety disorders. Its use has been associated with increased slow-wave sleep, the deep, restorative phase of the sleep cycle.

2.2 Cases Reported:

For example, a well-cited study published in the Journal of Alternative and Complementary Medicine found that participants exposed to lavender aroma before sleep reported higher levels of sleep quality compared to those who did not receive the lavender treatment.

Further, cases of individuals with anxiety-related sleep disturbances have shown positive responses to lavender. The anxiolytic (anxiety-reducing) properties of lavender contribute to its effectiveness as a sleep aid, helping to relax the mind and body and facilitate the onset of sleep. [3]

3. Chamomile

Chamomile, with its gentle, apple-like aroma, is perhaps best known as a tea, though its benefits extend far beyond a warm bedtime beverage. This gentle herb contains apigenin, an antioxidant that binds to certain receptors in the brain that may promote sleepiness and reduce insomnia. It’s thought to work similarly to benzodiazepines, medications that induce sleep by acting on the brain’s GABA system.

3.1 Benefits:

Consuming Chamomile has been linked to an improvement in overall sleep quality. It’s particularly noted for its ability to aid in falling asleep more quickly and staying asleep longer.

3.2 Cases Reported:

A study in 2017 aimed to assess the impact of chamomile extract on the sleep quality of elderly individuals. Sixty participants aged sixty and above, residing in the Kahrizak day care nursing home in Karaj, Iran, were randomly divided into two groups: a treatment group and a control group. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index at four different times: before the start, two weeks into, immediately after, and two weeks post the intervention period.

There was a significant improvement in sleep quality in the treatment group compared to the control group (P<0.05). Chamomile extract has been shown to significantly enhance sleep quality in the elderly, suggesting its potential as a safe and effective option for improving sleep in this population. [4]

 Conclusion

The quest for a night of restful sleep need not lead to the pharmacy. Nature offers its own potent remedies in the form of Valerian Root, Lavender, and Chamomile. Each of these herbs brings its own unique benefits to the table, from deepening sleep to easing the anxiety that often precedes insomnia.

While they are generally safe for most people, it’s important to consider personal health conditions and consult with a healthcare provider before integrating these or any supplements into your nightly routine. For more sleep-assisting herbs, you can check Stanford Chemicals (SCC). In a world where sleep often eludes us, turning to the gentle embrace of these herbal extracts can be a significant step towards embracing the restorative sleep our bodies and minds so desperately need.

Reference:

[1] Guadagna S, Barattini DF, Rosu S, Ferini-Strambi L. Plant Extracts for Sleep Disturbances: A Systematic Review. Evid Based Complement Alternat Med. 2020 Apr 21;2020:3792390. doi: 10.1155/2020/3792390. PMID: 32382286; PMCID: PMC7191368.

[2] Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. doi: 10.1177/2515690X20967323. PMID: 33086877; PMCID: PMC7585905.

[3] Kasper S, Anghelescu I, Dienel A. Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep–A randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2015 Nov;25(11):1960-7. doi: 10.1016/j.euroneuro.2015.07.024. Epub 2015 Aug 7. PMID: 26293583.

[4] Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complement Ther Med. 2017 Dec;35:109-114. doi: 10.1016/j.ctim.2017.09.010. Epub 2017 Oct 13. PMID: 29154054.

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Micro Hyaluronic Acid generally refers to hyaluronic acid (HA) with a smaller molecular weight. It is a form of hyaluronic acid typically within the low molecular weight range (below 100k Daltons or lower).
Hyaluronic acid, often referred to as HA, is a naturally occurring sugar in our skin that helps retain water, keeping it hydrated and plump. What’s remarkable about it is its ability to hold up to 1,000 times its weight in water. Beyond simply holding water, it helps lock moisture in the skin, preventing evaporation into the air.

To put that in perspective, just ONE gram of Micro Hyaluronic Acid can hold six liters of water. It also regulates moisture within the skin cells so as to not drown them. Not only can Micro Hyaluronic Acid boost your skin’s moisture levels, but it keeps your skin hydrated for long-term positive effects. You may also find it as sodium hyaluronate, which is derived from HA and is the sodium salt portion of HA that has been isolated.

Micro Hyaluronic Acid vs. High Molecular Weight Hyaluronic Acid

Micro hyaluronic acid has stronger penetration compared to other molecular weights of hyaluronic acid, allowing it to pass through the skin barrier and reach the dermis. Its low molecular weight structure enables faster absorption, enhancing the efficiency of skincare products. Micro hyaluronic acid performs exceptionally well in anti-aging skincare and is often combined with high molecular weight hyaluronic acid to achieve the dual effect of deep hydration and surface protection.

Why Is Micro Hyaluronic Acid Used in Skincare?

With all of that, if you’re looking for plump, elastic, skin, Micro Hyaluronic Acid is going to be a favorite of yours. If a topical product claims to be hydrating, it likely is powered by Micro HA. But aging and environmental aggressors reduce the naturally occurring Micro HA in your body, making it an incredibly valuable active ingredient.

What Are the Top Benefits of Micro Hyaluronic Acid for Your Skin?

• It hydrates and plumps skin, reducing the appearance of fine lines and wrinkles as well as generally reducing signs of aging.
• It promotes a healing environment in the skin, reducing redness and dermatitis.
• It has antioxidant properties, which could protect the skin from environmental aggressors.
• It’s ideal for all skin types, even sensitive, acne-prone, or oily skin.
Because of all these incredible benefits, Micro Hyaluronic Acid is one of the best skincare active ingredients on the market.

What Is the Right Way To Apply Micro Hyaluronic Acid?

There are many forms of Micro Hyaluronic Acid. It exists naturally in your body, for example, but it also exists as an injectable filler (like Juvéderm and Restylane). However, you’re likely most familiar with it as the active ingredient in topical products from serums to face masks to moisturizers and more. The most popular Micro Hyaluronic Acid products are serums, which are best used after toner and before moisturizing.

The post What Are the Top Benefits of Micro Hyaluronic Acid for Your Skin? appeared first on Stanford Chemicals.

Sodium Hyaluronate for Skin

Sodium Hyaluronate can be found abundantly in the dermis, helping skin retain its moisture.

The skin remains hydrated and the surface is supple when the skin contains adequate concentrations of hyaluronic acid.

Sodium Hyaluronate for Joint

Joint fluid and articular cartilage contain hyaluronic acid at high concentrations. HA serves as a lubricant (preventing bone-to-bone friction) and as a cushion. This function allows our joints to move smoothly.
A joint function-improving agent with hyaluronic acid as its active pharmaceutical ingredient is a prescription drug.

Sodium Hyaluronate is injected into joints to treat patients suffering from knee osteoarthritis, periarthritis of the shoulder (also known as frozen shoulder syndrome), and knee pain from rheumatoid arthritis. Hyaluronic acid has been reported to have anti-inflammatory and pain-relieving effects in such uses.

Sodium Hyaluronate for Eyes

The vitreous body contains high concentrations of Sodium Hyaluronate, which provides cushioning and plays a role in maintaining the shape of the eyeball.

The post Top Benefits of Sodium Hyaluronate for Our Body appeared first on Stanford Chemicals.

1. Get a Proper Diagnosis

Many causes of joint pain are not related to arthritis. These include fractures, nerve damage (sciatica from back problems), a torn meniscus (knee) bursitis, synovitis, tendonitis, myositis, and even cancer. Always get a proper diagnosis first.

2. Start an Exercise Program

Moderate exercise is an integral part of treating arthritis. Although exercise may sometimes cause discomfort, proper exercise will help nourish the cartilage, strengthen the muscles, and may prolong the life of your joints. Check with your doctor before starting any exercise program to obtain permission, precautions, or guidelines.

3. Modify Your Activities

Proper body mechanics can lead to more effective use of your body and less strain on your joints.

Following these activity modification guidelines may prove helpful:
• Avoid slouching and practice good posture by standing up straight.
• Avoid sitting in low chairs to reduce stress on your knees when sitting and rising.
• While traveling, get up and move around every hour or so to avoid stiff joints.
• Avoid impact-loading activities (running, etc.).

4. Nutritional Supplements

Recently, nutritional supplements have become popular with patients with arthritis. Glucosamine and Chondroitin have been the most widely used.

Glucosamine – This natural building block found in cartilage may also be labeled as a hydrochloride or sulfate. Studies have shown Glucosamine to be useful in strengthening, repairing, and revitalizing cartilage, and in reducing pain.

Chondroitin Sulfate – This supplement is commonly taken along with glucosamine. It is found in cartilage and acts as a sponge for the fluid found in cartilage. This makes the cartilage more elastic and spongy. Chondroitin may also help prevent the breakdown of cartilage.

Vitamin C and D – Some studies indicate that patients low in Vitamin D and C may have a higher incidence of arthritis. Although a direct cause and effect are not established, it is recommended that arthritis patients take vitamins regularly.

Calcium – Some people confuse osteoporosis with osteoarthritis. Osteoporosis is thinning of the bone, not the joint. Calcium is known to help strengthen the bones and may help prevent the onset of osteoporosis.

5. Apply Heat/Cold

Heat and/or cold may be used to decrease pain and increase flexibility. Cold decreases blood flow and helps relieve joint pain and swelling. Heat increases blood flow and helps relax muscles.

6. Consider Injections

Hyaluronate Injections – sodium hyaluronate injections have been approved for arthritis of the knee. The injections may help relieve osteoarthritis pain and restore joint function. Hyaluronate is a naturally occurring substance in the joint fluid that provides lubrication and cushioning to the joint. Several synthetic forms of hyaluronate have been developed for use in the knee joint. To be effective, you must receive three to five injections weekly. The effectiveness is usually not noticed for a month or so. Studies have shown that the more severe arthritis, the less effective the injections. When effective, however, the relief may last six months.

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