According to its purpose, HA can be divided into cosmetic-grade, food-grade, medical-grade, and injectable-grade. Of them, injectable-grade HA is extensively used in cosmetic surgery, joint therapy, and medical lubrication. How to choose suitable injectable-grade HA according to the particular requirement? Let’s discuss that.

What is Injectable-Grade Hyaluronic Acid

Injection-grade hyaluronic acid represents high-quality HA developed especially for medical and cosmetic injection purposes. It undergoes extensive purification processes to remove impurities and possible allergens, ensuring the following features:

• High Purity: It is of medical-grade quality, thus safe to be injected.
• High Biocompatibility: Very similar in structure to human tissues for maximum safety.
• Long-Lasting Stability: It degrades much more slowly, prolonging its effect.

This kind of HA is used for filling facial hollows, and lubricating joints, and can even enhance the smooth operation of surgical tools.

Key Considerations When Choosing Injectable-Grade Hyaluronic Acid

The key to selecting the right injectable-grade HA lies in understanding your application needs. Of course, we have summarized some core indicators here to help you understand your needs.

1. Molecular Weight

Molecular weight defines the viscoelasticity, absorption rate, and degradation time of HA. Generally speaking, high molecular weight works better for lubrication and support, while low to medium molecular weight serves for penetration and drug delivery.

2. Purity and Sterility

HA injections should have ultra-high purity, be free from impurities, and be manufactured under sterile conditions to minimize infection risk.

3. Biocompatibility

Good quality HA should be strictly tested for compatibility with human tissues to minimize inflammation or adverse reactions upon its use.

4. Certification and Credentials

Only choose products certified by international authorities such as FDA or CE to ensure good quality and safety.

Products meeting this criterion will perform well in the intended applications.

Read more: How is Hyaluronic Acid Powder Made

Suitable Molecular Weights for Different Scenarios

–Cosmetic Procedures

HA is commonly used in cosmetic procedures to fill facial hollows, reduce fine lines, and improve skin elasticity.

Studies have shown that HA with molecular weights in the range of 1,300 kDa–1,800 kDa provides optimal viscoelasticity and volumizing effects, which are crucial for facial contouring and dermal filler applications.[i]

The medium to high molecular weight provides the structural integrity needed to sculpt facial contours while maintaining biocompatibility and longer-lasting effects due to slower degradation rates.

–Joint Injections

For patients with osteoarthritis, HA injections are essential for pain relief and improved joint mobility.

The high molecular weight ensures a thick, viscous solution capable of providing cushioning for joints, mimicking natural synovial fluid.

–Medical Lubricants

HA is often used as a lubricant during surgical procedures to minimize friction between instruments and tissues, improving procedural efficiency.

Medium molecular weight (800 kDa–1,300 kDa) HA is well-documented for its flowability and lubricating properties, essential for reducing friction during surgical procedures.[ii]

Medium molecular weight strikes a balance between being easy to handle and highly effective as a lubricant, making it suitable for surgical applications requiring precise, smooth interactions.

Conclusion

It is easy to select the proper injectable-grade hyaluronic acid once the application scenario is clear. Cosmetic procedures require medium and high molecular weight products for excellent support and longevity of results. High molecular weight HA has better application in joint injections, as it maintains lubrication and cushioning.

Meanwhile, in medical lubricant applications, medium molecular weight HA remains flowable with safety features. Regardless of the application, always prioritize purity, sterility, and certifications to ensure safety and effectiveness.

Pure Injection Hyaluronic Acid (HA) Powder from Stanford Chemicals Company

Injection-grade hyaluronic acid from Stanford Chemicals Company (SCC) is GMP, CEP, and DMF certificated and the factory passed an on-site inspection by the US FDA. It is all fermented products, non-animal sources, non-GMO, and non-BSE/TSE risk.

Main Products:

References:

The 5 Common Uses of Injectable Hyaluronic Acid

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

[i] Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x. PMID: 19207319.

[ii] Cowman MK, Schmidt TA, Raghavan P, Stecco A. Viscoelastic Properties of Hyaluronan in Physiological Conditions. F1000Res. 2015 Aug 25;4:622. doi: 10.12688/f1000research.6885.1. PMID: 26594344; PMCID: PMC4648226.

The post How to Choose the Right Injectable-Grade Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. Its salt form, sodium hyaluronate (SH), was initially isolated from the eye’s vitreous body. Sodium hyaluronate has a wide distribution in animal or human tissues, generally located in the extracellular matrix. It has a high concentration in the vitreous humor, aqueous humor, synovial fluid, skin, and umbilical cord.

Sodium hyaluronate is known for its excellent viscoelasticity, unique rheological properties, pseudoplasticity, non-toxicity, and superior biocompatibility.

Fig 1. Artificial tears with hyaluronic acid as the main ingredient

Basis for Sodium Hyaluronate in Ophthalmology Applications

It is highly moisturizing. Sodium hyaluronate can bind water several hundred times its weight, maintaining the ocular surface moisture balance. Its viscoelastic nature allows it to form a stable film on the eye surface, providing lubrication and protection while reducing friction.

As a natural constituent of human tissues, sodium hyaluronate possesses excellent biocompatibility with minimal risk of rejection or irritation. Furthermore, it provides an enhancement in corneal repair and regeneration, reduces inflammation, and soothes discomfort due to environmental stimuli or surgical procedures.

Given these properties, sodium hyaluronate is widely used in ophthalmic products such as artificial tears, surgical viscoelastic fillers, ophthalmic injectables, and corneal repair agents. Its applications range from routine eye care to advanced surgical procedures.

Fig 2. Viscoelasticity of hyaluronic acid

Applications of Sodium Hyaluronate in Eye Health

The uses of sodium hyaluronate in ophthalmology can be roughly divided into two categories. There is ophthalmic viscoelasticity, mainly used in all sorts of ophthalmic surgeries including glaucoma and cataract surgery; another one is eye drops, mainly used in treating dry eyes and corneal burns.

1. Ophthalmic Viscoelastic Agents

1.1 Role in Surgery

Sodium hyaluronate is used as a viscoelastic agent in many eye surgeries. It has a high molecular weight and excellent viscoelasticity, providing mechanical protection for the surgery to take place. Therefore, it maintains structure and prevents tissue collapse or damage caused by surgical instruments.

• Glaucoma Surgery

Sodium hyaluronate protects intraocular tissues, maintains the shape of the anterior chamber, and reduces friction and damage from surgical tools, thus enhancing safety.

• Cataract Surgery

It acts to safeguard the cornea endothelium and to serve as an aid to the implantation of an intraocular lens. It provides a clearer surgical field and minimizes mechanical trauma to the cornea during surgery.

• Trauma Repair Surgery

Sodium hyaluronate serves as a lubricant for the surgical procedure in ocular traumatized patients, inhibits the adhesion of tissues, and provides an optimal environment for healing after surgery.

• Corneal Laser Surgery

The protective film helps prevent excessive drying of tissues and reduces mechanical irritation from surgical instruments.

1.2 Recovery Post-Surgery

Sodium hyaluronate after surgery promotes the repair of tissues, reduces inflammation, and speeds up healing. It keeps the environment moistened to reduce any discomfort for the patients in recovery.

2. Eye Drops

Sodium hyaluronate is used in eye drops for moisturizing and lubrication, relieving dry eyes, protecting the ocular surface, and promoting corneal repair. It is suitable for sensitive people and postoperative care.

2.1 Treatment for Dry Eye

Dry Eye is a chronic condition caused by insufficient tear production or excessive evaporation, leading to symptoms such as dryness, fatigue, and a foreign body sensation. Sodium hyaluronate excels in treating dry eye due to its strong moisturizing properties.

• It forms a uniform protective film on the ocular surface, enhancing tear film stability and preventing tear evaporation.
• Its high water retention alleviates dryness and improves patient comfort.
• It enhances the repair ability of ocular surface cells, preventing more severe damage caused by chronic dryness.

2.2 Corneal Burn Repair

Sodium hyaluronate plays a vital role in treating corneal burns, where the cornea experiences water loss, cell damage, and inflammation. It helps in several ways:

• Moisturizing and Lubricating
• Promoting Cell Regeneration
• Reducing Inflammation

2.3 Daily Eye Care

Sodium hyaluronate-based eye drops are also widely used for daily eye care, especially by individuals who use electronic devices for extended periods or wear contact lenses. These drops effectively relieve discomfort caused by eye strain or insufficient tears, providing long-lasting hydration and lubrication.

Product Recommendations

Stanford Chemical Company (SCC) is one of the leading US-based wholesalers of hyaluronic acid, offering a range of pure hyaluronic acid powders in medical, food, cosmetic, and injectable grades. These cover high, medium, and low molecular weights and also support customization.

The main products in eye health:

References:

Sodium Hyaluronate Used in Anterior Segment Eye Surgery

Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes

The post From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health appeared first on Stanford Chemicals.

Polyglutamic Acid in Skincare: High-Efficiency Moisturizer

γ-PGA is capable of absorbing 5,000 times its weight in water; thus, it is much more effective in moisture retention compared to hyaluronic acid. It further forms a thin film on the surface of the skin to prevent water loss. In fact, one such study shows that this protecting layer may reduce water evaporation by about 10% to 20%. Besides, γ-PGA promotes the renewal of keratinocytes, reducing the impact of external irritants on the skin.

Table 1. Comparison of the skin care functions of polyglutamic acid with hyaluronic acid and collagen

Reference: Polyglutamic Acid: A “Better Alternative” to Hyaluronic Acid for Moisturizing Power

Polyglutamic Acid in the Food: Antioxidant for Extending Shelf Life

Non-toxic and tasteless, polyglutamic acid has functions of water retaining and thickening. It is mainly used in bakery products as a thickener and moisturizer, enhancing the taste of food. γ-PGA impairs starch aging by 20% to 30% and keeps the food soft and fresh. It enhances calcium absorption, increasing about 40% when combined with γ-PGA[i]. Being so, it is used worldwide in quite several functional foods and health aids. Besides, γ-PGA can increase the flavor of food and make dishes more attractive. If you enjoy eating fried foods, then consider adding gamma -PGA as it reduces body fat buildup.

Table 2. Applications and benefits of polyglutamic acid in foods

Polyglutamic Acid in Agriculture: The Soil Conditioner

Polyglutamic acid is a very effective conditioner for the soil and an additive to fertilizers. It improves the structure of the soil very much. Studies have shown that γ-PGA may increase the water retention of the soil by about 30% to 40%[ii], which keeps the water in the soil for longer and reduces crop stress due to drought. Besides, it accelerates the activities and reproduction of microorganisms, which increases the flow of nutrients in the soil.

Added to fertilizers, γ-PGA increases the utilization rate of fertilizers’ nutrients by 10%-15% and increases crop yield. It also enhances resistance to stress in plants, including those caused by pests and diseases. When γ-PGA is introduced into the soil, it forms a thin film on the root hair surface. This membrane protects not only the root hairs themselves but also serves as an interface for effective nutrient-water exchange to enable better nutrient absorption.

Polyglutamic Acid in Water Treatment: Natural Heavy Metal Adsorbent and Flocculant

It can function as an adsorbent of heavy metal ions and a flocculant. Its application in water treatment is mainly based on its strong heavy metal chelation and flocculation properties. For example, studies have shown that γ-PGA can realize more than 90% chelation efficiency for lead, cadmium, and mercury ions, which can significantly reduce the content of heavy metals in the water. Besides, compared with general flocculants, as a natural flocculant, γ-PGA is 20% to 25% more efficient in the removal of suspended solid and organic pollutants from water.

Polyglutamic Acid in the Medical Field: Promote Drug Delivery

In the field of medicine, γ-PGA is extensively used in drug delivery systems because it possesses excellent biocompatibility and biodegradability. According to some research, the carriers based on γ-PGA could prolong the time of drug release from 3 to 5 times and accordingly enhance the therapeutic effect. It can also be applied in surgical sutures and dressings of wounds.

During the process of degradation, there is no toxic by-product of γ-PGA, reducing inflammation and problems of infection caused after surgery. It seems that studies have shown that γ-PGA in repairing bone and other materials can increase bone tissue regeneration; the speed of bone healing can be accelerated by 15% to 20%.

Conclusion

Due to all these different applications of PGAs in skin care, food, agriculture, water treatment, and medicine, they can be considered one of the most versatile, safe, and promising natural biomaterials with huge perspectives for their applications in the future.

Stanford Chemical Company (SCC) has over 16 years of experience in manufacturing and marketing phytochemicals, pharmaceutical intermediates, catalysts, laboratory equipment, and a variety of specialty fine chemicals. The company offers a variety of skin care ingredients (polyglutamic acid, hyaluronic acid, collagen, etc.), food additives, feed additives and more. For more information, you can visit our homepage or use the search box to find the product you need.

[i] Yang, Li-Chan & wu, Jinbin & Ho, Guan-Huei & Yang, Shih-Ching & Huang, Yun-Pen & Lin, Wen-Chuan. (2009). Effects of poly-gamma-glutamic acid on calcium absorption in rats.. Bioscience, biotechnology, and biochemistry. 72. 3084-90. 10.1271/bbb.80024.

[ii] Zhang L, Yang X, Gao D, Wang L, Li J, Wei Z, Shi Y. Effects of poly-γ-glutamic acid (γ-PGA) on plant growth and its distribution in a controlled plant-soil system. Sci Rep. 2017 Jul 20;7(1):6090. doi: 10.1038/s41598-017-06248-2. PMID: 28729559; PMCID: PMC5519684.

The post 5 Uses of Polyglutamic Acid: From Skincare to Agricultural Production appeared first on Stanford Chemicals.

History of Hyaluronic Acid

In 1934, scientists Karl Meyer and John Palmer first isolated HA from the vitreous of cow eyes, discovering its unique moisturizing and lubricating properties. HA’s medical applications began over 70 years ago. Using time as a clue, we can clearly see the application history of hyaluronic acid.

• 1934 – HA was first isolated.
• 1930s-40s – HA was extracted from synovial fluid, skin, umbilical cords, tumors, and rooster combs.
• 1940s-50s – HA began to be used in medicine and eye surgeries, especially in cataract treatments.
• 1951 – The chemical structure of HA was determined.
• 1970s – Cartilage proteoglycans were found to interact specifically with HA.
• 1980s – HA was widely used to treat arthritis and introduced into cosmetics and skincare.
• 1993 – Hyaluronate synthase was discovered and cloned from Group A streptococcus.
• 1999 – The first purification of active HA synthase.
• Today – HA is mainly produced through bacterial fermentation, an efficient and eco-friendly method widely applied in pharmaceuticals, skincare, and biotechnology.

Medical Value of Hyaluronic Acid

Hyaluronic acid has a wide range of applications in the medical field: cell proliferation and differentiation, regulation of inflammation, vascular generation, and treatment of tumor cancer.

Fig 1. Benefits of Medical-Grade HA

1. Promoting Cell Proliferation and Differentiation

HA is an important substance in cell proliferation and differentiation. As an essential component of the ECM, HA could create a proper microenvironment for cell regeneration to help in wound healing and repair of cartilage tissue. For example, HA enhances chondrocyte cell proliferation, which is very effective in cartilage regeneration and also in the functional recovery process.

2. Modulating Inflammation

HA is an important mediator in the regulation of inflammatory processes. It may modulate the activity of immune cells, thereby reducing excessive inflammation, which may prevent tissue damage. In this respect, intra-articular injections of HA may reduce pain and improve functional ability in certain clinical conditions such as osteoarthritis. It reduces inflammation during the healing of skin wounds and hence promotes tissue repair.

3. Enhancing Vascular Generation

HA contributes to the process of angiogenesis-or, new blood vessel formation-which is important in processes such as wound healing and tissue regeneration and some pathologies such as tumor growth. HA functions through interaction with its receptors to enhance migration and proliferation of endothelial cells and, thus, hastens vascular formation. This mechanism not only helps accelerate wound healing, but can also play a positive role in certain therapeutic areas, such as the treatment of ischemic diseases.

Read more: Top 10 Benefits of Hyaluronic Acid

4. Cancer Cells Inhibition

HA has been in focus in application to cancer treatment. In the case of low molecular weight HA, Exogenous LMW-HA may exert anti-tumor effects by directly triggering an immune response, decreasing the proliferation of tumor cells, or remodeling the tumor microenvironment. Though partially unclear, Exogenous LMW-HA has been proposed to interact with specific immune cells and interfere with tumor cell signaling. More recently, HA has been suggested for application in improving the diagnosis of cancer and as part of targeted drug delivery systems, offering higher specificity in cancer treatments.

Reference: Does Hyaluronic Acid Cause Cancer

Table 1. Overview of the medical value and application of hyaluronic acid

Biomedical Products Based on HA

Due to its biocompatibility, biodegradability, non-toxic, and non-immunogenic properties, several biomedical products have been developed based on HA:

• Injectables: Used for skin fillers, joint lubrication, and anti-aging treatments, such as facial fillers and joint injections.
• Oral Supplements: Often used to improve skin hydration, quality, and joint health.
• Drug Delivery Systems: HA serves as a carrier for slow drug release, improving absorption and bioavailability at specific sites.
• Ophthalmic Solutions: Such as artificial tears and corneal repair solutions, used to alleviate dry eyes and promote corneal healing.
• Wound Dressings: HA promotes wound healing and is used in treating burns, ulcers, and other injuries.
• Bone Tissue Engineering Materials: Used to promote bone and cartilage regeneration.
• Contact Lens Lubricants: Provides comfort and relieves dryness for contact lens wearers.

Fig 2. Biomedical Products Based on HA

Conclusion

As a biocompatible and biodegradable compound, HA holds immense potential as a bioactive molecule for various physiological and pathological conditions. Its applications span from skincare benefits to cancer treatment, inflammation regulation, and chronic disease management. With advancing technology, we can expect more efficient production processes and innovative therapeutic products in the future.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

List of Medical-Grade Sodium Hyaluronate Powder：

• HA-EM2.0-SC
• HA-EM2.4-SC
• HA-EM3.0-SC

Reference:

Iaconisi, G.N.; Lunetti, P.; Gallo, N.; Cappello, A.R.; Fiermonte, G.; Dolce, V.; Capobianco, L. Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review. Int. J. Mol. Sci. 2023, 24, 10296. https://doi.org/10.3390/ijms241210296

The post Exploring the Medical Value of Hyaluronic Acid (HA) appeared first on Stanford Chemicals.

Hyaluronic acid (HA) plays an important role in the human body. It is widely used in various fields, such as skin care, relieving joint pain, wound healing, and lubrication in eye surgeries.

No exaggeration, Hyaluronic Acid has become one of the most popular active ingredients in cosmetic formulations today. Its exceptional moisturizing and anti-aging properties have made it highly sought after in the beauty industry. Both professionals and consumers are intrigued by how HA helps rejuvenate the skin and maintain its health. This article provides a comprehensive summary of the benefits and applications of HA in beauty.

Fig 1. Wide application of HA

Benefits of HA: A Natural Moisturizer and Repair Agent

Hyaluronic acid holds a key position in beauty due to its unique properties. Its main benefits include:

• High Moisture Retention: Effectively absorbs and locks in moisture, keeping the skin hydrated.
• Viscoelasticity: Forms a soft and elastic film that reduces moisture loss.
• Biocompatibility: Naturally compatible with the skin, reducing the risk of allergic reactions.
• Non-immunogenic: Unlikely to cause immune responses, suitable for all skin types.

Moreover, hyaluronic acid has significant effects on reducing inflammation, promoting skin regeneration, and fighting aging. These characteristics make it a key ingredient in anti-aging products. The different effects of hyaluronic acid depend on its molecular weight. As shown in the figure 2.

Fig 2. Different effects of high, medium, and low molecular weight HA[1]

Read more: Top 10 Benefits of Hyaluronic Acid

Hyaluronic Acid in Skincare and Beauty

Hyaluronic Acid is widely used in beauty products, ranging from daily skincare to professional aesthetic treatments.

Fig 3. Cosmetic and nutricosmetic effects of HA.

–Moisturizing Products

HA’s superior moisturizing ability makes it a core ingredient in many hydrating products. Its high moisture absorption helps draw and lock water from the environment, keeping the skin hydrated. In products like creams, serums, and lotions, HA forms a thin film on the skin’s surface, reducing moisture evaporation and leaving the skin soft and smooth. This moisturizing effect is especially suitable for dry skin or dry environments.

–Anti-aging Products

Hyaluronic Acid is extensively used in anti-aging products. As we age, the natural HA in our skin decreases, leading to moisture loss, reduced elasticity, and wrinkles. Anti-aging products containing HA (like wrinkle creams and serums) help restore moisture and reduce the appearance of fine lines and wrinkles. Different molecular weights of HA work at various skin layers—low molecular weight HA penetrates deeply, improving elasticity and firmness, while high molecular weight HA forms a protective barrier to reduce water loss.

–Sunscreen Products

In sunscreens, Hyaluronic Acid not only enhances the moisturizing effect but also protects the skin from UV damage through its antioxidant properties. UV rays accelerate skin aging, but HA helps neutralize free radicals, slowing the aging process. Additionally, HA in sunscreens improves skin smoothness and texture, keeping the skin soft even after sun exposure.

–Injectable Fillers in Aesthetic Medicine

Hyaluronic Acid is widely used as an injectable filler in aesthetic medicine. HA injections fill facial wrinkles, nasolabial folds, and sunken areas, instantly enhancing facial contours and reducing signs of aging. This non-surgical cosmetic treatment is popular due to its safety, short recovery time, and natural results. Furthermore, HA injections stimulate collagen production, making the skin firmer and more elastic.

–Wound Healing and Skin Repair

Hyaluronic Acid’s healing properties make it an essential ingredient in wound care and skin repair products. Its powerful moisturizing ability keeps wounds moist, aiding tissue regeneration and minimizing scar formation. HA also has anti-inflammatory properties, helping reduce skin irritation and inflammation, and speeding up the healing process. In beauty products, HA is often added to repair creams to help restore damaged skin and alleviate irritation caused by sun exposure, acne, and other skin issues.

Read more: Hyaluronic Acid Powder: The Acne-Prone Skin Savior

Conclusion

With its diverse functions and outstanding effectiveness, HA has become an irreplaceable ingredient in the beauty industry. From daily skincare to professional aesthetic treatments, HA consistently demonstrates its excellent moisturizing, anti-aging, and repair capabilities. As technology advances, the application of HA in beauty will continue to expand, bringing more possibilities for skin health and beauty.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

List of Cosmetic-grade Sodium Hyaluronate Powder：

• HAC-Micro-SC
• HAC-Oligo-SC
• HAC-N-SC
• HAC-L-SC
• HAC-M-SC
• HAC-H-SC

[1] Juncan, A.M.; Moisă, D.G.; Santini, A.; Morgovan, C.; Rus, L.-L.; Vonica-Țincu, A.L.; Loghin, F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules 2021, 26, 4429. https://doi.org/10.3390/molecules26154429

The post Comprehensive Summary: The Application of Hyaluronic Acid in Beauty appeared first on Stanford Chemicals.

The Mechanism of Chondroitin Sulfate

Chondroitin sulfate is a naturally occurring substance found in the cartilage of the human body. Its primary function is to help maintain the elasticity and hydration of cartilage. Healthy cartilage is essential for the normal functioning of joints, as it reduces friction during joint movement and absorbs shock, thus protecting the bones from damage. Structurally, chondroitin is similar to glycosaminoglycans, which play a crucial role in the matrix of cartilage by providing both structure and support.

Chondroitin (Ch) works by absorbing water, maintaining the elasticity and lubrication of cartilage. When the level of chondroitin decreases, cartilage can become fragile and lose its normal function, worsening arthritis symptoms. The theory behind supplementing with Ch is to increase the concentration in the joints, improve cartilage quality, and, as a result, relieve pain and stiffness.

Video: Chondroitin Sulfate For your Joint

Clinical Research Evidence

Despite its widespread use in joint health supplements, the effectiveness of Ch remains a topic of debate in the scientific community. Numerous clinical studies have been conducted to evaluate its impact on arthritis, but the results are not entirely consistent.

Some early studies suggested that chondroitin possesses anti-inflammatory properties, reducing joint pain and improving function. For instance, a study published in 2007 found that chondroitin sulfate significantly reduced pain scores in patients with knee osteoarthritis and improved their ability to move. These findings provided theoretical support for the use of chondroitin and prompted more people to try it as a supplement.

However, more recent large-scale randomized controlled trials have produced mixed results. One such study, funded by the National Institutes of Health (NIH) and known as the GAIT (Glucosamine/Chondroitin Arthritis Intervention Trial), found that the combination of chondroitin and glucosamine did not show significant benefits for patients with mild to moderate osteoarthritis. However, in patients with more severe osteoarthritis, the combination appeared to provide some relief. This result sparked widespread discussion about the effectiveness of Ch among both academics and the general public.

Fig 1. Chondroitin sulfate powder

Why the Inconsistent Results

The varying results across different studies could be attributed to several factors. First, the effectiveness of Ch may depend on the severity of the patient’s condition. In some studies, participants may have had relatively mild arthritis, where the cartilage damage was not yet pronounced. As a result, supplementing with chondroitin sulfate may not have produced significant effects. In contrast, in studies involving patients with more advanced arthritis, where cartilage was more severely damaged, chondroitin may have had a more noticeable impact.

Second, differences in study design and methodology could also explain the inconsistent results. Factors such as the dosage of Ch, duration of use, and whether it was combined with other supplements or medications all influence the outcome. Additionally, the quality and formulation of chondroitin supplements vary between products, potentially affecting their efficacy.

Fig 2. Chondroitin sulfate structure and the benefit of shock absorber

Considerations for Using Chondroitin

Although some studies have shown improvements in arthritis symptoms with Ch, it is essential to approach its use with caution. First, chondroitin sulfate is not a quick fix. According to clinical research, it may take at least three months of consistent use before noticeable results are observed. Therefore, individuals looking for fast pain relief may find chondroitin insufficient on its own.

Secondly, while chondroitin is generally considered safe, some mild side effects have been reported, such as gastrointestinal discomfort, nausea, and diarrhea. Furthermore, chondroitin may interact with certain medications, particularly blood thinners. Thus, it is advisable to consult with a healthcare professional before starting chondroitin sulfate, especially for individuals taking other medications.

Is Chondroitin Right for You

Chondroitin may offer some benefits for people with arthritis, particularly those with more severe symptoms. However, its effectiveness may be limited in individuals with mild osteoarthritis. If you are considering using Ch to relieve joint pain, it’s crucial to assess your specific condition, including the severity of your arthritis, your treatment goals, and the potential for side effects. A discussion with your doctor can help you make an informed decision about whether long-term use of chondroitin is appropriate for you.

Read more: Hyaluronic Acid VS. Glucosamine VS. Chondroitin: Which Is Best for Joints?

Other Ways to Manage Arthritis

In addition to chondroitin, managing arthritis often involves a multi-faceted approach. For example, regular exercise can help maintain joint flexibility and muscle strength, reducing stress on the joints. Physical therapy and rehabilitation exercises can also effectively relieve joint pain and improve joint function.

Medications play an important role in arthritis management as well. For patients with more severe pain, nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may be recommended. Injections of hyaluronic acid are also a common method. In recent years, newer biological therapies and disease-modifying drugs have been developed to control the inflammatory response and progression of arthritis.

Conclusion

Chondroitin sulfate, as a natural substance, theoretically helps protect and repair joint cartilage. However, its actual effectiveness varies among individuals, especially in patients with mild to moderate osteoarthritis, where the scientific evidence remains inconclusive. For patients with more advanced symptoms, Ch supplementation may offer some relief. When choosing whether to use chondroitin sulfate or other supplements, it’s important to consider your health condition, consult with a doctor, and adopt a comprehensive approach to managing arthritis to achieve the best possible outcomes.

Stanford Chemicals Company (SCC) has developed the manufacturing and selling of Chondroitin Sulfate for over 16 years. Our products included pharmaceutical-grade and food-grade chondroitin sulfate. The sources are bovine, shark cartilage, etc.

The post Does Chondroitin Sulfate Help with Arthritis appeared first on Stanford Chemicals.

With the rapid development of modern medicine and cosmetic technology, injectable hyaluronic acid is attached importance to in many respects. Being an excellent moisturizer with its biocompatibility, hyaluronic acid has developed a wide scope of applications in the field of structure and function improvement. It plays a central role in skin, joint, and eye care and further in surgical treatment in the field of eye diseases. This article shall focus on the five most common applications of injectable hyaluronic acid and further consider its safety record and possible side effects.

What Is Injectable Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring polysaccharide in the connective tissues of the body, skin, and eyes. It is known to hold up to 1000 times its weight in water; this helps in lubricating and keeping tissues elastic. Other functions of hyaluronic acid are tissue hydration, cell repair, anti-inflammatory, and as a lubricant in joints and in eye surgery. The injectable hyaluronic acid is extracted and purified in a unique way so that it is safe for injection.

–The Benefits of Hyaluronic Acid

• Moisturizing and hydration: It is able to absorb a lot of water and hold it, thereby keeping skin and tissues hydrated and elastic.
• Tissue repair: The very nature of hyaluronic acid promotes cell growth and tissue repair; thus, it creates less scarring after injury.
• Anti-inflammatory and lubrication properties: In joints and eye surgery, this acts to reduce inflammation and friction, thereby protecting tissues from damage.

The 5 Common Uses

Due to above these properties, hyaluronic acid finds wide application in medical and cosmetic treatments alike.

1. Viscosupplementation

Hyaluronic acid is one of the essential elements used in orthopedics as a joint lubricant. In patients who have osteoarthritis, the reduction in the volume of the fluid may increase the friction and thereby result in pain and inflammation.

Hyaluronic acid is administered into the articulation space. And then it increases the viscosity of the fluid within the joint cavity, facilitating lubrication and cushioning. This relieves pains and improves functions, mostly for those suffering from osteoarthritis of the knee, and possibly delays surgical procedures.

Fig 1. Benefits of HA for joints

2. Ophthalmic Surgery Aid

Hyaluronic acid finds applications in ophthalmic surgery, primarily as an intra-ocular filler. Hyaluronic acid facilitates smooth functioning and protects the corneal endothelial cells. In addition, HA can maintain the structural integrity of the eyeball during procedures such as cataract removal or corneal transplants.

At the same time, its high viscosity and elasticity minimize trauma during surgery and allow a much smoother operation. HA further eases recovery from the surgery and reduces post-operative complications.

Fig 2. Ophthalmic Surgery Aid

3. Dermal Fillers

Hyaluronic acid has been one of the finest uses in non-surgical facial treatments as a dermal filler. HA, when injected into the skin, fills in wrinkles and restores volume to the skin, giving the skin elasticity and more radiance. Such products are used in plumping up the lips, smoothing out nasolabial folds, defining cheek bones, and the chin.

The advantage of hyaluronic acid when used as a filling material is that it appears natural and is reversible. That is, the injected substance can be dissolved with an enzyme injection in unsatisfactory results.

Fig 3. Comparison of HA facial filler effects

4. Skin Repair Products

Apart from its cosmetic and surgical uses, hyaluronic acid is used in many skin repair processes. Since hyaluronic acid is injectable, it can enhance the healing process and regeneration of the skin to treat burns, wounds, and other injuries caused after surgery.

It keeps the wounds moist and prevents scabbing. This, in turn, reduces the occurrence of scarring. It can also help sunken scars and improve the overall texture of the skin by filling these depressions.

Fig 4. Wound healing process

5. Low Scarring Cosmetic Fillers

Hyaluronic acid also enjoys wide application in minimally invasive aesthetic treatments. Given its very good modeling properties, combined with safety, it is applied not only to non-surgical aesthetic treatments. For example, nose reshaping, chin contouring, and tear trough filling but also for facial contours.

These treatments are in demand since they have quick results and short recovery time, with the results appearing natural. Hyaluronic acid injections adjust facial contours subtly to create a more personified, pain-free, riskless aesthetic outcome for surgery.

Is Injectable Hyaluronic Acid Safe

Injectable hyaluronic acid is quite safe due to its high compatibility with the body. Most people tolerate it well and do not experience serious adverse reactions after injection, though it may lead to some mild adverse reactions, including reddening, bruising, slight pain, and allergic reactions at the site of injection. However, all of these may be temporary and will subside on their own.

–Side Effects of Injectable HA

Rarely, they can also occur in more severe types, such as infection, nodules or lumps at the injection site, and skin necrosis. More specifically, erroneous injection techniques, particularly for facial filling with hyaluronic acid, may cause vexing complications, such as vascular occlusion. It is hence very important to select an experienced and qualified professional to give the injection and practice stringent sterile techniques in a bid to prevent these complications.

Where to Buy Safe Injectable HA

Stanford Chemical Company (SCC) is specialized in providing tailored molecular weight, injection-grade HAF-C-SC. The injection-grade hyaluronic acid from SCC is GMP, CEP, and DMF certified, and the factory passed an on-site inspection by the US FDA. Our Injection-Grade HA is all fermentation products, of non-animal origin, non-GMO, and non-BSE/TSE risk.

What differentiates our product is the origin. Our pure HA Powder comes just from fermentation processes, thus being completely free of animal sources, non-GMO, and Vegan. The hyaluronic acid thus presents a conscientious choice for those seeking products that are sourced ethically and naturally in tune with values of sustainability and purity.

Recommended products:

• HA-EP1.8-SC
• HA-EP2.4-SC
• HA-EP3.0-SC

Conclusion

Injectable hyaluronic acid is regarded as an important tool in modern medicine and cosmetic treatments due to its excellent biological properties and remarkable versatility. From dermal fillers and joint lubricants to the aid for ophthalmic surgery and minimally invasive fillers in cosmetic procedures, HA has found application in these areas and hence shown its effectiveness in promoting health and beauty. Even though relatively safe, proper injection techniques help assure the best aesthetic result and will limit potential side effects. As advances in technology continue, the scope for which hyaluronic acid is used will expand and offer users ever more possibilities.

Related articles:

Solubility of Hyaluronic Acid in Different Solvents and Its Influencing Factors

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

Top 10 Benefits of Hyaluronic Acid

The post The 5 Common Uses of Injectable Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic Acid (HA) is a natural polysaccharide widely present in living organisms and plays a vital role in maintaining tissue health. In horses, HA not only has a significant impact on joint health, but also plays an important role in muscle and skin health. This article will elaborate on the many benefits of hyaluronic acid on horse health from the perspectives of horse joints, horse muscles and horse skin.

Hyaluronic Acid Benefits for Equine Joint Health

Anyone who owns horses knows that as horses age, joint problems often occur because of wear and tear. Hyaluronic acid is a key substance in treating joint diseases in horses. Because it has many benefits for the horse’s joints.

1. Joint lubrication

For horses, especially those involved in high-intensity sports such as horse racing and jumping, joint lubrication is crucial. Because good lubrication can ensure smooth joint movement and reduce wear caused by friction, thereby extending the service life of the joints.

Over time, the life of horse joints can be extended. It is worth mentioning that synovial fluid plays this lubrication role in the joint cavity. This substance reduces friction between cartilage and bone. And hyaluronic acid is the main component of this synovial fluid.

2. Buffering effect

Hyaluronic acid is highly viscoelastic, which allows it to act as a cushion in joints. During high-intensity exercise, equine joints bear tremendous impact. Hyaluronic acid reduces direct damage to joint structures by absorbing and dispersing these impact forces, thereby protecting joint cartilage and surrounding tissues.

3. Anti-inflammatory effect

Hyaluronic acid has natural anti-inflammatory properties. Arthritis is a common joint disease in horses that causes pain, swelling, and limited movement. Hyaluronic acid reduces the inflammatory response and relieves arthritis symptoms by inhibiting the activity of inflammatory mediators and enzymes. Not only does this help improve your horse’s mobility, but it also improves their quality of life.

4. Promote joint repair

Hyaluronic acid also plays an important role in promoting the proliferation and repair of chondrocytes. HA provides necessary nutrients and support to promote the regeneration of cartilage tissue, thereby repairing damaged joint structures. This is especially important for horses that have suffered joint injuries or suffer from chronic joint diseases.

Fig 1. Anatomy of the healthy and osteoarthritic knee joint[1]

Hyaluronic Acid Benefits for Horse Muscle Health

In addition to treating and preventing horse joint diseases, sodium hyaluronate is also very helpful in maintaining muscle healthy.

1. Increase muscle elasticity

Hyaluronic acid is not only found in joints but also plays an important role in muscle tissue. HA helps maintain muscle elasticity and flexibility, allowing muscles to better adapt to stretch and contraction during exercise. This is especially important for horses involved in high-intensity training and competition to reduce the risk of muscle strains and other sports injuries.

2. Relieve muscle pain

Horses often experience muscle soreness and fatigue after strenuous exercise. Hyaluronic acid helps relieve muscle pain and stiffness after exercise and speeds up the recovery process by promoting blood circulation and cell repair. This allows the horse to return to peak condition more quickly and be ready for the next training session or race.

3. Improve muscle metabolism

Hyaluronic acid helps improve the metabolic function of muscle cells and improves muscle endurance and strength. By optimizing the cellular environment and improving cellular energy utilization efficiency, hyaluronic acid allows horses to maintain efficient performance for longer during high-intensity exercise.

Fig 2. Horse muscular system[2]

Hyaluronic Acid Benefits for Horse Skin Health

Joints and muscles are two critical aspects of horse health. But the health of a horse’s skin is also deserved to pay attention. Healthy horse skin not only makes the horse more beautiful, but also effectively prevents many diseases. Hyaluronic acid has many properties that can be used to keep your horse’s skin healthy.

1. Moisturize and repair

Hyaluronic acid is widely known for its excellent moisturizing abilities. It absorbs and locks in thousands of times its own weight in water, thereby maintaining skin’s moisture and elasticity. For horses, especially in dry and hot environments, hyaluronic acid prevents dryness and cracking of the skin, keeping the skin healthy and shiny.

2. Promote wound healing

HA also plays an important role in promoting skin wound healing. It can accelerate the migration and proliferation of cells at the edge of the wound and promote the formation of new tissue, thus accelerating the wound healing process. This is particularly important for horses that have been injured during training or competition, reducing the risk of infection and healing time.

3. Anti-inflammatory and antibacterial

HA also has certain anti-inflammatory and antibacterial properties. It reduces skin inflammation and relieves redness, swelling and itching caused by allergies or infections. At the same time, it can also inhibit the growth of certain pathogenic bacteria and protect the skin from infection. This makes hyaluronic acid an effective skin care ingredient for a variety of skin concerns.

Fig 3. Horses with skin disease and healthy skin[3]

Conclusion

Hyaluronic acid has a wide range of applications in maintaining horse health, offering improvements in joint health, muscles, and skin.

This compound is known for its ability to lubricate joints, making it a vital component in reducing inflammation and ensuring smooth joint movements. Additionally, it promotes muscle elasticity and metabolism, which is essential for horses’ overall performance and recovery. Hyaluronic acid also retains skin moisture and accelerates wound healing, keeping horses’ skin healthy and resilient. By providing comprehensive health support, hyaluronic acid helps in enhancing the quality of life and athletic performance of horses, making it a valuable addition to the care regimen for horse breeders and enthusiasts.

While hyaluronic acid offers numerous benefits, it is essential to be aware of potential side effects. Some horses may experience mild reactions such as swelling or discomfort at the injection site. In rare cases, allergic reactions may occur. It is crucial to consult with a veterinarian before starting any new treatment to ensure it is appropriate for your horse.

Understanding and rational use of hyaluronic acid can significantly improve horses’ well-being, making it a critical element in equine health management, whether in daily care or disease treatment.

Stanford Chemical Company (SCC) is at the forefront of HA powder development. We offer injectable grade, food grade, cosmetic grade and medical grade sodium hyaluronate powder. For more information about these HAs, please check out our homepage.

Related articles:

Hyaluronic Acid: Relieves Equine Arthritis

[1] Fig 1. Anatomy of the healthy and osteoarthritic knee joint. Created via canvas. Source: Smith, Abbi & Sigurbjörnsdóttir. (2022). Hedgehog signaling in bone and osteoarthritis: the role of Smoothened and cholesterol. The FEBS Journal. 290. 10.1111/febs.16440.
[2] Fig 2. Horse muscular system. Source: http://www.equisearch.com/horses_care/health/illnesses_injuries/backpain_causes_070803/
[3] Fig 3. Horses with skin disease and healthy skin. Source: https://agsolutions.com.au/skin-coat-conditions/

The post What Are the Benefits of Hyaluronic Acid for Horse Health appeared first on Stanford Chemicals.

Micro Hyaluronic Acid generally refers to hyaluronic acid (HA) with a smaller molecular weight. It is a form of hyaluronic acid typically within the low molecular weight range (below 100k Daltons or lower).
Hyaluronic acid, often referred to as HA, is a naturally occurring sugar in our skin that helps retain water, keeping it hydrated and plump. What’s remarkable about it is its ability to hold up to 1,000 times its weight in water. Beyond simply holding water, it helps lock moisture in the skin, preventing evaporation into the air.

To put that in perspective, just ONE gram of Micro Hyaluronic Acid can hold six liters of water. It also regulates moisture within the skin cells so as to not drown them. Not only can Micro Hyaluronic Acid boost your skin’s moisture levels, but it keeps your skin hydrated for long-term positive effects. You may also find it as sodium hyaluronate, which is derived from HA and is the sodium salt portion of HA that has been isolated.

Micro Hyaluronic Acid vs. High Molecular Weight Hyaluronic Acid

Micro hyaluronic acid has stronger penetration compared to other molecular weights of hyaluronic acid, allowing it to pass through the skin barrier and reach the dermis. Its low molecular weight structure enables faster absorption, enhancing the efficiency of skincare products. Micro hyaluronic acid performs exceptionally well in anti-aging skincare and is often combined with high molecular weight hyaluronic acid to achieve the dual effect of deep hydration and surface protection.

Why Is Micro Hyaluronic Acid Used in Skincare?

With all of that, if you’re looking for plump, elastic, skin, Micro Hyaluronic Acid is going to be a favorite of yours. If a topical product claims to be hydrating, it likely is powered by Micro HA. But aging and environmental aggressors reduce the naturally occurring Micro HA in your body, making it an incredibly valuable active ingredient.

What Are the Top Benefits of Micro Hyaluronic Acid for Your Skin?

• It hydrates and plumps skin, reducing the appearance of fine lines and wrinkles as well as generally reducing signs of aging.
• It promotes a healing environment in the skin, reducing redness and dermatitis.
• It has antioxidant properties, which could protect the skin from environmental aggressors.
• It’s ideal for all skin types, even sensitive, acne-prone, or oily skin.
Because of all these incredible benefits, Micro Hyaluronic Acid is one of the best skincare active ingredients on the market.

What Is the Right Way To Apply Micro Hyaluronic Acid?

There are many forms of Micro Hyaluronic Acid. It exists naturally in your body, for example, but it also exists as an injectable filler (like Juvéderm and Restylane). However, you’re likely most familiar with it as the active ingredient in topical products from serums to face masks to moisturizers and more. The most popular Micro Hyaluronic Acid products are serums, which are best used after toner and before moisturizing.

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