1. Why Choose Hyaluronic Acid for Injections?

Hyaluronic acid is favored for injections because of its exceptional biocompatibility and lubricating properties. As a naturally occurring polysaccharide in the human body, HA is widely distributed in the skin, joints, and connective tissues, providing superior hydration and lubrication.

In cosmetics, HA is used to:

✓ Fill facial wrinkles

✓ Enhance facial volume

✓ Improve skin elasticity by replenishing moisture for a youthful, smooth appearance

In joint treatments, HA:

✓ Increases synovial fluid viscosity

✓ Improves joint lubrication and shock absorption

✓ Alleviates arthritis symptoms

Thanks to its high safety profile and low risk of immune reactions, HA is a top choice for injectable treatments.

2. Which Body Parts Can Receive Hyaluronic Acid Injections?

HA injections are versatile, targeting multiple areas with distinct purposes and effects.

The table below summarizes the main applications of sodium hyaluronate in different areas of the body:

3. What Is the Difference between Cosmetic Injections and Joint Injections?

Although both cosmetic injections and joint injections use hyaluronic acid as the primary material, there are significant differences in the types of hyaluronic acid used and injection techniques due to their different purposes and treatment goals.

Cosmetic injections are primarily aimed at improving appearance, such as reducing wrinkles, enhancing facial contours, and increasing lip volume. Common injection sites include the face, hands, lips, and neck – areas that require aesthetic enhancement. To achieve durable yet natural-looking results, cosmetic injections typically utilize high molecular weight (>1000kDa) cross-linked hyaluronic acid, which offers superior filling capacity and longer-lasting effects. However, the formulation must be carefully customized according to the treatment area (for example, lower cross-linking for lip injections) and individual tissue characteristics. Furthermore, cosmetic injections demand highly precise technique from practitioners to ensure natural-looking results while avoiding asymmetry or nodule formation.

In contrast, joint injections primarily focus on relieving pain and improving joint function by enhancing synovial fluid lubrication. The molecular weight selection depends on the arthritis stage. Low molecular weight HA provides rapid anti-inflammatory effects in early stages, while moderate-to-high molecular weight or cross-linked HA is preferred for advanced cases to optimize lubrication and shock absorption. Joint injections require even greater technical precision, as practitioners must accurately deliver HA into the joint space with exact depth and positioning to achieve optimal therapeutic outcomes.

4. How Does the Purity of Hyaluronic Acid Affect Injection Results?

The purity of hyaluronic acid directly affects the safety and efficacy of the injection. High-purity hyaluronic acid contains fewer impurities and potential allergens, which not only reduces the risk of allergic reactions and adverse effects but also ensures its longevity and biocompatibility within the body.

5. How Does the Molecular Weight of Sodium Hyaluronate Affect Injection Results?

The molecular weight of sodium hyaluronate determines its physical properties and therapeutic effects within the body.

How to choose?

High molecular weight hyaluronic acid (when combined with cross-linking) is indeed more suitable for deep-layer filling, but its core advantage lies in mechanical support rather than mere water absorption capability. Low molecular weight HA excels in permeability and biological activity but requires attention to its potential inflammatory risks. Clinical selection should comprehensively consider molecular weight, degree of cross-linking, and injection depth, rather than relying on a single parameter.

6. How Does the Solubility of Hyaluronic Acid Affect Injection Results

Choosing the appropriate solubility of hyaluronic acid is crucial for achieving the desired injection outcomes. Highly soluble hyaluronic acid is more suitable for areas requiring fine, natural effects, while low solubility products should be used with caution, typically in conjunction with professional injection techniques to avoid adverse reactions. The injection effects of different solubility HA are as follows:

Highly Soluble Hyaluronic Acid:

• Uniform Distribution: Can spread more evenly in the injection area, reducing the risk of local lump formation.
• Natural Filling Effect: Ensures a smooth skin surface post-injection, making it difficult to detect granularity or irregular lumps.
• Balanced Absorption: Aids in the uniform absorption of hyaluronic acid within the body, prolonging maintenance time.

Low Solubility Hyaluronic Acid:

• Easily Forms Granules: May result in noticeable granules or nodules during the injection process, affecting aesthetics.
• Uneven Filling: Can cause localized bulges or depressions, impacting the overall effect.
• Increased Irritation: Local accumulation might trigger inflammation or discomfort.

7. What Are the Advantages of Cross-Linked HA Gels?

Cross-linked HA gel are the preferred material in cosmetic injections because they can provide patients with more lasting and natural aesthetic results. Cross-linked hyaluronic acid (HA) hydrogels form a stable cross-linked structure between HA molecules through chemical or physical methods. This cross-linked structure enhances the mechanical strength and durability of the HA hydrogel, slowing its degradation rate within the body and extending the longevity of the injection effects. Moreover, cross-linked HA hydrogels can better maintain their shape after injection, reducing diffusion and migration. What’s more, the cross-linking process can further purify HA, removing impurities and lowering the risks of immune reactions and allergic responses.

8. How Long Do Hyaluronic Acid Injections Last for the Knee and Face?

The duration of HA injections depends on the treatment area and individual factors such as metabolism, activity level, and the specific HA product used. Generally, the duration is as follows:

9. What Are the Side Effects of Hyaluronic Acid Injections?

Due to the biocompatibility of hyaluronic acid (HA), injections of HA are generally considered safe. However, like any medical procedure, they may produce potential side effects. Common side effects include:

Local Reactions:

• Redness and Swelling: Temporary inflammation at the injection site.
• Pain and Tenderness: Mild discomfort during and after the injection.
• Bruising: Minor bruising may occur at the injection site.

Rare Side Effects:

• Allergic Reactions: Although rare, some individuals may experience allergic reactions, including itching, rash, or hives.
• Lumps and Bumps: Small lumps or nodules may form subcutaneously, which might require massaging and, in extremely rare cases, medical intervention.
• Infection: As with any injection, there is a slight risk of infection at the injection site.
• Vascular Occlusion: A very rare but severe complication where HA is inadvertently injected into a blood vessel, potentially causing tissue necrosis or vision problems if it occurs near the eyes.

Mitigation Measures:

• Experienced Practitioners: Ensure that injections are performed by qualified and experienced medical professionals to minimize risks.
• Proper Disinfection: Maintain a sterile environment to reduce the risk of infection.
• Patch Testing: Conduct skin tests on individuals known to be allergic to HA or related substances.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

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Solubility of Sodium Hyaluronate

The solubility of sodium hyaluronate is the foundation of its application. Solubility not only affects its dispersibility in different solutions but also directly influences its bioavailability and efficacy. The solubility is influenced by various factors, including solvent type, temperature, pH, and the molecular weight of hyaluronic acid.

–How Long Does It Take for Sodium Hyaluronate to Dissolve

The solubility of sodium hyaluronate varies in different solvents. In water, it can dissolve quickly, forming a transparent and viscous solution. In glycerol, its solubility is moderate, though not as high as in water. This is why glycerol and hyaluronic acid are often found together in cosmetics. In ethanol, the solubility of hyaluronic acid is low, and it usually requires mixing with other solvents. In acetone, sodium hyaluronate is almost insoluble and is generally not used in such solvents.

Table 1. A comparison of the solubility of sodium hyaluronate in different solvents:

Stanford Chemical Company (SCC) is a trusted supplier of sodium hyaluronate powder. We provide customers with high-purity, non-animal-derived, non-GMO hyaluronic acid powder (including food grade, cosmetic grade, injection grade, medical grade, eye drop grade, cross-linked gel). Enjoy bulk purchase discounts and contract pricing.

• SDS of Sodium Hyaluronate
• Sodium Hyaluronate production flow chart

–How to Dissolve Sodium Hyaluronate Quickly

In addition to solvent type, several factors influence the solubility of sodium hyaluronate. A previous article discussed this topic in detail. If interested, you can click to read: Solubility of Hyaluronic Acid in Different Solvents and Its Influencing Factors

To accelerate dissolution, the following methods are commonly used:

• Stirring: Mechanical stirring can speed up the dispersion and dissolution of HA in water. The stirring speed and duration significantly affect the dissolution efficiency.
• Heating: Moderate heating (usually not exceeding 60°C) can increase the dissolution rate, but care must be taken to avoid degradation caused by high temperatures. Temperature should be controlled, and prolonged high-temperature treatment should be avoided.
• Premixing: Premixing sodium hyaluronate with a small amount of glycerol or ethanol before diluting with water can improve dissolution efficiency. This method is particularly suitable for preparing high-concentration sodium hyaluronate solutions.

Viscosity of Sodium Hyaluronate

Viscosity is one of the important physical properties of sodium hyaluronate, directly affecting its application in cosmetics and medicine.

–How Viscosity Affects the Efficacy of Sodium Hyaluronate

The viscosity of hyaluronic acid is closely related to its molecular weight. High-viscosity hyaluronic acid forms a protective film on the skin surface, effectively locking in moisture, while low-viscosity sodium hyaluronate penetrates deeper into the skin, providing deep hydration. Viscosity also affects the flowability and distribution uniformity of sodium hyaluronate during injection or application.

–What Factors Affect the Viscosity of HA

Molecular weight, concentration, temperature, pH value.

Higher molecular weight results in higher viscosity. High molecular weight hyaluronic acid has longer molecular chains and stronger intermolecular interactions, leading to higher viscosity.

Higher concentration leads to higher viscosity. In high-concentration sodium hyaluronate solutions, molecules are closer together, resulting in stronger interactions and increased viscosity.

Higher temperatures reduce viscosity. Increased molecular motion at high temperatures weakens intermolecular interactions, causing a decrease in viscosity.

Hyaluronic acid exhibits the most stable viscosity within a pH range of 6-8. Under acidic or alkaline conditions, sodium hyaluronate molecules may undergo hydrolysis or cross-linking, leading to changes in viscosity.

Fig 2. Relationship between the relative viscosity of LMW-HA/HMW-HA aqueous solutions and the HMW-HA content.[1]

Stability of Sodium Hyaluronate

The stability of sodium hyaluronate is another critical factor in its application. Stability not only affects its storage and shelf life but also influences the durability of its efficacy.

The Impact of Temperature on Stability

Hyaluronic acid is prone to degradation at high temperatures, so high-temperature environments should be avoided during storage and use. Typically, sodium hyaluronate is most stable within a temperature range of 4°C to 25°C.

The Impact of pH on Stability

Hyaluronic acid is susceptible to hydrolysis in acidic or alkaline environments, leading to molecular chain breakage. Therefore, maintaining the pH of sodium hyaluronate solutions within the range of 6-8 is crucial for ensuring stability.

The Impact of Light and Oxidation on Stability

Hyaluronic acid is prone to degradation under light and oxidative conditions. Therefore, it should be stored away from light, and antioxidants should be added to extend its stability.

Read more: How to Maintain the Stability of Hyaluronic Acid Products

Table 2 below is a comparison of the stability of HA under different conditions:

[1] Saitarly, Svetlana & Pushkarev, Yuriy & Nesterkina, Mariia & Ozturk, Serhat & Salih, Bekir & Kravchenko, Iryna. (2021). Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics. Biointerface Research in Applied Chemistry. 12. 1907-1915. 10.33263/BRIAC122.19071915.

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Hyaluronic Acid vs. Collagen: Performing Different Roles

Hyaluronic acid, also known as hyaluronan, is widely distributed in joint fluid, skin, and eyes. It is a high-level polysaccharide composed of repeating units of D-glucuronic acid and N-acetylglucosamine, and it is an important component of the extracellular matrix.

Collagen is a biological macromolecule primarily used to fill fine wrinkles and minor soft tissue defects. It is mainly distributed in bones, eyes, teeth, tendons, internal organs, and other areas. In the skin, it accounts for 70% of its composition, making it the most abundant protein in the human body.

Fig 1. Human skin structure

In the structure of skin tissues, hyaluronic acid acts as a moisture reservoir and locks in moisture, while collagen affects the skin’s fullness.

–Hyaluronic Acid: The Skin’s “Natural Reservoir”

Hyaluronic acid acts like a “sponge” in the skin, quickly replenishing moisture.

Fig 2. HA’s powerful moisturizing effect

1. Core Function: Strong Hydration

Hyaluronic acid has an extremely high water-absorbing capacity, capable of absorbing 1,000 times its own weight in water, thereby improving dryness. A 2% pure hyaluronic acid aqueous solution can firmly retain 98% of moisture, making it the best natural moisturizer discovered, known as the Natural Moisturizing Factor (NMF).

2. Anti-Aging Function: Filling Fine Lines

Hyaluronic acid can fill the fine lines on the skin’s surface, making the skin appear plumper and smoother. However, it does not directly enhance skin elasticity; it primarily keeps the skin youthful through hydration.

3. Repair Function: Gentle Repair

Hyaluronic acid possesses gentle repair capabilities, promoting wound healing and making it suitable for sensitive or barrier-damaged skin. It also helps repair the skin’s natural barrier, enhancing its moisture-locking ability.

–Collagen: The Skin’s “Support Framework”

Collagen forms a network structure, an “elastic net” that supports the skin.

Fig 3. The supporting effect of the triple helix structure

1. Core Function: Enhancing Elasticity

Collagen is the main component of the dermis, responsible for maintaining skin elasticity and firmness. As age increases and this protein is lost, the skin gradually becomes loose and develops wrinkles. Supplementing collagen can help restore the skin’s support structure and enhance elasticity.

2. Anti-Aging Function: Deep Anti-Aging

Collagen can improve the skin’s elastic fiber network from the deep layers, reducing wrinkles and sagging. Compared to hyaluronic acid, its anti-aging effects are more lasting but require long-term use to see significant improvements.

3. Repair Function: Promoting Tissue Regeneration

Collagen can accelerate the repair of skin tissues, reduce scar formation, and is suitable for repairing deep injuries or post-surgical care.

–Summary

From a hydration perspective, hyaluronic acid is superior; from an anti-aging perspective, collagen can directly and quickly help restore skin elasticity. Both possess skin repair functions.

Hyaluronic Acid and Collagen: Complementing Each Other

In skin tissue, collagen affects skin elasticity, while hyaluronic acid acts as a moisture reservoir. Although there are differences between the two, they complement each other.

Both are indispensable in human skin.

• Lack of Hyaluronic Acid — Dryness, roughness, flakiness
• Lack of Collagen — Sagging, drooping, aging

As age increases, the body’s collagen content gradually decreases, weakening the skin’s support function. At this point, hyaluronic acid plays an important role. It can promote the synthesis and maintenance of collagen, thereby slowing the skin aging process.

Hyaluronic acid’s strong moisturizing ability can adsorb and lock a large amount of moisture inside the skin. This moisturizing effect not only keeps the skin hydrated but also reduces moisture loss, making the skin elastic. Hyaluronic acid can also form a protective film to prevent environmental stimuli and damage to the skin, while helping other active ingredients penetrate deeper into the skin.

The coordinated relationship between collagen and hyaluronic acid is very important in skin care. When collagen levels decline, the role of hyaluronic acid becomes particularly significant. It can improve skin elasticity and firmness by increasing collagen synthesis. At the same time, hyaluronic acid’s moisturizing function helps maintain the skin’s moisture balance, preventing dryness and moisture loss. Additionally, hyaluronic acid can promote the metabolism of skin cells, accelerating the process of skin repair and regeneration.

Where to Buy

Stanford Chemical Company (SCC) is a trusted supplier of sodium hyaluronate and collagen peptides.

We offer:

• Sodium hyaluronate Powder: High purity, non-animal, non-GMO, cosmetic grade, medical grade, food grade, injectable grade.
• Collagen Peptides: Extracted using targeted enzymatic digestion technology and advanced membrane separation technology from animal tissues (fish scales, cow bones, chicken breast cartilage).

Enjoy bulk purchase discounts and contract pricing.

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They all have moisturizing effects: one is an acid, one is a salt, and one is a hydrolyzed product.

Hyaluronic Acid (HA) is certainly familiar to everyone. Essentially, it is a high molecular weight acidic glycosaminoglycan. In the structure of Hyaluronic Acid, there are numerous hydrogen bonds, which can easily combine with water molecules and absorb up to 1000 times its own weight in water, thus possessing superior water retention properties. HA can increase the skin’s ability to retain water, enhance skin elasticity, plump and fill in fine lines and wrinkles, delaying aging.

Fig 1. The benefits of Hyaluronic Acid

Additionally, Hyaluronic Acid is an important component of human joint lubricant and the vitreous humor in the eyes, playing roles in regulation, permeability, and lubrication. Besides its current use in plastic surgery treatments, it is also widely used clinically in procedures such as intraocular lens implantation, ophthalmic surgeries, and arthritis treatments.

Summary:

• Chemical Structure: HA is a high molecular weight acidic glycosaminoglycan, a type of glycosaminoglycan. Its structure consists of repeating disaccharide units (D-glucuronic acid and N-acetylglucosamine) linked by β-1,4 and β-1,3 glycosidic bonds.
• Molecular Weight: The molecular weight of Hyaluronic Acid ranges widely, from several million Daltons (high molecular weight) to several thousand Daltons (low molecular weight).
• Solubility: It has excellent moisturizing properties in water, but high molecular weight Hyaluronic Acid may form highly viscous solutions during dissolution, making it difficult to disperse evenly.

Sodium Hyaluronate: The Stable Derivative of Hyaluronic Acid with Wide Applications

Like Hyaluronic Acid, Sodium Hyaluronate (SH, Sodium HA) is a component of human skin, present in connective tissues and the dermis. In skincare products, Sodium Hyaluronate is a common form of commercial Hyaluronic Acid, and HA is generally referred to as Sodium HA, serving moisturizing and hydrating functions.

Similar to Hyaluronic Acid, Sodium Hyaluronate can keep the skin soft, smooth, and delicate, and is widely used in the high-end cosmetics industry as well as in the treatment of ocular syndromes.

At the same time, medical Sodium HA has good biocompatibility with the skin, capable of deeply repairing the skin base, hydrating and brightening, fading spots, and reducing acne scars. SH with a purity of 95% is active and plays roles in wound healing and antiviral activity. Therefore, in wound care, it is used to promote the proliferation and differentiation of epidermal cells, accelerate cell regeneration, and promote the healing of damaged areas.

When added to cosmetics, it can provide a barrier protective film for the skin, keeping it smooth, hydrated, delicate, and elastic. It can also be used as a food additive, widely added to dairy products, beverages, alcoholic drinks, and chocolates, but daily intake should not be excessive; the daily intake should be below 200 milligrams.

Summary:

• Chemical Structure: Sodium Hyaluronate is the sodium salt form of HA, formed by neutralizing the carboxyl groups in HA.
• Molecular Weight: Similar to original Hyaluronic Acid, adjustable according to needs.
• Solubility: Solubility and stability are usually better than non-salted Hyaluronic Acid. Its sodium salt form presents lower viscosity upon dissolution in water, making it easier to apply to various products.

Hydrolyzed Sodium Hyaluronate: Advanced Derivative Enhancing Permeability and Bioavailability

Hyaluronic Acid can be broadly divided into high molecular, medium molecular, low molecular, and ultra-low molecular weights, with differences in skin feel, viscosity, and efficacy. Hydrolyzed Sodium Hyaluronate is a form of extremely low molecular weight Hyaluronic Acid, also known as Oligomeric Hyaluronic Acid. Its molecular weight is generally less than 10 KDa, for example, HA-Oligo.

Typically, high molecular Hyaluronic Acid is broken down by enzymes to obtain Hydrolyzed Sodium Hyaluronate with slightly lower molecular weight to improve permeability. Hydrolyzed Sodium Hyaluronate can penetrate through pores and intercellular spaces into the deeper layers of the skin, reaching the dermis to play a foundational repair effect.

Summary:

• Chemical Structure: Hydrolyzed SH is a low molecular weight form obtained by chemically or enzymatically hydrolyzing Sodium Hyaluronate. During hydrolysis, the long chains of Sodium Hyaluronate are cut into shorter polysaccharide or oligosaccharide chains.
• Molecular Weight: Typically less than 10 KDa.
• Solubility: Due to the lower molecular weight, Hydrolyzed Sodium Hyaluronate has higher solubility and lower viscosity in water.

The table 1 below summarizes the differences among Hyaluronic Acid, Sodium Hyaluronate, and Hydrolyzed Sodium Hyaluronate from four dimensions: chemical structure, molecular weight, solubility, and applications.

Table 1. Hyaluronic Acid vs. Sodium Hyaluronate vs. Hydrolyzed Sodium Hyaluronate

Stanford Chemical Company (SCC) is a trusted supplier of Sodium Hyaluronate Powder. We provide customers with high-purity, non-animal, non-GMO Hyaluronic Acid powder, Sodium HA Powder, and HA-Oligo. Enjoy bulk purchase discounts and contract pricing.

• SDS of Sodium Hyaluronate
• Sodium Hyaluronate production flow chart

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As a key moisturizing ingredient, sodium hyaluronate is widely recognized. Let’s begin with a brief introduction.

Sodium hyaluronate (the sodium salt form of hyaluronic acid) is a polysaccharide naturally present in human tissues. It is a transparent, viscous substance with excellent moisturizing, lubricating, and anti-inflammatory properties. It is a common ingredient in skincare products and an effective component in eye drops for relieving dry eyes.

So, what is ectoine?

Ectoine is an amino acid derivative found in “Halophile” that thrives in extreme environments. In 1985, German scientist Professor Galinski discovered ectoine in the saline lakes of the Egyptian desert.

It regulates cell osmotic pressure, acting as a natural “protective shield” that enables halophilic bacteria to survive in extreme conditions like high temperatures, high salinity, and intense UV radiation. Biotech companies identified its potential and began producing ectoine (C₆H₁₀N₂O₂) through fermentation. Today, ectoine is used in biomedicine (eye drops, nasal sprays, oral sprays) and skincare products.

Fig 1. Desert salt lake with no grass growing

Sodium Hyaluronate vs Ectoine: Which is Better for Skin

Sodium hyaluronate has been used in skincare products since the 1980s. The exceptional moisturizing ability has made it a star ingredient in the skincare industry. Ectoine, widely adopted by skincare brands since 2019, has gained recognition for its outstanding moisturizing and repair effects, leading to rapid growth in its applications.

Let’s compare the effects of the two

1. Moisturizing

Both ingredients provide moisturizing benefits, but their mechanisms and results differ.

Sodium hyaluronate molecules can absorb hundreds to thousands of times their weight in water. It draws moisture from the environment and locks it in, keeping the skin hydrated. It also forms a breathable hydrating film on the skin’s surface, reducing water evaporation and preventing dryness. What’s more, low-molecular-weight HA can penetrate the dermis, offering deep hydration.

Fig 2. HA for skin

Ectoine’s moisturizing function differs, focusing more on protection and regulation. It binds with water molecules to form a stable hydration shell around cells, creating a protective shield. This shield effectively prevents water loss from skin cells and maintains water balance inside and outside the cells. Additionally, by stabilizing cell membranes and protein structures, ectoine enhances cellular resistance to external stressors like dryness, UV rays, and high temperatures, reducing water loss risks.

Fig 3. The moisturizing principle of Ecdoin

Conclusion: Ectoine’s moisturizing ability leans toward “protective hydration,” without directly absorbing water like sodium hyaluronate. For those focused on hydration, sodium hyaluronate offers more immediate results.

2. Skin Repair:

Sodium hyaluronate is popular in skincare for its skin repair properties. It stabilizes and attracts growth factors (EGF), accelerating cell proliferation, tissue regeneration, and wound healing. It also has anti-inflammatory and soothing effects, reducing damage caused by inflammation.

Ectoine’s repair function is more prominent, especially for sensitive and inflamed skin. When exposed to environmental stressors like high temperatures, UV radiation, hypoxia, heavy metal toxicity, or viral infections, ectoine triggers emergency protective and regenerative responses, helping cells maintain normal physiological activity. Merck data shows that 1.0% Ecdoin can induce a faster stress response, prevent cell damage, and increase the speed of self-healing by 2-3 times.

Conclusion: For skin sensitivity, barrier damage, acne-related breakouts, or sunburn-induced redness, products with ectoine can quickly provide repair and soothing effects.

Key Characteristics Comparison:

Sodium Hyaluronate vs Ectoine: Which is Better for Eyes

Sodium hyaluronate and ectoine are both vital ingredients in eye drops, but their benefits differ in focus.

Sodium hyaluronate is more suitable for individuals with dry eye syndrome, contact lens wearers, or those needing immediate hydration. Its properties allow it to absorb water and form a hydrating film on the eye surface, relieving dryness. Moreover, its natural presence in human tissues ensures high safety with minimal irritation.

Ectoine, on the other hand, is ideal for individuals with eye inflammation, sensitivity, or exposure to harsh environments. By forming a “hydration shell,” ectoine enhances the stability of ocular cells, protecting them from external irritants. It also stabilizes the lipid layer of the tear film, preventing excessive evaporation.

–Synergistic Effects of Sodium Hyaluronate and Ectoine

Studies show that combining ectoine with sodium hyaluronate delivers enhanced synergy in relieving dry eyes. This combination significantly improves water-binding ability, effectively hydrates the eyes, stabilizes the tear film, and reduces tear evaporation. Additionally, it forms a durable hydrating film on the eye surface, firmly adhering to the cornea and ocular surface to provide robust protection against external irritants. Furthermore, this combination is highly effective in alleviating irritation caused by environmental dryness, inflammation symptoms, and itching or burning sensations during allergic reactions.

Stanford Chemical Company (SCC) is an excellent supplier of sodium hyaluronate powder and ectoine powder. In addition, we also provide chondroitin sulfate for cataract surgery eye drops and joints. For more information on these materials, please check out our home page.

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What is Hyaluronic Acid

Hyaluronic Acid (HA) is recognized as one of the best moisturizing substances currently discovered, regarded as the optimal humectant. It has an exceptional water-absorbing ability, capable of retaining water up to 1,000 times its own volume. HA is abundantly present in the skin, forming one of the main components of the skin’s extracellular matrix. This substance can bind with proteins to form larger proteoglycan molecules, ultimately creating a gel-like structure of hyaluronic acid-protein-water, which plays a crucial role in maintaining the skin’s moisture.

The Importance of Hyaluronic Acid for the Skin：

HA within the dermis provides space and nutrients for collagen and elastic fibers, forming a structural framework for the skin. This is essential for maintaining the stability, integration, and elasticity of skin tissues.

Hyaluronic Acids by Molecular Weight

Hyaluronic acid can be classified based on its molecular weight into:

• High Molecular Weight HA (HMW-HA): Above 1,800 KDa.
• Medium Molecular Weight HA (MMW-HA): Between 200 KDa and 1,800 KDa.
• Low Molecular Weight HA (LMW-HA): Between 5 KDa and 200 KDa.
• Oligomeric Hyaluronic Acid (Oligo-HA): Below 10 KDa.

Further subdivision identifies Micro-Hyaluronic Acid (Micro-HA) with a molecular weight below 5 KDa.

Learning more: Comparative Analysis of Hyaluronic Acid with Different Molecular Weights

Each molecular weight category has distinct physicochemical properties and application areas. HMW-HA is commonly used in ophthalmic and orthopedic surgical products due to its excellent viscoelasticity and lubricating properties. MMW-HA finds widespread applications in cosmetics, pharmaceuticals, and health products. LMW-HA is often used in cosmetics and health supplements for its better absorption. Oligo-HA and Micro-HA are primarily utilized in medical and cosmetic products.

What is Micro-Hyaluronic Acid

Micro-HA refers to ultra-low molecular weight HA fragments (below 5 KDa) obtained through the degradation of hyaluronic acid. Studies have shown that Micro-HA can quickly penetrate beneath the stratum corneum, providing long-lasting hydration to the skin. As a natural component of the human body, Micro-HA has excellent biocompatibility, offering comprehensive moisturizing and anti-aging effects. It represents a new generation of hyaluronic acid products.

Micro- Hyaluronic Acid vs. Regular Hyaluronic Acid

Micro-sodium hyaluronate stands out from regular sodium hyaluronate with the following features:

• Ultra-Low Molecular Weight: Micro-sodium hyaluronate has a molecular weight of less than 5 kDa.
• Strong Permeability: Its superior permeability allows it to penetrate the stratum corneum and reach the basal layer of the skin.
• Enhanced Moisturizing Ability: The moisturizing effect of micro-sodium hyaluronate is 6-7 times stronger than that of regular sodium hyaluronate.
• Superior Skin Affinity: While regular sodium hyaluronate forms a film on the skin’s surface that is easily washed off, micro-sodium hyaluronate binds to skin cells, providing robust hydration support and protection that is less prone to being washed away.

Advantages of Micro-Hyaluronic Acid

1. Deep Moisturization

Micro-HA can penetrate the skin and provide deep hydration, significantly increasing skin moisture content. When combined with high molecular weight HA, the moisturizing effect is further enhanced synergistically.

2. Repair of Damaged Cells

Micro-HA repairs damaged cells, enhancing cellular activity and reducing damage caused by external factors.

3. Free Radical Scavenging

Micro-HA eliminates reactive oxygen species induced by sunlight, enhancing cellular antioxidant capacity and improving the skin’s defense against UVB radiation.

4. Anti-Aging

Continuous use of skincare products containing Micro-HA improves skin elasticity, strengthens the skin barrier, reduces wrinkles, and provides anti-aging benefits.

How Does Micro-Hyaluronic Acid Benefit the Skin

High molecular weight hyaluronic acid cannot penetrate the normal skin barrier and forms a breathable thin film on the skin surface. Its primary function is to keep the skin smooth and moisturized while protecting it from bacteria, dust, and UV radiation. In contrast, low molecular weight HA can penetrate the skin barrier to the dermis, suppress inflammatory responses, promote angiogenesis, improve intermediate metabolism, enhance nutrient absorption, and reduce wrinkles.

In the dermis, Micro-HA participates in the metabolism of collagen and elastic fibers, providing moisture and nutrients and enhancing skin elasticity.

In vitro experiments have shown that Micro-HA can:

• Increase collagen synthesis (+100%)
• Activate glutamine transaminase (+100%)
• Reduce matrix metalloproteinase activity (-15%)

Collagen is a key extracellular matrix component responsible for skin strength, while the proper organization and alignment of collagen fibers involve glutamine transaminase. Matrix metalloproteinases degrade collagen fibers. In summary, Micro-HA exerts anti-wrinkle effects by acting on these substances within the body.

Where to Buy the Best Micro Hyaluronic Acid

Stanford Chemicals Company (SCC) is a wholesale supplier of pure organic hyaluronic acid in the USA. The company has rich experience in medical-grade, cosmetic-grade, Injection-Grade, and food-grade sodium hyaluronate. The high molecular weight, middle molecular weight, low molecular, and oligomeric weight hyaluronic acid powder are available as well. We offer hyaluronic acid raw materials to customers in the USA, Canada, and Europe. A detailed description of Micro-HA is listed below. For further information, please make your inquiry.

020-000-118 Micro Hyaluronic Acid Specification

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Natural Ingredients in Skincare Products

Generally, ingredients derived from natural resources and obtained through physical extraction or simple chemical processing are referred to as “natural ingredients.”

1. Herbal Extracts

Herbal extracts are common natural ingredients in cosmetics. For example, centella asiatica extract has repairing and anti-inflammatory effects. It is rich in triterpenoids, which promote collagen synthesis, speed up skin healing, and reduce inflammation, making it particularly beneficial for acne-prone and sensitive skin.

Chamomile extract is rich in flavonoids, which soothe the skin, reduce redness and itching, and provide antioxidant benefits, helping to relieve skin stress.

2. Natural Oils

Natural oils are moisturizing and nourishing ingredients in skincare products. For example, shea butter is rich in fatty acids and vitamins, which repair dry skin, enhance skin elasticity, and form a moisture-locking barrier on the skin surface.

Coconut oil has excellent penetrative properties, deeply moisturizing the skin. Its natural antibacterial properties help relieve inflammation, making it suitable for dry and sensitive skin.

3. Natural Polysaccharides and Proteins

Natural polysaccharides and proteins are important active ingredients in skincare products. For example, hyaluronic acid has exceptional hydrating properties. It can attract moisture and form a hydrating film on the skin surface, improving dryness and increasing elasticity.

Collagen is a natural protein that fills the gaps between skin cells, improving skin firmness and softness. Elastin is particularly effective in enhancing skin elasticity, suitable for anti-aging skincare needs.

4. Natural Acids

Natural acids are often used for exfoliation and brightening. For example, AHA (alpha-hydroxy acids), derived from fruit extracts, gently removes dead skin cells, improves dullness, and refines skin texture.

BHA (beta-hydroxy acids), derived from willow bark, penetrates pores to dissolve oil, reducing blackheads and acne. Lactic acid is known for its gentle exfoliation, making it suitable for sensitive skin.

5. Natural Minerals

Natural minerals are mainly used for sun protection and oil control. For example, titanium dioxide is a natural mineral sunscreen that reflects UV rays, protecting the skin from photoaging.

Kaolin clay is an absorbent mineral that effectively removes excess oil and impurities, purifies pores, and is often used in skin-cleansing products.

6. Other Natural Active Substances

Other natural active substances also play important roles in cosmetics. For instance, honey is a natural humectant rich in various sugars and minerals that deeply hydrate the skin and improve its barrier function.

Pearl powder is popular for its rich calcium and amino acid content, which not only whitens the skin but also reduces fine lines and dullness. Algae extracts contain a variety of minerals and polysaccharides, providing hydration, antioxidation, and enhanced skin repair. Spirulina, rich in proteins and vitamins, is one of the best ingredients for anti-aging skincare.

Chemical Ingredients in Skincare Products

Some ingredients, such as niacinamide (Vitamin B3), are naturally present in many foods, but extracting them directly from these sources is not economical. Their natural content is low, and the extraction cost is high, making it difficult to meet large-scale, high-purity demands. In such cases, synthetic production becomes a more reasonable choice.

Main Chemical Ingredients Overview

Which Is Safer

Natural ingredients come from nature, retaining the diversity and potential synergistic effects found in their natural state. For example, chamomile extract offers both anti-inflammatory and soothing properties for the skin. In contrast, chemically synthesized ingredients lack these characteristics and primarily serve a single function.

However, despite the many advantages of natural ingredients in cosmetics, there are challenges and considerations to keep in mind. First, natural ingredients may be less stable than synthetic ones and can be easily affected by environmental factors such as temperature and light. Second, the extraction and processing of natural ingredients require strict controls to ensure their quality and safety. Additionally, even natural ingredients can sometimes cause allergic reactions, particularly for individuals with sensitive skin.

Of course, some chemical ingredients (such as high-concentration salicylic acid and paraben preservatives) can also cause irritation or even raise health concerns. Moreover, it is worth noting that certain chemical ingredients, such as silicones, may pose potential environmental risks.

Market Trends: Natural Ingredients Replacing Synthetic Ones

As health and environmental awareness grow, consumers are more inclined to choose cosmetics containing natural ingredients. This trend is driving companies to make changes.

Firstly, companies are focusing on selecting environmentally and socially friendly alternatives that do not compromise product efficacy, safety, or shelf life. Advances in green chemistry and biotechnology have provided solutions, such as replacing petroleum-derived emollients with plant-based oils or squalane from sustainable sources.

Replacing synthetic preservatives with natural ones is another significant shift. Plant extracts and essential oils, such as tea tree, cinnamon, and thyme extracts, are leading this change by offering effective antibacterial protection and enhancing the sensory properties of products.

Stanford Chemicals Company (SCC) has over 16 years of experience in the manufacture and sale of skin care and personal care ingredients. We offer skin care ingredient raw materials to meet a variety of skin care needs.

Reference:

Common Skin Care Ingredients You Need to Know

Acids in Skincare: What Are the Different Uses and Precautions

Hyaluronic Acid vs. Retinol vs. Vitamin C: Which Is Best for Skincare?

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Multiple Functions of Sodium Hyaluronate

From skincare to medicine, joint care to genetic engineering, sodium hyaluronate has become an indispensable part of modern technology and daily life.

Fig 1. Wide range of uses for hyaluronic acid

–A Multifunctional Skincare Ingredient

Sodium hyaluronate is a star in skincare products. It boasts excellent moisturizing properties, repairs the skin barrier, and fights aging. It quickly increases the skin’s water content, restoring its radiance. Whether it’s a luxury serum or an affordable mask, you’re likely to find its presence.

Read more: Hyaluronic Acid vs Glycerin: Which is More Hydrating

–A Star Ingredient in the Beauty Industry

It is not only a key ingredient in skincare but also a celebrity in the beauty field. From injectable fillers and skin tightening to restoring elasticity, sodium hyaluronate plays a crucial role.

— A Key Component of Artificial Tears

For modern individuals who spend extended periods staring at screens, dry eye syndrome has become a common issue. Sodium hyaluronate, with its excellent lubricating and moisturizing properties, is widely used in artificial tears, effectively alleviating eye discomfort and fatigue.

Read more: From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health

— A Miracle Ingredient for Joint Pain Relief

Joint problems are often caused by the loss of hyaluronic acid in synovial fluid. Sodium hyaluronate is used in joint injection solutions to provide lubrication, reduce friction and pain, and restore mobility for osteoarthritis patients.

— Significant Applications in Medicine

In surgeries, sodium hyaluronate serves as a tissue filler or drug carrier, accelerating tissue healing and reducing inflammation. Additionally, it is used in wound repair and oral care, demonstrating extraordinary medical value.

How Molecular Weight Affects Sodium Hyaluronate Uses

The molecular weight of sodium hyaluronate determines its characteristics in absorption, penetration, lubrication, and repair, making it a crucial reference for its specific applications.

Fig 2. HA with different molecular weights has different permeability

–High Molecular Weight HA: Preferred for Barrier and Lubrication

High molecular weight (>1,800 kDa) sodium hyaluronate tends to remain on the surface, forming a viscoelastic film.

• Joint Treatment: In osteoarthritis therapy, it enhances the viscoelasticity of joint fluid, reduces friction, and alleviates pain.
• Ophthalmology: Its lubricating properties protect the cornea and alleviate discomfort in dry eyes, particularly for contact lens wearers.
• Food Industry: Used as a food additive to improve oral and esophageal lubrication, aiding those with swallowing difficulties.

— Medium Molecular Weight HA: Balanced Properties for Broad Applications

Medium molecular weight (200–1,800 kDa) sodium hyaluronate offers a balance of surface action and penetration.

• Medical Dressings: Exhibits excellent tissue repair properties for burns and wounds, covering surfaces while promoting regeneration.
• Drug Delivery: Used as a matrix material for drug delivery systems, enabling slow drug release and improved bioavailability.

— Low Molecular Weight HA: Core for Penetration and Repair

Low molecular weight (5-200 kDa) sodium hyaluronate has excellent penetration properties, reaching deep into tissues or cells.

Aesthetic Treatments: Used for deep tissue filling in injections, such as correcting depressions or scar repair.

• Drug Development: Its penetration performance makes it an effective drug carrier for cancer and immune regulation treatments.
• Anti-inflammatory and Immune Regulation: It modulates inflammatory responses, aiding in pathological inflammation suppression in immunological research and therapies.

— Ultra-Low Molecular Weight HA: Exploring Frontier Functions

Ultra-low molecular weight (<5 kDa) sodium hyaluronate has drawn attention in modern medicine and biotechnology.

• Gene Therapy: Serves as a new type of gene delivery vector, efficiently transporting gene fragments into nuclei for gene editing and cancer treatment.
• Anti-Aging Research: Directly activates repair mechanisms at the cellular level, potentially reversing aging processes.

Table 1. Comparison of high, medium, low, and ultra-low molecular weight hyaluronic acid: HA with different molecular weights has different water solubility, viscoelasticity, and uses.

Read more: Comparative Analysis of Hyaluronic Acid with Different Molecular Weights

Production Method: Microbial Fermentation

The microbial fermentation method employs microorganisms such as streptococci to produce sodium hyaluronate through fermentation. This process is more eco-friendly and safer than traditional animal tissue extraction, avoiding allergic risks from animal sources. It also allows precise control of molecular weight and purity, meeting diverse industry needs.

Read more: How is Hyaluronic Acid Powder Made

Derivatives of Hyaluronic Acid

To expand the applications of sodium hyaluronate, scientists have developed various derivatives through chemical modifications. For example, cross-linked hyaluronic acid is a derivative where molecular chains are connected with cross-linking agents to form a more stable 3D network structure.

These modifications significantly enhance its resistance to degradation while maintaining elasticity and water retention. Cross-linked hyaluronic acid is primarily used in long-lasting cosmetic fillers for wrinkle removal and shaping. It is also used in joint cavity injections to increase lubrication and alleviate pain.

Stanford Chemical Company (SCC) is a pioneer in the development of hyaluronic acid. Products include food-grade, medical-grade, cosmetic-grade, injectable-grade hyaluronic acid, and hyaluronic acid derivatives (Sodium Acetylated Hyaluronate and Cross-linked Hyaluronic Acid Gel). We can also provide customers with customized molecular-weight sodium hyaluronate powder. For more information or specific applications, please visit our homepage.

The post Sodium Hyaluronate: Uses, Molecular Weight, Production and Derivatives appeared first on Stanford Chemicals.

According to its purpose, HA can be divided into cosmetic-grade, food-grade, medical-grade, and injectable-grade. Of them, injectable-grade HA is extensively used in cosmetic surgery, joint therapy, and medical lubrication. How to choose suitable injectable-grade HA according to the particular requirement? Let’s discuss that.

What is Injectable-Grade Hyaluronic Acid

Injection-grade hyaluronic acid represents high-quality HA developed especially for medical and cosmetic injection purposes. It undergoes extensive purification processes to remove impurities and possible allergens, ensuring the following features:

• High Purity: It is of medical-grade quality, thus safe to be injected.
• High Biocompatibility: Very similar in structure to human tissues for maximum safety.
• Long-Lasting Stability: It degrades much more slowly, prolonging its effect.

This kind of HA is used for filling facial hollows, and lubricating joints, and can even enhance the smooth operation of surgical tools.

Key Considerations When Choosing Injectable-Grade Hyaluronic Acid

The key to selecting the right injectable-grade HA lies in understanding your application needs. Of course, we have summarized some core indicators here to help you understand your needs.

1. Molecular Weight

Molecular weight defines the viscoelasticity, absorption rate, and degradation time of HA. Generally speaking, high molecular weight works better for lubrication and support, while low to medium molecular weight serves for penetration and drug delivery.

2. Purity and Sterility

HA injections should have ultra-high purity, be free from impurities, and be manufactured under sterile conditions to minimize infection risk.

3. Biocompatibility

Good quality HA should be strictly tested for compatibility with human tissues to minimize inflammation or adverse reactions upon its use.

4. Certification and Credentials

Only choose products certified by international authorities such as FDA or CE to ensure good quality and safety.

Products meeting this criterion will perform well in the intended applications.

Read more: How is Hyaluronic Acid Powder Made

Suitable Molecular Weights for Different Scenarios

–Cosmetic Procedures

HA is commonly used in cosmetic procedures to fill facial hollows, reduce fine lines, and improve skin elasticity.

Studies have shown that HA with molecular weights in the range of 1,300 kDa–1,800 kDa provides optimal viscoelasticity and volumizing effects, which are crucial for facial contouring and dermal filler applications.[i]

The medium to high molecular weight provides the structural integrity needed to sculpt facial contours while maintaining biocompatibility and longer-lasting effects due to slower degradation rates.

–Joint Injections

For patients with osteoarthritis, HA injections are essential for pain relief and improved joint mobility.

The high molecular weight ensures a thick, viscous solution capable of providing cushioning for joints, mimicking natural synovial fluid.

–Medical Lubricants

HA is often used as a lubricant during surgical procedures to minimize friction between instruments and tissues, improving procedural efficiency.

Medium molecular weight (800 kDa–1,300 kDa) HA is well-documented for its flowability and lubricating properties, essential for reducing friction during surgical procedures.[ii]

Medium molecular weight strikes a balance between being easy to handle and highly effective as a lubricant, making it suitable for surgical applications requiring precise, smooth interactions.

Conclusion

It is easy to select the proper injectable-grade hyaluronic acid once the application scenario is clear. Cosmetic procedures require medium and high molecular weight products for excellent support and longevity of results. High molecular weight HA has better application in joint injections, as it maintains lubrication and cushioning.

Meanwhile, in medical lubricant applications, medium molecular weight HA remains flowable with safety features. Regardless of the application, always prioritize purity, sterility, and certifications to ensure safety and effectiveness.

Pure Injection Hyaluronic Acid (HA) Powder from Stanford Chemicals Company

Injection-grade hyaluronic acid from Stanford Chemicals Company (SCC) is GMP, CEP, and DMF certificated and the factory passed an on-site inspection by the US FDA. It is all fermented products, non-animal sources, non-GMO, and non-BSE/TSE risk.

Main Products:

References:

The 5 Common Uses of Injectable Hyaluronic Acid

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

[i] Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x. PMID: 19207319.

[ii] Cowman MK, Schmidt TA, Raghavan P, Stecco A. Viscoelastic Properties of Hyaluronan in Physiological Conditions. F1000Res. 2015 Aug 25;4:622. doi: 10.12688/f1000research.6885.1. PMID: 26594344; PMCID: PMC4648226.

The post How to Choose the Right Injectable-Grade Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. Its salt form, sodium hyaluronate (SH), was initially isolated from the eye’s vitreous body. Sodium hyaluronate has a wide distribution in animal or human tissues, generally located in the extracellular matrix. It has a high concentration in the vitreous humor, aqueous humor, synovial fluid, skin, and umbilical cord.

Sodium hyaluronate is known for its excellent viscoelasticity, unique rheological properties, pseudoplasticity, non-toxicity, and superior biocompatibility.

Fig 1. Artificial tears with hyaluronic acid as the main ingredient

Basis for Sodium Hyaluronate in Ophthalmology Applications

It is highly moisturizing. Sodium hyaluronate can bind water several hundred times its weight, maintaining the ocular surface moisture balance. Its viscoelastic nature allows it to form a stable film on the eye surface, providing lubrication and protection while reducing friction.

As a natural constituent of human tissues, sodium hyaluronate possesses excellent biocompatibility with minimal risk of rejection or irritation. Furthermore, it provides an enhancement in corneal repair and regeneration, reduces inflammation, and soothes discomfort due to environmental stimuli or surgical procedures.

Given these properties, sodium hyaluronate is widely used in ophthalmic products such as artificial tears, surgical viscoelastic fillers, ophthalmic injectables, and corneal repair agents. Its applications range from routine eye care to advanced surgical procedures.

Fig 2. Viscoelasticity of hyaluronic acid

Applications of Sodium Hyaluronate in Eye Health

The uses of sodium hyaluronate in ophthalmology can be roughly divided into two categories. There is ophthalmic viscoelasticity, mainly used in all sorts of ophthalmic surgeries including glaucoma and cataract surgery; another one is eye drops, mainly used in treating dry eyes and corneal burns.

1. Ophthalmic Viscoelastic Agents

1.1 Role in Surgery

Sodium hyaluronate is used as a viscoelastic agent in many eye surgeries. It has a high molecular weight and excellent viscoelasticity, providing mechanical protection for the surgery to take place. Therefore, it maintains structure and prevents tissue collapse or damage caused by surgical instruments.

• Glaucoma Surgery

Sodium hyaluronate protects intraocular tissues, maintains the shape of the anterior chamber, and reduces friction and damage from surgical tools, thus enhancing safety.

• Cataract Surgery

It acts to safeguard the cornea endothelium and to serve as an aid to the implantation of an intraocular lens. It provides a clearer surgical field and minimizes mechanical trauma to the cornea during surgery.

• Trauma Repair Surgery

Sodium hyaluronate serves as a lubricant for the surgical procedure in ocular traumatized patients, inhibits the adhesion of tissues, and provides an optimal environment for healing after surgery.

• Corneal Laser Surgery

The protective film helps prevent excessive drying of tissues and reduces mechanical irritation from surgical instruments.

1.2 Recovery Post-Surgery

Sodium hyaluronate after surgery promotes the repair of tissues, reduces inflammation, and speeds up healing. It keeps the environment moistened to reduce any discomfort for the patients in recovery.

2. Eye Drops

Sodium hyaluronate is used in eye drops for moisturizing and lubrication, relieving dry eyes, protecting the ocular surface, and promoting corneal repair. It is suitable for sensitive people and postoperative care.

2.1 Treatment for Dry Eye

Dry Eye is a chronic condition caused by insufficient tear production or excessive evaporation, leading to symptoms such as dryness, fatigue, and a foreign body sensation. Sodium hyaluronate excels in treating dry eye due to its strong moisturizing properties.

• It forms a uniform protective film on the ocular surface, enhancing tear film stability and preventing tear evaporation.
• Its high water retention alleviates dryness and improves patient comfort.
• It enhances the repair ability of ocular surface cells, preventing more severe damage caused by chronic dryness.

2.2 Corneal Burn Repair

Sodium hyaluronate plays a vital role in treating corneal burns, where the cornea experiences water loss, cell damage, and inflammation. It helps in several ways:

• Moisturizing and Lubricating
• Promoting Cell Regeneration
• Reducing Inflammation

2.3 Daily Eye Care

Sodium hyaluronate-based eye drops are also widely used for daily eye care, especially by individuals who use electronic devices for extended periods or wear contact lenses. These drops effectively relieve discomfort caused by eye strain or insufficient tears, providing long-lasting hydration and lubrication.

Product Recommendations

Stanford Chemical Company (SCC) is one of the leading US-based wholesalers of hyaluronic acid, offering a range of pure hyaluronic acid powders in medical, food, cosmetic, and injectable grades. These cover high, medium, and low molecular weights and also support customization.

The main products in eye health:

References:

Sodium Hyaluronate Used in Anterior Segment Eye Surgery

Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes

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