What Is Dihydromyricetin (DHM)

Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound known for its antioxidant properties. This compound is found predominantly in the Japanese raisin tree (Hovenia dulcis) and the Ampelopsis grossedentata plant.

These compounds help protect the body against oxidative stress and inflammation, which can lead to various chronic diseases. DHM, in particular, has gained attention for its unique properties and wide range of potential health benefits. It is commonly extracted from the Japanese raisin tree and is available in various forms.

Fig 1. Plant origin and chemical structure of dihydromyricetin

What Is Dihydromyricetin Used For

DHM is utilized for various purposes, because of its diverse therapeutic properties. Some of the primary uses include:

• Alcohol Hangover Relief: One of the most popular uses of DHM is to alleviate hangover symptoms.
• Anxiety Reduction: DHM has shown promise in reducing anxiety and promoting relaxation.
• Skin Health: Its antioxidant properties contribute to improved skin health and anti-aging effects.
• Hair Health: DHM may support hair growth and strength.
• Liver Protection: It offers hepatoprotective benefits, safeguarding the liver against damage.
• Headache Relief: DHM might help in reducing the frequency and severity of headaches.

Fig 2. The Benefits of Dihydromyricetin

–Dihydromyricetin for Hangovers

DHM has gained a lot of praise for its ability to lessen hangover symptoms. People think it works by speeding up how the liver breaks down alcohol and lowering alcohol’s effects on the brain. Research points to DHM changing the GABA receptors in the brain, which alcohol impacts. By getting these receptors back to normal, DHM can help ease symptoms like headaches feeling sick, being tired, and having a foggy mind that often comes with hangovers.

–Dihydromyricetin for Anxiety

Research indicates that DHM may have anxiolytic (anxiety-reducing) properties. It is thought to interact with the central nervous system in a way that promotes relaxation and reduces stress. The modulation of GABA receptors not only helps with hangovers but also plays a crucial role in anxiety management. By enhancing the calming effects of GABA, DHM can potentially reduce feelings of anxiety and improve overall mental well-being.

–Dihydromyricetin for Skin

DHM’s antioxidant qualities make it useful for skin health. Antioxidants fight free radicals, which can trigger oxidative stress and speed up aging and skin damage. By fighting these free radicals, DHM keeps skin elastic, cuts down on wrinkles, and helps maintain a young look. What’s more, it can calm irritated skin and lower the chances of acne and other skin issues because of its power to reduce inflammation.

–Dihydromyricetin for Hair

DHM also helps hair health. Its antioxidant traits shield hair roots from oxidative harm leading to healthier and stronger hair. Also, by boosting blood flow and cutting down on inflammation, DHM might help hair grow and stop hair loss. Using DHM supplements or putting it on your skin could result in thicker, shinier, and tougher hair.

–Dihydromyricetin for Liver

Dihydromyricetin offers a big plus: it guards the liver. Your liver cleans toxins from your body, and too much booze can hurt it. Studies show that DHM shields the liver from this harm. It does this by boosting enzymes that break down alcohol and cutting down on cell stress. This makes DHM a key helper for keeping your liver healthy especially if you drink alcohol.

Dihydromyricetin vs. Milk Thistle

People often compare milk thistle to DHM as a supplement for liver health. Both help protect the liver, but they work. Milk thistle has silymarin, which shields liver cells from toxins and helps the liver grow back. DHM speeds up how the body breaks down alcohol and cuts down on oxidative stress. While both supplements boost liver health, DHM might work better for quick hangover relief. Milk thistle, however, might offer wider liver protection over time.

Read more: Introduction to Milk Thistle: A Fatty Liver Savior

–Dihydromyricetin for Headache

Besides easing hangovers, DHM might also help reduce headaches. It affects GABA receptors and lowers inflammation, which can ease the pain and discomfort of headaches. Its support for liver function also plays a part. A healthy liver can clean toxins from the body more and cut down on things that trigger headaches.

Is Dihydromyricetin Safe

DHM has a reputation for safety among most users when consumed in proper amounts. Still, like any supplement, it might cause side effects. Some people could feel a bit sick to their stomach maybe feeling queasy or having loose stools. It’s crucial to check with your doctor before you start taking DHM if you have health issues or you’re on other meds. Pregnant and breastfeeding women should also seek medical advice before using DHM.

Dihydromyricetin: How Long to Work

The onset of DHM’s effects can vary depending on the individual and the context in which it is used. For hangover relief, many users report feeling better within 30 minutes to an hour after taking DHM. For anxiety reduction, it may take a few days of regular use to notice significant improvements. When used for skin and hair health, the benefits may become apparent over several weeks of consistent use. The protective effects on the liver can also be seen over time with regular supplementation.

Stanford Chemical Company (SCC) is an excellent supplier of herb extracts. We provide Dihydromyricetin (DHM), Swertiamarin, Shikimic Acid, and other extracts. For more information on these materials, please check our home page.

Conclusion

Dihydromyricetin is a versatile and beneficial supplement with a wide range of health applications. From alleviating hangovers and reducing anxiety to promoting skin and hair health and protecting the liver, DHM offers numerous advantages. While generally safe, it is essential to use DHM responsibly and consult with a healthcare provider before starting any new supplement regimen. As research continues, the full potential of DHM will likely become even more evident, solidifying its place in the world of natural health and wellness.

The post The Power of Dihydromyricetin: Uses, Benefits, and Safety appeared first on Stanford Chemicals.

Fig 1. Top 5 Benefits of DHM

1. DHM: The Antioxidant for Health and Wellness

Dihydromyricetin has excellent antioxidant activity, which offers several benefits.

Benefits of DHM in Antioxidant

DHM can scavenge free radicals. We know that excessive free radicals can cause cell damage and oxidative stress. Dihydromyricetin can react with free radicals and neutralize them.

Moreover, DHM can inhibit lipid peroxidation. Because the formation of lipid peroxides is prevented, the integrity of the cell membrane is protected.

In addition, Dihydromyricetin can upregulate the activity of antioxidant enzymes in the body. And then it can enhance the body’s antioxidant defense ability.

Applications Based on Antioxidant Properties:

This antioxidant effect shows great potential in various applications.

• Antioxidant Supplements: DHM is widely used in antioxidant supplements to help consumers neutralize excess free radicals, protect cells, slow aging, and prevent chronic diseases.
• Food Additives: DHM’s antioxidant properties make it an ideal natural food preservative, preventing lipid oxidation in foods, extending shelf life, and maintaining freshness and nutritional value.
• Anti-aging Skincare: Dihydromyricetin is commonly used in anti-aging skincare products. It can neutralize free radicals in the skin and prevent oxidative damage. Apart from that, DHM can reduce wrinkles and fine lines, and maintain skin elasticity and radiance.
• Sunscreen Products: DHM’s antioxidant effect helps counteract oxidative stress caused by UV radiation. It then protects the skin by reducing sun damage and photoaging.

2. DHM: The Natural Solution for Inflammation Relief

Extensive basic research and animal experiments have evidenced the anti-inflammatory effects of DHM. Clinical studies also provide compelling evidence of DHM’s anti-inflammatory efficacy in humans.

Benefits of DHM in Anti-inflammatory

Experimental evidence suggests that dihydromyricetin exerts its anti-inflammatory effects mainly through:

• Inhibition of Inflammatory Mediator Production: DHM reduces the production of cytokines and other inflammatory mediators.
• Regulation of Inflammatory Signaling Pathways: Dihydromyricetin modulates pathways such as NF-κB, which are crucial for the inflammatory response.
• Inhibition of Inflammatory Cell Migration and Activation: DHM prevents the movement and activation of cells involved in inflammation.

Fig 2. Anti-inflammatory effects of dihydromyricetin

Applications in Anti-inflammatory Treatments:

The above studies will provide a more solid scientific basis for the application of DHM in anti-inflammatory treatment.

• Anti-inflammatory Drugs: Dihydromyricetin is a promising candidate for developing drugs to treat various acute and chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
• Anti-inflammatory Health Supplements: Dihydromyricetin is used in health supplements to help consumers reduce chronic inflammation and prevent chronic diseases.
• Anti-inflammatory Skincare: DHM is used in skincare products to alleviate skin inflammation, such as acne and eczema, promoting skin health.
• Soothing Repair Products: The anti-inflammatory and antioxidant properties of Dihydromyricetin make it an ideal component in products designed to repair damaged skin and reduce inflammation.

More information: Dihydromyricetin (DHM) for Inflammatory Diseases and Anxiety Disorders

3. DHM: Nature’s Weapon Against Cancer

Multiple studies have shown that Dihydromyricetin can effectively inhibit the proliferation of various cancer cells in vitro, including liver cancer, breast cancer, gastric cancer, and lung cancer. In animal models, Dihydromyricetin has been proven to significantly suppress tumor growth. For instance, a study demonstrated that DHM significantly reduced tumor volume and weight in a mouse model of breast cancer while lowering tumor angiogenesis.[i]

Benefits of DHM in Anticancer:

• Inhibition of Cancer Cell Proliferation: DHM blocks the cell cycle, preventing cancer cells from dividing and growing.
• Induction of Cancer Cell Apoptosis: Dihydromyricetin triggers apoptosis, or programmed cell death, in cancer cells.
• Inhibition of Tumor Angiogenesis: DHM prevents the formation of new blood vessels that supply nutrients to tumors.
• Inhibition of Cancer Cell Invasion and Metastasis: DHM reduces the ability of cancer cells to invade surrounding tissues and spread to other parts of the body.

Applications in Cancer Treatment:

Although existing clinical research is still in its early stages, Dihydromyricetin, as a natural, low-toxic anticancer compound, has broad application prospects.

• Cancer Drug Development: DHM’s multiple anticancer mechanisms make it a potential candidate for developing anticancer drugs. It can be used alone or in combination with other chemotherapeutic agents to enhance efficacy and reduce side effects.
• Adjunctive Therapy: Dihydromyricetin can be used as an adjunctive treatment for cancer patients. It helps to mitigate the side effects of chemotherapy and radiation therapy.

4. DHM: Nature’s Defense for Liver Health

Dihydromyricetin is recognized for its potent antioxidant, anti-inflammatory, and antifibrotic properties, making it an effective liver-protective agent.

Benefits of DHM in Liver Protection:

Dihydromyricetin has a strong antioxidant effect and can reduce the damage of oxidative stress to liver cells. In addition, DHM can inhibit the production of inflammatory mediators, reduce inflammatory response, and thus protect the liver.

Additionally, dihydromyricetin can inhibit the progression of liver fibrosis. It reduces the degree of liver fibrosis by reducing the deposition of collagen and the activation of hepatic stellate cells.

DHM also can promote the regeneration and repair of liver cells and enhance the self-repair ability of the liver.

Applications in Liver Health:

DHM’s liver-protecting effect makes it widely used in health products and medicines.

• Liver Health Supplements: DHM is widely used in liver health supplements to improve liver function and prevent or mitigate alcohol-induced liver damage.
• Hangover Remedies: DHM is a key ingredient in hangover remedies. It aids in the acceleration of alcohol consumption and reduces hangover symptoms. Ultimately, it protects the liver from alcohol damage. Maybe you are interested: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?
• Anti-fibrotic drugs: Dihydromyricetin has anti-fibrotic properties. Therefore, It is a potential candidate for drugs to treat various fibrotic liver diseases.
• Hepatitis treatment: Dihydromyricetin is expected to reduce liver damage caused by viral hepatitis. So, it is used to develop drugs for hepatitis treatment.
• Functional foods: Dihydromyricetin is added to functional foods to enhance their health benefits.

5. DHM: A Natural Solution for Cardiovascular Health

Dihydromyricetin exhibits significant antithrombotic and lipid-lowering effects, which contribute to cardiovascular protection.

Benefits of DHM in Cardiovascular Protection

It can inhibit platelet aggregation and reduce the risk of thrombosis. In addition, DHM maintains the normal function of blood vessels by enhancing endothelial function, promoting vasodilation, and inhibiting vasoconstriction.

Applications in Cardiovascular Health:

DHM’s effects on the cardiovascular system have been applied in the healthcare and medical industries.

• Cardiovascular Health Supplements: DHM is used in supplements to help consumers prevent cardiovascular diseases and improve cardiovascular function. Its antioxidant and anti-inflammatory properties make it an ideal cardiovascular protective agent.
• Anti-Atherosclerotic Drugs: DHM’s anti-inflammatory and antioxidant actions make it a potential candidate for developing drugs to prevent and treat atherosclerosis.
• Lipid-Lowering Drugs: DHM’s ability to regulate lipid levels suggests it could be used in developing drugs to lower cholesterol and reduce the risk of cardiovascular diseases.

Additional Benefits of Dihydromyricetin

Dihydromyricetin is a versatile natural compound with a wide range of health benefits. In addition to the five benefits listed above, dihydromyricetin has other benefits.

1. Neuroprotective Effects

Dihydromyricetin has shown promising neuroprotective effects. DHM may help in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies suggest that DHM improves cognitive performance and memory by reducing oxidative stress and inflammation in the brain​.

2. Metabolic Health

DHM has been found to have beneficial effects on metabolic health.

• Improving Insulin Sensitivity: DHM enhances insulin sensitivity, which can help in managing blood sugar levels and reducing the risk of type 2 diabetes​.
• Reducing Fat Accumulation: DHM can inhibit the differentiation of preadipocytes into adipocytes, thus reducing fat accumulation and helping in weight management​.
• Lowering Blood Glucose Levels: DHM has been shown to lower fasting blood glucose levels in animal studies, indicating potential benefits for diabetic patients​.

Fig 3. blood glucose

3. Anti-aging Properties

Beyond its antioxidant effects, dihydromyricetin contributes to overall anti-aging. It’s because DHM may extend the lifespan of cells by protecting them from oxidative stress.​

4. Skin Health

DHM can reduce Hyperpigmentation and promote collagen production. In addition, dihydromyricetin’s antioxidant properties protect the skin from damage caused by UV radiation.

5. Immune System Support

DHM can modulate the immune system by enhancing immune response and regulating inflammatory responses.

Stanford Chemical Company (SCC) is a premium supplier of hyaluronic acid and herbal extracts. We offer Dihydromyricetin and Medical-grade Pure HA Powder. For more information on these products or specific applications, please contact us and check out our home pages.

Conclusion

The multiple health benefits of Dihydromyricetin make it a valuable compound for various applications in health and medicine. Its powerful antioxidant, anti-inflammatory, anticancer, liver-protective, and cardiovascular-protective properties provide a strong foundation for developing new health supplements, functional foods, and pharmaceuticals. As research continues, DHM’s full potential in promoting health and preventing disease will likely be further realized, offering new avenues for enhancing human well-being.

[i] Chen, L., Yang, Z.S., Zhou, Y.Z., Deng, Y., Jiang, P., Tan, S.L. (2020). Dihydromyricetin inhibits cell proliferation, migration, and invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells. Journal of Cancer, 11(19), 5689-5699. https://doi.org/10.7150/jca.45970.

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Dihydromyricetin (DHM) from the Japanese raisin tree carries a rich history in traditional medicine. It has traditional applications in mitigating upset stomachs and purportedly easing hangover symptoms. DHM also finds a place in modern supplements.

DHM from Raison Trees [1]

This article is going to discuss the diverse aspects of DHM. Hope that you can learn about its potential side effects, interactions with medications, etc.

What Are DHM?

Dihydromyricetin (DHM) is a prominent flavonoid compound. It is renowned for its origins in the Japanese raisin tree, termed Hovenia dulcis. You can also find its presence in various other plant sources.

This natural compound also has an alternate name ampelopsin. It holds a distinguished place in traditional medicine, particularly in Asian cultures.

• Antioxidant Powerhouse: DHM showcases robust antioxidant properties. This feature aids in combating oxidative stress and neutralizing free radicals. It potentially benefits overall health as well.
• Hangover Relief: DHM is not only notable for its historical use in traditional medicine. It also finds applications in modern supplements. This remedy alleviates hangover symptoms and settles upset stomachs.
• Liver Protection and Overall Health: DHM can support liver health and function. It has become a subject of ongoing research in liver protection. It is also being researched for its potential to mitigate oxidation and inflammation.

Related reading: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?

Does DHM Have Any Side Effects?

The reported side effects of DHM remain notably limited based on current available research. There are lots of related studies. Most of them are carried out on animals. These experiments consistently illustrate a lack of adverse effects, even when administered at relatively high doses.

Sparse customer reviews note occasional mild discomfort like abdominal discomfort, nausea, or diarrhea. However, these instances are infrequent and largely anecdotal. While human studies on this topic are limited, the developing safety profile shows promise.

In a word, the existing evidence hints at a safety profile for DHM. As the scientific exploration continues, a more thorough understanding of DHM’s safety profile will offer clearer insights.

Can DHM Have Interactions with Medications?

The potential interactions between supplements such as DHM and prescribed medications are a significant concern in healthcare considerations.

There are limited studies examining DHM’s impact on liver enzymes in animal models. Their varying outcomes prompt caution in DHM’s use. Namely, these herbal supplements might influence the liver enzymes responsible for metabolizing medications. This influence may result in altered drug effectiveness or potential toxicity risks.

Thus, it is advisable to seek guidance from healthcare professionals before integrating DHM with prescribed medications. In this way, we can mitigate potential adverse effects and ensure patient safety.

What Is the Recommended Amount of DHM?

Determining the ideal dosage of DHM for human consumption is an ongoing area of research.

Recent animal studies investigating DHM dosages have presented encouraging outcomes. These studies consistently administer high doses of DHM to animal subjects without observable adverse reactions. However, despite these promising findings in animal models, the establishment of precise and safe DHM dosages for human consumption requires further extensive research.

This pursuit aims to enhance safety measures and optimize the advantageous use of DHM across various applications.

How to Get Quality DHM?

Ensuring the quality of DHM requires several factors and reliable suppliers:

–Opt for Reputable Manufacturers:

Select DHM supplements or products from established and reputable manufacturers. Look for companies that operate in certified Good Manufacturing Practice (GMP) facilities. Manufacturers adhering to GMP guidelines ensure stringent quality control measures.

–Thoroughly Examine Product Labels:

Carefully scrutinize product labels to assess the ingredients and purity of DHM-containing supplements. Look for clear and transparent labeling. For instance, check the concentration of DHM per serving, additional additives, and any potential allergens.

Products with detailed and accurate labeling often reflect a commitment to quality and transparency.

–Research Supplier Track Record:

Conduct research on suppliers or manufacturers of DHM-containing products. You can refer to local authorities’ databases or consumer protection agencies. Check for any reported issues or complaints against these suppliers.

Verified positive track records and the absence of regulatory issues work. Such evidences provide confidence in the reliability and quality of the supplier’s offerings.

–Seek Third-Party Testing and Certifications:

Look for DHM supplements that undergo third-party testing by independent laboratories. Certifications or endorsements from reputable third-party organizations attest to the product’s quality, purity, and compliance with safety standards. Products with such certifications often display a higher level of commitment to quality and transparency.

–Consider Customer Reviews and Recommendations:

Explore customer reviews and feedback regarding DHM supplements or products from various suppliers. Genuine customer experiences can offer insights into the product’s efficacy, potential side effects, and overall satisfaction. Positive reviews and recommendations from consumers can guide them towards trustworthy suppliers offering quality DHM products.

–Consult Healthcare Professionals:

Consult healthcare professionals or nutritionists before choosing DHM supplements or putting them into your routine. Be more careful if you have existing health conditions or are taking medications. Healthcare professionals can offer personalized guidance and recommendations tailored to your specific health needs.

Conclusion

Current research and customer reviews suggest DHM is generally safe. Yet, comprehensive human studies are essential for conclusive evidence. As research into DHM continues, its safety profile and potential benefits will likely become clearer. So, it can provide more definitive guidance for consumers.

At Stanford Chemicals Company (SCC), we offer exclusively the finest quality Dihydromyricetin (DHM). Our DHM undergoes meticulous testing procedures to ensure both purity and effectiveness. For further information, please explore our homepage.

Reference:

[1] Raison Trees. (2024, August 9). In Wikipedia. https://en.wikipedia.org/wiki/Hovenia_dulcis

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In recent years, the exploration of natural compounds in the realm of medicinal research has gained significant attention. Among these compounds, dihydromyricetin (DHM) has emerged as a subject of interest.

This article is going to explore its properties in addressing two distinct yet interconnected health concerns: inflammatory diseases and anxiety disorders. Hope that you can have a further understanding of DHM’s uses.

Clinical Researches

What Is Dihydromyricetin (DHM)?

Dihydromyricetin comes from the ampelopsis plant species. It is a flavonoid known for its antioxidant and anti-inflammatory attributes. It has spurred investigations into its potential applications in combating various health issues.

–Antioxidant Powerhouse

One of the standout features is its robust antioxidant capacity. DHM has the ability to scavenge these free radicals. It serves as a potent defender against oxidative stress. Thus, DHM potentially aids in the prevention of various chronic diseases and promotes overall health.

–Anti-Inflammatory Properties

DHM has demonstrated notable anti-inflammatory effects in several studies. DHM has the potential to inhibit inflammatory pathways and reduce inflammation markers. It can manage inflammatory diseases like arthritis, inflammatory bowel diseases, and other systemic inflammatory conditions.

–Liver Protection and Detoxification

Research has indicated DHM properties to protect livers. Namely, it plays a role in safeguarding the liver from damage caused by toxins and oxidative stress. It supports liver function, aids in detoxification processes, and promotes liver health.

–Neuroprotective Effects

The influence of DHM extends to the brain. These are studies highlighting its neuroprotective potential. It has shown promise in protecting neurons from damage and supporting cognitive function. Moreover, DHM’s interaction with neurotransmitter pathways hints at its possible role in managing anxiety and stress-related disorders.

Related reading: DHM Dihydromyricetin: The Hangover Helper You Need

How Can Dihydromyricetin (DHM) Alleviate Inflammatory Diseases?

DHM shows new potential in the realm of medicinal research. Here are two notable examples:

Inflammation is a natural response by the immune system. It can escalate into chronic conditions if unchecked. DHM has shown promise in mitigating inflammation markers and modulating inflammatory pathways. Thus, DHM offers a glimpse of hope in managing inflammatory diseases.

–Mechanisms:

Research studies have indicated DHM’s ability to hinder the activation of certain inflammatory signaling molecules. By doing so, it potentially curtails the cascade of events that lead to heightened inflammatory responses. This property has attracted attention in the medical community for its possible implications in conditions like arthritis, inflammatory bowel diseases, and other systemic inflammatory disorders. [1]

–Other Potentials:

The anti-inflammatory potential of DHM extends beyond molecular pathways. Studies have observed its ability to reduce oxidative stress, which is a crucial factor in the progression of inflammatory diseases. By combating oxidative damage, DHM demonstrates a multifaceted approach to potentially mitigating the severity of these conditions.

How Does DHM Work in Anxiety Disorder Management?

Anxiety disorders are characterized by excessive worry, fear, and physiological responses. It affects millions worldwide. Emerging research hints at DHM’s capability to influence neurotransmitter activity in the brain. Thus, it serves as a potential treatment avenue for anxiety-related conditions.

–Mechanisms:

Neurotransmitters like GABA (gamma-aminobutyric acid) play a pivotal role in regulating anxiety. DHM has exhibited modulatory effects on GABA receptors, which could contribute to its anxiolytic properties. By enhancing GABAergic transmission, DHM might assist in calming the nervous system and reducing anxiety symptoms. [2]

–Other Potentials:

Furthermore, studies exploring DHM’s impact on brain receptors associated with anxiety responses have revealed promising results. Its interaction with specific neural pathways suggests a potential to alleviate anxiety symptoms by regulating the intricate balance of neurotransmitters involved in mood regulation.

The Need for Further Research

While preliminary findings regarding DHM’s efficacy in addressing inflammatory diseases and anxiety disorders are encouraging, it’s crucial to acknowledge the need for extensive research.

Clinical trials involving human subjects are indispensable to validate the safety, efficacy, and optimal dosage of DHM as a therapeutic agent. Comprehensive studies will offer a clearer understanding of its mechanisms of action and its potential side effects.

Conclusion: A Glimpse of Promise

The evolving landscape of natural compounds in healthcare continues to unravel potential solutions for prevalent health concerns. Dihydromyricetin, with its anti-inflammatory and potential anxiolytic properties, stands at the threshold of therapeutic advancement.

The journey of DHM from botanical origins to clinical applications holds promise in reshaping the approach to managing inflammatory diseases and anxiety disorders. While the initial research showcases its potential, further exploration and rigorous scientific inquiry are imperative to harness its full therapeutic potential and pave the way for its integration into mainstream healthcare practices.

As research advances, the potential of dihydromyricetin may offer hope for individuals grappling with the burdens of inflammatory diseases and anxiety disorders, presenting a natural alternative in the pursuit of improved health and well-being. For more information, please check our homepage at https://www.stanfordchem.com/.

Reference:

[1] Sun Y, Liu S, Yang S, Chen C, Yang Y, Lin M, Liu C, Wang W, Zhou X, Ai Q, Wang W, Chen N. Mechanism of Dihydromyricetin on Inflammatory Diseases. Front Pharmacol. 2022 Jan 18;12:794563. doi: 10.3389/fphar.2021.794563. PMID: 35115939; PMCID: PMC8804380.

[2] Dr Jing Liang (2021, January 29). Dihydromyricetin shows promise as an anxiety disorder treatment. Research Outreach. Retrieved December 27, 2023, from https://researchoutreach.org/articles/dihydromyricetin-shows-promise-anxiety-disorder-treatment/

The post Dihydromyricetin (DHM) for Inflammatory Diseases and Anxiety Disorders appeared first on Stanford Chemicals.

Dihydromyricetin (DHM) has emerged as a subject of growing interest in clinical research due to its diverse pharmacological properties and potential therapeutic applications. Current investigations are shedding light on its promising implications across various health conditions. This condition paves the way for potential clinical uses and future directions in medical practice.

Research and Innovations

This article is going to discuss the features and uses of DHM. Hope that you can have a better comprehensive understanding.

What Is Dihydromyricetin (DHM)?

Dihydromyricetin (DHM) is a natural flavonoid compound. It is derived from certain plant sources, notably from the Hovenia Dulcis tree. It’s recognized for its various pharmacological properties and has gained attention for its potential health benefits.

DHM possesses several notable characteristics:

1. Antioxidative Properties: It exhibits strong antioxidative effects, so it helps to neutralize free radicals in the body, and reduces oxidative stress and potential cell damage caused by reactive oxygen species.
2. Anti-inflammatory Activity: DHM demonstrates anti-inflammatory properties. Thus, it may help alleviate inflammation-related issues by modulating the body’s inflammatory responses.
3. Hepatoprotective Effects: It’s been studied for its potential to protect the liver from damage caused by toxins or alcohol consumption. DHM shows promise in supporting liver health and mitigating liver damage.
4. Metabolic Effects: Recent research indicates DHM’s role in influencing metabolic processes. It’s being investigated for its potential in regulating glucose metabolism, improving insulin sensitivity, and its effects on lipid metabolism.

Further research is ongoing to ascertain its effectiveness and optimal usage in clinical settings.

Related reading: DHM Dihydromyricetin: The Hangover Helper You Need

What Are the Clinical Uses of Dihydromyricetin (DHM)？

The clinical uses of DHM are still being extensively researched and explored. Ongoing studies and preliminary research suggest several potential clinical uses for DHM:

–Metabolic Disorders:

DHM is able to regulate metabolic parameters. That has attracted attention in addressing conditions like diabetes, obesity, and dyslipidemia. Clinical studies exploring its impact on insulin sensitivity, glucose regulation, and lipid metabolism are underway. It also has potential as an adjunct therapy for managing metabolic disorders.

In the realm of diabetes, early research has shown promising outcomes related to DHM’s influence on insulin sensitivity. Studies suggest that DHM might assist in enhancing insulin sensitivity, a critical aspect of managing diabetes. By potentially improving the body’s response to insulin, DHM could offer a pathway toward better glycemic control and, in turn, help regulate blood sugar levels more effectively.

Moreover, investigations into DHM’s effects on glucose regulation have yielded intriguing results. Preliminary studies hint at its ability to modulate glucose metabolism, potentially contributing to maintaining optimal blood glucose levels. This avenue of research presents a promising prospect for individuals grappling with diabetes or those at risk of developing the condition.

–Liver Health:

There is much more research focusing on DHM’s effects on liver-related issues, particularly non-alcoholic fatty liver disease (NAFLD) because DHM has the capacity to mitigate hepatic steatosis and reduce inflammation in the liver. Clinical trials investigating its role in liver health and potential applications in liver disease management are ongoing.

NAFLD is a prevalent liver condition. NAFLD is characterized by the accumulation of fat in the liver cells. This condition often occurs in individuals without excessive alcohol consumption. DHM has emerged as a potential therapeutic agent due to its observed effects on mitigating hepatic steatosis. Preliminary research suggests that DHM might hold promise in reducing the buildup of fat in liver cells, which is a crucial step in managing NAFLD.

Moreover, the compound’s anti-inflammatory properties have been of particular interest in the context of liver health. Inflammation plays a pivotal role in the progression of liver diseases, including NAFLD. DHM’s potential to reduce inflammation in the liver has sparked clinical trials aiming to delve deeper into its mechanisms and effectiveness in attenuating liver inflammation.

–Anti-inflammatory Properties:

DHM’s anti-inflammatory characteristics have implications for conditions associated with chronic inflammation, such as metabolic syndrome and related disorders. Clinical studies aim to elucidate its impact on inflammatory markers and its role in reducing systemic inflammation.

–Neuroprotective Potential:

Preliminary research suggests DHM’s neuroprotective properties. That means it has the potential to address neurological conditions. Clinical investigations focusing on its effects on neurodegenerative diseases and cognitive health are in progress, exploring its possible therapeutic role.

–Safety and Tolerance:

Ongoing clinical trials are assessing DHM’s safety profile, including its dosage, potential side effects, and long-term safety. Understanding its pharmacokinetics and ensuring its tolerability in various patient populations is critical for its clinical translation.

However, while the findings above are promising, comprehensive clinical trials elucidating DHM’s efficacy, safety profile, and optimal usage in varied patient populations are still needed for clinical practice. Continued research endeavors will shape its potential as a valuable therapeutic tool in addressing a spectrum of health conditions.

Conclusion

Dihydromyricetin (DHM) stands at the forefront of clinical exploration due to its various pharmacological properties and therapeutic applications. As research continues to unravel its diverse mechanisms and effects, DHM shows promising prospects across various health conditions. Its antioxidative, anti-inflammatory, hepatoprotective, and metabolic-regulatory attributes have sparked keen interest in the medical community.

Stanford Chemicals Company (SCC) exclusively offers top-tier Dihydromyricetin (DHM) and firmly backs our product’s quality. Our DHM is produced within the United States. These products undergo rigorous testing protocols to ensure unmatched purity and effectiveness. Feel free to reach out to us if you’re interested.

The post Clinical Research of Dihydromyricetin (DHM) appeared first on Stanford Chemicals.

We’ve all been there—waking up after a night of celebration only to be greeted with the dreaded hangover. The pounding headache, queasy stomach, and overall feeling of exhaustion can put a damper on your day. While there’s no magical cure for a hangover, there is a natural extract that may help alleviate some of those symptoms. Enter DHM Dihydromyricetin, the hangover helper you need.

Excessive Drinking

Understanding DHM Dihydromyricetin

DHM is derived from the Japanese Raisin Tree (Hovenia dulcis) and has long been used in traditional medicine for its potential to support liver health and ease the aftereffects of excessive alcohol consumption. Recent scientific research has shed light on its mechanisms of action and its ability to provide relief from hangover symptoms. Let’s dive into the reasons why DHM is gaining popularity as a go-to hangover remedy.

Related reading: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?

DHM

Mechanisms of DHM Dihydromyricetin

–Enhanced Alcohol Metabolism

One of the primary causes of hangovers is the accumulation of acetaldehyde, a toxic byproduct of alcohol metabolism. DHM has been shown to enhance the breakdown of acetaldehyde, helping the body process alcohol more efficiently. By promoting faster metabolism, it may reduce the duration and severity of hangover symptoms, allowing you to bounce back more quickly.

–Reduced Inflammation

Alcohol consumption can lead to increased inflammation in the body, contributing to hangover symptoms such as headaches and body aches. DHM has demonstrated anti-inflammatory properties, helping mitigate inflammation and reduce discomfort. By soothing the inflammatory response, it provides relief from these nagging hangover symptoms and supports a quicker recovery.

–Antioxidant Protection

Alcohol consumption generates free radicals in the body, leading to oxidative stress and cell damage. DHM exhibits strong antioxidant properties, helping neutralize these free radicals and reduce oxidative stress. By providing antioxidant protection, it contributes to overall health and aid in the recovery process after a night of indulgence.

–Liver Detoxification

Excessive alcohol intake puts a significant strain on the liver, leading to liver damage and compromised detoxification processes. DHM has been found to have hepatoprotective effects. It can enhance the activity of detoxifying enzymes, reduce inflammation in the liver, and provide antioxidant support, all of which contribute to a healthier liver and more efficient detoxification processes. Besides, DHM has shown potential in regulating cholesterol levels by reducing LDL (bad cholesterol) and increasing HDL (good cholesterol) levels, thus helping maintain healthy cholesterol levels.

–Improved Cognitive Function

The neuroprotective effects of DHM have also attracted attention from researchers. DHM has shown promising results in protecting brain cells from damage caused by oxidative stress and neurotoxic substances. It may help enhance cognitive function, improve memory, and even have potential applications in the prevention and treatment of neurodegenerative diseases.

While more research is needed to fully understand the extent of its neuroprotective effects, DHM’s properties make it an intriguing candidate for neurological health.

Incorporating DHM Dihydromyricetin into Your Routine

DHM is available in supplement form, making it convenient to incorporate into your routine. When choosing a DHM supplement, be sure to select a reputable brand that offers a high-quality product. Follow the recommended dosage instructions provided by the manufacturer, and if you have any underlying health conditions or are taking medications, it’s always best to consult with a healthcare professional before starting any new supplement regimen.

Remember, while DHM can support your body’s recovery after drinking, it’s important to consume alcohol responsibly and in moderation. It is not a license to overindulge but rather a natural aid to help your body recover more efficiently.

Conclusion

In a word, DHM Dihydromyricetin offers potential relief from hangover symptoms through enhanced alcohol metabolism, reduced inflammation, antioxidant protection, liver support, and improved cognitive function. Consider adding DHM to your hangover recovery toolkit and embrace the potential benefits of this natural extract. Also, please stay hydrated, eat nourishing foods, and get plenty of rest to aid in your recovery.

Stanford Chemicals Company (SCC) provides quality Dihydromyricetin (DHM) and stands behind our product. Our DHM products are rigorously tested for purity and effectiveness. For more information, please check our homepage.

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Dihydromyricetin (DHM, or Ampelopsin) is a herbal hangover treatment. It is a special type of flavonoid extracted from the oriental raisin trees. Dihydromyricetin has been used as traditional medicine for alcohol-related diseases in China, Japan, and other parts of Asia, and it received popularity in the West recently.

Dihydromyricetin stands out for its anti-alcohol effect. It could relieve hangover symptoms by promoting alcohol metabolism and enhancing the liver. DHM also has potential effects on alcohol addiction and other alcohol-related illnesses. Dihydromyricetin has anti-oxidation, anti-inflammation, and anti-tumor effects as well. Let’s discuss the strong anti-alcohol effect of this natural vine tea extract in detail.

2.   Does DHM (Dihydromyricetin) actually reduce hangovers?

Alcohol-related diseases have dogged us for years. According to World Health Organization, 5.1% of the global burden of disease and injury is attributable to alcohol [1]. There are 88, 000 alcohol-related deaths in the U.S. and 3 million deaths around the world every year [2]. Not to mention, drunkenness could trigger unpleasant feelings including headache, nausea, vomiting, anxiety, clumsiness, and disordered speech.

Thanks to its anti-alcohol effect and hepatoprotective feature, dihydromyricetin can reduce these symptoms in the following ways:

• Reducing alcohol level:

Dihydromyricetin enhances the performance of two alcohol-eating enzymes, so the alcohol intoxication level is reduced more quickly and efficiently.

Excessive consumption of alcohol leads to an excessive amount of ethanol and acetaldehyde, which increase the burden on livers and accumulate toxic byproducts. Two enzymes, ADH and ALDH, help your body to break down them. DHM helps produce more ADH and ALDH and increases their activities, so alcohol inside would be reduced faster.

• Avoiding liver damage

Potential liver-related damage can be avoided because dihydromyricetin eases the burden of the liver and reduces toxic products in the liver.

For one thing, DHM reduces the burden on the liver by breaking down ethanol and acetaldehyde faster. For another, DHM reduces the fat accumulation and inflammation elements in the liver. Fat increases the possibility of liver diseases such as cirrhosis. Inflammation factors like cytokines bring about cellular damage to the liver and other organs. Such damage would be avoided due to DHM.

• Curing alcohol withdrawal symptoms

There is a large possibility that DHM helps to cure alcohol addiction and withdrawal diseases like anxiety, tolerance, and seizures.

3.   Is dihydromyricetin safe?

Dihydromyricetin is quite safe to take. First, it has been used as a natural hangover treatment for over 500 years in Asia. There is no side effect report in academic research on animals and human beings since DHM has been applied to reduce hangovers. Additionally, you could find thousands of positive reviews of DHM-contained hangover supplements. However, please use DHM properly and drink alcohol wisely.

4.   How do you use dihydromyricetin powders?

Based on current research on animals, the recommended dosage of dihydromyricetin range is 80-1200mg, and the best dosage of DHM is around 300mg. However, healthier drinking habits work much better. Please drink more water and have something to eat before dining out.

The best time to use dihydromyricetin varies. If you use DHM as prevention, it is recommended to take the herbal supplement 30 minutes before you drink alcohol. If you take it to reduce hangovers, it is always the best time. DHM can do better work in your sleep.

5.   Conclusion

The article above offers a detailed discussion about the effect, usage, and safety of dihydromyricetin. Hope you can have a better understanding of DHM and its effect on drunkenness. Stanford Chemicals is a leading supplier of the most effective hangover treatment. DHM products are stored in cool and dry places, and they are protected from direct sunlight and heat. The specifications of our products are listed as follows.

Table 1 Dihydromyricetin Specifications

Furthering Reading: Everything You Need to Know About Dihydromyricetin

Reference:

[1] World Health Organization (2022, May 9). Alcohol. Retrieved January 16, 2023, from https://www.who.int/news-room/fact-sheets/detail/alcohol

[2] World Health Organization. Global Status Report on Alcohol and Health. 2014. Geneva, Switzerland: World Health Organization; 2014.

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What Are Flavonoids?

Flavonoids are chemicals produced by plants, having a wide range of benefits to both the plant and prospective immunocompromised patients. Some of these functions include: protecting plants from stress and contributing to the smell and color of fruit and flowers. To the human body, they help in the regulation of cellular activity and wrestle against free radicals responsible for oxidative stress. Flavonoids are more like antioxidant agents.

What Does Dihydromyricetin Treat?

The usefulness of Dihydromyricetin cuts across, improving a wide range of both medical and even mental complications. This includes its ability to cure infections inflicted by parasites and counteract the harmful effect of drug abuse or overdose. They are also effective in treating anxiety, depression, and other mental issues.

Other functions include regulation of cancer activity, cell death mediating activity, metabolism mediating activity, neuroprotective activity, and anti-inflammatory activity. Dihydromyricetin activates enzymes such as alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), which are responsible for breaking down and metabolizing alcohol faster, hence its characteristics preventing hangovers.

Chemical Properties of Dihydromyricetin

PubChem CID: 161557

Molecular Formula:  C₁₅H₁₂O₈

Molecular Weight: 320.25

Structure:

How Do You Use Dihydromyricetin Powders?

The quickest way to start feeling the impact of dihydromyricetin is by consuming the powdered state. This rapidly enhances its potency. The ingestion method is a very effective way to take in the drug. You can dissolve some milligrams of the DHM powder in a glass of juice of your choice and then drink.

You can also dissolve the powder in water before consumption in some cases. In this way, however, you get to taste the herb, and it may not precisely give that sweet taste you’d probably hoped for. It is advisable to take the mixture at home and rest afterward.

Recommended dosage:  You can consume 300-4000mg of dihydromyricetin powder.

How Do You Use Dihydromyricetin Capsules or Pills?

If you’re comfortable swallowing capsules and pills, you may consider taking this option. DHM pills or capsules may not be as fast as the DHM powder, but the effects vary. The capsules are designed to be easy to swallow with water or juice.

You can take the dihydromyricetin pills or capsule anywhere: in a gathering of friends, in your home, or workplace, or just wherever you feel comfortable. Since these are capsules, it would take your system some time to dissolve when you swallow them. Therefore, it takes a while to see its effect.

Recommended dosage: 1-2 pills are okay for consumption, depending on the case.

For Hangover Prevention, Should I Take DHM Before or After Drinking?

It is best to take the drug just immediately after drinking. In this way, you get to feel the drug’s effect more intensely. Some persons, in several reviews, have attested to the effective working power of the drug, rating it about 97-100% effective. It is important to note that DHM will not stop you from getting drunk. It only reduces the impact of alcohol.

How Safe is Dihydromyricetin?

There’s no need to be bothered about how safe consuming this drug is. The herb has been used for ages, in some parts of the world, and all the while, it has worked well, without posing severe health implications.

However, this is not to say that there may not arise cases where dihydromyricetin may tend to cause some side effects. It is just that generally, these side effects are both rare and mild. However, should you experience any form of reaction just after consuming the drug, it is advisable to visit a doctor.

Conclusion

Dihydromyricetin is an anti-oxidation drug that reduces blood glucose levels and protects the liver. At Stanford Chemicals, we sell high-quality Dihydromyricetin (DHM) powders following the best standard practices to ensure that they are tested rigorously for purity and effectiveness. Contact us to get your Dihydromyricetin powder with a purity above 98%, or call us at (949) 812 6690 or (949) 468 0555 to place your order.

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The Biological Experiment of Dihydromyricetin Extract

It is reported that on January 13, 2012, the Oriental Morning Post reported that researchers at the University of California in Los Angeles developed a new drug using Fructus aurantii extract, which could be injected into mice to relieve alcohol, which could relieve the “top” symptoms in a short period of time.

The researchers used the Fructus aurantii extract Dihydromyricetin (DHM) to observe the antialcoholism efficacy of different medicinal herbs. They let the mice drink a certain amount of alcohol in 2 hours, which was equivalent to drinking 15 to 20 bottles of beer. As expected, most of the mice were drunk and the rest had not been touched even after being knocked down. Within 1 hour, the symptoms of drunkenness began to weaken, and mice gradually resumed their control of the body.

In the second part of the experiment, the researchers injected the mice with alcohol and injected them with dihydromyricetin, and found that the mice increased their ability to control their own behavior, delayed the onset of drunken symptoms, and recovered about 15 minutes after drunkenness.

Moreover, rats injected with dihydromyricetin for two days in a row were less excited, had spasticity and other drunken symptoms, and were not “greedy”, which meant that dihydromyricetin had a certain inhibitory effect on alcohol addiction.

It is observed that the effect of dihydromyricetin is effective. Drinking and ingestion of rattan tea containing dihydromyricetin can quickly remove alcohol and make the problem of hangovers effectively restrained.

Antibacterial Effect of Dihydromyricetin Extract

The pharmacological experiments showed that Dihydromyricetin had bacteriostasis effect on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, bacilli, Saccharomyces cerevisiae, myxomyces, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor, and Rhizopus, especially gram positive, gram negative cocci.

It has many functions:

1) Dihydromyricetin can Clear the free radical in the body and Antioxidation:

The vine tea extract can effectively level down lipid peroxidation. It can prevent the oxidative damage of antioxidase in the body caused by the free radical. Then it can improve the oxidation resistance of the human body;

2) Dihydromyricetin can Antibiotic Action:

The vine tea extract has the strong inhibitory action of staphylococcus aureus and Bacillus subtilis. It also has inhibitory action of Aspergillus flavus, Aspergillus niger, Penicillium, and Alternaria. Dihydromyricetin has the inhibitory action of Staphylococcus aureus, Staphylococcus aureus(S. aureus), and Pseudomonas aeruginosa.

3) Dihydromyricetin can Protect the Liver:

Dihydromyricetin has a strong inhibitory action on the rise of ALT and AST in the blood Serum. It can lower the total bilirubin in the blood serum. So it has the strong action of lowing the aminotransferase and jaundice. The vine tea extract can restrain liver fibrosis in the rat.

4) Dihydromyricetin can Reduce the levels of blood sugar and blood fat:

Dihydromyricetin can reduce the blood fat levels in the mouse. It can decrease the damage to liver cells caused by high blood fat levels and improve the antioxidation ability. At the same time, it can lower the levels of high blood sugar.

5) Dihydromyricetin can Anti-inflammation:

The vine tea extract can effectively restrain the mouse pinna swelling caused by xylene. It can also restrain the writhing response in the mouse caused by acetic acid.

6) Dihydromyricetin can Anti-tumor:

The vine tea extract has effectively restrained to cell proliferation of some tumor cells.

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1. Drink water

To wake up feeling refreshed the next day after drinking, make sure you don’t dehydrate before you start drinking. Drinking prevents the production of a chemical called vasopressin. This helps our kidneys to deliver water directly to the bladder, rather than to absorb it into your body. In fact, drinking means that you drain more than four times the water than usual. This can lead to dehydration, which is the main cause of hangover headaches and dry mouth. So before you start drinking, your goal is to drink more water. You can drink up to eight glasses of water a day.

2. Eat greasy food

Food helps to slow down the absorption of alcohol. In particular, if you eat greasy food before drinking, fat will line up on the wall of your stomach. This will help slow down the speed at which alcohol enters the bloodstream, which means that you need more time to get drunk. You can also drink a full glass of milk or olive oil, which may help.

3. Drink coffee and take aspirin

A  study published in the Journal PIOS ONE in 2010 found that caffeine in coffee and anti-inflammatory ingredients in aspirin reacts to compounds of ethanol (pure alcohol). Ethanol causes a headache due to the chemical acetate.
However, it is important to know that coffee does dehydrate. However, it can cause an increase in adrenaline, which will give rise to false energy. Be careful when drinking coffee and taking painkillers at the same time.

4. Take a bath

Taking a cold bath can refresh your mind and make you feel active. You can also try switching between hot and cold water. But be careful when you do this because it will impact your body and cause more damage.

5. Exercise

When you exercise, endorphins are released to boost your mood. It also helps to consume the calories you get when you drink alcohol. However, make sure you drink water while exercising so that you don’t become more dehydrated. Exercise may require some willpower, but it will certainly help improve your body and mind.

6. Take a break

Sleeping for a while will help your body recover. An extra hour or two in bed will help your body get the rest it needs. You may need to postpone your plan for a day. However, if you need to work, you’d better take an aspirin and go back to work.

7. Try traditional Chinese medicine therapy

Maybe you feel like a witch stirring her beer, but Chinese medicine therapy can help you replenish lost nutrients. Dihydromyricetin can effectively help relieve hangover headaches.

8. Keep drinking water or juice

You still need to keep your body hydrated. Supplementing your body with water or fruit, Vitamin C, or vegetable juice will help you regain the balance you want. It is a good choice to add lemon juice to warm water.

9. Eat toast or crackers

In hangovers, original bagels, toast, and biscuits are good choices. Although they may not be the most delicious snacks, chances are you don’t like them. But hangovers can cause your blood sugar levels to drop – pure carbohydrates will help raise your blood sugar and stop vomiting.

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