Hyaluronic acid (HA, or (C14H21NO11) n) is highly hydrating, and it is widely used in the cosmetic industry. It is a polymer of sugar commonly found in human skin, eyes, and joints. All these HA inside keep your body moist, soft, and smooth.

A range of hyaluronic acid products is used for water retention. According to its different usages, it can be divided into four types: the cosmetic grade, the food grade, the medical grade, and the injection grade. The cosmetic grade is quite popular among beauty lovers, yet the food grade hyaluronic acid is also of great importance thanks to its moisture and anti-aging effect. Here we discuss the benefits, usage, and more of food-grade hyaluronic acid in the article.

Food Grade Hyaluronic Acid

Is Food Grade Hyaluronic Acid Worthwhile?

Absolutely yes. You can easily find food-grade hyaluronic acid content in beverages, vitamins, capsules, and supplements because of the following advantages.

1. It helps your body and skin lock water inside your body.

The weight of water that HA attracts is more than 1,000 times that of itself. Therefore, you just need to take a tiny amount of HA to give a big drink of water to your skin. In addition, your skin will look refreshing in the long term.

2. It assists you to fight against aging and other skin problems.

Food-grade hyaluronic acid supplements reduce your skin’s wrinkles and make it more flexible. It also protects your body from harmful elements such as UV rays and environmental pollutants. HA could accelerate cell growth as well.

Related reading: What are the Top Benefits of Micro Hyaluronic Acid for Your Skin?

Is There A Plant-based Hyaluronic Acid?

There are mainly two ways to produce hyaluronic acid: animal sources and fermentation. Stanford Chemicals provide non-animal food-grade hyaluronic acid for supplementation. You can make inquiries to buy quality food grade HA.

1. Plant-based HA is obtained from microbial fermentation.

This is a method extensively used to make food-grade hyaluronic acid because it is more cost-effective and eco-friendly.

2. Animal sources were used in the past.

The earliest source to get HA is the combs of roosters, yet it was abandoned for low efficiency and complicated process.

Stanford Chemicals is a supplier of high-purity food-grade hyaluronic acid powder. We ensure that our hyaluronic acid is non-animal and environmental-friendly. Here are the specifications of these products.

Table 1 Specifications of

Food Grade Hyaluronic Acid

How to Take Food-Grade Hyaluronic Acid?

Food-grade hyaluronic acid is taken in the form of common food like jelly, dairy, and drinks. You can get this natural humectant from tablets, capsules, and other healthy foods as well.

1. HA supplementation by mouth could be useful and safe if the dosage is under 200 mg every day.
2. Remember to talk to a healthcare provider whenever needed.
3. Besides, the amount of HA used varies. For instance, it is suggested to take 5 mg for one cycle to cure thumb osteoarthritis.

Can You Safely Ingest Hyaluronic Acid?

Yes. Food-grade hyaluronic acid is rather safe for ingestion. The reason is listed as follows.

1. HA is a substance found in the human body.
2. Report on the adverse effects of HA is rare.
3. However, take professional instructions from doctors if needed.
4. Take caution if you are allergic or pregnant.

Conclusion

Food-grade hyaluronic acid is a natural humectant with numerous applications, and it could attract water to your skin under normal dosage. Hope that you can have a better comprehension of food-grade hyaluronic acid and its usage. Stanford Chemicals have rich experience in the manufacturing and sale of HA. Sodium hyaluronate powder and other derivatives of HA are also available. Check our website to find great food-grade hyaluronic acid products.

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Dihydromyricetin (DHM, or Ampelopsin) is a herbal hangover treatment. It is a special type of flavonoid extracted from the oriental raisin trees. Dihydromyricetin has been used as traditional medicine for alcohol-related diseases in China, Japan, and other parts of Asia, and it received popularity in the West recently.

Dihydromyricetin stands out for its anti-alcohol effect. It could relieve hangover symptoms by promoting alcohol metabolism and enhancing the liver. DHM also has potential effects on alcohol addiction and other alcohol-related illnesses. Dihydromyricetin has anti-oxidation, anti-inflammation, and anti-tumor effects as well. Let’s discuss the strong anti-alcohol effect of this natural vine tea extract in detail.

2.   Does DHM (Dihydromyricetin) actually reduce hangovers?

Alcohol-related diseases have dogged us for years. According to World Health Organization, 5.1% of the global burden of disease and injury is attributable to alcohol [1]. There are 88, 000 alcohol-related deaths in the U.S. and 3 million deaths around the world every year [2]. Not to mention, drunkenness could trigger unpleasant feelings including headache, nausea, vomiting, anxiety, clumsiness, and disordered speech.

Thanks to its anti-alcohol effect and hepatoprotective feature, dihydromyricetin can reduce these symptoms in the following ways:

• Reducing alcohol level:

Dihydromyricetin enhances the performance of two alcohol-eating enzymes, so the alcohol intoxication level is reduced more quickly and efficiently.

Excessive consumption of alcohol leads to an excessive amount of ethanol and acetaldehyde, which increase the burden on livers and accumulate toxic byproducts. Two enzymes, ADH and ALDH, help your body to break down them. DHM helps produce more ADH and ALDH and increases their activities, so alcohol inside would be reduced faster.

• Avoiding liver damage

Potential liver-related damage can be avoided because dihydromyricetin eases the burden of the liver and reduces toxic products in the liver.

For one thing, DHM reduces the burden on the liver by breaking down ethanol and acetaldehyde faster. For another, DHM reduces the fat accumulation and inflammation elements in the liver. Fat increases the possibility of liver diseases such as cirrhosis. Inflammation factors like cytokines bring about cellular damage to the liver and other organs. Such damage would be avoided due to DHM.

• Curing alcohol withdrawal symptoms

There is a large possibility that DHM helps to cure alcohol addiction and withdrawal diseases like anxiety, tolerance, and seizures.

3.   Is dihydromyricetin safe?

Dihydromyricetin is quite safe to take. First, it has been used as a natural hangover treatment for over 500 years in Asia. There is no side effect report in academic research on animals and human beings since DHM has been applied to reduce hangovers. Additionally, you could find thousands of positive reviews of DHM-contained hangover supplements. However, please use DHM properly and drink alcohol wisely.

4.   How do you use dihydromyricetin powders?

Based on current research on animals, the recommended dosage of dihydromyricetin range is 80-1200mg, and the best dosage of DHM is around 300mg. However, healthier drinking habits work much better. Please drink more water and have something to eat before dining out.

The best time to use dihydromyricetin varies. If you use DHM as prevention, it is recommended to take the herbal supplement 30 minutes before you drink alcohol. If you take it to reduce hangovers, it is always the best time. DHM can do better work in your sleep.

5.   Conclusion

The article above offers a detailed discussion about the effect, usage, and safety of dihydromyricetin. Hope you can have a better understanding of DHM and its effect on drunkenness. Stanford Chemicals is a leading supplier of the most effective hangover treatment. DHM products are stored in cool and dry places, and they are protected from direct sunlight and heat. The specifications of our products are listed as follows.

Table 1 Dihydromyricetin Specifications

Furthering Reading: Everything You Need to Know About Dihydromyricetin

Reference:

[1] World Health Organization (2022, May 9). Alcohol. Retrieved January 16, 2023, from https://www.who.int/news-room/fact-sheets/detail/alcohol

[2] World Health Organization. Global Status Report on Alcohol and Health. 2014. Geneva, Switzerland: World Health Organization; 2014.

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Hyaluronic acid (HA, or (C14H21NO11) n) is an important humectant. It is a polymer of disaccharides composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid is an important component of the human intercellular matrix, such as the body’s connective and neural tissues.

Hyaluronic acid locks water molecules inside the human body like skin and joints. It is applied to a variety of fields for its water retention function. HA can also promote cell proliferation and differentiation and remove oxygen-free radicals, so it is generally used to make skin-care products for moisture and anti-aging. Additionally, this humectant is also found in the medical field to treat arthritis and cataract.

Hyaluronic acid is commonly manufactured by industrial synthesis. Stanford Chemicals Company is an experienced supplier of hyaluronic acid of different grades. For more information about HA and related products, please check our website.

2.   What is sodium hyaluronate?

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of sugar, and it is composed of Na-glucoronate-N-acetyl glucosamine. This sodium salt could be found in the extracellular matrix of mammalian connective, neural tissues, and the corneal endothelium.

Sodium hyaluronate is a synonym for hyaluronic acid. In fact, the two terms are often used interchangeably in the skincare field. Sodium hyaluronate can keep moisture and promotes cell growth and renewal as well. This humectant is applied to different beauty products to keep moisture and reduce the effect of aging. It is also used in medical surgeries.  Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier.

Similarly, sodium hyaluronate is obtained from animal tissues or bacterial fermentation. Stanford Chemicals Company provides high-quality sodium hyaluronate within a short lead time.

3.   What are the differences between hyaluronic acid and sodium hyaluronate?

Hyaluronic acid and sodium hyaluronate are both popular choices for cosmetic uses. They are both hydrating and anti-aging. Consumers can find hyaluronic acid and its salt form in many products like serums and creams. They are also applied to oral supplements.

What is the biggest difference? Sodium hyaluronate has a smaller molecular size, which means that it can penetrate the skin better. Other than that, they both offer the same benefits.

They have a slight difference in terms of features.

• Sodium hyaluronate is more stable than hyaluronic acid. The salt form is a more stable version, and it could resist oxidation for its higher stability.
• It is easier for sodium hyaluronate to penetrate the skin surface and enhance the skin barrier. Sodium hyaluronate has a lower molecular size, so it could penetrate deeper and provide intense hydration.
• In short, hyaluronic acid attracts water molecules on the surface, while its sodium salt moist cells deeper. Other than that, they offer the same benefits for beauty lovers.

4.   Can you use hyaluronic acid and sodium hyaluronate together?

Beauty lovers can use hyaluronic acid and sodium hyaluronate together to moisturize their skin. These chemicals are both gentle and highly hydrating. Both ingredients are suitable for all skin types and compatible with other ingredients. Use them together for an intense hydration effect.

Cosmetic products like serums, moisturizers, and facial oil containing hyaluronic acid and sodium hyaluronate  can provide diverse benefits as listed:

• Hydration Effect: The key benefit of these two chemicals is hydration. They could continuously draw moisture in from the surrounding environment and provide lasting hydration for the skin in the long term.
• Repairing Effect: They are helpful to protect our body from harmful toxins like UV rays, environmental pollution, and drastic temperature changes.
• Protective Barrier: In the long term, hyaluronic acid and its sodium salt could form a complex mesh structure and strengthen the protective barrier for the skin. Wrinkles would be reduced and the plump and glowing skin would be obtained.

5.    Conclusion

Hyaluronic acid and sodium hyaluronate nearly represent the same chemical, and the two terms are often used interchangeably in the skincare and medical world. You can use them at the same time for a better hydrating effect. The slight difference is that sodium hyaluronate is more stable and penetrates the surface of the skin more easily than hyaluronic acid.

Stanford Chemicals Company is a pure organic hyaluronic acid wholesale supplier. Hyaluronic acids of medical grade, cosmetic grade, and food grade are available on our website. High molecular weight, middle molecular weight, and low molecular weight sodium hyaluronate are also available. They are applied to a range of fields including food supplements, cosmetics, eye drops, and pharmaceuticals. For more detailed information, please visit our website.

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Hyaluronic acid (abbreviated HA), or (C14H21NO11) n, was discovered in 1934 by Karl Meyer and John Palmer from the vitreous body in a cow’s eye. Its structure was analyzed later. It is a disaccharide unit glycosaminoglycan composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid belongs to the intercellular matrix of the human body, and it plays an essential role in water retention and regulation of osmotic pressure. Hyaluronic acid keeps moisture and offers a protective barrier for the human body, especially in the eyes, joints, and skin. It is an important chemical substance used in many industries, especially the cosmetic industry.

What Is Micro Hyaluronic Acid?

Micro hyaluronic acid is a type of hyaluronic acid with a relatively smaller size and larger impact. It is a low molecular weight HA (<5K Da), even lower than mini HA (<10K Da). As introduced at the beginning, hyaluronic acid is a polymer. Large molecules of hyaluronic acid, it is difficult to penetrate the skin. Yet tiny molecules could get deeper into the skin and promote cell proliferation and differentiation. So, smaller fragments like the Micro hyaluronic acid can penetrate the skin much easier and have a better regenerating effect.

Micro-HA Super Active Hyaluronic Acid is a new low molecular weight active ingredient. It is made by a unique enzymatic degradation technology with superb biological activity. Micro-HA can keep moisture, protect the skin against inflammation and sensitivity, and get into the epidermis and the dermis to scavenge free radicals. For more information about Micro-HA and related quality products, please check our website.

How to Get Micro Hyaluronic Acid?

There are three ways to obtain micro hyaluronic acid. Their advantages and disadvantages are listed as follows.

• Animal Sources: This was the earliest way to get Micro hyaluronic acid. However, it was abandoned for the low extraction rate, the huge cost, and the complex isolation process.
• Industrial Synthesis: It is the most common way to get Micro hyaluronic acid nowadays. Micro hyaluronic acid can be produced quickly and efficiently.
• Microbial Fermentation: It is a new method to produce hyaluronic acid to replenish the HA in the human body.

What Are the Benefits of Micro Hyaluronic Acid?

Micro Hyaluronic Acid in the Cosmetic Industry

Micro hyaluronic acid is widely used for cosmetic products. A range of products, from initial cream, lotion, essence capsules, and film paste to bath liquid, powder, lipstick, shampoo, and conditioner, use this substance and provide a great user experience for beauty lovers.

1. Hydration

The key benefit of micro hyaluronic acid is hydration. Micro hyaluronic acid contains numerous carboxyl and hydroxyl groups, so it can be linked with a large amount of water – it can absorb more than 1,000 times its weight in water. Generally, using a small amount of micro hyaluronic acid is like a big drink of water for your skin. What’s more, it could continue to draw moisture in from the surrounding environment and provide lasting hydration for the skin in the long term.

2. Repairing

Micro hyaluronic acid is helpful to protect our body from harmful toxins every day. A lot of things from UV rays to environmental pollution like drastic temperature changes can cause damage to our skin, such as more wrinkles, dark spots, and drier skin. Other harmful factors include excessive cleaning, excessive skin care, and excessive makeup. While micro hyaluronic acid promotes cell growth and accelerates the repairing of these damages.

3. Protection

It also has some preventive effects, such as regulating inflammatory factors, promoting cell proliferation and differentiation, and scavenging free radicals. In the long term, it forms a complex mesh structure and serves as a good protective barrier for the skin.

4. Increase Resilience

Micro hyaluronic acid is easy to penetrate into the epidermis and dermis because of its extremely low molecular weight. According to statistics, the absorptivity of Micro hyaluronic acid was 35.6% after 0.5 hours, 52.5% after 1 hour, 81.9% after 8 hours, and more than 90% after 24 hours. Compared with its equivalent, Micro hyaluronic acid is more protective.

Micro Hyaluronic Acid in Other Sectors

Micro hyaluronic acid is not only a substance used for skincare products. It is also used in medical sectors, research, etc.

• It is used to treat osteoarthritis of the knee via intra-articular injection.
• It is used to create artificial tears to treat dry eyes.
• Due to its high biocompatibility, it is used in tissue engineering research and regenerative medicine research.
• Medical hyaluronic acid could be used in eye surgery like cataract surgery, glaucoma surgery, and surgery to repair a retinal detachment.

Where to Buy the Best Micro Hyaluronic Acid?

Stanford Chemicals Company is a pure organic hyaluronic acid wholesale supplier in the USA. The company has rich experience in the production and sales of medical-grade, cosmetic-grade, and food-grade hyaluronic acid (HA). The high molecular weight, middle molecular weight, and low molecular weight hyaluronic acid powder are available as well. We offer hyaluronic acid raw materials to customers in the USA, Canada, and Europe. A detailed description of Micro hyaluronic acid is listed below. For further information, please make your inquiry.

020-000-118 Micro Hyaluronic Acid Specification

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Micro Hyaluronic Acid is a sugar that is found naturally in our skin that holds water and helps keep it hydrated and plump. It’s so impressive, that not only can it hold a thousand times its weight in water, but keep that water from leaving the skin and evaporating into the air.

To put that in perspective, just ONE gram of Micro Hyaluronic Acid can hold six liters of water. It also regulates moisture within the skin cells so as to not drown them. Not only can Micro Hyaluronic Acid boost your skin’s moisture levels, but it keeps your skin hydrated for long-term positive effects. You may also find it as sodium hyaluronate, which is derived from HA and is the sodium salt portion of HA that has been isolated.

Why Is Micro Hyaluronic Acid Used in Skincare?

With all of that, if you’re looking for plump, elastic, skin, Micro Hyaluronic Acid is going to be a favorite of yours. If a topical product claims to be hydrating, it likely is powered by Micro Hyaluronic Acid. But aging and environmental aggressors reduce the naturally occurring Micro Hyaluronic Acid in your body, making it an incredibly valuable active ingredient.

What Are the Top Benefits of Micro Hyaluronic Acid for Your Skin?

• It hydrates and plumps skin, reducing the appearance of fine lines and wrinkles as well as generally reducing signs of aging.
• It promotes a healing environment in the skin, reducing redness and dermatitis.
• It has antioxidant properties, which could protect the skin from environmental aggressors.
• It’s ideal for all skin types, even sensitive, acne-prone, or oily skin.
Because of all these incredible benefits, Micro Hyaluronic Acid is one of the best skincare active ingredients on the market.

What Is the Right Way To Apply Micro Hyaluronic Acid?

There are many forms of Micro Hyaluronic Acid. It exists naturally in your body, for example, but it also exists as an injectable filler (like Juvéderm and Restylane). However, you’re likely most familiar with it as the active ingredient in topical products from serums to face masks to moisturizers and more. The most popular Micro Hyaluronic Acid products are serums, which are best used after toner and before moisturizing.

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Sodium Hyaluronate for Skin

Sodium Hyaluronate can be found abundantly in the dermis, helping skin retain its moisture.

The skin remains hydrated and the surface is supple when the skin contains adequate concentrations of hyaluronic acid.

Sodium Hyaluronate for Joint

Joint fluid and articular cartilage contain hyaluronic acid at high concentrations. HA serves as a lubricant (preventing bone-to-bone friction) and as a cushion. This function allows our joints to move smoothly.
A joint function-improving agent with hyaluronic acid as its active pharmaceutical ingredient is a prescription drug.

Sodium Hyaluronate is injected into joints to treat patients suffering from knee osteoarthritis, periarthritis of the shoulder (also known as frozen shoulder syndrome), and knee pain from rheumatoid arthritis. Hyaluronic acid has been reported to have anti-inflammatory and pain-relieving effects in such uses.

Sodium Hyaluronate for Eyes

The vitreous body contains high concentrations of Sodium Hyaluronate, which provides cushioning and plays a role in maintaining the shape of the eyeball.

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Sodium Hyaluronate Powder for Skin

It provides comprehensive and multi-layered care for the skin. It provides long-lasting moisturization, reaching the bottom of the skin to restore hydration and radiance.
It is composed of various derivatives of sodium hyaluronate, cationic hyaluronic acid, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, 1,2-pentanediol, 1,2-secanediol, glycerin, and water.

What Happens If You Apply Sodium Hyaluronate Powder to Dry Skin?

1. Adsorbs on the surface of skin hairs, is rinse-resistant and plays a continuous hydrating role.
2. Forms a breathable film to lock in moisture and isolate it from UV rays.
3. It can nourish the skin and increase the elasticity of the skin.
4. Mild and non-irritating, the acetyl group introduced penetrates into the muscle base and moisturizes deeply.
5. Penetrates the skin, deeply hydrates, and revitalizes cellular activity.
6. Deep penetration to form an invisible dense protective film, anti-inflammatory and allergy-relieving cell barrier.
7. It can moisturize for a long time, reach the bottom of the muscle and replenish water efficiently, make the skin recover hydrated and glowing, and enhance the key role of permeability, water locking and moisturizing, anti-aging, etc. on the basis of single sodium hyaluronate moisturizing properties.

What Are the Features of Sodium Hyaluronate Powder?

1. Golden ratio: Based on the characteristics of sodium hyaluronate and its derivatives with different molecular weights, it is scientifically proportioned through research and testing.
2. Multi-level action: Multi-molecular weight sodium hyaluronate and its derivatives play different efficacy roles to build a three-dimensional action framework and stronger water-locking and moisturizing performance.
3, Safe and stable: raw material compliance production, quality system strict control, to ensure the quality of the product and safety.

What Are the Applications of Sodium Hyaluronate Powder?

Hair care: shampoo, conditioner, hair mask, etc.
Skincare: moisturizing water, lotion, cream, essence, etc.
Washing and care: facial cleanser, makeup remover, etc.
External medical devices: cold compresses, moisturizing patches, etc.

Conclusion

STANFORD CHEMICALS keeps improving its own R&D capability and quality management system,  insists on green scientific production, and helps SCC brand to build a powerful Sodium Hyaluronate Powder for functional skin care products!

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1, Medium molecular weight sodium hyaluronate

Highly effective in moisturizing and lubricating the skin.

2, High molecular weight sodium hyaluronate

Excellent moisturizing and film-forming properties, efficient thickening effect, and enhanced lubricating feeling when applying products.

3, Sodium Oligomeric Hyaluronate

Efficient moisturizing and lubricating effect on the skin. Enzymatic cutting process, molecular weight less than 10000, real transdermal absorption, deep moisturizing, anti-aging, after-sun repair.

4, low molecular weight sodium hyaluronate

Nutritious skin, breathable and moisturizing, will not bring any sticky skin feeling.

Cosmetic-grade sodium hyaluronate application

1. Formulation application

Medium to high molecular HA to enhance the lubrication of the skin
Medium to high molecular HA increases the consistency of the system
Medium-high molecule HA provides an immediate tightening sensation when absorbed quickly
Oligomeric HA for fast transdermal absorption, enhancing product absorption efficiency

2. Moisturizing and anti-wrinkle effects

The moisture level of skin is closely related to the HA content, as we age, the HA content in the skin decreases, making the water retention function of the skin weaken, resulting in wrinkles. Oligomeric HA can penetrate into the dermis and replenish the endogenous HA of the human body. The HA filled in the dermis can promote the targeted growth of collagen and elastin fibers, tighten the skin and delay the aging process.

3. Skin damage repair and prevention effect

HA promotes the regeneration of injured skin by promoting the proliferation and differentiation of epidermal cells.

Advantages of sodium hyaluronate

– Controlled environment

Standardized clean production plants, strict production management processes, and advanced production equipment avoid the introduction of impurities and contamination by pathogenic microorganisms during the production process.

– High purity

The sodium hyaluronate produced by SCC is refined by fermentation and extraction of Streptococcus oryzae as the strain, with high purity and low content of protein, heavy metal, and other impurities.

– Sodium Oligomeric Hyaluronate

We use sodium hyaluronate hydrolase enzymatic digestion to obtain the product with extremely low molecular weight, and the quality reaches the international first-class level, which is the oligomeric sodium hyaluronate with a molecular weight of less than 10,000.

– Aseptic

Medical-grade sodium hyaluronate is produced with injection water and a partially sterile production plant to ensure the production of sterile products with endotoxin below 0.05 EU/mg.

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Intra-articular injection

It is used to treat knee pain in patients with osteoarthritis who are not receiving relief from other treatments. It is injected into the joint capsule to act as a shock absorber and lubricant for the joint. Thus, sodium hyaluronate is used as a viscosupplement to increase the viscosity of the synovial fluid through a series of injections into the knee joint, helping to lubricate, cushion, and reduce joint pain. It is often used as a last resort before surgery and provides symptomatic treatment to relieve pain by restoring viscoelasticity to the joint fluid and stimulating the production of new substances from the synovial fluid.

The use of sodium hyaluronate may reduce the need for joint replacement. Injections appear to improve effectiveness at 4 weeks, peak at 8 weeks, and maintain some effectiveness at 6 months, with greater benefit for osteoarthritis than oral analgesics. It may also be effective when used with the ankle joint.

Intraocular viscoelastic injection

It is used as an adjuvant for atrial and vitreous humor in ophthalmic surgery, such as for cataract extraction (intracapsular and extracapsular), IOL implantation, corneal transplantation, glaucoma filtration, and retinal attachment surgery, and for the treatment of the dry eye.

In surgical procedures on the anterior segment of the eye, the viscoelasticity of sodium hyaluronate drops enables the maintenance of a deep chamber during surgical operations, as the solution does not flow out of the open anterior chamber, thus allowing efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues of the eye. Its viscoelasticity also helps push the vitreous face back and prevents the formation of a postoperative flattened cavity.

In posterior segment surgery, sodium hyaluronate is used as a surgical aid to gently separate, manipulate and fix the tissue. It creates a clear field of view for intraoperative and postoperative examination of the retina and photocoagulation.

Sodium hyaluronate is also used to coat the bladder lining in the treatment of interstitial cystitis.

Skin injections in plastic surgery

Sodium hyaluronate is injected to reduce the appearance of wrinkles on the face. As of 2017, the FDA has approved 13 hyaluronate preparations as so-called dermal fillers. They are also used as fillers for the lips or other parts of the body, although not approved by the FDA. The filler effect is temporary, lasting about six months or longer in most people.

Topical application

The topical application of sodium hyaluronate promotes the absorption of biomolecules (i.e., drugs) and acts as a nano-carrier. Its effect on the skin depends on the hyaluronate formulation and skin health: in skin lacking a barrier, it limits the delivery of biomacromolecules to the stratum corneum and the viable epidermis. In normal skin, low molecular weight hyaluronate (5 kDa) enhances the penetration into the epidermis.

Transepidermal water loss increased by 55.5% in the low molecular weight group, decreased by 28% in the cross-linked elastic group, and decreased by 16% in the HMW group. The addition of skin care creams became popular in the second millennium. Its efficacy on wrinkles has not been tested in clinical trials.

Dry, scaly skin, such as that caused by atopic dermatitis, can be treated with lotions or other skin products that contain sodium hyaluronate as their active ingredient.

Higher molecular weight hyaluronates appear to last longer in the lungs after dropping into the lungs, but if >215 kD, lung infiltration and mucociliary clearance are poor. Hyaluronates may allow access to lymph nodes that drain the lung bed.

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With the loss of facial sodium hyaluronate with aging, the skin will appear dehydrated, with fine wrinkles and facial depressions, which very much affects the five features of the candidate, hyaluronic acid. Human skin also contains a substance that contains a large number of water molecules, and therefore loved by the majority of candidates.

Beauty and skin care

Human skin maturation and aging process also change with the content and metabolism of hyaluronic acid, which can improve skin nutrient metabolism, make skin soft, and smooth, wrinkle, increase elasticity, prevent aging, and is a good transdermal absorption promoter at the same time as moisturizing.
Used in combination with other nutrients, it can have a more desirable effect of promoting nutrient absorption.

Wrinkle removal

As we age, staying up late, smoking and gravitational traction will lead to the loss of hyaluronic acid, which in turn will gradually reduce collagen and skin elastic fibers, causing skin laxity and resulting in facial wrinkles, which can be effectively solved by hyaluronic acid for a variety of wrinkles.

Fillers

It can be used for shaping the nose and chin as well as filling in depressed scars.

Hyaluronic acid is very effective whether it is to improve skin condition, lighten fine lines, or fill facial depressions, but it should be noted that there are many types of hyaluronic acid and different types of hyaluronic acid improve different problems.

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